Epoth_00080
Epoth_00090 : CDS information
Location
| Organism | Sorangium cellulosum |
|---|---|
| Strain | So ce90 |
| Entry name | Epothilone |
| Contig | AF210843 |
| Start / Stop / Direction | 21,746 / 43,519 / + [in whole cluster] 21,746 / 43,519 / + [in contig] |
| Location | 21746..43519 [in whole cluster] 21746..43519 [in contig] |
| Type | CDS |
| Length | 21,774 bp (7,257 aa) |
Annotation
| Category | 1.1 PKS |
|---|---|
| Product | polyketide synthase |
| Product (GenBank) | polyketide synthase |
| Gene | |
| Gene (GenBank) | epoC |
| EC number | |
| Keyword | |
| Note | |
| Note (GenBank) |
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| Reference |
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| Related Reference |
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PKS/NRPS Module
| 3 |  | malonyl-CoA |
| 4 | | malonyl-CoA for Epothilone A methylmalonyl-CoA for Epothilone B |
| 5 |  | malonyl-CoA |
| 6 | | methylmalonyl-CoA not conserved YASHS(Y->V) |
Sequence
>polyketide synthase [polyketide synthase] MTTRGPTAQQNPLKQAAIIIQRLEERLAGLAQAELERTEPIAIVGIGCRFPGGADAPEAF WELLDAERDAVQPLDMRWALVGVAPVEAVPHWAGLLTEPIDCFDAAFFGISPREARSLDP QHRLLLEVAWEGLEDAGIPPRSIDGSRTGVFVGAFTADYARTVARLPREERDAYSATGNM LSIAAGRLSYTLGLQGPCLTVDTACSSSLVAIHLACRSLRAGESDLALAGGVSALLSPDM MEAAARTQALSPDGRCRTFDASANGFVRGEGCGLVVLKRLSDAQRDGDRIWALIRGSAIN HDGRSTGLTAPNVLAQETVLREALRSAHVEAGAVDYVETHGTGTSLGDPIEVEALRATVG PARSDGTRCVLGAVKTNIGHLEAAAGVAGLIKAALSLTHERIPRNLNFRTLNPRIRLEGS ALALATEPVPWPRTDRPRFAGVSSFGMSGTNAHVVLEEAPAVELWPAAPERSAELLVLSG KSEGALDAQAARLREHLDMHPELGLGDVAFSLATTRSAMSHRLAVAVTSREGLLAALSAV AQGQTPAGAARCIASSSRGKLAFLFTGQGAQTPGMGRGLCAAWPAFREAFDRCVALFDRE LDRPLREVMWAEAGSAESLLLDQTAFTQPALFAVEYALTALWRSWGVEPELLVGHSIGEL VAACVAGVFSLEDGVRLVAARGRLMQGLSAGGAMVSLGAPEAEVAAAVAPHAASVSIAAV NGPEQVVIAGVEQAVQAIAAGFAARGARTKRLHVSHAFHSPLMEPMLEEFGRVAASVTYR RPSVSLVSNLSGKVVTDELSAPGYWVRHVREAVRFADGVKALHEAGAGTFVEVGPKPTLL GLLPACLPEAEPTLLASLRAGREEAAGVLEALGRLWAAGGSVSWPGVFPTAGRRVPLPTY PWQRQRYWIEAPAEGLGATAADALAQWFYRVDWPEMPRSSVDSRRARSGGWLVLADRGGV GEAAAAALSSQGCSCAVLHAPAEASAVAEQVTQALGGRNDWQGVLYLWGLDAVVEAGASA EEVAKVTHLAAAPVLALIQALGTGPRSPRLWIVTRGACTVGGEPDAAPCQAALWGMGRVA ALEHPGSWGGLVDLDPEESPTEVEALVAELLSPDAEDQLAFRQGRRRAARLVAAPPEGNA APVSLSAEGSYLVTGGLGALGLLVARWLVERGAGHLVLISRHGLPDREEWGRDQPPEVRA RIAAIEALEAQGARVTVAAVDVADAEGMAALLAAVEPPLRGVVHAAGLLDDGLLAHQDAG RLARVLRPKVEGAWVLHTLTREQPLDLFVLFSSASGVFGSIGQGSYAAGNAFLDALADLR RTQGLAALSIAWGLWAEGGMGSQAQRREHEASGIWAMPTSRALAAMEWLLGTRATQRVVI QMDWAHAGAAPRDASRGRFWDRLVTATKEASSSAVPAVERWRNASVVETRSALYELVRGV VAGVMGFTDQGTLDVRRGFAEQGLDSLMAVEIRKRLQGELGMPLSATLAFDHPTVERLVE YLLSQALELQDRTDVRSVRLPATEDPIAIVGAACRFPGGVEDLESYWQLLTEGVVVSTEV PADRWNGADGRVPGSGEAQRQTYVPRGGFLREVETFDAAFFHISPREAMSLDPQQRLLLE VSWEAIERAGQDPSALRESPTGVFVGAGPNEYAERVQELADEAAGLYSGTGNMLSVAAGR LSFFLGLHGPTLAVDTACSSSLVALHLGCQSLRRGECDQALVGGVNMLLSPKTFALLSRM HALSPGGRCKTFSADADGYARAEGCAVVVLKRLSDAQRDRDPILAVIRGTAINHDGPSSG LTVPSGPAQEALLRQALAHAGVVPADVDFVECHGTGTALGDPIEVRALSDVYGQARPADR PLILGAAKANLGHMEPAAGLAGLLKAVLALGQEQIPAQPELGELNPLLPWEALPVAVARA AVPWPRTDRPRFAGVSSFGMSGTNAHVVLEEAPAVELWPAAPERSAELLVLSGKSEGALD AQAARLREHLDMHPELGLGDVAFSLATTRSAMNHRLAVAVTSREGLLAALSAVAQGQTPP GAARCIASSSRGKLAFLFTGQGAQTPGMGRGLCAAWPAFREAFDRCVALFDRELDRPLRE VMWAEPGSAESLLLDQTAFTQPALFTVEYALTALWRSWGVEPELVAGHSAGELVAACVAG VFSLEDGVRLVAARGRLMQGLSAGGAMVSLGAPEAEVAAAVAPHAASVSIAAVNGPEQVV IAGVEQAVQAIAAGFAARGARTKRLHVSHASHSPLMEPMLEEFGRVAASVTYRRPSVSLV SNLSGKVVADELSAPGYWVRHVREAVRFADGVKALHEAGAGTFVEVGPKPTLLGLLPACL PEAEPTLLASLRAGREEAAGVLEALGRLWAAGGSVSWPGVFPTAGRRVPLPTYPWQRQRY WPDIEPDSRRHAAADPTQGWFYRVDWPEIPRSLQKSEEASRGSWLVLADKGGVGEAVAAA LSTRGLPCVVLHAPAETSATAELVTEAAGGRSDWQVVLYLWGLDAVVGAEASIDEIGDAT RRATAPVLGLARFLSTVSCSPRLWVVTRGACIVGDEPAIAPCQAALWGMGRVAALEHPGA WGGLVDLDPRASPPQASPIDGEMLVTELLSQETEDQLAFRHGRRHAARLVAAPPQGQAAP VSLSAEASYLVTGGLGGLGLIVAQWLVELGARHLVLTSRRGLPDRQAWCEQQPPEIRARI AAVEALEARGARVTVAAVDVADVEPMTALVSSVEPPLRGVVHAAGVSVMRPLAETDETLL ESVLRPKVAGSWLLHRLLHGRPLDLFVLFSSGAAVWGSHSQGAYAAANAFLDGLAHLRRS QSLPALSVAWGLWAEGGMADAEAHARLSDIGVLPMSTSAALSALQRLVETGAAQRTVTRM DWARFAPVYTARGRRNLLSALVAGRDIIAPSPPAAATRNWRGLSVAEARVALHEIVHGAV