Epoth_00090 Epoth_00090   Epoth_00110 Epoth_00110

Epoth_00100 : CDS information

close this sectionLocation

Organism
StrainSo ce90
Entry nameEpothilone
Contig
Start / Stop / Direction43,524 / 54,920 / + [in whole cluster]
43,524 / 54,920 / + [in contig]
Location43524..54920 [in whole cluster]
43524..54920 [in contig]
TypeCDS
Length11,397 bp (3,798 aa)
Click on the icon to see Genetic map.

close this sectionAnnotation

Category1.1 PKS
Productpolyketide synthase
Product (GenBank)polyketide synthase
Gene
Gene (GenBank)epoD
EC number
Keyword
Note
Note (GenBank)
  • EPOS D
Reference
ACC
PmId
[10662695] The biosynthetic gene cluster for the microtubule-stabilizing agents epothilones A and B from Sorangium cellulosum So ce90. (Chem Biol. , 2000)
[11217802] Studies on the biosynthesis of epothilones: the biosynthetic origin of the carbon skeleton. (J Antibiot (Tokyo). , 2000)
comment
[PMID: 10662695](2000)
生合成cluster報告論文。
EPOS DはPKS(9modules)のmodule 6, 7をコード。

Mod 6; KS, ATp, KR, ACP
Mod 7; KS, ATp, DH, MT, KR*, ACP

module 7のKRはnon-functionalかもしれない。
epothiloneの特徴であるmacrolide環のC4でのgem-dimethyl基のうち、ひとつはpropionate extender unitから供給される。
もうひとつのmethyl基はmodule 7のDH domainとKR domainの間にあるC-methyltransferase domainによってS-adenosylmethionineから導入される（実験確認なし）。

--
[PMID:11217802](2000)UniProt登録外
取り込み実験によりepothilone骨格の由来を調査。
gem-dimethyl基がpropionateとmethionineに由来することも確認されている。
Related Reference
ACC
Q9KIZ6
PmId
[10649995] Cloning and heterologous expression of the epothilone gene cluster. (Science. , 2000)
[10831849] Isolation and characterization of the epothilone biosynthetic gene cluster from Sorangium cellulosum. (Gene. , 2000)
comment
2nd(Q9KIZ6) 98%, 0.0
Sorangium cellulosum (Polyangium cellulosum)_epoE
EpoE

Strain SMP44
Streptomyces coelicolorでepothilone biosynthetic gene clusterを発現してepothilone A and B産生を確認。

close this sectionPKS/NRPS Module

7 methylmalonyl-CoA
not conserved YASHS(Y->V)
8 methylmalonyl-CoA
not conserved YASHS(Y->V)
KS35..405
AT560..876
KR1145..1334
ACP1430..1500
KS1522..1896
AT2052..2368
dh2421..2588
MT2863..2963
kr3393..3573
ACP3669..3742

