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Function : Vancomycin resistance (via D-Ala-D-Lac precursor)

Function Description

ID NFUNC_0089
Created 2014-07-28
Description Resistance to vancomycin is due to the presence of operons that encode enzymes (1) for synthesis of low-affinity precursors, in which the C-terminal D-alanine residue is replaced by D-lactate, thus modifying the vancomyin-binding target; and (2) for elimination of the high-affinity precursors that are normally produced by the host, thus removing the vancomycin-binding target.
Comment Not assigned
Cross Reference Wikipedia Vancomycin
MetaCyc vancomycin resistance I
PMID 16323116
PMID 24220108

Function Constitution

TypePattern Component Gene
Vancomycin resistance (via D-Ala-D-Lac precursor)(NFUNC_0089)
RequireA
VANA
(NRULE_0265)
D-alanine--D-lactate ligase
VANH
(NRULE_0266)
D-specific alpha-keto acid dehydrogenase
VANX
(NRULE_0267)
D-alanyl-D-alanine dipeptidase
Participant 
VANYA
(NRULE_0274)
D-alanyl-D-alanine carboxypeptidase
 
VANYB
(NRULE_0275)
D-alanyl-D-alanine carboxypeptidase
 
VANYD
(NRULE_0276)
D-alanyl-D-alanine carboxypeptidase
 
VANY
(NRULE_0277)
D-alanyl-D-alanine carboxypeptidase
 
VANYN
(NRULE_0278)
D-alanyl-D-alanine dipeptidase/D-alanyl-D-alanine carboxypeptidase
 
VANRA
(NRULE_0279)
Two-component system response regulator VanR
 
VANRB
(NRULE_0280)
Two-component system response regulator VanR
 
VANRD
(NRULE_0282)
Putative two-component system response regulator VanR
 
VANR
(NRULE_0284)
Two-component system response regulator VanR
 
VANSA
(NRULE_0285)
Two-component system histidine kinase VanS
 
VANSB
(NRULE_0286)
Two-component system histidine kinase VanS
 
VANSD
(NRULE_0288)
Putative two-component system histidine kinase VanS
 
VANSM
(NRULE_0289)
Putative two-component system histidine kinase VanS
 
VANS
(NRULE_0290)
Two-component system histidine kinase VanS
 
VANZ
(NRULE_0291)
Teicoplanin resistance protein
 
VANW
(NRULE_0292)
Putative vancomycin resistance protein
 
VANJ
(NRULE_0295)
Teicoplanin resistance protein
 
VANK
(NRULE_0296)
Glycyltransferase VanK
 
MURF2
(NRULE_0297)
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-lactate ligase

Potential Functional Microbe

Scientific nameNBRC No.
Amycolatopsis azurea14573
Amycolatopsis mediterranei13415
Catenulispora acidiphila102108
Conexibacter woesei100937
Kribbella flavida14399
Saccharothrix espanaensis15066
Stackebrandtia nassauensis102104
Streptomyces sviceus13980
Tsukamurella paurometabola16120