ARVLGFLDPSALDPGMGFNEQGLDSLMAVEIRNLLQAELDVRLSTTLAFDHPTVQRLVEH LLVDVLKLEDRSDTQHVRSLASDEPIAIVGAACRFPGGVEDLESYWQLLAEGVVVSAEVP ADRWDAADWYDPDPEIPGRTYVTKGAFLRDLQRLDATFFRISPREAMSLDPQQRLLLEVS WEALESAGIAPDTLRDSPTGVFVGAGPNEYYTQRLRGFTDGAAGLYGGTGNMLSVTAGRL SFFLGLHGPTLAMDTACSSSLVALHLACQSLRLGECDQALVGGVNVLLAPETFVLLSRMR ALSPDGRCKTFSADADGYARGEGCAVVVLKRLRDAQRAGDSILALIRGSAVNHDGPSSGL TVPNGPAQQALLRQALSQAGVSPVDVDFVECHGTGTALGDPIEVQALSEVYGPGRSGDRP LVLGAAKANVAHLEAASGLASLLKAVLALRHEQIPAQPELGELNPHLPWNTLPVAVPRKA VPWGRGARPRRAGVSAFGLSGTNVHVVLEEAPEVEPAPAAPARPVELVVLSAKSAAALDA AAARLSAHLSAHPELSLGDVAFSLATTRSPMEHRLAIATTSREALRGALDAAAQQKTPQG AVRGKAVSSRGKLAFLFTGQGAQMPGMGRGLYETWPAFREAFDRCVALFDREIDQPLREV MWAAPGLAQAARLDQTAYAQPALFALEYALAALWRSWGVEPHVLLGHSIGELVAACVAGV FSLEDAVRLVAARGRLMQALPAGGAMVAIAASEAEVAASVAPHAATVSIAAVNGPDAVVI AGAEVQVLALGATFAARGIRTKRLAVSHAFHSPLMDPMLEDFQRVAATIAYRAPDRPVVS NVTGHVAGPEIATPEYWVRHVRSAVRFGDGAKALHAAGAATFVEVGPKPVLLGLLPACLG EADAVLVPSLRADRSECEVVLAALGAWYAWGGALDWKGVFPDGARRVALPMYPWQRERHW MDLTPRSAAPAGIAGRWPLAGVGLCMPGAVLHHVLSIGPRHQPFLGDHLVFGKVVVPGAF HVAVILSIAAERWPERAIELTGVEFLKAIAMEPDQEVELHAVLTPEAAGDGYLFELATLA APETERRWTTHARGRVQPTDGAPGALPRLEVLEDRAIQPLDFAGFLDRLSAVRIGWGPLW RWLQDGRVGDEASLATLVPTYPNAHDVAPLHPILLDNGFAVSLLSTRSEPEDDGTPPLPF AVERVRWWRAPVGRVRCGGVPRSQAFGVSSFVLVDETGEVVAEVEGFVCRRAPREVFLRQ ESGASTAALYRLDWPEAPLPDAPAERIEESWVVVAAPGSEMAAALATRLNRCVLAEPKGL EAALAGVSPAGVICLWEAGAHEEAPAAAQRVATEGLSVVQALRDRAVRLWWVTMGAVAVE AGERVQVATAPVWGLGRTVMQERPELSCTLVDLEPEADAARSADVLLRELGRADDETQVA FRSGKRRVARLVKATTPEGLLVPDAESYRLEAGQKGTLDQLRLAPAQRRAPGPGEVEIKV TASGLNFRTVLAVLGMYPGDAGPMGGDCAGVATAVGQGVRHVAVGDAVMTLGTLHRFVTV DARLVVRQPAGLTPAQAATVPVAFLTAWLALHDLGNLRRGERVLIHAAAGGVGMAAVQIA RWIGAEVFATASPSKWAAVQAMGVPRTHIASSRTLEFAETFRQVTGGRGVDVVLNALAGE FVDASLSLLSTGGRFLEMGKTDIRDRAAVAAAHPGVRYRVFDILELAPDRTREILERVVE GFAAGHLRALPVHAFAITKAEAAFRFMAQARHQGKVVLLPAPSAAPLAPTGTVLLTGGLG ALGLHVARWLAQQGVPHMVLTGRRGLDTPGAAKAVAEIEALGARVTIAASDVADRNALEA VLQAIPAEWPLQGVIHAAGALDDGVLDEQTTDRFSRVLAPKVTGAWNLHELTAGNDLAFF VLFSSMSGLLGSAGQSNYAAANTFLDALAAHRRAEGLAAQSLAWGPWSDGGMAAGLSAAL QARLARHGMGALSPAQGTALLGQALARPETQLGAMSLDVRAASQASGAAVPPVWRALVRA EARHTAAGAQGALAARLGALPEARRADEVRKVVQAEIARVLSWSAASAVPVDRPLSDLGL DSLTAVELRNVLGQRVGATLPATLAFDHPTVDALTRWLLDKVLAVAEPSVSSAKSSPQVA LDEPIAIIGIGCRFPGGVADPESFWRLLEEGSDAVVEVPHERWDIDAFYDPDPDVRGKMT TRFGGFLSDIDRFDPAFFGISPREATTMDPQQRLLLETSWEAFERAGILPERLMGSDTGV FVGLFYQEYAALAGGIEAFDGYLGTGTTASVASGRISYVLGLKGPSLTVDTACSSSLVAV HLACQALRRGECSVALAGGVALMLTPATFVEFSRLRGLAPDGRCKSFSAAADGVGWSEGC AMLLLKPLRDAQRDGDPILAVIRGTAVNQDGRSNGLTAPNGSSQQEVIRRALEQAGLAPA DVSYVECHGTGTTLGDPIEVQALGAVLAQGRPSDRPLVIGSVKSNIGHTQAAAGVAGVIK VALALERGLIPRSLHFDAPNPHIPWSELAVQVAAKPVEWTRNGVPRRAGVSSFGVSGTNA HVVLEEAPAAAFAPAAARSAELFVLSAKSAAALDAQAARLSAHVVAHPELGLGDLAFSLA TTRSPMTYRLAVAATSREALSAALDTAAQGQAPPAAARGHASTGSAPKVVFVFPGQGSQW LGMGQKLLSEEPVFRDALSACDRAIQAEAGWSLLAELAADETTSQLGRIDVVQPALFAIE VALSALWRSWGVEPDAVVGHSMGEVAAAHVAGALSLEDAVAIICRRSLLLRRISGQGEMA VVELSLAEAEAALLGYEDRLSVAVSNSPRSTVLAGEPAALAEVLAILAAKGVFCRRVKVD VASHSPQIDPLRDELLAALGELEPRQATVSMRSTVTSTIMAGPELVASYWADNVRQPVRF AEAVQSLMEDGHGLFVEMSPHPILTTSVEEIRRATKREGVAVGSLRRGQDERLSMLEALG ALWVHGQAVGWERLFSAGGAGLRRVPLPTYPWQRERYWVDAPTGGAAGGSRFAHAGSHPL LGEMQTLSTQRSTRVWETTLDLKRLPWLGDHRVQGAVVFPGAAYLEMALSSGAEALGDGP LQVSDVVLAEALAFADDTPAAVQVMATEERPGRLQFHVASRVPGHGGAAFRSHARGVLRQ IERAEVPARLDLAALRARLQASAPAAATYAALAEMGLEYGPAFQGLVELWRGEGEALGRV RLPEAAGSPAACRLHPALLDACFHVSSAFADRGEATPWVPVEIGSLRWFQRPSGELWCHA RSVSHGKPTPDRRSTDFWVVDSTGAIVAEISGLVAQRLAGGVRRREEDDWFMEPAWEPTA VPGSEVMAGRWLLIGSGGGLGAALHSALTEAGHSVVHATGRGTSAAGLQALLTASFDGQA PTSVVHLGSLDERGVLDADAPFDADALEESLVRGCDSVLWTVQAVAGAGFRDPPRLWLVT RGAQAIGAGDVSVAQAPLLGLGRVIALEHAELRCARIDLDPARRDGEVDELLAELLADDA EEEVAFRGGERRVARLVRRLPETDCREKIEPAEGRPFRLEIDGSGVLDDLVLRATERRPP GPGEVEIAVEAAGLNFLDVMRAMGIYPGPGDGPVALGAECSGRIVAMGEGVESLRIGQDV VAVAPFSFGTHVTIDARMLAPRPAALTAAQAAALPVAFMTAWYGLVHLGRLRAGERVLIH SATGGTGLAAVQIARHLGAEIFATAGTPEKRAWLREQGIAHVMDSRSLDFAEQVLAATKG EGVDVVLNSLSGAAIDASLSTLVPDGRFIELGKTDIYADRSLGLAHFRKSLSYSAVDLAG LAVRRPERVAALLAEVVDLLARGALQPLPVEIFPLSRAADAFRKMAQAQHLGKLVLALED PDVRIRVPGESGVAIRADGAYLVTGGLGGLGLSVAGWLAEQGAGHLVLVGRSGAVSAEQQ TAVAALEAHGARVTVARADVADRAQMERILREVTASGMPLRGVVHAAGILDDGLLMQQTP ARFRAVMAPKVRGALHLHALTREAPLSFFVLYASGAGLLGSPGQGNYAAANTFLDALAHH RRAQGLPALSIDWGLFADVGLAAGQQNRGARLVTRGTRSLTPDEGLWALERLLDGDRTQA GVMPFDVRQWVEFYPAAASSRRLSRLMTARRVASGRLAGDRDLLERLATAEAGARAGMLQ EVVRAQVSQVLRLSEGKLDVDAPLTSLGMDSLMGLELRNRIEAVLGITMPATLLWTYPTV AALSAHLASHVVSTGDGESARPPDTGSVAPTTHEVASLDEDGLFALIDESLARAGKR