close this sectionSequence

selected fasta
>polyketide synthase [polyketide synthase]
MTDREGQLLERLREVTLALRKTLNERDTLELEKTEPIAIVGIGCRFPGGAGTPEAFWELL
DDGRDAIRPLEERWALVGVDPGDDVPRWAGLLTEAIDGFDAAFFGIAPREARSLDPQHRL
LLEVAWEGFEDAGIPPRSLVGSRTGVFVGVCATEYLHAAVAHQPREERDAYSTTGNMLSI
AAGRLSYTLGLQGPCLTVDTACSSSLVAIHLACRSLRARESDLALAGGVNMLLSPDTMRA
LARTQALSPNGRCQTFDASANGFVRGEGCGLIVLKRLSDARRDGDRIWALIRGSAINQDG
RSTGLTAPNVLAQGALLREALRNAGVEAEAIGYIETHGAATSLGDPIEIEALRAVVGPAR
ADGARCVLGAVKTNLGHLEGAAGVAGLIKATLSLHHERIPRNLNFRTLNPRIRIEGTALA
LATEPVPWPRTGRTRFAGVSSFGMSGTNAHVVLEEAPAVEPEAAAPERAAELFVLSAKSA
AALDAQAARLRDHLEKHVELGLGDVAFSLATTRSAMEHRLAVAASSREALRGALSAAAQG
HTPPGAVRGRASGGSAPKVVFVFPGQGSQWVGMGRKLMAEEPVFRAALEGCDRAIEAEAG
WSLLGELSADEAASQLGRIDVVQPVLFAMEVALSALWRSWGVEPEAVVGHSMGEVAAAHV
AGALSLEDAVAIICRRSRLLRRISGQGEMALVELSLEEAEAALRGHEGRLSVAVSNSPRS
TVLAGEPAALSEVLAALTAKGVFWRQVKVDVASHSPQVDPLREELIAALGAIRPRAAAVP
MRSTVTGGVIAGPELGASYWADNLRQPVRFAAAAQALLEGGPALFIEMSPHPILVPPLDE
IQTAAEQGGAAVGSLRRGQDERATLLEALGTLWASGYPVSWARLFPAGGRRVPLPTYPWQ
HERCWIEVEPDARRLAAADPTKDWFYRTDWPEVPRAAPKSETAHGSWLLLADRGGVGEAV
AAALSTRGLSCTVLHASADASTVAEQVSEAASRRNDWQGVLYLWGLDAVVDAGASADEVS
EATRRATAPVLGLVRFLSAAPHPPRFWVVTRGACTVGGEPEASLCQAALWGLARVAALEH
PAAWGGLVDLDPQKSPTEIEPLVAELLSPDAEDQLAFRSGRRHAARLVAAPPEGDVAPIS
LSAEGSYLVTGGLGGLGLLVARWLVERGARHLVLTSRHGLPERQASGGEQPPEARARIAA
VEGLEAQGARVTVAAVDVAEADPMTALLAAIEPPLRGVVHAAGVFPVRHLAETDEALLES
VLRPKVAGSWLLHRLLRDRPLDLFVLFSSGAAVWGGKGQGAYAAANAFLDGLAHHRRAHS
LPALSLAWGLWAEGGMVDAKAHARLSDIGVLPMATGPALSALERLVNTSAVQRSVTRMDW
ARFAPVYAARGRRNLLSALVAEDERAASPPVPTANRIWRGLSVAESRSALYELVRGIVAR
VLGFSDPGALDVGRGFAEQGLDSLMALEIRNRLQRELGERLSATLAFDHPTVERLVAHLL
TDVLKLEDRSDTRHIRSVAADDDIAIVGAACRFPGGDEGLETYWRHLAEGMVVSTEVPAD
RWRAADWYDPDPEVPGRTYVAKGAFLRDVRSLDAAFFAISPREAMSLDPQQRLLLEVSWE
AIERAGQDPMALRESATGVFVGMIGSEHAERVQGLDDDAALLYGTTGNLLSVAAGRLSFF
LGLHGPTMTVDTACSSSLVALHLACQSLRLGECDQALAGGSSVLLSPRSFVAASRMRLLS
PDGRCKTFSAAADGFARAEGCAVVVLKRLRDAQRDRDPILAVVRSTAINHDGPSSGLTVP
