BLAST table : Chro_00150

DB	UniProtKB

	accession	Evalue	Score	Ident.	link	product	gene	organism	ec
1	Q70J83_STRGR (Q70J83)	0.0	689	100%	UniProt GenBank	C-methyltransferase	cmmMII	Streptomyces griseus subsp. griseus
2	Q194P8_STRAA (Q194P8)	5e-91	339	52%	UniProt GenBank	C-methyltransferase	mtmMII	Streptomyces argillaceus
3	F4FBQ8_VERMA (F4FBQ8)	6e-89	332	50%	UniProt GenBank	O-methyltransferase involved in albicidin biosynthesis protein	VAB18032_18030	Verrucosispora maris (strain AB-18-032)
4	D6MSU9_9ACTO (D6MSU9)	1e-55	221	39%	UniProt GenBank	SsfM3	ssfM3	Streptomyces sp. SF2575
5	Q84HG5_PSEFL (Q84HG5)	1e-49	201	35%	UniProt GenBank	QbsL	qbsL	Pseudomonas fluorescens
6	B9XKT9_9BACT (B9XKT9)	3e-46	190	37%	UniProt GenBank	Methyltransferase type 12	Cflav_PD2489	Pedosphaera parvula Ellin514
7	B2J4Q3_NOSP7 (B2J4Q3)	9e-42	175	32%	UniProt GenBank	Methyltransferase type 12	Npun_R0239	Nostoc punctiforme (strain ATCC 29133 / PCC 73102)
8	B4DC13_9BACT (B4DC13)	2e-41	174	35%	UniProt GenBank	Methyltransferase type 12	CfE428DRAFT_6454	Chthoniobacter flavus Ellin428
9	D2UDG0_XANAP (D2UDG0)	6e-39	166	32%	UniProt GenBank	O-methyltransferase involved in albicidin biosynthesis protein	albII XALc_1530	Xanthomonas albilineans (strain GPE PC73 / CFBP 7063)	2.1.1.- niceE keggE
10	Q9AIT2_XANAL (Q9AIT2)	6e-39	166	32%	UniProt GenBank	Albicidin biosynthesis methyltransferase Putative O-methyltransferase	albII	Xanthomonas albilineans
11	Q025E9_SOLUE (Q025E9)	2e-38	164	33%	UniProt GenBank	Methyltransferase type 12	Acid_2381	Solibacter usitatus (strain Ellin6076)
12	D2MKW0_9BACT (D2MKW0)	1e-36	158	30%	UniProt GenBank	O-methyltransferase, family 2	POR_1326	Candidatus Poribacteria sp. WGA-A3
13	B8HL71_CYAP4 (B8HL71)	8e-35	152	31%	UniProt GenBank	O-methyltransferase family 2	Cyan7425_2963	Cyanothece sp. (strain PCC 7425 / ATCC 29141)
14	F2A5S2_RHIET (F2A5S2)	7e-32	142	32%	UniProt GenBank	Putative SAM-dependent methyltransferase protein	RHECNPAF_1700036	Rhizobium etli CNPAF512
15	B3Q3D0_RHIE6 (B3Q3D0)	6e-31	139	33%	UniProt GenBank	Putative SAM-dependent methyltransferase protein	RHECIAT_PC0000609	Rhizobium etli (strain CIAT 652)
16	B3PQJ2_RHIE6 (B3PQJ2)	2e-30	137	30%	UniProt GenBank	Putative SAM-dependent methyltransferase protein	RHECIAT_CH0000851	Rhizobium etli (strain CIAT 652)
17	B3DV12_METI4 (B3DV12)	6e-29	132	28%	UniProt GenBank	SAM-dependent methyltransferase	smtA Minf_1110	Methylacidiphilum infernorum (isolate V4) Methylokorus infernorum (strain V4)
18	B6A367_RHILW (B6A367)	8e-29	132	33%	UniProt GenBank	Methyltransferase type 12	Rleg2_5675	Rhizobium leguminosarum bv. trifolii (strain WSM2304)
19	Q74DV1_GEOSL (Q74DV1)	2e-26	124	32%	UniProt GenBank	Tetracenomycin polyketide synthesis 8-o-methyltransferase, putative	GSU1214	Geobacter sulfurreducens
20	D7AHZ5_GEOSK (D7AHZ5)	2e-26	124	32%	UniProt GenBank	O-methyltransferase, family 2	KN400_1188	Geobacter sulfurreducens (strain DL-1 / KN400)
21	E3T6I1_9BACT (E3T6I1)	1e-23	115	28%	UniProt GenBank	O-methyltransferase family 2		uncultured bacterium 70
22	Q8TM93_METAC (Q8TM93)	2e-23	114	29%	UniProt GenBank	O-methyltransferase	MA_2773	Methanosarcina acetivorans (strain ATCC 35395 / DSM 2834 / JCM 12185 / C2A)
23	B9LZX0_GEOSF (B9LZX0)	3e-21	107	28%	UniProt GenBank	O-methyltransferase family 2	Geob_0567	Geobacter sp. (strain FRC-32)
24	C0QH96_DESAH (C0QH96)	5e-21	106	29%	UniProt GenBank	SAM-dependent methyltransferase	HRM2_47060	Desulfobacterium autotrophicum (strain ATCC 43914 / DSM 3382 / HRM2)
25	A1ARH0_PELPD (A1ARH0)	2e-20	104	28%	UniProt GenBank	O-methyltransferase, family 2	Ppro_2333	Pelobacter propionicus (strain DSM 2379)