>polyketide synthase [polyketide synthase] ATGACTACTCGCGGTCCTACGGCACAGCAGAATCCGCTGAAACAAGCGGCCATCATCATT CAGCGGCTGGAGGAGCGGCTCGCTGGGCTCGCACAGGCGGAGCTGGAACGGACCGAGCCG ATCGCCATCGTCGGTATCGGCTGCCGCTTCCCTGGCGGTGCGGACGCTCCGGAAGCGTTT TGGGAGCTGCTCGACGCGGAGCGCGACGCGGTCCAGCCGCTCGACATGCGCTGGGCGCTG GTGGGTGTCGCTCCCGTCGAGGCCGTGCCGCACTGGGCGGGGCTGCTCACCGAGCCGATA GATTGCTTCGATGCTGCGTTCTTCGGCATCTCGCCTCGGGAGGCGCGATCGCTCGACCCG CAGCATCGTCTGTTGCTGGAGGTCGCTTGGGAGGGGCTCGAGGACGCCGGTATCCCGCCC CGGTCCATCGACGGGAGCCGCACCGGTGTGTTCGTCGGCGCTTTCACGGCGGACTACGCG CGCACGGTCGCTCGGCTGCCGCGCGAGGAGCGAGACGCGTACAGCGCCACCGGCAACATG CTCAGCATCGCCGCCGGACGGCTGTCGTACACGCTGGGGTTGCAGGGACCTTGCCTGACC GTCGACACGGCGTGCTCGTCATCGCTGGTGGCGATTCACCTCGCCTGCCGCAGCCTGCGC GCAGGAGAGAGCGATCTCGCGTTGGCGGGAGGGGTCAGCGCGCTCCTCTCCCCCGACATG ATGGAAGCCGCGGCGCGCACGCAAGCGCTGTCGCCCGATGGTCGTTGCCGGACCTTCGAT GCTTCGGCCAACGGGTTCGTCCGTGGCGAGGGCTGTGGCCTGGTCGTCCTCAAACGGCTC TCCGACGCGCAACGGGATGGCGACCGCATCTGGGCGCTGATCCGGGGCTCGGCCATCAAC CATGATGGCCGGTCGACCGGGTTGACCGCGCCCAACGTGCTGGCTCAGGAGACGGTCTTG CGCGAGGCGCTGCGGAGCGCCCACGTCGAAGCTGGGGCCGTCGATTACGTCGAGACCCAC GGAACAGGGACCTCGCTGGGCGATCCCATCGAGGTCGAGGCGCTGCGGGCGACGGTGGGG CCGGCGCGCTCCGACGGCACACGCTGCGTGCTGGGCGCGGTGAAGACCAACATCGGCCAT CTCGAGGCCGCGGCAGGCGTAGCGGGCCTGATCAAGGCAGCGCTTTCGCTGACGCACGAG CGCATCCCGAGAAACCTCAACTTCCGCACGCTCAATCCGCGGATCCGGCTCGAGGGCAGC GCGCTCGCGTTGGCGACCGAGCCGGTGCCGTGGCCGCGCACGGACCGCCCGCGCTTCGCG GGGGTGAGCTCGTTCGGGATGAGCGGAACGAACGCGCATGTGGTGCTGGAAGAGGCGCCG GCGGTGGAGCTGTGGCCTGCCGCGCCGGAGCGCTCGGCGGAGCTTTTGGTGCTGTCGGGC AAGAGCGAGGGGGCGCTCGATGCGCAGGCGGCGCGGCTGCGCGAGCACCTGGACATGCAC CCGGAGCTCGGGCTCGGGGACGTGGCGTTCAGCCTGGCGACGACGCGCAGCGCGATGAGC CACCGGCTCGCGGTGGCGGTGACGTCGCGCGAGGGGCTGCTGGCGGCGCTCTCGGCCGTG GCGCAGGGGCAGACGCCGGCGGGGGCGGCGCGCTGCATCGCGAGCTCCTCGCGCGGCAAG CTGGCGTTCCTGTTCACCGGACAGGGCGCGCAGACGCCGGGCATGGGCCGGGGGCTTTGC GCGGCGTGGCCAGCGTTCCGGGAGGCGTTCGACCGGTGCGTGGCGCTGTTCGACCGGGAG CTGGACCGCCCGCTGCGCGAGGTGATGTGGGCGGAGGCGGGGAGCGCCGAGTCGTTGTTG CTCGACCAGACGGCGTTCACCCAGCCCGCGCTCTTCGCGGTGGAGTACGCGCTGACGGCG CTGTGGCGGTCGTGGGGCGTAGAGCCGGAGCTCCTGGTTGGGCATAGCATCGGGGAGCTG GTGGCGGCGTGCGTGGCGGGGGTGTTCTCGCTGGAAGATGGGGTGAGGCTCGTGGCGGCG CGCGGGCGGCTGATGCAGGGGCTCTCGGCGGGCGGCGCGATGGTGTCGCTCGGAGCGCCG GAGGCGGAGGTGGCGGCGGCGGTGGCGCCGCACGCGGCGTCGGTGTCGATCGCGGCGGTC AATGGGCCGGAGCAGGTGGTGATCGCGGGCGTGGAGCAAGCGGTGCAGGCGATCGCGGCG GGGTTCGCGGCGCGCGGCGCGCGCACCAAGCGGCTGCATGTCTCGCACGCGTTCCACTCG CCGCTGATGGAACCGATGCTGGAGGAGTTCGGGCGGGTGGCGGCGTCGGTGACGTACCGG CGGCCAAGCGTTTCGCTGGTGAGCAACCTGAGCGGGAAGGTGGTCACGGACGAGCTGAGC GCGCCGGGGTACTGGGTGCGGCACGTGCGGGAGGCGGTGCGCTTCGCGGACGGGGTGAAG GCGCTGCACGAAGCCGGCGCGGGGACGTTCGTCGAAGTGGGCCCGAAGCCGACGCTGCTC GGGCTGTTGCCAGCCTGCCTGCCGGAGGCGGAGCCGACGCTGCTGGCGTCGTTGCGCGCC GGGCGCGAGGAGGCTGCGGGGGTGCTCGAGGCGCTGGGCAGGCTGTGGGCCGCCGGCGGC TCGGTCAGCTGGCCGGGCGTCTTCCCCACGGCTGGGCGGCGGGTGCCGCTGCCGACCTAT CCGTGGCAGCGGCAGCGGTACTGGATCGAGGCGCCGGCCGAAGGGCTCGGAGCCACGGCC GCCGATGCGCTGGCGCAGTGGTTCTACCGGGTGGACTGGCCCGAGATGCCTCGCTCATCC GTGGATTCGCGGCGAGCCCGGTCCGGCGGGTGGCTGGTGCTGGCCGACCGGGGTGGAGTC GGGGAGGCGGCCGCGGCGGCGCTTTCGTCGCAGGGATGTTCGTGCGCCGTGCTCCATGCG CCCGCCGAGGCCTCCGCGGTTGCCGAGCAGGTGACCCAGGCCCTCGGTGGCCGCAACGAC TGGCAGGGGGTGCTGTACCTGTGGGGTCTGGACGCCGTCGTGGAGGCGGGGGCATCGGCC GAAGAGGTCGCCAAAGTCACCCATCTTGCCGCGGCGCCGGTGCTCGCGCTGATTCAGGCG CTCGGCACGGGGCCGCGCTCACCCCGGCTCTGGATCGTGACCCGAGGGGCCTGCACGGTG GGCGGCGAGCCTGACGCTGCCCCCTGTCAGGCGGCGCTGTGGGGTATGGGCCGGGTCGCG GCGCTAGAGCATCCCGGCTCCTGGGGCGGGCTCGTGGACCTGGATCCGGAGGAGAGCCCG ACGGAGGTCGAGGCCCTGGTGGCCGAGCTGCTTTCGCCGGACGCCGAGGATCAGCTGGCA TTCCGCCAGGGGCGCCGGCGCGCAGCGCGGCTTGTGGCCGCCCCACCGGAGGGAAACGCA GCGCCGGTGTCGCTGTCTGCGGAGGGGAGTTACTTGGTGACGGGTGGGCTGGGCGCCCTT GGCCTCCTCGTTGCGCGGTGGTTGGTGGAGCGCGGGGCGGGGCACCTTGTGCTGATCAGC CGGCACGGATTGCCCGACCGCGAGGAATGGGGCCGAGATCAGCCGCCAGAGGTGCGCGCG