SGPAQQALLRQALAQAGVAPAEVDFVECHGTGTALGDPIEVQALGAVYGRGRPAERPLWL
GAVKANLGHLEAAAGLAGVLKVLLALEHEQIPAQPELDELNPHIPWAELPVAVVRRAVPW
PRGARPRRAGVSAFGLSGTNAHVVLEEAPAVEPVAAAPERAAELFVLSAKSAAALDAQAA
RLRDHLEKHVELGLGDVAFSLATTRSAMEHRLAVAASSREALRGALSAAAQGHTPPGAVR
GRASGGSAPKVVFVFPGQGSQWVGMGRKLMAEEPVFRAALEGCDRAIEAEAGWSLLGELS
ADEAASQLGRIDVVQPVLFAMEVALSALWRSWGVEPEAVVGHSMGEVAAAHVAGALSLED
AVAIICRRSRLLRRISGQGEMALVELSLEEAEAALRGHEGRLSVAVSNSPRSTVLAGEPA
ALSEVLAALTAKGVFWRQVKVDVASHSPQVDPLREELIAALGAIRPRAAAVPMRSTVTGG
VIAGPELGASYWADNLRQPVRFAAAAQALLEGGPALFIEMSPHPILVPPLDEIQTAAEQG
GAAVGSLRRGQDERATLLEALGTLWASGYPVSWARLFPAGGRRVPLPTYPWQHERYWIED
SVHGSKPSLRLRQLRNGATDHPLLGAPLLVSARPGAHLWEQALSDERLSYLSEHRVHGEA
VLPSAAYVEMALAAGVDLYGTATLVLEQLALERALAVPSEGGRIVQVALSEEGPGRASFQ
VSSREEAGRSWVRHATGHVCSGQSSAVGALKEAPWEIQRRCPSVLSSEALYPLLNEHALD
YGPCFQGVEQVWLGTGEVLGRVRLPGDMASSSGAYRIHPALLDACFQVLTALLTTPESIE
IRRRLTDLHEPDLPRSRAPVNQAVSDTWLWDAALDGGRRQSASVPVDLVLGSFHAKWEVM
ERLAQAYIIGTLRIWNVFCAAGERHTIDELLVRLQISVVYRKVIKRWMEHLVAIGILVGD
GEHFVSSQPLPEPDLAAVLEEAGRVFADLPVLFEWCKFAGERLADVLTGKTLALEILFPG
GSFDMAERIYRDSPIARYSNGIVRGVVESAARVVAPSGMFSILEIGAGTGATTAAVLPVL
LPDRTEYHFTDVSPLFLARAEQRFRDYPFLKYGILDVDQEPAGQGYAHQRFDVIVAANVI
HATRDIRATAKRLLSLLAPGGLLVLVEGTGHPIWFDITTGLIEGWQKYEDDLRIDHPLLP
ARTWCDVLRRVGFADAVSLPGDGSPAGILGQHVILSRAPGIAGAACDSSGESATESPAAR
AVRQEWADGSADVVHRMALERMYFHRRPGRQVWVHGRLRTGGGAFTKALAGDLLLFEDTG
QVVAEVQGLRLPQLEASAFAPRDPREEWLYALEWQRKDPIPEAPAAASSSSAGAWLVLMD
QGGTGAALVSLLEGRGEACVRVIAGTAYACLAPGLYQVDPAQPDGFHTLLRDAFGEDRIC
RAVVHMWSLDATAAGERATAESLQADQLLGSLSALSLVQALVRRRWRNMPRLWLLTRAVH
AVGAEDAAASVAQAPVWGLGRTLALEHPELRCTLVDVNPAPSPEDAAALAVELGASDRED
QVALRSDGRYVARLVRSSFSGKPATDCGIRADGSYVITDGMGRVGLSVAQWMVMQGARHV
VLVDRGGASEASRDALRSMAEAGAEVQIVEADVARRDDVARLLSKIEPSMPPLRGIVYVD
GTFQGDSSMLELDARRFKEWMYPKVLGAWNLHALTRDRSLDFFVLYSSGTSLLGLPGQGS
RAAGDAFLDAIAHHRCKVGLTAMSINWGLLSEASSPATPNDGGARLEYRGMEGLTLEQGA
AALGRLLARPRAQVGVMRLNLRQWLEFYPNAARLALWAELLKERDRADRGASNASNLREA
