遺伝子 : Glutamate/gamma-aminobutyrate antiporter (GADC)

遺伝子情報

ID	NRULE_0234
遺伝子ID	GADC
作成日	2013/07/25
タンパク質名	Protein name Full Glutamate/gamma-aminobutyrate antiporter
遺伝子名	gadC
遺伝子条件	TIGRFAMs; TIGR00910; hit=1
参照	Gene Ontology GO GO:0016021, C:integral to membrane, IEA:UniProtKB-KW GO:0005886, C:plasma membrane, IEA:UniProtKB-SubCell GO:0015171, F:amino acid transmembrane transporter activity, IEA:InterPro GO:0015297, F:antiporter activity, IEA:UniProtKB-KW Phylogenomic databases eggNOG COG0531, - HOGENOM HOG000058004, - Family and domain databases InterPro IPR002293, AA/rel_permease1 IPR004759, Glu_antiport PIRSF PIRSF006060, AA_transporter, 1 TIGRFAMs TIGR00910, 2A0307_GadC, 1
配列の特徴	該当データなし
注釈	Function Involved in glutamate-dependent acid resistance. Imports glutamate inside the cell while simultaneously exporting to the periplasm the GABA produced by GadA and GadB. The gad system helps to maintain a near-neutral intracellular pH when cells are exposed to extremely acidic conditions. The ability to survive transit through the acidic conditions of the stomach is essential for successful colonization of the mammalian host by commensal and pathogenic bacteria Sequence similarities Belongs to the amino acid-polyamine-organocation (APC) superfamily. Glutamate:GABA antiporter (GGA) (TC 2.A.3.7) family
参考文献	O30417 Lactococcus lactis subsp. cremoris (strain MG1363). 9484886 A chloride-inducible acid resistance mechanism in Lactococcus lactis and its regulation. (Mol Microbiol. 1998) P63235 Escherichia coli (strain K12). 9097039 A 570-kb DNA sequence of the Escherichia coli K-12 genome corresponding to the 28.0-40.1 min region on the linkage map. (DNA Res. 1996)

関与する機能

機能名
Acid resistance (by GABA antiporter)

該当CDS

学名	NBRC番号	CDS	タンパク質名
Enterococcus pallens	100697	I588_01843	glutamate/gamma-aminobutyrate antiporter
Escherichia coli	3972	EcolC_2165	glutamate/g-aminobutyrate antiporter
Escherichia coli	13500	WFL_07930	putative glutamate/gamma-aminobutyrate antiporter
Escherichia coli	12713	Y75_1488	predicted glutamate:gamma-aminobutyric acid antiporter
Escherichia fergusonii	102419	EFER_1577	glutamate:gamma-aminobutyric acid antiporter
Proteus mirabilis	105697	HMPREF0693_0979	glutamate:gamma-aminobutyrate antiporter
Providencia alcalifaciens	105687	PROVALCAL_03591	glutamate:gamma-aminobutyrate antiporter
Yersinia rohdei	105715	yrohd0001_34150	glutamate/gamma-aminobutyrate antiporter