CGCATTGCGGCGATCGAGGCGCTGGAGGCGCAGGGCGCGCGGGTCACCGTGGCGGCGGTC GACGTGGCCGATGCCGAAGGCATGGCGGCGCTCTTGGCGGCCGTCGAGCCGCCGCTGCGG GGGGTAGTGCACGCCGCGGGTCTGCTCGACGACGGGCTGCTGGCCCACCAGGACGCTGGT CGGCTCGCCCGGGTGTTGCGCCCCAAGGTGGAGGGGGCATGGGTGCTGCACACCCTTACC CGCGAGCAGCCGCTGGACCTCTTCGTACTGTTTTCCTCGGCGTCGGGCGTCTTCGGCTCG ATCGGCCAGGGCAGCTACGCGGCAGGCAATGCCTTTTTGGACGCGCTGGCGGACCTCCGC CGAACGCAGGGGCTCGCCGCCCTGAGCATCGCCTGGGGCCTGTGGGCGGAGGGGGGGATG GGCTCGCAGGCGCAGCGCCGGGAACACGAGGCATCGGGAATCTGGGCGATGCCGACGAGT CGGGCCCTGGCGGCGATGGAATGGCTGCTCGGTACGCGCGCGACGCAGCGCGTGGTCATC CAGATGGATTGGGCCCATGCGGGAGCGGCGCCGCGCGACGCGAGCCGAGGCCGCTTCTGG GATCGGCTGGTAACTGCCACGAAAGAGGCCTCCTCCTCGGCCGTGCCAGCTGTGGAGCGC TGGCGCAACGCGTCTGTTGTGGAGACCCGCTCGGCGCTCTACGAGCTTGTGCGCGGCGTG GTCGCCGGGGTGATGGGCTTTACCGACCAGGGCACGCTCGACGTGCGACGAGGCTTCGCC GAGCAGGGCCTCGACTCCCTGATGGCCGTGGAGATCCGCAAACGGCTTCAGGGTGAGCTG GGTATGCCGCTGTCGGCGACGCTAGCGTTCGACCATCCGACCGTGGAGCGGCTGGTGGAA TACTTGCTGAGCCAGGCGCTGGAGCTGCAGGACCGCACCGACGTGCGGAGCGTTCGGTTG CCGGCGACAGAGGACCCGATCGCCATCGTGGGTGCCGCCTGCCGCTTCCCGGGCGGGGTC GAGGACCTGGAGTCCTACTGGCAGCTGTTGACCGAGGGCGTGGTGGTCAGCACCGAGGTG CCGGCCGACCGGTGGAATGGGGCAGACGGGCGCGTCCCCGGCTCGGGAGAGGCACAGAGA CAGACCTACGTGCCCAGGGGTGGCTTTCTGCGCGAGGTGGAGACGTTCGATGCGGCGTTC TTCCACATCTCGCCTCGGGAGGCGATGAGCCTGGACCCGCAACAGCGGCTGCTGCTGGAA GTGAGCTGGGAGGCGATCGAGCGCGCGGGCCAGGACCCGTCGGCGCTGCGCGAGAGCCCC ACGGGCGTGTTCGTGGGCGCGGGCCCCAACGAATATGCCGAGCGGGTGCAGGAACTCGCC GATGAGGCGGCGGGGCTCTACAGCGGCACCGGCAACATGCTCAGCGTTGCGGCGGGACGG CTATCATTTTTCCTGGGCCTGCACGGGCCGACCCTGGCTGTGGATACGGCGTGCTCCTCG TCGCTGGTGGCGCTGCACCTCGGCTGCCAGAGCTTGCGACGGGGCGAGTGCGACCAAGCC CTGGTTGGCGGGGTCAACATGCTGCTCTCGCCGAAGACCTTCGCGCTGCTCTCACGGATG CACGCACTTTCGCCCGGCGGGCGGTGCAAGACGTTCTCGGCCGACGCGGACGGCTACGCG CGGGCCGAGGGCTGCGCCGTGGTGGTGCTCAAGCGGCTCTCCGACGCGCAGCGCGACCGC GACCCCATCCTGGCGGTGATCCGGGGTACGGCGATCAATCATGATGGCCCGAGCAGCGGG CTGACAGTGCCCAGCGGCCCTGCCCAGGAGGCGCTGTTACGCCAGGCGCTGGCGCACGCA GGGGTGGTTCCGGCCGACGTCGATTTCGTGGAATGCCACGGGACCGGGACGGCGCTGGGC GACCCGATCGAGGTGCGTGCGCTGAGCGACGTGTACGGGCAAGCCCGCCCTGCGGACCGA CCGCTGATCCTGGGAGCCGCCAAGGCCAACCTTGGGCACATGGAGCCCGCGGCGGGCCTG GCCGGCTTGCTCAAGGCGGTGCTCGCGCTGGGGCAAGAGCAAATACCAGCCCAGCCGGAG CTGGGCGAGCTCAACCCGCTCTTGCCGTGGGAGGCGCTGCCGGTGGCGGTGGCCCGCGCA GCGGTGCCGTGGCCGCGCACGGACCGCCCGCGCTTCGCGGGGGTGAGCTCGTTCGGGATG AGCGGAACGAACGCGCATGTGGTGCTGGAAGAGGCGCCGGCGGTGGAGCTGTGGCCTGCC GCGCCGGAGCGCTCGGCGGAGCTTTTGGTGCTGTCGGGCAAGAGCGAGGGGGCGCTCGAT GCGCAGGCGGCGCGGCTGCGCGAGCACCTGGACATGCACCCGGAGCTCGGGCTCGGGGAC GTGGCGTTCAGCCTGGCGACGACGCGCAGCGCGATGAACCACCGGCTCGCGGTGGCGGTG ACGTCGCGCGAGGGGCTGCTGGCGGCGCTTTCGGCCGTGGCGCAGGGGCAGACGCCGCCG GGGGCGGCGCGCTGCATCGCGAGCTCGTCGCGCGGCAAGCTGGCGTTCCTGTTCACCGGA CAGGGCGCGCAGACGCCGGGCATGGGCCGGGGGCTTTGCGCGGCGTGGCCAGCGTTCCGG GAGGCGTTCGACCGGTGCGTGGCGCTGTTCGACCGGGAGCTGGACCGCCCGCTGCGCGAG GTGATGTGGGCGGAGCCGGGGAGCGCCGAGTCGTTGTTGCTCGACCAGACGGCGTTCACC CAGCCCGCGCTCTTCACGGTGGAGTACGCGCTGACGGCGCTGTGGCGGTCGTGGGGCGTA GAGCCGGAGCTGGTGGCTGGGCATAGCGCCGGGGAGCTGGTGGCGGCGTGCGTGGCGGGG GTGTTCTCGCTGGAAGATGGGGTGAGGCTCGTGGCGGCGCGCGGGCGGCTGATGCAGGGG CTCTCGGCGGGCGGCGCGATGGTGTCGCTCGGAGCGCCGGAGGCGGAGGTGGCGGCGGCG GTGGCGCCGCACGCGGCGTCGGTGTCGATCGCGGCGGTCAATGGGCCGGAGCAGGTGGTG ATCGCGGGCGTGGAGCAAGCGGTGCAGGCGATCGCGGCGGGGTTCGCGGCGCGCGGCGCG CGCACCAAGCGGCTGCATGTCTCGCACGCGTCCCACTCGCCGCTGATGGAACCGATGCTG GAGGAGTTCGGGCGGGTGGCGGCGTCGGTGACGTACCGGCGGCCAAGCGTTTCGCTGGTG AGCAACCTGAGCGGGAAGGTGGTCGCGGACGAGCTGAGCGCGCCGGGGTACTGGGTGCGG CACGTGCGGGAGGCGGTGCGCTTCGCGGACGGGGTGAAGGCGCTGCACGAAGCCGGTGCG GGCACGTTCGTCGAAGTGGGCCCGAAGCCGACGCTGCTCGGGCTGTTGCCAGCCTGCCTG CCGGAGGCGGAGCCGACGCTGCTGGCGTCGTTGCGCGCCGGGCGCGAGGAGGCTGCGGGG GTGCTCGAGGCGCTGGGCAGGCTGTGGGCCGCCGGCGGCTCGGTCAGCTGGCCGGGCGTC TTCCCCACGGCTGGGCGGCGGGTGCCGCTGCCGACCTATCCGTGGCAGCGGCAGCGGTAC TGGCCCGACATCGAGCCTGACAGCCGTCGCCACGCAGCCGCGGATCCGACCCAAGGCTGG TTCTATCGCGTGGACTGGCCGGAGATACCTCGCAGCCTCCAGAAATCAGAGGAGGCGAGC CGCGGGAGCTGGCTGGTATTGGCGGATAAGGGTGGAGTCGGCGAGGCGGTCGCTGCAGCG CTGTCGACACGTGGACTTCCATGCGTCGTGCTCCATGCGCCGGCAGAGACATCCGCGACC GCCGAGCTGGTGACCGAGGCTGCCGGCGGTCGAAGCGATTGGCAGGTAGTGCTCTACCTG TGGGGTCTGGACGCCGTCGTCGGTGCGGAGGCGTCGATCGATGAGATCGGCGACGCGACC CGTCGTGCTACCGCGCCGGTGCTCGGCTTGGCTCGGTTTCTGAGCACCGTGTCTTGTTCG