LQSARPEDRQLILEKHLSELLGRGLRLPPERIERHVPFSNLGMDSLIGLELRNRIEAALG
ITVPATLLWTYPNVAALSGSLLDILFPNAGATHAPATEREKSFENDAADLEALRGMTDEQ
KDALLAEKLAQLAQIVGE
selected fasta
>polyketide synthase [polyketide synthase]
GTGACAGACCGAGAAGGCCAGCTCCTGGAGCGCTTGCGTGAGGTTACTCTGGCCCTTCGC
AAGACGCTGAACGAGCGCGATACCCTGGAGCTCGAGAAGACCGAGCCGATCGCCATCGTG
GGGATCGGCTGCCGCTTCCCCGGCGGAGCGGGCACTCCGGAGGCGTTCTGGGAGCTGCTC
GACGACGGGCGCGACGCGATCCGGCCGCTCGAGGAGCGCTGGGCGCTCGTAGGTGTCGAC
CCAGGCGACGACGTACCGCGCTGGGCGGGGCTGCTCACCGAGGCCATCGACGGCTTCGAC
GCCGCGTTCTTCGGTATCGCCCCCCGGGAGGCACGGTCGCTCGACCCGCAGCATCGCCTG
CTGCTGGAGGTCGCCTGGGAGGGGTTCGAAGACGCCGGCATCCCGCCCAGGTCCCTCGTC
GGGAGCCGCACCGGCGTGTTCGTCGGCGTCTGCGCCACGGAGTACCTCCACGCCGCCGTC
GCGCACCAGCCGCGCGAAGAGCGGGACGCGTACAGCACCACCGGCAACATGCTCAGCATC
GCCGCCGGACGGCTATCGTACACGCTGGGGCTGCAGGGACCTTGCCTGACCGTCGATACG
GCGTGCTCGTCATCGCTGGTGGCCATTCACCTCGCCTGCCGCAGCCTGCGCGCTCGAGAG
AGCGATCTCGCGCTGGCGGGAGGGGTCAACATGCTTCTCTCCCCCGACACGATGCGAGCT
CTGGCGCGCACCCAGGCGCTGTCGCCCAATGGCCGTTGCCAGACCTTCGACGCGTCGGCC
AACGGGTTCGTCCGTGGGGAGGGCTGCGGTCTGATCGTGCTCAAGCGATTGAGCGACGCG
CGGCGGGATGGGGACCGGATCTGGGCGCTGATCCGAGGATCGGCCATCAATCAGGACGGC
CGGTCGACGGGGTTGACGGCGCCCAACGTGCTCGCCCAGGGGGCGCTCTTGCGCGAGGCG
CTGCGGAACGCCGGCGTCGAGGCCGAGGCCATCGGTTACATCGAGACCCACGGGGCGGCA
ACCTCGCTGGGCGACCCCATCGAGATCGAAGCGCTGCGCGCTGTGGTGGGGCCGGCGCGA
GCCGACGGAGCGCGCTGCGTGCTGGGCGCGGTGAAGACCAACCTCGGCCACCTGGAGGGC
GCTGCCGGCGTGGCGGGCCTGATCAAGGCGACGCTTTCGCTACATCACGAGCGCATCCCG
AGGAACCTCAACTTTCGTACGCTCAATCCGCGGATCCGGATCGAGGGGACCGCGCTCGCG
TTGGCGACCGAACCGGTGCCCTGGCCGCGGACGGGCCGGACGCGCTTCGCGGGAGTGAGC
TCGTTCGGGATGAGCGGGACCAACGCGCATGTGGTGTTGGAGGAGGCGCCGGCGGTGGAG
CCTGAGGCCGCGGCCCCCGAGCGCGCAGCGGAGCTGTTCGTCCTGTCGGCGAAGAGCGCG
GCGGCGCTGGATGCGCAGGCAGCCCGGCTGCGGGACCACCTGGAGAAGCACGTCGAGCTT
GGCCTCGGCGATGTGGCGTTCAGCCTGGCGACGACGCGCAGCGCGATGGAGCACCGGCTG
GCGGTGGCCGCGAGCTCGCGCGAGGCGCTGCGAGGGGCGCTTTCGGCCGCAGCGCAGGGG
