遺伝子 : Macrolide export ATP-binding/permease protein MacB (MACB)

遺伝子情報

ID	NRULE_0167
遺伝子ID	MACB
作成日	2013/03/19
タンパク質名	Protein name Full Macrolide export ATP-binding/permease protein MacB EC EC 3.6.3.-
遺伝子名	macB
遺伝子条件	PFAM; PF12704; hit=1ANDPFAM; PF02687; hit=1ANDPFAM; PF00005; hit=1ANDBLASTP; P75831; hit=1; score=1200; pid=40
参照	Gene Ontology GO GO:0016021, C:integral to membrane, IDA:EcoliWiki GO:0005886, C:plasma membrane, IEA:UniProtKB-SubCell GO:0042895, F:antibiotic transporter activity, IMP:EcoCyc GO:0005524, F:ATP binding, IEA:UniProtKB-KW GO:0016887, F:ATPase activity, IEA:InterPro GO:0016820, F:hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances, IEA:InterPro GO:0006200, P:ATP catabolic process, IEA:GOC GO:0006855, P:drug transmembrane transport, IMP:EcoCyc GO:0046677, P:response to antibiotic, IDA:EcoCyc Phylogenomic databases KO K05685, - Family and domain databases InterPro IPR003593, AAA+_ATPase IPR003439, ABC_transporter-like IPR017871, ABC_transporter_CS IPR017911, ABC_transptr_macrolide_ATP-bd IPR025857, MacB_PCD IPR003838, Permease_FtsX-like Pfam PF00005, ABC_tran, 1 PF02687, FtsX, 1 PF12704, MacB_PCD, 1 SMART SM00382, AAA, 1 PROSITE PS00211, ABC_TRANSPORTER_1, 1 PS50893, ABC_TRANSPORTER_2, 1 PS51267, MACB, 1
配列の特徴	P75831 Escherichia coli (strain K12). NP_BIND 41 - 48 ATP (Potential).
注釈	Function Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation Domain In MacB the ATP-binding domain (NBD) and the transmembrane domain (TMD) are fused Sequence similarities Belongs to the ABC transporter superfamily. Macrolide exporter (TC 3.A.1.122) family Contains 1 ABC transporter domain
参考文献	P75831 Escherichia coli (strain K12). 11544226 Novel macrolide-specific ABC-type efflux transporter in Escherichia coli. (J Bacteriol. 2001)

関与する機能

機能名
Macrolide antibiotic resistance

該当CDS

学名	NBRC番号	CDS	タンパク質名
Acinetobacter radioresistens	102413	ACRAD_05_00090	macrolide ABC transporter ATP-binding/permease protein MacB
Acinetobacter sp.	100985	ACT4_006_00350	macrolide export ATP-binding/permease protein MacB
Alteromonas macleodii	102226	MASE_01875	ABC transporter-like protein
Bradyrhizobium diazoefficiens	14792	bll3707	probable ATP-binding protein
Chromobacterium violaceum	12614	CV_2704	probable ABC transporter, ATP-binding protein
Chrysiogenes arsenatis		P304_RS0109080	MacB family efflux pump subunit
Enterobacter aerogenes	13534	EAE_15025	macrolide transporter ATP-binding /permease protein
Enterobacter cloacae subsp. cloacae	13535	ECL_00381	Macrolide-specific ABC-type efflux carrier
		ECL_02770	macrolide transporter ATP-binding /permease protein
Enterobacter hormaechei	105718	HMPREF9086_0945	ABC superfamily ATP binding cassette transporter, ABC/membrane protein
Escherichia coli	3972	EcolC_2717	ABC transporter related
Escherichia coli	13500	WFL_04810	macrolide transporter ATP-binding /permease protein
Escherichia coli	12713	Y75_0856	fused macrolide transporter subunits and ATP-binding component and membrane component of ABC superfamily
Escherichia fergusonii	102419	EFER_1027	fused macrolide transporter subunits of ABC superfamily: ATP-binding component ; membrane component
Escherichia hermannii	105704	EH105704_01_04940	putative ABC transporter ATP-binding/permease protein
		EH105704_01_06920	putative ABC transporter ATP-binding/permease protein
Halomonas elongata	15536	HELO_4250	ABC-type transport system ATP-binding/permease protein
Holophaga foetida		HOLFODRAFT_RS0202420	MacB family efflux pump subunit
Hylemonella gracilis	14920	HGR_07216	transmembrane ATP-binding ABC transporter protein
Hyphomonas neptunium	14232	HNE_1647	putative macrolide efflux ABC transporter, permease/ATP-binding protein
Nitrosomonas europaea	14298	NE1081	probable ATP-binding/permease fusion ABC transporter
Ochrobactrum anthropi	15819	Oant_1258	ABC transporter related
		Oant_3558	ABC transporter related
Ochrobactrum intermedium	15820	OINT_1002017	Macrolide export ATP-binding/permease protein macB
		OINT_2000644	Macrolide export ATP-binding/permease protein macB
Pelobacter propionicus	103807	Ppro_2219	ABC transporter related protein
Proteus mirabilis	105697	HMPREF0693_2040	ABC transporter, ATP-binding protein
Providencia alcalifaciens	105687	PROVALCAL_00735	ABC transporter, ATP-binding protein
Pseudomonas putida	100650	PP_4210	ABC export system, permease/ATP-binding protein, putative
Rahnella aquatilis	105701	Rahaq2_0060	ABC-type antimicrobial peptide transport system, ATPase component
Rhizobium sp.	101917	NGR_c19790	macrolide export ATP-binding/permease protein MacB
Rhodobacter capsulatus	16581	RCAP_rcc00357	macrolide export ABC transporter, ATP-binding/permease protein MacB
Serratia odorifera	102598	HMPREF0758_4460	ABC transporter, ATP-binding protein
Starkeya novella	14993	Snov_3914	ABC transporter related protein
Thauera linaloolentis	102519	C666_08150	ABC transporter ATP-binding protein/permease
		C666_12040	macrolide export ATP-binding/permease MacB
Vibrio alginolyticus	15630	N646_3660	macrolide-specific ABC-type efflux carrier
Vibrio metschnikovii	103153	VIB_001361	macrolide export ATP-binding/permease protein macB
Yersinia bercovieri	105717	yberc0001_12490	Macrolide export ATP-binding/permease protein macB
		yberc0001_25810	Macrolide export ATP-binding/permease protein macB
		yberc0001_38680	Macrolide export ATP-binding/permease protein macB
Yersinia rohdei	105715	yrohd0001_22860	ABC transporter related
		yrohd0001_31150	Macrolide export ATP-binding/permease protein macB 2
		yrohd0001_4350	ABC transporter related