26	D1CH44_THET1 (D1CH44)	3e-20	103	30%	UniProt GenBank	Methyltransferase type 11	Tter_2164	Thermobaculum terrenum (strain ATCC BAA-798 / YNP1)
27	E1YL11_9DELT (E1YL11)	3e-20	103	29%	UniProt GenBank	Putative uncharacterized protein	N47_E43060	uncultured Desulfobacterium sp
28	D1JE23_9ARCH (D1JE23)	4e-20	103	24%	UniProt GenBank	Putative uncharacterized protein	BSM_02580	uncultured archaeon
29	D2L0U2_9DELT (D2L0U2)	5e-20	103	31%	UniProt GenBank	O-methyltransferase family 2	DFW101DRAFT_0305	Desulfovibrio sp. FW1012B
30	E1K028_DESFR (E1K028)	7e-20	102	29%	UniProt GenBank	O-methyltransferase family 2	DesfrDRAFT_3228	Desulfovibrio fructosovorans JJ
31	A8ZX85_DESOH (A8ZX85)	2e-19	101	29%	UniProt GenBank	O-methyltransferase family 2	Dole_2661	Desulfococcus oleovorans (strain DSM 6200 / Hxd3)
32	A2AXE8_STRCM (A2AXE8)	2e-19	101	27%	UniProt GenBank	SAM-dependent O-methyltransferase	fnq9	Streptomyces cinnamonensis
33	F6CIK7_9FIRM (F6CIK7)	3e-19	100	31%	UniProt GenBank	Acetylserotonin O-methyltransferase	Desku_0280	Desulfotomaculum kuznetsovii DSM 6115	2.1.1.4 niceE keggE
34	B5ECP9_GEOBB (B5ECP9)	3e-19	100	30%	UniProt GenBank	O-methyltransferase, family 2	Gbem_2071	Geobacter bemidjiensis (strain Bem / ATCC BAA-1014 / DSM 16622)
35	Q469X3_METBF (Q469X3)	4e-19	100	29%	UniProt GenBank	O-methyltransferase	Mbar_A2399	Methanosarcina barkeri (strain Fusaro / DSM 804)
36	E8WKM5_GEOS8 (E8WKM5)	5e-19	100	30%	UniProt GenBank	Methyltransferase type 12	GM18_2143	Geobacter sp. (strain M18)
37	D7C8A1_STRBB (D7C8A1)	7e-19	99.8	29%	UniProt GenBank	O-methyltransferase family 2	SBI_03169	Streptomyces bingchenggensis (strain BCW-1)
38	Q70DX3_9ACTO (Q70DX3)	1e-18	98.6	32%	UniProt GenBank	RemH protein	remH	Streptomyces resistomycificus
39	F8C9S7_MYXFU (F8C9S7)	2e-18	98.2	29%	UniProt GenBank	Putative O-methyltransferase	LILAB_00725	Myxococcus fulvus
40	D2S9W6_GEOOG (D2S9W6)	3e-18	97.4	32%	UniProt GenBank	Methyltransferase type 11	Gobs_1070	Geodermatophilus obscurus (strain ATCC 25078 / DSM 43160 / JCM 3152 / G-20)
41	D1C231_SPHTD (D1C231)	3e-18	97.4	30%	UniProt GenBank	O-methyltransferase family 2	Sthe_0861	Sphaerobacter thermophilus (strain DSM 20745 / S 6022)
42	F2YRZ2_9ACTO (F2YRZ2)	6e-18	96.3	28%	UniProt GenBank	O-methyltransferase	sky37	Streptomyces sp. Acta 2897
43	A3ZPN0_9PLAN (A3ZPN0)	7e-18	96.3	29%	UniProt GenBank	Putative methyltransferase	DSM3645_29042	Blastopirellula marina DSM 3645
44	D2QXW1_PIRSD (D2QXW1)	7e-18	96.3	29%	UniProt GenBank	O-methyltransferase family 2	Psta_3374	Pirellula staleyi (strain ATCC 27377 / DSM 6068 / ICPB 4128) Pirella staleyi
45	D8FA20_9DELT (D8FA20)	7e-18	96.3	29%	UniProt GenBank	O-methyltransferase	NPH_0216	delta proteobacterium NaphS2
46	A7BPT9_9GAMM (A7BPT9)	2e-17	95.1	26%	UniProt GenBank	O-methyltransferase, family 2	BGP_5272	Beggiatoa sp. PS
47	Q09BC6_STIAD (Q09BC6)	3e-17	94	28%	UniProt GenBank	O-methyltransferase Tetracenomycin polyketide synthesis 8-o-methyltransferase, putative	STAUR_1267 STIAU_8618	Stigmatella aurantiaca (strain DW4/3-1)
48	F4FBS8_VERMA (F4FBS8)	3e-17	94	28%	UniProt GenBank	O-methyltransferase family 2	VAB18032_18130	Verrucosispora maris (strain AB-18-032)
49	O32456_9ACTO (O32456)	3e-17	94	29%	UniProt GenBank	ORF 6 PdmF	pdmF	Actinomadura hibisca
50	Q1DBW9_MYXXD (Q1DBW9)	3e-17	94	27%	UniProt GenBank	Putative O-methyltransferase	MXAN_1602	Myxococcus xanthus (strain DK 1622)
51	B1HC95_BURPS (B1HC95)	4e-17	93.6	28%	UniProt GenBank	O-methyltransferase	BURPSS13_J0094	Burkholderia pseudomallei S13	2.-.-.- niceE keggE