CACACGCCGCCGGGAGCCGTGCGTGGGCGGGCCTCGGGCGGCAGCGCGCCGAAGGTGGTC
TTCGTGTTTCCCGGTCAGGGCTCGCAGTGGGTGGGCATGGGCCGAAAGCTCATGGCCGAA
GAGCCGGTCTTCCGGGCGGCGCTGGAGGGTTGCGACCGGGCCATCGAGGCGGAAGCGGGC
TGGTCGCTGCTCGGGGAGCTCTCCGCCGACGAGGCCGCCTCGCAGCTCGGGCGCATCGAC
GTGGTTCAGCCGGTGCTCTTCGCCATGGAAGTAGCGCTTTCTGCGCTGTGGCGGTCGTGG
GGAGTGGAGCCGGAAGCGGTGGTGGGCCACAGCATGGGCGAGGTTGCGGCGGCGCACGTG
GCCGGCGCGCTGTCGCTCGAGGACGCGGTGGCGATCATCTGCCGGCGCAGCCGGCTGCTG
CGGCGGATCAGCGGTCAGGGGGAGATGGCGCTGGTCGAGCTGTCGCTGGAGGAGGCCGAG
GCGGCGCTGCGTGGCCATGAGGGTCGGCTGAGCGTGGCGGTGAGCAACAGCCCGCGCTCG
ACCGTGCTCGCCGGCGAGCCGGCGGCGCTCTCGGAGGTGCTGGCGGCGCTGACGGCCAAG
GGGGTGTTCTGGCGGCAGGTGAAGGTGGACGTCGCCAGCCATAGCCCGCAGGTCGACCCG
CTGCGCGAAGAGCTGATCGCGGCGCTGGGAGCGATCCGGCCGCGAGCGGCTGCGGTGCCG
ATGCGCTCGACGGTGACGGGCGGGGTGATCGCGGGTCCGGAGCTCGGTGCGAGCTACTGG
GCGGACAACCTTCGGCAGCCGGTGCGCTTCGCTGCGGCGGCGCAAGCGCTGCTGGAGGGT
GGCCCCGCGCTGTTCATCGAGATGAGCCCGCACCCGATCCTGGTGCCGCCCCTGGACGAG
ATCCAGACGGCGGCCGAGCAAGGGGGCGCTGCGGTGGGCTCGCTGCGGCGAGGGCAGGAC
GAGCGCGCGACGCTGCTGGAGGCGCTGGGGACGCTGTGGGCGTCCGGCTATCCGGTGAGC
TGGGCTCGGCTGTTCCCCGCGGGCGGCAGGCGGGTTCCGCTGCCGACCTATCCCTGGCAG
CACGAGCGGTGCTGGATCGAGGTCGAGCCTGACGCCCGCCGCCTCGCCGCAGCCGACCCC
ACCAAGGACTGGTTCTACCGAACGGACTGGCCCGAGGTGCCCCGCGCCGCCCCGAAATCG
GAGACAGCTCATGGGAGCTGGCTGCTGTTGGCCGACAGGGGTGGGGTCGGTGAGGCGGTC
GCTGCAGCGCTGTCGACGCGCGGACTTTCCTGCACCGTGCTTCATGCGTCGGCTGACGCC
TCCACCGTCGCCGAGCAGGTATCCGAAGCTGCCAGTCGCCGAAACGACTGGCAGGGAGTC
CTCTACCTGTGGGGCCTCGACGCCGTCGTCGATGCTGGGGCATCGGCCGACGAAGTCAGC
GAGGCTACCCGCCGTGCCACCGCACCCGTCCTTGGGCTGGTTCGATTCCTGAGCGCTGCG
CCCCATCCTCCTCGCTTCTGGGTGGTGACCCGCGGGGCATGCACGGTGGGCGGCGAGCCA
GAGGCCTCTCTTTGCCAAGCGGCGTTGTGGGGCCTCGCGCGCGTCGCGGCGCTGGAGCAC
CCCGCTGCCTGGGGTGGCCTCGTGGACCTGGATCCTCAGAAGAGCCCGACGGAGATCGAG
CCCCTGGTGGCCGAGCTGCTTTCGCCGGACGCCGAGGATCAACTGGCGTTCCGCAGCGGT
CGCAGGCACGCAGCACGCCTTGTAGCCGCCCCGCCGGAGGGCGACGTCGCACCGATATCG
CTGTCCGCGGAGGGGAGCTACCTGGTGACGGGCGGGCTGGGTGGCCTTGGTCTGCTCGTG
GCTCGGTGGCTGGTGGAGCGGGGAGCTCGACATCTGGTGCTCACCAGCCGGCACGGGCTG
