遺伝子 : Aminoglycoside 3'-phosphotransferase (APH3)

遺伝子情報

ID	NRULE_0156
遺伝子ID	APH3
作成日	2013/03/06
タンパク質名	Protein name Full Aminoglycoside 3'-phosphotransferase EC EC 2.7.1.- Synonym Full APH(3') Kanamycin kinase Neomycin-kanamycin phosphotransferase Streptomycin 3''-phosphotransferase
遺伝子名	aphA, aphE
遺伝子条件	PIRSF; PIRSF000706; hit=1
参照	Gene Ontology GO GO:0005524, F:ATP binding, IEA:UniProtKB-KW GO:0008910, F:kanamycin kinase activity, IEA:EC GO:0050299, F:streptomycin 3'-kinase activity, IEA:EC GO:0046677, P:response to antibiotic, IEA:UniProtKB-KW Family and domain databases InterPro IPR002575, Aminoglycoside_PTrfase Pfam PF01636, APH, 1 PIRSF PIRSF000706, Kanamycin_kin, 1
配列の特徴	P00551 Escherichia coli. ACT_SITE 198 Proton acceptor (By similarity).
注釈	Function The aminoglycoside phosphotransferases achieve inactivation of their antibiotic substrates by phosphorylation Catalytic activity ATP + streptomycin = ADP + streptomycin 3''- phosphate ATP + kanamycin = ADP + kanamycin 3'- phosphate Sequence similarities Belongs to the aminoglycoside phosphotransferase family
参考文献	P00551 Escherichia coli. 2823223 The nucleotide sequence of an aminoglycoside 3'-phosphotransferase gene from E. coli. (Nucleic Acids Res. 1987) P18150 Streptomyces griseus. 2167474 PCR cloning of a streptomycin phosphotransferase (aphE) gene from Streptomyces griseus ATCC 12475. (Nucleic Acids Res. 1990)

関与する機能

機能名
Aminoglycoside resistance (by aminoglycoside O-phosphotransferase)
Kanamycin resistance
Streptomycin resistance

該当CDS

学名	NBRC番号	CDS	タンパク質名
Catenulispora acidiphila	102108	Caci_6179	aminoglycoside phosphotransferase
Cellulomonas flavigena	3775	Cfla_1184	aminoglycoside phosphotransferase
Coprobacillus sp.		HMPREF1021_01850	hypothetical protein
Deinococcus proteolyticus	101906	Deipr_1927	aminoglycoside phosphotransferase
Escherichia fergusonii	102419	EFER_p0048	Streptomycin 3''-kinase (Streptomycin 3''-phosphotransferase) (Streptomycin 6-phosphotransferase) (Streptomycin 6-kinase)
Kribbella flavida	14399	Kfla_3320	Antimicrobial 3''-kinase
Meiothermus silvanus	106475	Mesil_0966	aminoglycoside phosphotransferase
Ochrobactrum anthropi	15819	Oant_1320	aminoglycoside phosphotransferase
Rhizobium etli	15573	RHE_CH02947	putative aminoglycoside 3`-phosphotransferase protein
Rhizobium tropici	15247	RTCIAT899_CH00745	streptomycin 3''-kinase
Saccharomonospora azurea	14651	SacazDRAFT_03149	aminoglycoside phosphotransferase
Saccharomonospora cyanea	14841	SaccyDRAFT_0433	aminoglycoside phosphotransferase
		SaccyDRAFT_2173	aminoglycoside phosphotransferase
Saccharomonospora glauca	14831	SacglDRAFT_00408	aminoglycoside phosphotransferase
Stackebrandtia nassauensis	102104	Snas_4099	3''-kinase
Streptomyces ghanaensis	15414	SSFG_07398	aminoglycoside phosphotransferase
Streptosporangium roseum	3776	Sros_0454	aminoglycoside 3'-phosphotransferase
		Sros_3941	3''-kinase
		Sros_6646	3''-kinase
Vibrio tubiashii	15644	VITU9109_06979	hypothetical protein