52	A8KQC1_BURPS (A8KQC1)	4e-17	93.6	28%	UniProt GenBank	O-methyltransferase	BURPSPAST_E0288	Burkholderia pseudomallei Pasteur 52237	2.-.-.- niceE keggE
53	C6E9A6_GEOSM (C6E9A6)	9e-17	92.4	29%	UniProt GenBank	O-methyltransferase family 2	GM21_2149	Geobacter sp. (strain M21)
54	A4XD35_SALTO (A4XD35)	9e-17	92.4	29%	UniProt GenBank	Methyltransferase type 12	Strop_4414	Salinispora tropica (strain ATCC BAA-916 / DSM 44818 / CNB-440)
55	A3NG08_BURP6 (A3NG08)	2e-16	91.7	28%	UniProt GenBank	O-methyltransferase	BURPS668_A0273	Burkholderia pseudomallei (strain 668)	2.-.-.- niceE keggE
56	B9L1M3_THERP (B9L1M3)	2e-16	91.7	28%	UniProt GenBank	Putative hydroxyindole O-methyltransferase	trd_1284	Thermomicrobium roseum (strain ATCC 27502 / DSM 5159 / P-2)
57	D2MJR9_9BACT (D2MJR9)	2e-16	91.7	23%	UniProt GenBank	O-methyltransferase, family 2:Generic methyltransferase	POR_0933	Candidatus Poribacteria sp. WGA-A3
58	A4LLS0_BURPS (A4LLS0)	2e-16	91.3	28%	UniProt GenBank	O-methyltransferase	BURPS305_3596	Burkholderia pseudomallei 305	2.-.-.- niceE keggE
59	C7QHK0_CATAD (C7QHK0)	3e-16	90.9	30%	UniProt GenBank	Methyltransferase type 12	Caci_2106	Catenulispora acidiphila (strain DSM 44928 / NRRL B-24433 / NBRC 102108 / JCM 14897)
60	A3P1L5_BURP0 (A3P1L5)	3e-16	90.9	28%	UniProt GenBank	O-methyltransferase	BURPS1106A_A0182	Burkholderia pseudomallei (strain 1106a)	2.-.-.- niceE keggE
61	C5ZN66_BURPS (C5ZN66)	3e-16	90.9	28%	UniProt GenBank	O-methyltransferase	BURPS1106B_1808	Burkholderia pseudomallei 1106b	2.-.-.- niceE keggE
62	C4I5J6_BURPS (C4I5J6)	3e-16	90.9	28%	UniProt GenBank	O-methyltransferase	GBP346_B2849	Burkholderia pseudomallei MSHR346
63	C0YC34_BURPS (C0YC34)	3e-16	90.9	28%	UniProt GenBank	O-methyltransferase	BUH_4471	Burkholderia pseudomallei Pakistan 9	2.-.-.- niceE keggE
64	B2H618_BURPS (B2H618)	3e-16	90.9	28%	UniProt GenBank	O-methyltransferase	BURPS1655_C0558	Burkholderia pseudomallei 1655	2.-.-.- niceE keggE
65	Q3JHZ9_BURP1 (Q3JHZ9)	3e-16	90.9	28%	UniProt GenBank	Putative methyltransferase	BURPS1710b_A1647	Burkholderia pseudomallei (strain 1710b)
66	C6U643_BURPS (C6U643)	3e-16	90.9	28%	UniProt GenBank	O-methyltransferase	BURPS1710A_A2675	Burkholderia pseudomallei 1710a	2.-.-.- niceE keggE
67	B7CT03_BURPS (B7CT03)	3e-16	90.9	28%	UniProt GenBank	O-methyltransferase	BUC_4303	Burkholderia pseudomallei 576	2.-.-.- niceE keggE
68	D8PIA8_9BACT (D8PIA8)	4e-16	90.5	28%	UniProt GenBank	Putative O-methyltransferase, family 2	NIDE3307	Candidatus Nitrospira defluvii	2.1.1.- niceE keggE
69	D8I4M6_AMYMU (D8I4M6)	5e-16	90.1	30%	UniProt GenBank	O-methyltransferase family protein	AMED_5440	Amycolatopsis mediterranei (strain U-32)
70	D8P817_9BACT (D8P817)	7e-16	89.7	29%	UniProt GenBank	Putative O-methyltransferase, family 2	NIDE3979	Candidatus Nitrospira defluvii	2.1.1.- niceE keggE
71	Q2T8U0_BURTA (Q2T8U0)	8e-16	89.4	27%	UniProt GenBank	Putative uncharacterized protein	BTH_II0207	Burkholderia thailandensis (strain E264 / ATCC 700388 / DSM 13276 / CIP 106301)
72	D6A8Q4_9ACTO (D6A8Q4)	9e-16	89.4	26%	UniProt GenBank	O-methyltransferase family 2	SSFG_07273	Streptomyces ghanaensis ATCC 14672
73	F4BYU8_METCG (F4BYU8)	1e-15	88.6	25%	UniProt GenBank	Methyltransferase	MCON_0961	Methanosaeta concilii (strain ATCC 5969 / DSM 3671 / JCM 10134 / NBRC 103675 / OCM 69 / GP-6) Methanothrix concilii
74	Q39UW0_GEOMG (Q39UW0)	2e-15	88.2	29%	UniProt GenBank	O-methyltransferase, family 2	Gmet_1733	Geobacter metallireducens (strain GS-15 / ATCC 53774 / DSM 7210)
75	Q2RIK5_MOOTA (Q2RIK5)	2e-15	88.2	26%	UniProt GenBank	O-methyltransferase, family 2	Moth_1421	Moorella thermoacetica (strain ATCC 39073)