CCAGAGCGACAGGCGTCGGGCGGAGAGCAGCCGCCGGAGGCCCGCGCGCGCATCGCAGCG
GTCGAGGGGCTGGAAGCGCAGGGCGCGCGGGTGACCGTGGCAGCGGTGGATGTCGCCGAG
GCCGATCCCATGACGGCGCTGCTGGCCGCCATCGAGCCCCCGTTGCGCGGGGTGGTGCAC
GCCGCCGGCGTCTTCCCCGTGCGTCACCTGGCGGAGACGGACGAGGCCCTGCTGGAGTCG
GTGCTCCGTCCCAAGGTGGCCGGGAGCTGGCTGCTGCACCGGCTGCTGCGCGACCGGCCT
CTCGACCTGTTCGTGCTGTTCTCGTCGGGCGCGGCGGTGTGGGGTGGCAAAGGCCAAGGC
GCATACGCCGCGGCCAATGCGTTCCTCGACGGGCTCGCGCACCATCGCCGCGCGCACTCG
CTGCCGGCGTTGAGCCTCGCCTGGGGCTTATGGGCCGAGGGAGGCATGGTTGATGCAAAG
GCTCATGCACGTCTGAGCGACATCGGGGTCCTGCCCATGGCCACGGGGCCGGCCTTGTCG
GCGCTGGAGCGCCTGGTGAACACCAGCGCTGTCCAGCGTTCGGTCACACGGATGGACTGG
GCGCGCTTCGCGCCGGTCTATGCCGCGCGAGGGCGGCGCAACTTGCTTTCGGCTCTGGTC
GCGGAGGACGAGCGCGCTGCGTCTCCCCCGGTGCCGACGGCAAACCGGATCTGGCGCGGC
CTGTCCGTTGCGGAGAGCCGCTCAGCCCTCTACGAGCTCGTTCGCGGCATCGTCGCCCGG
GTGCTGGGCTTCTCCGACCCGGGCGCGCTCGACGTCGGCCGAGGCTTCGCCGAGCAGGGG
CTCGACTCCCTGATGGCTCTGGAGATCCGTAACCGCCTTCAGCGCGAGCTGGGCGAACGG
CTGTCGGCGACTCTGGCCTTCGACCACCCGACGGTGGAGCGGCTGGTGGCGCATCTCCTC
ACCGACGTGCTGAAGCTGGAGGACCGGAGCGACACCCGGCACATCCGGTCGGTGGCGGCG
GATGACGACATCGCCATCGTCGGTGCCGCCTGCCGGTTCCCAGGTGGGGATGAGGGCCTG
GAGACATACTGGCGGCATCTGGCCGAGGGCATGGTGGTCAGCACCGAGGTGCCAGCCGAC
CGGTGGCGCGCGGCGGACTGGTACGACCCCGATCCGGAGGTTCCGGGCCGGACCTATGTG
GCCAAGGGTGCCTTCCTCCGCGATGTGCGCAGCTTGGATGCGGCGTTCTTCGCCATTTCC
CCTCGTGAGGCGATGAGCCTGGACCCGCAACAGCGGCTGTTGCTGGAGGTGAGCTGGGAG
GCGATCGAGCGCGCTGGCCAGGACCCGATGGCGCTGCGCGAGAGCGCCACGGGCGTGTTC
GTGGGCATGATCGGGAGCGAGCACGCCGAGCGGGTGCAGGGCCTCGACGACGACGCGGCG
TTGCTGTACGGCACCACCGGCAACCTGCTCAGCGTCGCCGCTGGACGGCTGTCGTTCTTC
CTGGGTCTGCACGGCCCGACGATGACGGTGGACACCGCCTGCTCGTCGTCGCTGGTGGCG
TTGCACCTCGCCTGCCAGAGCCTGCGATTGGGCGAGTGCGACCAGGCCCTGGCCGGCGGG
TCCAGCGTGCTTTTGTCGCCGCGGTCATTCGTCGCGGCGTCGCGCATGCGTTTGCTTTCG
CCAGATGGGCGGTGCAAGACGTTCTCGGCCGCTGCAGACGGCTTTGCGCGGGCCGAGGGC
TGCGCCGTGGTGGTGCTCAAGCGGCTCCGTGACGCGCAGCGCGACCGCGACCCCATCCTG
GCGGTGGTCAGGAGCACGGCGATCAACCACGATGGCCCGAGCAGCGGGCTCACGGTGCCC