CCCCGACTCTGGGTCGTGACCCGGGGGGCATGCATCGTTGGCGACGAGCCTGCGATCGCC CCTTGTCAGGCGGCGTTATGGGGCATGGGCCGGGTGGCGGCGCTCGAGCATCCCGGGGCC TGGGGCGGGCTCGTGGACCTGGATCCCCGAGCGAGCCCGCCCCAAGCCAGCCCGATCGAC GGCGAGATGCTCGTCACCGAGCTATTGTCGCAGGAGACCGAGGATCAGCTCGCCTTCCGC CATGGGCGCCGGCACGCGGCACGGCTGGTGGCCGCCCCGCCACAGGGGCAAGCGGCACCG GTGTCGCTGTCTGCGGAGGCGAGCTACCTGGTGACGGGAGGCCTCGGTGGGCTGGGCCTG ATCGTGGCCCAGTGGCTGGTGGAGCTGGGAGCGCGGCACTTGGTGCTGACCAGCCGGCGC GGGTTGCCCGACCGGCAGGCGTGGTGCGAGCAGCAGCCGCCTGAGATCCGCGCGCGGATC GCAGCGGTCGAGGCGCTGGAGGCGCGGGGTGCACGGGTGACCGTGGCAGCGGTGGACGTG GCCGACGTCGAACCGATGACAGCGCTGGTTTCGTCGGTCGAGCCCCCGCTGCGAGGGGTG GTGCACGCCGCTGGCGTCAGCGTCATGCGTCCACTGGCGGAGACGGACGAGACCCTGCTC GAGTCGGTGCTCCGTCCCAAGGTGGCCGGGAGCTGGCTGCTGCACCGGCTGCTGCACGGC CGGCCTCTCGACCTGTTCGTGCTGTTCTCGTCGGGCGCAGCGGTGTGGGGTAGCCATAGC CAGGGTGCGTACGCGGCGGCCAACGCTTTCCTCGACGGGCTCGCGCATCTTCGGCGTTCG CAATCGCTGCCTGCGTTGAGCGTCGCGTGGGGTCTGTGGGCCGAGGGAGGCATGGCGGAC GCGGAGGCTCATGCACGTCTGAGCGACATCGGGGTTCTGCCCATGTCGACGTCGGCAGCG TTGTCGGCGCTCCAGCGCCTGGTGGAGACCGGCGCGGCTCAGCGCACGGTGACCCGGATG GACTGGGCGCGCTTCGCGCCGGTGTACACCGCTCGAGGGCGTCGCAACCTGCTTTCGGCG CTGGTCGCAGGGCGCGACATCATCGCGCCTTCCCCTCCGGCGGCAGCAACCCGGAACTGG CGTGGCCTGTCCGTTGCGGAAGCCCGCGTGGCTCTGCACGAGATCGTCCATGGGGCCGTC GCTCGGGTGCTGGGCTTCCTCGACCCGAGCGCGCTCGATCCTGGGATGGGGTTCAATGAG CAGGGCCTCGACTCGTTGATGGCGGTGGAGATCCGCAACCTCCTTCAGGCTGAGCTGGAC GTGCGGCTTTCGACGACGCTGGCCTTTGATCATCCGACGGTACAGCGGCTGGTGGAGCAT CTGCTCGTCGATGTACTGAAGCTGGAGGATCGCAGCGACACCCAGCATGTTCGGTCGTTG GCGTCAGACGAGCCCATCGCCATCGTGGGAGCCGCCTGCCGCTTCCCGGGCGGGGTGGAG GACCTGGAGTCCTACTGGCAGCTATTGGCCGAGGGCGTGGTGGTCAGCGCCGAGGTGCCG GCCGACCGGTGGGATGCGGCGGACTGGTACGACCCTGATCCGGAGATCCCAGGCCGGACT TACGTGACCAAAGGCGCCTTCCTGCGCGATTTGCAGAGATTGGATGCGACCTTCTTCCGC ATCTCGCCTCGCGAGGCGATGAGCCTCGACCCGCAGCAGCGGTTGCTCCTGGAGGTAAGC TGGGAAGCGCTCGAGAGCGCGGGTATCGCTCCGGATACGCTGCGAGATAGCCCCACCGGG GTGTTCGTGGGTGCGGGGCCCAATGAGTACTACACGCAGCGGCTGCGAGGCTTCACCGAC GGAGCGGCAGGGTTGTACGGCGGCACCGGGAACATGCTCAGCGTTACGGCTGGACGGCTG TCGTTTTTCCTGGGTCTGCACGGCCCGACGCTGGCCATGGATACGGCGTGCTCGTCATCC CTGGTCGCGCTGCACCTCGCCTGCCAGAGCCTGCGACTGGGCGAGTGCGATCAAGCGCTG GTTGGCGGGGTCAACGTGCTGCTCGCGCCGGAGACCTTCGTGCTGCTCTCACGGATGCGC GCGCTTTCGCCCGACGGGCGGTGCAAGACGTTCTCGGCCGACGCGGACGGCTACGCGCGG GGCGAGGGGTGCGCCGTGGTGGTGCTCAAGCGGCTGCGCGATGCGCAGCGCGCCGGCGAC TCCATCCTGGCGCTGATCCGGGGAAGCGCGGTGAACCACGACGGCCCGAGCAGCGGGCTG ACCGTACCCAACGGACCCGCCCAGCAAGCATTGCTGCGCCAGGCGCTTTCGCAAGCAGGC GTGTCTCCGGTCGACGTTGATTTTGTGGAGTGTCACGGGACAGGGACGGCGCTGGGCGAC CCGATCGAGGTGCAGGCGCTGAGCGAGGTGTATGGTCCAGGGCGCTCCGGGGACCGACCG CTGGTGCTGGGGGCCGCCAAGGCCAACGTCGCGCATCTGGAGGCGGCATCTGGCTTGGCC AGCCTGCTCAAGGCCGTGCTTGCGCTGCGGCACGAGCAGATCCCGGCCCAGCCGGAGCTG GGGGAGCTCAACCCGCACTTGCCGTGGAACACGCTGCCGGTGGCGGTGCCACGTAAGGCG GTGCCGTGGGGGCGCGGCGCACGCCCGCGTCGGGCCGGCGTGAGCGCGTTCGGGTTGAGC GGAACCAACGTGCATGTCGTGCTGGAGGAGGCACCGGAGGTGGAGCCGGCGCCCGCGGCG CCGGCGCGACCGGTGGAGCTGGTCGTGCTATCGGCCAAGAGCGCGGCGGCGCTGGACGCC GCGGCGGCACGGCTCTCGGCGCACCTGTCCGCGCACCCGGAGCTGAGCCTCGGCGACGTG GCGTTCAGCCTGGCGACGACGCGCAGCCCGATGGAGCACCGGCTCGCCATCGCGACGACC TCGCGCGAGGCCCTGCGAGGCGCGCTGGACGCCGCGGCGCAGCAAAAGACGCCGCAGGGC GCGGTGCGCGGCAAGGCCGTGTCCTCACGCGGTAAGCTGGCTTTCCTGTTCACCGGACAG GGCGCGCAAATGCCGGGCATGGGCCGTGGGCTGTACGAAACGTGGCCTGCGTTCCGGGAG GCGTTCGACCGGTGCGTGGCGCTCTTCGATCGGGAGATCGACCAGCCTCTGCGCGAGGTG ATGTGGGCTGCGCCGGGCCTCGCTCAGGCGGCGCGGCTCGATCAGACCGCGTACGCGCAG CCGGCTCTCTTTGCGCTGGAGTACGCGCTGGCTGCCCTGTGGCGTTCGTGGGGCGTGGAG CCGCACGTACTGCTCGGTCATAGCATCGGCGAGCTGGTCGCCGCCTGCGTGGCGGGCGTG TTCTCGCTCGAAGATGCGGTGAGGTTGGTGGCCGCGCGCGGGCGGCTGATGCAGGCGCTA CCCGCCGGCGGTGCCATGGTAGCCATCGCAGCGTCCGAGGCCGAGGTGGCCGCCTCCGTG GCGCCCCACGCCGCCACGGTGTCGATCGCCGCGGTCAACGGTCCTGACGCCGTCGTGATC GCCGGCGCCGAGGTACAGGTGCTCGCCCTCGGCGCGACGTTCGCGGCGCGTGGGATACGC ACGAAGAGGCTCGCCGTCTCCCATGCGTTCCACTCGCCGCTCATGGATCCGATGCTGGAA GACTTCCAGCGGGTCGCTGCGACGATCGCGTACCGCGCGCCAGACCGCCCGGTGGTGTCG AATGTCACCGGCCACGTCGCAGGCCCCGAGATCGCCACGCCCGAGTATTGGGTCCGGCAT GTGCGAAGCGCCGTGCGCTTCGGCGACGGGGCAAAGGCGTTGCATGCCGCGGGTGCCGCC ACGTTCGTCGAGGTTGGCCCGAAGCCGGTCCTGCTCGGGCTGTTGCCAGCGTGCCTCGGG GAAGCGGACGCGGTCCTCGTGCCGTCGCTACGCGCGGACCGCTCGGAATGCGAGGTGGTC