76	Q63P15_BURPS (Q63P15)	3e-15	87.8	27%	UniProt GenBank	Putative methyltransferase	BPSS0133	Burkholderia pseudomallei Pseudomonas pseudomallei
77	A8EJG6_BURPS (A8EJG6)	3e-15	87.8	27%	UniProt GenBank	O-methyltransferase	BURPS406E_P0306	Burkholderia pseudomallei 406e	2.-.-.- niceE keggE
78	D1JHL1_9ARCH (D1JHL1)	3e-15	87.4	22%	UniProt GenBank	Putative uncharacterized protein	BSM_14960 BSM_19810	uncultured archaeon
79	F6LWA4_9BACT (F6LWA4)	4e-15	87	27%	UniProt GenBank	O-methyltransferase	abeM3	uncultured bacterium AB1650
80	Q1Q4M5_9BACT (Q1Q4M5)	4e-15	87	24%	UniProt GenBank	Similar to tetracenomycin polyketide synthesis 8-O-methyltransferase	tcmO kuste4198	Candidatus Kuenenia stuttgartiensis	2.1.1.- niceE keggE
81	Q70DX4_9ACTO (Q70DX4)	4e-15	87	26%	UniProt GenBank	RemG protein	remG	Streptomyces resistomycificus
82	Q2FNY8_METHJ (Q2FNY8)	4e-15	87	28%	UniProt GenBank	O-methyltransferase, family 2	Mhun_1315	Methanospirillum hungatei (strain JF-1 / DSM 864)
83	B3EAK3_GEOLS (B3EAK3)	4e-15	87	27%	UniProt GenBank	O-methyltransferase family 2	Glov_1725	Geobacter lovleyi (strain ATCC BAA-1151 / DSM 17278 / SZ)
84	A8TIU8_9PROT (A8TIU8)	6e-15	86.7	28%	UniProt GenBank	Probable acetylserotonin O-methyltransferase	BAL199_15988	alpha proteobacterium BAL199
85	A7DWL9_STRTE (A7DWL9)	6e-15	86.3	30%	UniProt GenBank	Putative O-methyltransferase	llpMVI	Streptomyces tendae	2.1.1.- niceE keggE
86	E6TEW6_MYCSR (E6TEW6)	8e-15	86.3	27%	UniProt GenBank	Methyltransferase family protein	Mspyr1_33380	Mycobacterium sp. (strain Spyr1)
87	D8FED2_9DELT (D8FED2)	9e-15	85.9	26%	UniProt GenBank	O-methyltransferase	NPH_5510	delta proteobacterium NaphS2
88	F3NRW5_9ACTO (F3NRW5)	1e-14	85.5	26%	UniProt GenBank	O-methyltransferase	SGM_5879	Streptomyces griseoaurantiacus M045
89	TCMO_STRGA (P39896)	1e-14	85.1	29%	UniProt GenBank	Tetracenomycin polyketide synthesis 8-O-methyl transferase tcmO	tcmO	Streptomyces glaucescens	2.1.1.- niceE keggE
90	F3YWU3_DESAF (F3YWU3)	2e-14	84.7	29%	UniProt GenBank	Acetylserotonin O-methyltransferase	Desaf_3380	Desulfovibrio africanus str. Walvis Bay	2.1.1.4 niceE keggE
91	D1JCX7_9ARCH (D1JCX7)	2e-14	84.7	24%	UniProt GenBank	Putative uncharacterized protein	BSM_34360	uncultured archaeon
92	Q0BF90_BURCM (Q0BF90)	2e-14	84.3	27%	UniProt GenBank	O-methyltransferase, family 2	Bamb_1625	Burkholderia ambifaria (strain ATCC BAA-244 / AMMD) Burkholderia cepacia (strain AMMD)
93	Q2L6E6_9ACTO (Q2L6E6)	3e-14	84.3	27%	UniProt GenBank	Probable methyltransferase		Streptomyces sp. KO-3988
94	A0QPE2_MYCS2 (A0QPE2)	5e-14	83.6	26%	UniProt GenBank	O-demethylpuromycin-O-methyltransferase	MSMEG_0367	Mycobacterium smegmatis (strain ATCC 700084 / mc(2)155)	2.1.1.38 niceE keggE
95	A4TCK4_MYCGI (A4TCK4)	6e-14	83.2	27%	UniProt GenBank	Methyltransferase type 12	Mflv_3993	Mycobacterium gilvum (strain PYR-GCK) Mycobacterium flavescens (strain ATCC 700033 / PYR-GCK)
96	F8CAC2_MYXFU (F8CAC2)	8e-14	82.8	27%	UniProt GenBank	Putative O-methyltransferase	LILAB_13370	Myxococcus fulvus
97	D7BZK8_STRBB (D7BZK8)	1e-13	82.4	28%	UniProt GenBank	O-methyltransferase family protein	SBI_06793	Streptomyces bingchenggensis (strain BCW-1)
98	D3F6H0_CONWI (D3F6H0)	1e-13	82.4	25%	UniProt GenBank	O-methyltransferase family 2	Cwoe_2312	Conexibacter woesei (strain DSM 14684 / JCM 11494 / NBRC 100937 / ID131577)
99	A3YY93_9SYNE (A3YY93)	1e-13	82	28%	UniProt GenBank	O-methyltransferase, family 2	WH5701_08334	Synechococcus sp. WH 5701
100	F8K3U8_STRCT (F8K3U8)	2e-13	81.6	28%	UniProt GenBank	Polyketide synthesis 8-O-methyltransferase	SCAT_5274	Streptomyces cattleya	2.1.1.- niceE keggE

