| ID |
NRULE_0114 |
| 遺伝子ID |
VGB |
| 作成日 |
2013/01/17 |
| タンパク質名 |
Protein name
- Full
- Virginiamycin B lyase
- EC
- EC 4.2.99.-
Synonym
- Full
- Streptogramin B lyase
|
| 遺伝子名 |
vgb |
| 遺伝子条件 |
HAMAP; MF_01282; hit=1 |
| 参照 |
Gene Ontology
- GO
- GO:0016835, F:carbon-oxygen lyase activity, IEA:InterPro
- GO:0000287, F:magnesium ion binding, IEA:InterPro
- GO:0017001, P:antibiotic catabolic process, IEA:InterPro
- GO:0046677, P:response to antibiotic, IEA:UniProtKB-KW
Family and domain databases
- HAMAP
- MF_01282, VirginiamycinB_lyase, 1, -
- InterPro
- IPR011042, 6-blade_b-propeller_TolB-like
- IPR011217, Streptogrm_lyase
- PIRSF
- PIRSF026412, Streptogrm_lyase, 1
|
| 配列の特徴 |
| ACT_SITE | 270 | Proton acceptor. |
| METAL | 268 | Magnesium. |
| METAL | 284 | Magnesium. |
| BINDING | 228 | Substrate. |
|
| 注釈 |
- Function
- Inactivates the type B streptogramin antibiotics by linearizing the lactone ring at the ester linkage, generating a free phenylglycine carboxylate and converting the threonyl moiety into 2-amino-butenoic acid (By similarity)
- Cofactor
- Magnesium (By similarity)
- Subunit structure
- Monomer (By similarity)
- Sequence similarities
- Belongs to the vgb family
|
| 参考文献 |
- P17978 Staphylococcus aureus.
- 3149758
- Nucleotide sequence of a staphylococcal plasmid gene, vgb, encoding a hydrolase inactivating the B components of virginiamycin-like antibiotics. (Plasmid. 1988)
|
