遺伝子 : Histidine decarboxylase (HDC)

遺伝子情報

ID	NRULE_0245
遺伝子ID	HDC
作成日	2013/10/08
タンパク質名	Protein name Full Histidine decarboxylase Short HDC EC EC 4.1.1.22
遺伝子名	hdc
遺伝子条件	HAMAP; MF_00609; hit=1
参照	Gene Ontology GO GO:0004398, F:histidine decarboxylase activity, IEA:HAMAP GO:0030170, F:pyridoxal phosphate binding, IEA:InterPro GO:0019752, P:carboxylic acid metabolic process, IEA:InterPro Enzyme and pathway databases BRENDA 4.1.1.22;, Family and domain databases HAMAP MF_00609, Pyridoxal_decarbox, 1, - InterPro IPR023523, Hist_deCOase_bac IPR002129, PyrdxlP-dep_de-COase IPR015424, PyrdxlP-dep_Trfase IPR015421, PyrdxlP-dep_Trfase_major_sub1 IPR021115, Pyridoxal-P_BS Pfam PF00282, Pyridoxal_deC, 1 PROSITE PS00392, DDC_GAD_HDC_YDC, 1
配列の特徴	P05034 Morganella morganii (Proteus morganii). ACT_SITE 323 Potential. BINDING 120 Substrate (By similarity). MOD_RES 233 N6-(pyridoxal phosphate)lysine.
注釈	Catalytic activity L-histidine = histamine + CO(2) Cofactor Pyridoxal phosphate Subunit structure Homotetramer Sequence similarities Belongs to the group II decarboxylase family
参考文献	P05034 Morganella morganii (Proteus morganii). 3015950 Pyridoxal 5'-phosphate-dependent histidine decarboxylase. Nucleotide sequence of the hdc gene and the corresponding amino acid sequence. (J Biol Chem. 1986) 3733745 Pyridoxal 5'-phosphate-dependent histidine decarboxylase. Inactivation by alpha-fluoromethylhistidine and comparative sequences at the inhibitor- and coenzyme-binding sites. (J Biol Chem. 1986)

関与する機能

機能名
Histamine biosynthesis

該当CDS

学名	NBRC番号	CDS	タンパク質名
Enterobacter aerogenes	13534	EAE_02560	histidine decarboxylase
Halomonas elongata	15536	HELO_2826	histidine decarboxylase
Photobacterium damselae subsp. damselae corrig.	15633	VDA_002795	histidine decarboxylase