accession

alignment

Evalue

Score

Ident.

link

information

pubmed

Q194P8_STRAA
(Q194P8)

5e-91

339

52%

Product: C-methyltransferase
Gene: mtmMII
Organism: Streptomyces argillaceus

[pubmed all]
1uniprot[Pubmed] 8654997 [Medline] 96257259 Characterization of Streptomyces argillaceus genes encoding a polyketide synthase involved in the biosynthesis of the antitumor mithramycin.(Gene) [1996]
2uniprot[Pubmed] 8757400 [Medline] 96335144 An ABC transporter is essential for resistance to the antitumor agent mithramycin in the producer Streptomyces argillaceus.(Mol. Gen. Genet.) [1996]
3uniprot[Pubmed] 9150235 [Medline] 97294479 Cloning and insertional inactivation of Streptomyces argillaceus genes involved in the earliest steps of biosynthesis of the sugar moieties of the antitumor polyketide mithramycin.(J. Bacteriol.) [1997]
4uniprot[Pubmed] 9733697 [Medline] 98406047 Identification of two genes from Streptomyces argillaceus encoding glycosyltransferases involved in transfer of a disaccharide during biosynthesis of the antitumor drug mithramycin.(J. Bacteriol.) [1998]
5uniprot[Pubmed] 10102355 [Medline] 99200478 Analysis of two chromosomal regions adjacent to genes for a type II polyketide synthase involved in the biosynthesis of the antitumor polyketide mithramycin in Streptomyces argillaceus.(Mol. Gen. Genet.) [1999]
6uniprot[Pubmed] 9889148 [Medline] 99111236 Oxidative cleavage of premithramycin B is one of the last steps in the biosynthesis of the antitumor drug mithramycin.(Chem. Biol.) [1999]
7uniprot[Pubmed] 10660060 [Medline] 20123456 Characterization of two glycosyltransferases involved in early glycosylation steps during biosynthesis of the antitumor polyketide mithramycin by Streptomyces argillaceus.(Mol. Gen. Genet.) [2000]
8uniprot[Pubmed] 11254130 [Medline] 21148776 The mtmVUC genes of the mithramycin gene cluster in Streptomyces argillaceus are involved in the biosynthesis of the sugar moieties.(Mol. Gen. Genet.) [2001]
9uniprot[Pubmed] 12733914 [Medline] 22619809 Mithramycin SK, a novel antitumor drug with improved therapeutic index, mithramycin SA, and demycarosyl-mithramycin SK: three new products generated in the mithramycin producer Streptomyces argillaceus through combinatorial biosynthesis.(J. Am. Chem. Soc.) [2003]
10uniprot[Pubmed] 9917296 [Medline] 99115752 The structure of mithramycin reinvestigated.(J. Nat. Prod.) [1999]
11uniprot[Pubmed] 11853433 [Medline] 21843297 Ketopremithramycins and ketomithramycins, four new aureolic acid-type compounds obtained upon inactivation of two genes involved in the biosynthesis of the deoxysugar moieties of the antitumor drug mithramycin by Streptomyces argillaceus, reveal novel insights into post-PKS tailoring steps of the mithramycin biosynthetic pathway.(J. Am. Chem. Soc.) [2002]
12uniprot[Pubmed] 10652287 [Medline] 20119254 Characterization of two polyketide methyltransferases involved in the biosynthesis of the antitumor drug mithramycin by Streptomyces argillaceus.(J. Biol. Chem.) [2000]
13uniprot[Pubmed] 10779713 [Medline] 20243461 Insertional inactivation of mtrX and mtrY genes from the mithramycin gene cluster affects production and growth of the producer organism Streptomyces argillaceus.(FEMS Microbiol. Lett.) [2000]
14uniprot[Pubmed] 12022840 [Medline] 22017994 Rationally designed glycosylated premithramycins: hybrid aromatic polyketides using genes from three different biosynthetic pathways.(J. Am. Chem. Soc.) [2002]
15uniprot[Pubmed] 12813091 [Medline] 22697398 Purification and characterization of a monooxygenase involved in the biosynthetic pathway of the antitumor drug mithramycin.(J. Bacteriol.) [2003]
16uniprot[Pubmed] 8807845 [Medline] 97113238 Deciphering the biosynthetic origin of the aglycone of the aureolic acid group of anti-tumor agents.(Chem. Biol.) [1996]
17uniprot[Pubmed] 14660589 MtmMII-mediated C-methylation during biosynthesis of the antitumor drug mithramycin is essential for biological activity and DNA-drug interaction.(J. Biol. Chem.) [2004]
18uniprot[Pubmed] 9375253 [Medline] 98042823 Folding of the polyketide chain is not dictated by minimal polyketide synthase in the biosynthesis of mithramycin and anthracycline.(Chem. Biol.) [1997]
19uniprot[Pubmed] 15712316 Elucidation of the glycosylation sequence of mithramycin biosynthesis: isolation of 3A-deolivosylpremithramycin B and its conversion to premithramycin B by glycosyltransferase MtmGII.(Chembiochem) [2005]
20uniprot[Pubmed] 10760873 The Novel Hybrid Antitumor Compound Premithramycinone H Provides Indirect Evidence for a Tricyclic Intermediate of the Biosynthesis of the Aureolic Acid Antibiotic Mithramycin.(Angew. Chem. Int. Ed.) [2000]

F4FBQ8_VERMA
(F4FBQ8)

6e-89

332

50%

Product: O-methyltransferase involved in albicidin biosynthesis protein
Gene: VAB18032_18030
Organism: Verrucosispora maris (strain AB-18-032)

1uniprot[Pubmed] 21551311
Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.(J. Bacteriol.) [2011]

D6MSU9_9ACTO
(D6MSU9)

1e-55

221

39%

Product: SsfM3
Gene: ssfM3
Organism: Streptomyces sp. SF2575

1uniprot[Pubmed] 19908837
Biochemical analysis of the biosynthetic pathway of an anticancer tetracycline SF2575.(J. Am. Chem. Soc.) [2009]

Q84HG5_PSEFL
(Q84HG5)

1e-49

201

35%

Product: QbsL
Gene: qbsL
Organism: Pseudomonas fluorescens

1uniprot[Pubmed] 15066027
The Pseudomonas siderophore quinolobactin is synthesized from xanthurenic acid, an intermediate of the kynurenine pathway.(Mol. Microbiol.) [2004]

B9XKT9_9BACT
(B9XKT9)

3e-46

190

37%

Product: Methyltransferase type 12
Gene: Cflav_PD2489
Organism: Pedosphaera parvula Ellin514

1uniprot[Pubmed] 21460084
Genome Sequence of 'Pedosphaera parvula' Ellin514, an Aerobic Verrucomicrobial Isolate from Pasture Soil.(J. Bacteriol.) [2011]

B4DC13_9BACT
(B4DC13)

2e-41

174

35%

Product: Methyltransferase type 12
Gene: CfE428DRAFT_6454
Organism: Chthoniobacter flavus Ellin428

1uniprot[Pubmed] 21460085
Genome Sequence of Chthoniobacter flavus Ellin428, an Aerobic Heterotrophic Soil Bacterium.(J. Bacteriol.) [2011]

D2UDG0_XANAP
(D2UDG0)

6e-39

166

32%

Product: O-methyltransferase involved in albicidin biosynthesis protein
Gene: albII
XALc_1530
Organism: Xanthomonas albilineans (strain GPE PC73 / CFBP 7063)

1uniprot
The complete genome sequence of Xanthomonas albilineans provides new insights into the reductive genome evolution of the xylem-limited Xanthomonadaceae.(BMC Genomics) [2009]

Q9AIT2_XANAL
(Q9AIT2)

