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Rule : 3-oxoadipate enol-lactone hydrolase/4-carboxymuconolactone decarboxylase (PCAL)

Rule Description

ID NRULE_0071
Rule name PCAL
Created 2015-02-27
Protein name
Protein name
Full
3-oxoadipate enol-lactone hydrolase/4-carboxymuconolactone decarboxylase
EC
EC 3.1.1.24
EC 4.1.1.44
Gene name pcaL
Rule Trigger TIGRFAMs; TIGR02425; hit=1ANDTIGRFAMs; TIGR02427; hit=1
Cross Reference
Gene Ontology
GO
GO:0047570, F:3-oxoadipate enol-lactonase activity, IEA:UniProtKB-EC
GO:0047575, F:4-carboxymuconolactone decarboxylase activity, IEA:UniProtKB-EC
GO:0042952, P:beta-ketoadipate pathway, IEA:InterPro
GO:0019614, P:catechol-containing compound catabolic process, IEA:InterPro
Phylogenomic databases
KO
K14727, -
Enzyme and pathway databases
UniPathway
UPA00157, UER00266
UPA00157, UER00261
Family and domain databases
InterPro
IPR029058, AB_hydrolase
IPR000073, AB_hydrolase_1
IPR029032, AhpD-like
IPR003779, CMD-like
IPR012788, Decarb_PcaC
IPR026968, PcaD/CatD
Pfam
PF02627, CMD, 1
PRINTS
PR00111, ABHYDROLASE
TIGRFAMs
TIGR02425, decarb_PcaC, 1
TIGR02427, protocat_pcaD, 1
Feature Not assigned
General annotation
Catalytic activity
2-carboxy-2,5-dihydro-5-oxofuran-2-acetate = 4,5-dihydro-5-oxofuran-2-acetate + CO(2)
3-oxoadipate enol-lactone + H(2)O = 3-oxoadipate
Pathway
Aromatic compound metabolism; beta-ketoadipate pathway;
Reference
O67982 Rhodococcus opacus (Nocardia opaca).
9495744
Characterization of a protocatechuate catabolic gene cluster from Rhodococcus opacus 1CP: evidence for a merged enzyme with 4-carboxymuconolactone-decarboxylating and 3-oxoadipate enol-lactone-hydrolyzing activity. (J Bacteriol. 1998)
Q0SH24 Rhodococcus jostii (strain RHA1).
25558786
In vitro reconstitution of the catabolic reactions catalyzed by PcaHG, PcaB, and PcaL: the protocatechuate branch of the beta-ketoadipate pathway in Rhodococcus jostii RHA1. (Biosci Biotechnol Biochem. 2015)



Related Function

Function name
Catechol degradation (beta-ketoadipate pathway)
Protocatechuate degradation (beta-ketoadipate pathway)

CDS

Data Download
Scientific name NBRC No. CDS Product name
Azorhizobium caulinodans14845AZC_1444beta-ketoadipate enol-lactone hydrolase
Catenulispora acidiphila102108Caci_48873-oxoadipate enol-lactonase
Cupriavidus metallidurans102507Rmet_40163-oxoadipate enol-lactonase
Gordonia amarae15530GOAMR_52_000403-oxoadipate enol-lactone hydrolase/4-carboxymuconolactone decarboxylase
Rhodococcus erythropolis100887RER_528903-oxoadipate enol-lactone hydrolase/4-carboxymuconolactone decarboxylase
Rhodococcus opacus108011ROP_105403-oxoadipate enol-lactone hydrolase/4-carboxymuconolactone decarboxylase
Streptomyces avermitilis14893SAV1706putative 3-oxoadipate enol-lactone hydrolase
Streptomyces ghanaensis15414SSFG_009733-oxoadipate enol-lactone hydrolase
Streptomyces sviceus13980SSEG_089403-oxoadipate enol-lactonase
Thermobispora bispora14880Tbis_28323-oxoadipate enol-lactonase
Thermomonospora curvata15933Tcur_33473-oxoadipate enol-lactonase