| Acid resistance (by GABA antiporter)(NFUNC_0071) | 
| 必須 | A | GAD (NRULE_0231) | Glutamate decarboxylase | PROVALCAL_03590 | 
|---|
| GADC (NRULE_0234) | Glutamate/gamma-aminobutyrate antiporter | PROVALCAL_03591 | 
| Alanine racemization(NFUNC_0063) | 
| 必須 | A | ALR (NRULE_0228) | Alanine racemase | PROVALCAL_01821 PROVALCAL_01863 PROVALCAL_01354 | 
|---|
| Aminoglycoside resistance (by aminoglycoside N-acetyltransferase)(NFUNC_0041) | 
| 必須 | B | AAC6 (NRULE_0150) | Aminoglycoside N(6')-acetyltransferase | PROVALCAL_00921 | 
|---|
| Aminoglycoside resistance (by aminoglycoside O-nucleotidyltransferase)(NFUNC_0042) | 
| 必須 | A | ANT6 (NRULE_0151) | Aminoglycoside 6-adenylyltransferase | PROVALCAL_03279 | 
|---|
| Anthranilate biosynthesis(NFUNC_0038) | 
| 必須 | A | GLAT (NRULE_0142) | Glutamine amidotransferase | PROVALCAL_02618 PROVALCAL_01774 | 
|---|
| TRPE (NRULE_0143) | Anthranilate synthase component I | PROVALCAL_01773 | 
| Aromatic azo compounds degradation(NFUNC_0073) | 
| 必須 | A | AZOR (NRULE_0236) | FMN-dependent NADH-azoreductase | PROVALCAL_02954 PROVALCAL_00369 | 
|---|
| Beta-lactam antibiotic resistance(NFUNC_0033) | 
| 必須 | C | BLAC (NRULE_0124) | Beta-lactamase class C | PROVALCAL_02707 | 
|---|
| Betaine biosynthesis (from choline)(NFUNC_0049) | 
| 必須 | A | BETA (NRULE_0175) | Choline dehydrogenase | PROVALCAL_00577 | 
|---|
| Biotin biosynthesis(NFUNC_0051) | 
| 必須 | A | BIOF (NRULE_0182) | 8-amino-7-oxononanoate synthase | PROVALCAL_03258 | 
|---|
| BIOA (NRULE_0183) | Adenosylmethionine-8-amino-7-oxononanoate aminotransferase | PROVALCAL_03260 | 
| BIOD (NRULE_0184) | ATP-dependent dethiobiotin synthetase BioD | PROVALCAL_02856 PROVALCAL_03256 | 
| BIOB (NRULE_0185) | Biotin synthase | PROVALCAL_03259 | 
| Cephalosporin resistance(NFUNC_0048) | 
| 必須 | A | BLAC (NRULE_0124) | Beta-lactamase class C | PROVALCAL_02707 | 
|---|
| Folate biosynthesis(NFUNC_0044) | 
| 必須 | B | GLAT (NRULE_0142) | Glutamine amidotransferase | PROVALCAL_01774 PROVALCAL_02618 | 
|---|
| DHPS (NRULE_0144) | Dihydropteroate synthase | PROVALCAL_01054 | 
| FOLA (NRULE_0147) | Dihydrofolate reductase | PROVALCAL_00924 PROVALCAL_02266 | 
| FOLB (NRULE_0158) | Dihydroneopterin aldolase | PROVALCAL_02246 | 
| FOLK (NRULE_0159) | 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase | PROVALCAL_02383 | 
| FOLC (NRULE_0160) | Bifunctional protein FolC | PROVALCAL_03339 | 
| PABB (NRULE_0161) | Para-aminobenzoate synthase component I | PROVALCAL_01851 | 
| PABC (NRULE_0162) | Aminodeoxychorismate lyase | PROVALCAL_03905 | 
| GABA biosynthesis(NFUNC_0066) | 
| 必須 | A | GAD (NRULE_0231) | Glutamate decarboxylase | PROVALCAL_03590 | 
|---|
| Macrolide antibiotic resistance(NFUNC_0045) | 
| 必須 | B | RLMA (NRULE_0165) | 23S rRNA (guanine-N(1))-methyltransferase | PROVALCAL_01859 | 
|---|
| C | MACA (NRULE_0166) | Macrolide-specific efflux protein MacA | PROVALCAL_00734 | 
| MACB (NRULE_0167) | Macrolide export ATP-binding/permease protein MacB | PROVALCAL_00735 | 
| Metal-binding protein(NFUNC_0105) | 
| 必須 | A | MOP (NRULE_0322) | Putative molybdenum-binding protein | PROVALCAL_03270 PROVALCAL_00920 PROVALCAL_03263 | 
|---|
| B | MODE (NRULE_0323) | Putative molybdate-dependent transcriptional regulator | PROVALCAL_03270 | 
| C | MODA (NRULE_0324) | Molybdate ABC transporter substrate-binding protein | PROVALCAL_01715 PROVALCAL_01509 PROVALCAL_03619 PROVALCAL_03265 PROVALCAL_01669 | 
| E | CUER (NRULE_0328) | Copper-responsive transcriptional regulator CueR | PROVALCAL_02332 | 
| F | SOXR (NRULE_0329) | Redox-sensitive transcriptional activator SoxR | PROVALCAL_01294 | 