6e-39

166

32%

Product: Albicidin biosynthesis methyltransferase
Putative O-methyltransferase
Gene: albII
Organism: Xanthomonas albilineans

[pubmed all]
1uniprot[Pubmed] 11024293 [Medline] 20480700 Analysis of the genes flanking xabB: a methyltransferase gene is involved in albicidin biosynthesis in Xanthomonas albilineans.(Gene) [2000]
2uniprot[Pubmed] 15077674 Albicidin pathotoxin produced by Xanthomonas albilineans is encoded by three large PKS and NRPS genes present in a gene cluster also containing several putative modifying, regulatory, and resistance genes.(Mol. Plant Microbe Interact.) [2004]

Q025E9_SOLUE
(Q025E9)

2e-38

164

33%

Product: Methyltransferase type 12
Gene: Acid_2381
Organism: Solibacter usitatus (strain Ellin6076)

1uniprot[Pubmed] 19201974
Three genomes from the phylum Acidobacteria provide insight into the lifestyles of these microorganisms in soils.(Appl. Environ. Microbiol.) [2009]

D2MKW0_9BACT
(D2MKW0)

1e-36

158

30%

Product: O-methyltransferase, family 2
Gene: POR_1326
Organism: Candidatus Poribacteria sp. WGA-A3

1uniprot[Pubmed] 20613790
Single-cell genomics reveals the lifestyle of Poribacteria, a candidate phylum symbiotically associated with marine sponges.(ISME J.) [2010]

F2A5S2_RHIET
(F2A5S2)

7e-32

142

32%

Product: Putative SAM-dependent methyltransferase protein
Gene: RHECNPAF_1700036
Organism: Rhizobium etli CNPAF512

1uniprot[Pubmed] 21515775
Genome Sequence of Rhizobium etli CNPAF512, a Nitrogen-Fixing Symbiont Isolated from Bean Root Nodules in Brazil.(J. Bacteriol.) [2011]

B3DV12_METI4
(B3DV12)

6e-29

132

28%

Product: SAM-dependent methyltransferase
Gene: smtA
Minf_1110
Organism: Methylacidiphilum infernorum (isolate V4)
Methylokorus infernorum (strain V4)

1uniprot[Pubmed] 18593465
Complete genome sequence of the extremely acidophilic methanotroph isolate V4, Methylacidiphilum infernorum, a representative of the bacterial phylum Verrucomicrobia.(Biol. Direct) [2008]

Q74DV1_GEOSL
(Q74DV1)

2e-26

124

32%

Product: Tetracenomycin polyketide synthesis 8-o-methyltransferase, putative
Gene: GSU1214
Organism: Geobacter sulfurreducens

1uniprot[Pubmed] 14671304
Genome of Geobacter sulfurreducens: metal reduction in subsurface environments.(Science) [2003]

D7AHZ5_GEOSK
(D7AHZ5)

2e-26

124

32%

Product: O-methyltransferase, family 2
Gene: KN400_1188
Organism: Geobacter sulfurreducens (strain DL-1 / KN400)

1uniprot[Pubmed] 20544019
De Novo assembly of the complete genome of an enhanced electricity-producing variant of Geobacter sulfurreducens using only short reads.(PLoS ONE) [2010]

E3T6I1_9BACT
(E3T6I1)

1e-23

115

28%

Product: O-methyltransferase family 2
Gene
Organism: uncultured bacterium 70

1uniprot[Pubmed] 20729323
Comparative analysis of acidobacterial genomic fragments from terrestrial and aquatic metagenomic libraries, with emphasis on acidobacteria subdivision 6.(Appl. Environ. Microbiol.) [2010]

Q8TM93_METAC
(Q8TM93)

2e-23

114

29%

Product: O-methyltransferase
Gene: MA_2773
Organism: Methanosarcina acetivorans (strain ATCC 35395 / DSM 2834 / JCM 12185 / C2A)

1uniprot[Pubmed] 11932238 [Medline] 21929760
The genome of Methanosarcina acetivorans reveals extensive metabolic and physiological diversity.(Genome Res.) [2002]

C0QH96_DESAH
(C0QH96)

5e-21

106

29%

Product: SAM-dependent methyltransferase
Gene: HRM2_47060
Organism: Desulfobacterium autotrophicum (strain ATCC 43914 / DSM 3382 / HRM2)

1uniprot[Pubmed] 19187283
Genome sequence of Desulfobacterium autotrophicum HRM2, a marine sulfate reducer oxidizing organic carbon completely to carbon dioxide.(Environ. Microbiol.) [2009]

D1CH44_THET1
(D1CH44)

3e-20

103

30%

Product: Methyltransferase type 11
Gene: Tter_2164
Organism: Thermobaculum terrenum (strain ATCC BAA-798 / YNP1)

1uniprot
Complete genome sequence of Thermobaculum terrenum type strain (YNP1T).(Stand. Genomic Sci.) [2010]

E1YL11_9DELT
(E1YL11)

3e-20

103

29%

Product: Putative uncharacterized protein
Gene: N47_E43060
Organism: uncultured Desulfobacterium sp

1uniprot[Pubmed] 21176053
Genomic insights into the metabolic potential of the polycyclic aromatic hydrocarbon degrading sulfate-reducing Deltaproteobacterium N47.(Environ. Microbiol.) [2011]

D1JE23_9ARCH
(D1JE23)

4e-20

103

24%

Product: Putative uncharacterized protein
Gene: BSM_02580
Organism: uncultured archaeon

1uniprot
Metagenome and mRNA expression analyses of anaerobic methanotrophic archaea of the ANME-1 group.(Environ. Microbiol.) [2010]

A2AXE8_STRCM
(A2AXE8)

2e-19

101

27%

Product: SAM-dependent O-methyltransferase
Gene: fnq9
Organism: Streptomyces cinnamonensis

1uniprot[Pubmed] 17103476
A gene cluster for prenylated naphthoquinone and prenylated phenazine biosynthesis in Streptomyces cinnamonensis DSM 1042.(Chembiochem) [2006]