CTCGCGGCGCTCGGGGCTTGGTATGCCTGGGGGGGTGCGCTCGACTGGAAGGGCGTGTTC CCCGATGGCGCGCGCCGCGTGGCTCTGCCCATGTATCCATGGCAGCGTGAGCGCCATTGG ATGGACCTCACCCCGCGAAGCGCCGCGCCTGCAGGGATCGCAGGTCGCTGGCCGCTGGCT GGTGTCGGGCTCTGCATGCCCGGCGCTGTGTTGCACCACGTGCTCTCGATCGGACCACGC CATCAGCCCTTCCTCGGTGATCACCTCGTGTTTGGCAAGGTGGTGGTGCCCGGCGCCTTT CATGTCGCGGTGATCCTCAGCATCGCCGCCGAGCGCTGGCCCGAGCGGGCGATCGAGCTG ACAGGCGTGGAGTTCCTGAAGGCCATCGCGATGGAGCCCGACCAGGAGGTCGAGCTCCAC GCCGTGCTCACCCCCGAAGCCGCCGGGGATGGCTACCTGTTCGAGCTGGCGACCCTGGCG GCGCCGGAGACCGAACGCCGATGGACGACCCACGCCCGCGGTCGGGTGCAGCCGACAGAC GGCGCGCCCGGCGCGTTGCCGCGCCTCGAGGTGCTGGAGGACCGCGCGATCCAGCCCCTC GACTTCGCCGGATTCCTCGACAGGTTATCGGCGGTGCGGATCGGCTGGGGTCCGCTTTGG CGATGGCTGCAGGACGGGCGCGTCGGCGACGAGGCCTCGCTTGCCACCCTCGTGCCGACC TATCCGAACGCCCACGACGTGGCGCCCTTGCACCCGATCCTGCTGGACAACGGCTTTGCG GTGAGCCTGCTGTCAACCCGGAGCGAGCCGGAGGACGACGGGACGCCCCCGCTGCCGTTC GCCGTGGAACGGGTGCGGTGGTGGCGGGCGCCGGTTGGAAGGGTGCGGTGTGGCGGCGTG CCGCGGTCGCAGGCATTCGGTGTCTCGAGCTTCGTGCTGGTCGACGAAACTGGCGAGGTG GTCGCCGAGGTGGAGGGATTTGTTTGCCGCCGGGCGCCGCGAGAGGTGTTCCTGCGGCAG GAGTCGGGCGCGTCGACTGCAGCCTTGTACCGCCTCGACTGGCCCGAAGCGCCCTTGCCC GATGCGCCTGCGGAACGGATCGAGGAGAGCTGGGTCGTGGTGGCAGCACCTGGCTCGGAG ATGGCCGCGGCGCTCGCAACACGGCTCAACCGCTGCGTCCTCGCCGAACCCAAAGGCCTC GAGGCGGCCCTCGCGGGGGTGTCTCCCGCAGGTGTGATCTGCCTCTGGGAGGCTGGAGCC CACGAGGAAGCTCCGGCGGCGGCGCAGCGTGTGGCGACCGAGGGCCTCTCGGTGGTGCAG GCGCTCAGGGACCGCGCGGTGCGCCTGTGGTGGGTGACCATGGGCGCAGTGGCCGTCGAG GCCGGTGAGCGGGTGCAGGTCGCCACAGCGCCGGTATGGGGCCTCGGCCGGACAGTGATG CAGGAGCGCCCGGAGCTCAGCTGCACTCTGGTGGATTTGGAGCCGGAGGCCGATGCAGCG CGCTCAGCTGACGTTCTGTTGCGGGAGCTCGGTCGCGCTGACGACGAGACACAGGTGGCT TTCCGTTCCGGAAAGCGCCGCGTAGCGCGGCTGGTCAAAGCGACGACCCCCGAAGGGCTC CTGGTCCCTGACGCAGAGTCCTATCGACTGGAGGCTGGGCAGAAGGGCACATTGGACCAG CTCCGCCTCGCGCCGGCACAGCGCCGGGCACCTGGCCCGGGCGAGGTCGAGATCAAGGTA ACCGCCTCGGGGCTCAACTTCCGGACCGTCCTCGCTGTGCTGGGAATGTATCCGGGCGAC GCCGGGCCGATGGGCGGAGATTGTGCCGGTGTCGCCACGGCGGTGGGCCAGGGGGTGCGC CACGTCGCGGTCGGCGATGCTGTCATGACGCTGGGGACGTTGCATCGATTCGTCACGGTC GACGCGCGGCTGGTGGTCCGGCAGCCTGCAGGGCTGACTCCCGCGCAGGCAGCTACGGTG CCGGTCGCGTTCCTGACGGCCTGGCTCGCTCTGCACGACCTGGGGAATCTGCGGCGCGGC GAGCGGGTGCTGATCCATGCTGCGGCCGGCGGTGTGGGCATGGCCGCGGTGCAAATCGCC CGATGGATAGGGGCCGAGGTGTTCGCCACGGCGAGCCCGTCCAAGTGGGCAGCGGTTCAG GCCATGGGCGTGCCGCGCACGCACATCGCCAGCTCGCGGACGCTGGAGTTTGCTGAGACG TTCCGGCAGGTCACCGGCGGCCGGGGCGTGGACGTGGTGCTCAACGCGCTGGCCGGCGAG TTCGTGGACGCGAGCCTGTCCCTGCTGTCGACGGGCGGGCGGTTCCTCGAGATGGGCAAG ACCGACATACGGGATCGAGCCGCGGTCGCGGCGGCGCATCCCGGTGTTCGCTATCGGGTA TTCGACATCCTGGAGCTCGCTCCGGATCGAACTCGAGAGATCCTCGAGCGCGTGGTCGAG GGCTTTGCTGCGGGACATCTGCGCGCATTGCCGGTGCATGCGTTCGCGATCACCAAGGCC GAGGCAGCGTTTCGGTTCATGGCGCAAGCGCGGCATCAGGGCAAGGTCGTGCTGCTGCCG GCGCCCTCCGCAGCGCCCTTGGCGCCGACGGGCACCGTACTGCTGACCGGTGGGCTGGGA GCGTTGGGGCTCCACGTGGCCCGCTGGCTCGCCCAGCAGGGCGTGCCGCACATGGTGCTC ACAGGTCGGCGGGGCCTGGATACGCCGGGCGCTGCCAAAGCCGTCGCGGAGATCGAAGCG CTCGGCGCTCGGGTGACGATCGCGGCGTCGGATGTCGCCGATCGGAATGCGCTGGAGGCT GTGCTCCAGGCCATTCCGGCGGAGTGGCCGTTACAGGGCGTGATCCATGCAGCCGGAGCG CTCGATGATGGTGTGCTTGATGAGCAGACCACCGACCGCTTCTCGCGGGTGCTGGCACCG AAGGTGACTGGCGCCTGGAATCTGCATGAGCTCACGGCGGGCAACGATCTCGCTTTCTTC GTGCTGTTCTCCTCCATGTCGGGGCTCTTGGGCTCGGCCGGGCAGTCCAACTATGCGGCG GCCAACACCTTCCTCGACGCGCTGGCCGCGCATCGGCGGGCCGAAGGCCTGGCGGCGCAG AGCCTCGCGTGGGGCCCATGGTCGGACGGAGGCATGGCAGCGGGGCTCAGCGCGGCGCTG CAGGCGCGGCTCGCTCGGCATGGGATGGGAGCTCTGTCGCCGGCTCAGGGCACCGCGCTG CTCGGGCAGGCGCTGGCTCGGCCGGAAACGCAGCTCGGGGCGATGTCGCTCGACGTGCGT GCGGCAAGCCAAGCTTCGGGAGCGGCAGTGCCGCCTGTGTGGCGCGCGTTGGTGCGCGCG GAGGCGCGCCATACGGCGGCTGGGGCGCAGGGGGCATTGGCCGCGCGTCTTGGGGCGCTG CCCGAGGCGCGTCGCGCCGACGAGGTGCGCAAGGTCGTGCAGGCCGAGATCGCGCGCGTG CTTTCATGGAGCGCCGCGAGCGCCGTGCCCGTCGATCGGCCGCTGTCGGACTTGGGCCTC GACTCGCTCACGGCGGTGGAGCTGCGCAACGTGCTCGGCCAGCGGGTGGGTGCGACGCTG CCGGCGACGCTGGCATTCGATCACCCGACGGTCGACGCGCTCACGCGCTGGCTGCTCGAT AAGGTCCTGGCCGTGGCCGAGCCGAGCGTATCGTCCGCAAAGTCGTCGCCGCAGGTCGCC CTCGACGAGCCCATTGCCATCATCGGCATCGGCTGCCGTTTCCCAGGCGGCGTGGCCGAT CCGGAGTCGTTTTGGCGGCTGCTCGAAGAGGGCAGCGATGCCGTCGTCGAGGTGCCGCAT GAGCGATGGGACATCGACGCGTTCTATGATCCGGATCCGGATGTGCGCGGCAAGATGACG ACACGCTTTGGCGGCTTCCTGTCCGATATCGACCGGTTCGATCCGGCCTTCTTCGGCATC