| G | ZNTR (NRULE_0330) | Zinc-responsive transcriptional regulator ZntR | PROVALCAL_00038 | 
| I | ISCR (NRULE_0332) | Rrf2 family transcriptional regulator IscR | PROVALCAL_01699 | 
| Molybdate transport (ABC transporter)(NFUNC_0097) | 
| 必須 | A | MODA (NRULE_0324) | Molybdate ABC transporter substrate-binding protein | PROVALCAL_01669 PROVALCAL_03265 PROVALCAL_01715 PROVALCAL_01509 PROVALCAL_03619 | 
|---|
| 任意 |  | MODE (NRULE_0323) | Putative molybdate-dependent transcriptional regulator | PROVALCAL_03270 | 
|---|
|  | MODB (NRULE_0325) | Molybdate ABC transporter permease protein | PROVALCAL_03264 | 
|  | MODC (NRULE_0326) | Molybdate ABC transporter ATP-binding protein | PROVALCAL_03263 | 
| (R)-pantothenate biosynthesis(NFUNC_0030) | 
| 必須 | A | PAND (NRULE_0115) | Aspartate 1-decarboxylase | PROVALCAL_02386 | 
|---|
| PANB (NRULE_0116) | 3-methyl-2-oxobutanoate hydroxymethyltransferase | PROVALCAL_02384 | 
| PANE (NRULE_0117) | 2-dehydropantoate 2-reductase | PROVALCAL_00216 | 
| PANC (NRULE_0118) | Pantothenate synthetase | PROVALCAL_02385 | 
| Phenol degradation(NFUNC_0028) | 
| 必須 | B | PHEA1 (NRULE_0083) | Aromatic ring hydroxylase | PROVALCAL_00324 | 
|---|
| 任意 |  | FDR1 (NRULE_0032) | Oxygenase electron transfer component | PROVALCAL_00412 PROVALCAL_02753 PROVALCAL_03821 | 
|---|
|  | FADR1 (NRULE_0101) | NADH-dependent flavin reductase | PROVALCAL_01317 PROVALCAL_01298 PROVALCAL_00323 | 
| Polymyxin resistance(NFUNC_0036) | 
| 必須 | A | ARNA (NRULE_0132) | Bifunctional polymyxin resistance protein ArnA | PROVALCAL_02523 | 
|---|
| ARNB (NRULE_0133) | UDP-4-amino-4-deoxy-L-arabinose--oxoglutarate aminotransferase | PROVALCAL_02521 | 
| ARNC (NRULE_0134) | Undecaprenyl-phosphate 4-deoxy-4-formamido-L-arabinose transferase | PROVALCAL_02522 | 
| ARND (NRULE_0135) | Probable 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD | PROVALCAL_02524 | 
| ARNE (NRULE_0136) | Probable 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnE | PROVALCAL_02526 | 
| ARNF (NRULE_0137) | Probable 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnF | PROVALCAL_02527 | 
| ARNT (NRULE_0138) | Undecaprenyl phosphate-alpha-4-amino-4-deoxy-L-arabinose arabinosyl transferase | PROVALCAL_02525 | 
| Riboflavin biosynthesis(NFUNC_0058) | 
| 必須 | A | RIBB (NRULE_0200) | 3,4-dihydroxy-2-butanone 4-phosphate synthase | PROVALCAL_02253 | 
|---|
| RIBA (NRULE_0201) | GTP cyclohydrolase-2 | PROVALCAL_02828 | 
| RIBD (NRULE_0202) | Riboflavin biosynthesis protein RibD | PROVALCAL_00198 | 
| RIBH (NRULE_0203) | 6,7-dimethyl-8-ribityllumazine synthase | PROVALCAL_00199 | 
| RIBE (NRULE_0204) | Riboflavin synthase | PROVALCAL_03150 | 
| 任意 |  | RIBF (NRULE_0205) | Riboflavin biosynthesis protein RibF | PROVALCAL_00161 | 
|---|
| Streptomycin resistance(NFUNC_0054) | 
| 必須 | A | ANT6 (NRULE_0151) | Aminoglycoside 6-adenylyltransferase | PROVALCAL_03279 | 
|---|
| Uptake of osmoprotectant(NFUNC_0061) | 
| 必須 | C | BCCT (NRULE_0220) | BCCT family transporter | PROVALCAL_00337 PROVALCAL_00574 | 
|---|
| D | PROP (NRULE_0221) | Osmoprotectant transporter | PROVALCAL_02741 | 
| E | OPUE (NRULE_0222) | Sodium/proline symporter | PROVALCAL_00505 | 
| Vitamin B6 biosynthesis (PdxA/PdxJ pathway)(NFUNC_0060) | 
| 必須 | A | EPD (NRULE_0208) | D-erythrose-4-phosphate dehydrogenase | PROVALCAL_00260 | 
|---|
| PDXB (NRULE_0209) | Erythronate-4-phosphate dehydrogenase | PROVALCAL_03334 | 
| SERC (NRULE_0210) | Phosphoserine aminotransferase | PROVALCAL_00837 | 
| PDXA (NRULE_0211) | 4-hydroxythreonine-4-phosphate dehydrogenase | PROVALCAL_02270 | 
| PDXJ (NRULE_0212) | Pyridoxine 5'-phosphate synthase | PROVALCAL_01725 |