Q469X3_METBF
(Q469X3)

4e-19

100

29%

Product: O-methyltransferase
Gene: Mbar_A2399
Organism: Methanosarcina barkeri (strain Fusaro / DSM 804)

1uniprot[Pubmed] 16980466
The Methanosarcina barkeri genome: comparative analysis with Methanosarcina acetivorans and Methanosarcina mazei reveals extensive rearrangement within methanosarcinal genomes.(J. Bacteriol.) [2006]

D7C8A1_STRBB
(D7C8A1)

7e-19

99.8

29%

Product: O-methyltransferase family 2
Gene: SBI_03169
Organism: Streptomyces bingchenggensis (strain BCW-1)

1uniprot[Pubmed] 20581206
Genome sequence of the milbemycin-producing bacterium Streptomyces bingchenggensis.(J. Bacteriol.) [2010]

Q70DX3_9ACTO
(Q70DX3)

1e-18

98.6

32%

Product: RemH protein
Gene: remH
Organism: Streptomyces resistomycificus

1uniprot[Pubmed] 14982421
A gene cluster encoding resistomycin biosynthesis in Streptomyces resistomycificus; exploring polyketide cyclization beyond linear and angucyclic patterns.(J. Am. Chem. Soc.) [2004]

F2YRZ2_9ACTO
(F2YRZ2)

6e-18

96.3

28%

Product: O-methyltransferase
Gene: sky37
Organism: Streptomyces sp. Acta 2897

1uniprot[Pubmed] 21456593
Biosynthetic Gene Cluster of the Non-ribosomally Synthesized Cyclodepsipeptide Skyllamycin: Deciphering Unprecedented Ways of Unusual Hydroxylation Reactions.(J. Am. Chem. Soc.) [2011]

D2QXW1_PIRSD
(D2QXW1)

7e-18

96.3

29%

Product: O-methyltransferase family 2
Gene: Psta_3374
Organism: Pirellula staleyi (strain ATCC 27377 / DSM 6068 / ICPB 4128)
Pirella staleyi

1uniprot
Complete genome sequence of Pirellula staleyi type strain (ATCC 27377T).(Stand. Genomic Sci.) [2009]

D8FA20_9DELT
(D8FA20)

7e-18

96.3

29%

Product: O-methyltransferase
Gene: NPH_0216
Organism: delta proteobacterium NaphS2

1uniprot[Pubmed] 21124915
Genome Sequence of the Deltaproteobacterial Strain NaphS2 and Analysis of Differential Gene Expression during Anaerobic Growth on Naphthalene.(PLoS ONE) [2010]

F4FBS8_VERMA
(F4FBS8)

3e-17

28%

Product: O-methyltransferase family 2
Gene: VAB18032_18130
Organism: Verrucosispora maris (strain AB-18-032)

1uniprot[Pubmed] 21551311
Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.(J. Bacteriol.) [2011]

O32456_9ACTO
(O32456)

3e-17

29%

Product: ORF 6
PdmF
Gene: pdmF
Organism: Actinomadura hibisca

1uniprot[Pubmed] 9339544 [Medline] 97480928
Cloning and nucleotide sequence of the putative polyketide synthase genes for pradimicin biosynthesis from Actinomadura hibisca.(Biosci. Biotechnol. Biochem.) [1997]

Q1DBW9_MYXXD
(Q1DBW9)

3e-17

27%

Product: Putative O-methyltransferase
Gene: MXAN_1602
Organism: Myxococcus xanthus (strain DK 1622)

1uniprot[Pubmed] 17015832
Evolution of sensory complexity recorded in a myxobacterial genome.(Proc. Natl. Acad. Sci. U.S.A.) [2006]

B9L1M3_THERP
(B9L1M3)

2e-16

91.7

28%

Product: Putative hydroxyindole O-methyltransferase
Gene: trd_1284
Organism: Thermomicrobium roseum (strain ATCC 27502 / DSM 5159 / P-2)

1uniprot[Pubmed] 19148287
Complete genome sequence of the aerobic CO-oxidizing thermophile Thermomicrobium roseum.(PLoS ONE) [2009]

D2MJR9_9BACT
(D2MJR9)

2e-16

91.7

23%

Product: O-methyltransferase, family 2:Generic methyltransferase
Gene: POR_0933
Organism: Candidatus Poribacteria sp. WGA-A3

1uniprot[Pubmed] 20613790
Single-cell genomics reveals the lifestyle of Poribacteria, a candidate phylum symbiotically associated with marine sponges.(ISME J.) [2010]

C7QHK0_CATAD
(C7QHK0)

3e-16

90.9

30%

Product: Methyltransferase type 12
Gene: Caci_2106
Organism: Catenulispora acidiphila (strain DSM 44928 / NRRL B-24433 / NBRC 102108 / JCM 14897)

1uniprot
Complete genome sequence of Catenulispora acidiphila type strain (ID 139908).(Stand. Genomic Sci.) [2009]

D8PIA8_9BACT
(D8PIA8)

4e-16

90.5

28%

Product: Putative O-methyltransferase, family 2
Gene: NIDE3307
Organism: Candidatus Nitrospira defluvii

1uniprot
A Nitrospira metagenome illuminates the physiology and evolution of globally important nitrite-oxidizing bacteria.(Proc. Natl. Acad. Sci. U.S.A.) [2010]

D8I4M6_AMYMU
(D8I4M6)

5e-16

90.1

30%

Product: O-methyltransferase family protein
Gene: AMED_5440
Organism: Amycolatopsis mediterranei (strain U-32)

1uniprot[Pubmed] 20567260
Complete genome sequence of the rifamycin SV-producing Amycolatopsis mediterranei U32 revealed its genetic characteristics in phylogeny and metabolism.(Cell Res.) [2010]

D8P817_9BACT
(D8P817)

7e-16

89.7

29%

Product: Putative O-methyltransferase, family 2
Gene: NIDE3979
Organism: Candidatus Nitrospira defluvii

