遺伝子 : Glutathione transferase FosA (FOSA)

遺伝子情報

ID	NRULE_0098
遺伝子ID	FOSA
作成日	2012/12/07
タンパク質名	Protein name Full Glutathione transferase FosA EC EC 2.5.1.18 Synonym Full Fosfomycin resistance protein
遺伝子名	fosA
遺伝子条件	BLASTP; Q9I4K6; hit=1; score=300; pid=50
参照	Gene Ontology GO GO:0005737, C:cytoplasm, IEA:UniProtKB-SubCell GO:0004364, F:glutathione transferase activity, IEA:EC GO:0046872, F:metal ion binding, IEA:UniProtKB-KW GO:0046677, P:response to antibiotic, IEA:UniProtKB-KW Family and domain databases InterPro IPR025870, Glyoxalase-like_dom Pfam PF12681, Glyoxalase_2, 1
配列の特徴	Q56415 Serratia marcescens. METAL 7 Manganese. METAL 67 Manganese. METAL 113 Manganese.
注釈	Function Metalloglutathione transferase which confers resistance to fosfomycin by catalyzing the addition of glutathione to fosfomycin Catalytic activity RX + glutathione = HX + R-S-glutathione Cofactor Manganese Subunit structure Homodimer Subcellular location Cytoplasm Sequence similarities Belongs to the fosfomycin resistance protein family
参考文献	Q56415 Serratia marcescens. 1963292 Nucleotide sequence and intracellular location of the product of the fosfomycin resistance gene from transposon Tn2921. (Antimicrob Agents Chemother. 1990) 9115979 Fosfomycin resistance protein (FosA) is a manganese metalloglutathione transferase related to glyoxalase I and the extradiol dioxygenases. (Biochemistry. 1997) Q9I4K6 Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228). 12224946 Crystal structure of a genomically encoded fosfomycin resistance protein (FosA) at 1.19 A resolution by MAD phasing off the L-III edge of Tl(+). (J Am Chem Soc. 2002)

関与する機能

機能名
Fosfomycin resistance

該当CDS

学名	NBRC番号	CDS	タンパク質名
Chromobacterium violaceum	12614	CV_0163	fosfomycin resistance protein fofB
Enterobacter aerogenes	13534	EAE_10155	glutathione transferase
Enterobacter cloacae subsp. cloacae	13535	ECL_00705	Glutathione transferase fosA
Klebsiella pneumoniae	14438	KPR_0833
Klebsiella pneumoniae subsp. rhinoscleromatis	105682	HMPREF0484_5126	glutathione transferase FosA
Marinomonas mediterranea	103028	Marme_2376	Glutathione transferase
Serratia odorifera	102598	HMPREF0758_3311	glutathione transferase FosA
Vibrio tubiashii	15644	VITU9109_04037	hypothetical protein