TCGCCGCGCGAAGCGACGACCATGGATCCGCAGCAGCGGCTGCTCCTGGAGACGAGCTGG GAGGCGTTCGAGCGCGCCGGGATTTTGCCCGAGCGGCTGATGGGCAGCGATACCGGCGTG TTCGTGGGGCTCTTCTACCAGGAGTACGCTGCGCTCGCCGGCGGCATCGAGGCGTTCGAT GGCTATCTAGGCACCGGCACCACGGCCAGCGTCGCCTCGGGCAGGATCTCTTATGTGCTC GGGCTAAAGGGGCCGAGCCTGACGGTGGACACCGCGTGCTCCTCGTCGCTGGTCGCGGTG CACCTGGCCTGCCAGGCGCTGCGGCGGGGCGAGTGTTCGGTGGCGCTGGCCGGCGGCGTG GCGCTGATGCTCACGCCGGCGACGTTCGTGGAGTTCAGCCGGCTGCGAGGCCTGGCTCCC GACGGACGGTGCAAGAGCTTCTCGGCCGCAGCCGACGGCGTGGGGTGGAGCGAAGGCTGC GCCATGCTCCTGCTCAAACCGCTTCGCGATGCGCAGCGCGATGGGGATCCGATCCTGGCG GTGATCCGCGGCACCGCGGTGAACCAGGATGGGCGCAGCAACGGGCTGACGGCGCCCAAC GGGTCGTCGCAGCAAGAGGTGATCCGTCGGGCCCTGGAGCAGGCGGGGCTGGCTCCGGCG GACGTCAGCTACGTCGAGTGCCACGGCACCGGCACGACGTTGGGCGACCCCATCGAAGTG CAGGCCCTGGGCGCCGTGCTGGCACAGGGGCGACCCTCGGACCGGCCGCTCGTGATCGGG TCGGTGAAGTCCAATATCGGACATACGCAGGCTGCGGCGGGCGTGGCCGGTGTCATCAAG GTGGCGCTGGCGCTCGAGCGCGGGCTTATCCCGAGGAGCCTGCATTTCGACGCGCCCAAT CCGCACATTCCGTGGTCGGAGCTCGCCGTGCAGGTGGCCGCCAAACCCGTCGAATGGACG AGAAACGGCGTGCCGCGACGAGCCGGGGTGAGCTCGTTTGGCGTCAGCGGGACCAACGCG CACGTGGTGCTGGAGGAGGCGCCAGCGGCGGCGTTCGCGCCCGCGGCGGCGCGTTCAGCG GAGCTTTTCGTGCTGTCGGCGAAGAGCGCCGCGGCGCTGGACGCGCAGGCGGCGCGGCTT TCGGCGCACGTCGTTGCGCACCCGGAGCTCGGCCTCGGCGACCTGGCGTTCAGCCTGGCG ACGACCCGCAGCCCGATGACGTACCGGCTCGCGGTGGCGGCGACCTCGCGCGAGGCGCTG TCTGCCGCGCTCGACACAGCGGCGCAGGGGCAGGCGCCGCCCGCAGCGGCTCGCGGCCAC GCTTCCACAGGCAGCGCCCCAAAGGTGGTTTTCGTCTTTCCTGGCCAGGGCTCCCAGTGG CTGGGCATGGGCCAAAAGCTCCTCTCGGAGGAGCCCGTCTTCCGCGACGCGCTCTCGGCG TGTGACCGAGCGATTCAGGCCGAAGCCGGCTGGTCGCTGCTCGCCGAGCTCGCGGCCGAT GAGACCACCTCGCAGCTCGGCCGCATCGACGTGGTGCAGCCGGCGCTGTTCGCGATCGAG GTCGCGCTGTCGGCGCTGTGGCGGTCGTGGGGCGTCGAGCCGGATGCAGTGGTAGGCCAC AGCATGGGCGAAGTGGCGGCCGCGCACGTCGCCGGCGCCCTGTCGCTCGAGGATGCTGTA GCGATCATCTGCCGGCGCAGCCTGCTGCTGCGGCGGATCAGCGGCCAAGGCGAGATGGCG GTCGTCGAGCTTTCCCTGGCCGAGGCCGAGGCAGCGCTCCTGGGCTACGAAGACCGGCTC AGCGTGGCGGTGAGCAACAGCCCGCGCTCGACGGTGCTGGCGGGCGAGCCGGCAGCGCTC GCAGAGGTGCTGGCGATCCTTGCGGCAAAGGGGGTGTTCTGCCGTCGAGTCAAGGTGGAC GTCGCCAGCCACAGCCCACAGATCGACCCGCTGCGCGACGAGCTATTGGCAGCATTGGGC GAGCTCGAGCCGCGACAAGCGACCGTGTCGATGCGCTCGACGGTGACGAGCACGATCATG GCGGGCCCGGAGCTCGTGGCGAGCTACTGGGCGGACAACGTTCGACAGCCGGTGCGCTTC GCCGAAGCGGTGCAATCGTTGATGGAAGACGGTCATGGGCTGTTCGTGGAGATGAGCCCG CATCCGATCCTGACGACATCGGTCGAGGAGATCCGACGGGCGACGAAGCGGGAGGGAGTC GCGGTGGGCTCGTTGCGGCGTGGACAGGACGAGCGCCTGTCCATGTTGGAGGCGCTGGGA GCGCTCTGGGTACACGGCCAGGCGGTGGGCTGGGAGCGGCTGTTCTCCGCGGGCGGCGCG GGCCTCCGTCGCGTGCCGCTGCCGACCTATCCCTGGCAGCGCGAGCGGTACTGGGTCGAT GCGCCGACCGGCGGCGCGGCGGGCGGCAGCCGCTTTGCTCATGCGGGCAGTCACCCGCTC CTGGGTGAAATGCAGACCCTGTCGACCCAGAGGAGCACGCGCGTGTGGGAGACGACGCTG GATCTCAAACGGCTGCCGTGGCTCGGCGATCACCGGGTGCAGGGGGCGGTCGTGTTCCCG GGCGCGGCGTACCTGGAGATGGCGCTTTCGTCCGGGGCCGAGGCCTTGGGTGACGGTCCG CTCCAGGTCAGCGATGTGGTGCTCGCCGAGGCGCTGGCCTTCGCGGATGATACGCCGGCG GCGGTGCAGGTCATGGCGACCGAGGAGCGACCAGGCCGCCTGCAATTCCACGTTGCGAGC CGGGTGCCGGGCCACGGCGGTGCTGCCTTTCGAAGCCATGCCCGCGGGGTGCTGCGCCAG ATCGAGCGCGCCGAGGTCCCGGCGAGGCTGGATCTGGCCGCGCTTCGTGCCCGGCTTCAG GCCAGCGCACCCGCTGCGGCTACCTATGCGGCGCTGGCCGAGATGGGGCTCGAGTACGGC CCAGCGTTCCAGGGGCTTGTCGAGCTGTGGCGGGGGGAGGGCGAGGCGCTGGGACGTGTG CGGCTCCCCGAGGCCGCCGGCTCCCCAGCCGCGTGCCGGCTCCACCCCGCGCTCTTGGAT GCGTGCTTCCACGTGAGCAGCGCCTTCGCTGACCGCGGCGAGGCGACGCCATGGGTACCC GTGGAAATCGGCTCGCTGCGGTGGTTCCAGCGGCCGTCGGGGGAGCTGTGGTGTCATGCG CGGAGTGTGAGCCACGGAAAGCCAACACCCGACCGGCGGAGTACCGACTTCTGGGTGGTC GACAGCACGGGCGCGATCGTCGCCGAGATCTCCGGGCTCGTGGCGCAGCGGCTCGCGGGA GGTGTACGCCGGCGCGAAGAAGACGACTGGTTCATGGAGCCGGCTTGGGAACCGACCGCG GTCCCCGGATCCGAGGTCATGGCGGGCCGGTGGCTGCTCATCGGCTCGGGCGGCGGGCTC GGCGCTGCGCTCCACTCGGCGCTGACGGAAGCTGGCCATTCCGTCGTCCACGCGACAGGG CGCGGCACGAGCGCCGCCGGGTTGCAGGCACTCTTGACGGCGTCCTTCGACGGCCAGGCC CCGACGTCGGTGGTGCACCTCGGCAGCCTCGATGAGCGTGGCGTGCTCGACGCGGATGCC CCCTTCGACGCCGATGCGCTTGAGGAGTCGCTGGTGCGCGGCTGCGACAGCGTGCTCTGG ACCGTGCAGGCCGTGGCCGGGGCGGGCTTCCGAGATCCTCCGCGGTTGTGGCTCGTGACA CGCGGCGCTCAGGCCATCGGCGCCGGCGACGTCTCTGTGGCGCAAGCGCCGCTCCTGGGG CTGGGCCGCGTTATCGCCTTGGAGCACGCCGAGCTGCGCTGCGCTCGGATCGACCTCGAT CCAGCGCGGCGCGACGGAGAAGTCGATGAGCTGCTTGCCGAGCTGTTGGCCGACGACGCC GAGGAGGAAGTCGCGTTTCGCGGCGGTGAGCGGCGCGTGGCCCGGCTCGTCCGAAGGCTG CCCGAGACCGACTGCCGAGAGAAAATCGAGCCCGCGGAAGGCCGGCCGTTCCGGCTGGAG