1uniprot
A Nitrospira metagenome illuminates the physiology and evolution of globally important nitrite-oxidizing bacteria.(Proc. Natl. Acad. Sci. U.S.A.) [2010]

Q2T8U0_BURTA
(Q2T8U0)

8e-16

89.4

27%

Product: Putative uncharacterized protein
Gene: BTH_II0207
Organism: Burkholderia thailandensis (strain E264 / ATCC 700388 / DSM 13276 / CIP 106301)

1uniprot[Pubmed] 16336651
Bacterial genome adaptation to niches: divergence of the potential virulence genes in three Burkholderia species of different survival strategies.(BMC Genomics) [2005]

F4BYU8_METCG
(F4BYU8)

1e-15

88.6

25%

Product: Methyltransferase
Gene: MCON_0961
Organism: Methanosaeta concilii (strain ATCC 5969 / DSM 3671 / JCM 10134 / NBRC 103675 / OCM 69 / GP-6)
Methanothrix concilii

1uniprot[Pubmed] 21571998
Complete genome sequence of Methanosaeta concilii, a specialist in aceticlastic methanogenesis.(J. Bacteriol.) [2011]

Q2RIK5_MOOTA
(Q2RIK5)

2e-15

88.2

26%

Product: O-methyltransferase, family 2
Gene: Moth_1421
Organism: Moorella thermoacetica (strain ATCC 39073)

1uniprot[Pubmed] 18631365
The complete genome sequence of Moorella thermoacetica (f. Clostridium thermoaceticum).(Environ. Microbiol.) [2008]

Q63P15_BURPS
(Q63P15)

3e-15

87.8

27%

Product: Putative methyltransferase
Gene: BPSS0133
Organism: Burkholderia pseudomallei
Pseudomonas pseudomallei

1uniprot[Pubmed] 15377794
Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.(Proc. Natl. Acad. Sci. U.S.A.) [2004]

D1JHL1_9ARCH
(D1JHL1)

3e-15

87.4

22%

Product: Putative uncharacterized protein
Gene: BSM_14960
BSM_19810
Organism: uncultured archaeon

1uniprot
Metagenome and mRNA expression analyses of anaerobic methanotrophic archaea of the ANME-1 group.(Environ. Microbiol.) [2010]

F6LWA4_9BACT
(F6LWA4)

4e-15

27%

Product: O-methyltransferase
Gene: abeM3
Organism: uncultured bacterium AB1650

1uniprot[Pubmed] 21542592
Cloning and Characterization of an Environmental DNA-Derived Gene Cluster That Encodes the Biosynthesis of the Antitumor Substance BE-54017.(J. Am. Chem. Soc.) [2011]

Q1Q4M5_9BACT
(Q1Q4M5)

4e-15

24%

Product: Similar to tetracenomycin polyketide synthesis 8-O-methyltransferase
Gene: tcmO
kuste4198
Organism: Candidatus Kuenenia stuttgartiensis

1uniprot[Pubmed] 16598256
Deciphering the evolution and metabolism of an anammox bacterium from a community genome.(Nature) [2006]

Q70DX4_9ACTO
(Q70DX4)

4e-15

26%

Product: RemG protein
Gene: remG
Organism: Streptomyces resistomycificus

A7DWL9_STRTE
(A7DWL9)

6e-15

86.3

30%

Product: Putative O-methyltransferase
Gene: llpMVI
Organism: Streptomyces tendae

1uniprot
Isolation of the lysolipin gene cluster of Streptomyces tendae Tu 4042.(Gene) [2010]

D8FED2_9DELT
(D8FED2)

9e-15

85.9

26%

Product: O-methyltransferase
Gene: NPH_5510
Organism: delta proteobacterium NaphS2

1uniprot[Pubmed] 21124915
Genome Sequence of the Deltaproteobacterial Strain NaphS2 and Analysis of Differential Gene Expression during Anaerobic Growth on Naphthalene.(PLoS ONE) [2010]

F3NRW5_9ACTO
(F3NRW5)

1e-14

85.5

26%

Product: O-methyltransferase
Gene: SGM_5879
Organism: Streptomyces griseoaurantiacus M045

1uniprot[Pubmed] 21551298
Draft Genome Sequence of the Marine Bacterium Streptomyces griseoaurantiacus M045, Which Produces Novel Manumycin-Type Antibiotics with a pABA Core Component.(J. Bacteriol.) [2011]

TCMO_STRGA
(P39896)

1e-14

85.1

29%

Product: Tetracenomycin polyketide synthesis 8-O-methyl transferase tcmO
Gene: tcmO
Organism: Streptomyces glaucescens

1uniprot[Pubmed] 1548230 [Medline] 92193265
Nucleotide sequence of the tcmII-tcmIV region of the tetracenomycin C biosynthetic gene cluster of Streptomyces glaucescens and evidence that the tcmN gene encodes a multifunctional cyclase-dehydratase-O-methyl transferase.(J. Bacteriol.) [1992]

D1JCX7_9ARCH
(D1JCX7)

2e-14

84.7

24%

Product: Putative uncharacterized protein
Gene: BSM_34360
Organism: uncultured archaeon

1uniprot
Metagenome and mRNA expression analyses of anaerobic methanotrophic archaea of the ANME-1 group.(Environ. Microbiol.) [2010]

Q2L6E6_9ACTO
(Q2L6E6)

3e-14

84.3

27%

Product: Probable methyltransferase
Gene
Organism: Streptomyces sp. KO-3988

1uniprot[Pubmed] 16452404
Biosynthesis of a natural polyketide-isoprenoid hybrid compound, furaquinocin A: identification and heterologous expression of the gene cluster.(J. Bacteriol.) [2006]

D7BZK8_STRBB
(D7BZK8)

1e-13

82.4

28%

Product: O-methyltransferase family protein
Gene: SBI_06793
Organism: Streptomyces bingchenggensis (strain BCW-1)

1uniprot[Pubmed] 20581206
Genome sequence of the milbemycin-producing bacterium Streptomyces bingchenggensis.(J. Bacteriol.) [2010]