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機能 : Vancomycin resistance (via D-Ala-D-Ser precursor)

機能情報

ID NFUNC_0090
作成日 2014/07/28
説明 Resistance to vancomycin is due to the presence of operons that encode enzymes (1) for synthesis of low-affinity precursors, in which the C-terminal D-alanine residue is replaced by D-serine, thus modifying the vancomyin-binding target; and (2) for elimination of the high-affinity precursors that are normally produced by the host, thus removing the vancomycin-binding target.
コメント 該当データなし
参照 Wikipedia Vancomycin
MetaCyc vancomycin resistance II
PMID 16323116

機能構成

タイプパターン 構成遺伝子
Vancomycin resistance (via D-Ala-D-Ser precursor)(NFUNC_0090)
必須A
VANC
(NRULE_0268)
D-alanine--D-serine ligase
VANT
(NRULE_0269)
Serine/alanine racemase
VANXY
(NRULE_0270)
D-alanyl-D-alanine dipeptidase/D-alanyl-D-alanine carboxypeptidase
B
VANG
(NRULE_0271)
D-alanine--D-serine ligase
VANTG
(NRULE_0272)
Serine/alanine racemase
VANXYG
(NRULE_0273)
D-alanyl-D-alanine dipeptidase
任意 
VANRC
(NRULE_0281)
Putative two-component system response regulator VanR
 
VANRG
(NRULE_0283)
Putative two-component system response regulator VanR
 
VANSC
(NRULE_0287)
Putative two-component system histidine kinase VanS
 
VANWG
(NRULE_0293)
Putative vancomycin resistance protein
 
VANU
(NRULE_0294)
Putative transcriptional regulator

機能が推定される微生物

学名NBRC番号
Enterococcus gilvus100696