ATCGATGGGTCCGGCGTGCTCGACGACCTGGTGCTCCGAGCCACGGAGCGGCGCCCTCCT GGCCCGGGCGAGGTCGAGATCGCCGTCGAGGCGGCGGGGCTCAACTTTCTCGACGTGATG AGGGCCATGGGGATCTACCCTGGGCCCGGGGACGGTCCGGTTGCGCTGGGCGCCGAGTGC TCCGGCCGAATTGTCGCGATGGGCGAAGGTGTCGAGAGCCTTCGTATCGGCCAGGACGTC GTGGCCGTCGCGCCCTTCAGTTTCGGCACCCACGTCACCATCGACGCCCGGATGCTCGCA CCTCGCCCCGCGGCGCTGACGGCCGCGCAGGCAGCCGCGCTGCCCGTCGCATTCATGACG GCCTGGTACGGTCTCGTCCATCTGGGGAGGCTCCGGGCCGGCGAGCGCGTGCTCATCCAC TCGGCGACGGGGGGCACCGGGCTCGCTGCTGTGCAGATCGCCCGCCACCTCGGCGCGGAG ATATTTGCGACCGCTGGTACACCGGAGAAGCGGGCGTGGCTGCGCGAGCAGGGGATCGCG CACGTGATGGACTCGCGGTCGCTGGACTTCGCCGAGCAAGTGCTGGCCGCGACGAAGGGC GAGGGGGTCGACGTCGTGTTGAACTCGCTGTCTGGCGCCGCGATCGACGCGAGCCTTTCG ACCCTCGTGCCGGACGGCCGCTTCATCGAGCTCGGCAAGACGGACATCTATGCAGATCGC TCGCTGGGGCTCGCTCACTTCAGGAAGAGCCTGTCCTACAGCGCCGTCGATCTTGCGGGC TTGGCCGTGCGTCGGCCCGAGCGCGTCGCAGCGCTGCTGGCGGAGGTGGTGGACCTGCTC GCACGGGGAGCGCTGCAGCCGCTTCCGGTAGAGATCTTCCCCCTCTCGCGGGCCGCGGAC GCGTTCCGGAAAATGGCGCAAGCGCAGCATCTCGGGAAGCTCGTGCTCGCGCTGGAGGAC CCGGACGTGCGGATCCGCGTTCCGGGCGAATCCGGCGTCGCCATCCGCGCGGACGGCGCC TACCTCGTGACCGGCGGTCTGGGGGGGCTCGGTCTGAGCGTGGCTGGATGGCTGGCCGAG CAGGGGGCTGGGCATCTGGTGCTGGTGGGCCGCTCCGGCGCGGTGAGCGCGGAGCAGCAG ACGGCTGTCGCCGCGCTCGAGGCGCACGGCGCGCGTGTCACGGTAGCGAGGGCAGACGTC GCCGATCGGGCGCAGATGGAGCGGATCCTCCGCGAGGTTACCGCGTCGGGGATGCCGCTC CGCGGCGTCGTTCATGCGGCCGGAATCCTGGACGACGGGCTGCTGATGCAGCAAACCCCC GCGCGGTTCCGCGCGGTCATGGCGCCCAAGGTCCGAGGGGCCTTGCACCTGCATGCGTTG ACACGCGAAGCGCCGCTCTCCTTCTTCGTGCTGTACGCTTCGGGAGCAGGGCTCTTGGGC TCGCCGGGCCAGGGCAACTACGCCGCGGCCAACACGTTCCTCGACGCACTGGCACACCAC CGGAGGGCGCAGGGGCTGCCAGCATTGAGCATCGACTGGGGCCTGTTCGCGGACGTGGGT TTGGCCGCCGGGCAGCAAAATCGCGGCGCACGGCTGGTCACCCGCGGGACGCGGAGCCTC ACCCCCGACGAAGGGCTGTGGGCGCTCGAGCGCCTGCTCGACGGCGATCGCACCCAGGCC GGGGTCATGCCGTTCGACGTGCGGCAGTGGGTGGAGTTCTACCCGGCGGCGGCATCTTCG CGGAGGTTGTCGCGGCTCATGACGGCACGGCGCGTGGCTTCCGGTCGGCTCGCCGGGGAT CGGGACCTGCTCGAACGGCTCGCCACCGCCGAGGCGGGCGCGCGGGCAGGGATGCTGCAG GAGGTCGTGCGCGCGCAGGTCTCGCAGGTGCTGCGCCTCTCCGAAGGCAAGCTCGACGTG GATGCGCCGCTCACGAGCCTGGGAATGGACTCGCTGATGGGGCTAGAGCTGCGCAACCGC ATCGAGGCCGTGCTCGGCATCACCATGCCGGCGACCCTGCTGTGGACCTACCCCACGGTG GCAGCGCTGAGTGCGCATCTGGCTTCTCATGTCGTCTCTACGGGGGATGGGGAATCCGCG CGCCCGCCGGATACAGGGAGCGTGGCTCCAACGACCCACGAAGTCGCTTCGCTCGACGAA GACGGGTTGTTCGCGTTGATTGATGAGTCACTCGCGCGCGCGGGAAAGAGGTGA
Feature
| BLASTP Database:UniProtKB:2011_09 |
|
|---|---|
| InterPro Database:interpro:38.0 |
IPR001227 Acyl transferase domain (Domain)
IPR002364 Quinone oxidoreductase/zeta-crystallin, conserved site (Conserved_site)
IPR006162 Phosphopantetheine attachment site (PTM)
IPR009081 Acyl carrier protein-like (Domain)
IPR011032 GroES-like (Domain)
IPR013149 Alcohol dehydrogenase, C-terminal (Domain)
IPR013154 Alcohol dehydrogenase GroES-like (Domain)
IPR013968 Polyketide synthase, KR (Domain)
IPR014030 Beta-ketoacyl synthase, N-terminal (Domain)
IPR014031 Beta-ketoacyl synthase, C-terminal (Domain)
IPR014043 Acyl transferase (Domain)
IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase (Domain)
IPR016036 Malonyl-CoA ACP transacylase, ACP-binding (Domain)
IPR016038 Thiolase-like, subgroup (Domain)
IPR016039 Thiolase-like (Domain)
IPR016040 NAD(P)-binding domain (Domain)
IPR018201 Beta-ketoacyl synthase, active site (Active_site)
IPR020801 Polyketide synthase, acyl transferase domain (Domain)
IPR020806 Polyketide synthase, phosphopantetheine-binding domain (Domain)
IPR020807 Polyketide synthase, dehydratase domain (Domain)
IPR020841 Polyketide synthase, beta-ketoacyl synthase domain (Domain)
IPR020842 Polyketide synthase/Fatty acid synthase, KR (Domain)
IPR020843 Polyketide synthase, enoylreductase (Domain)
|
| SignalP | No significant hit |
| TMHMM | No significant hit |
![[560-685] G3DSA:3.40.366.10](../../img/X2.gif "[560-685] G3DSA:3.40.366.10"){kind=small}
![[4540-4561] PS01162](../../img/P.gif "[4540-4561] PS01162"){kind=small}
![[1436-1502] 2e-10 PF00550](../../img/H.gif "[1436-1502] 2e-10 PF00550"){kind=small}
![[1433-1503] PS50075](../../img/M.gif "[1433-1503] PS50075"){kind=small}
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