AGCGGTCCTGCCCAGCAGGCGTTGCTACGCCAGGCGCTGGCGCAAGCGGGCGTGGCGCCG
GCCGAGGTCGATTTCGTGGAGTGCCACGGGACGGGGACAGCGCTGGGTGACCCGATCGAG
GTGCAGGCGCTGGGCGCGGTGTACGGGCGGGGCCGCCCCGCGGAGCGGCCGCTCTGGCTG
GGCGCTGTCAAGGCCAACCTCGGCCACCTGGAGGCCGCGGCGGGCTTGGCCGGCGTGCTC
AAGGTGCTCTTGGCGCTGGAGCACGAGCAGATTCCGGCTCAACCGGAGCTCGACGAGCTC
AACCCGCACATCCCGTGGGCAGAGCTGCCAGTGGCCGTTGTCCGCAGGGCGGTCCCCTGG
CCGCGCGGCGCGCGCCCGCGTCGTGCAGGCGTGAGCGCTTTCGGCCTGAGCGGGACCAAC
GCGCATGTGGTGTTGGAGGAGGCGCCGGCGGTGGAGCCTGTGGCCGCGGCCCCCGAGCGC
GCAGCGGAGCTGTTCGTCCTGTCGGCGAAGAGCGCGGCGGCGCTGGATGCGCAGGCAGCC
CGGCTGCGGGACCACCTGGAGAAGCATGTCGAGCTTGGCCTCGGCGATGTGGCGTTCAGC
CTGGCGACGACGCGCAGCGCGATGGAGCACCGGCTGGCGGTGGCCGCGAGCTCGCGCGAG
GCGCTGCGAGGGGCGCTTTCGGCCGCAGCGCAGGGGCACACGCCGCCGGGAGCCGTGCGT
GGGCGGGCCTCGGGCGGCAGCGCGCCGAAGGTGGTCTTCGTGTTTCCCGGCCAGGGCTCG
CAGTGGGTGGGCATGGGCCGAAAGCTCATGGCCGAAGAGCCGGTCTTCCGGGCGGCGCTG
GAGGGTTGCGACCGGGCCATCGAGGCGGAAGCGGGCTGGTCGCTGCTCGGGGAGCTCTCC
GCCGACGAGGCCGCCTCGCAGCTCGGGCGCATCGACGTGGTTCAGCCGGTGCTGTTCGCC
ATGGAAGTAGCGCTTTCTGCGCTGTGGCGGTCGTGGGGAGTGGAGCCGGAAGCGGTGGTG
GGCCACAGCATGGGCGAGGTTGCGGCGGCGCACGTGGCCGGCGCGCTGTCGCTCGAGGAC
GCGGTGGCGATCATCTGCCGGCGCAGCCGGCTGCTGCGGCGGATCAGCGGTCAGGGGGAG
ATGGCGCTGGTCGAGCTGTCGCTGGAGGAGGCCGAGGCGGCGCTGCGTGGCCATGAGGGT
CGGCTGAGCGTGGCGGTGAGCAACAGCCCGCGCTCGACCGTGCTCGCCGGCGAGCCGGCG
GCGCTCTCGGAGGTGCTGGCGGCGCTGACGGCCAAGGGGGTGTTCTGGCGGCAGGTGAAG
GTGGACGTCGCCAGCCATAGCCCGCAGGTCGACCCGCTGCGCGAAGAGCTGATCGCGGCG
CTGGGAGCGATCCGGCCGCGAGCGGCTGCGGTGCCGATGCGCTCGACGGTGACGGGCGGG
GTGATCGCGGGTCCGGAGCTCGGTGCGAGCTACTGGGCGGACAACCTTCGGCAGCCGGTG
CGCTTCGCTGCGGCGGCGCAAGCGCTGCTGGAGGGTGGCCCCGCGCTGTTCATCGAGATG
AGCCCGCACCCGATCCTGGTGCCGCCCCTGGACGAGATCCAGACGGCGGCCGAGCAAGGG
GGCGCTGCGGTGGGCTCGCTGCGGCGAGGGCAGGACGAGCGCGCGACGCTGCTGGAGGCG
CTGGGGACGCTGTGGGCGTCCGGCTATCCGGTGAGCTGGGCTCGGCTGTTCCCCGCGGGC
GGCAGGCGGGTTCCGCTGCCGACCTATCCCTGGCAGCACGAGCGGTACTGGATCGAGGAC
AGCGTGCATGGGTCGAAGCCCTCGCTGCGGCTTCGGCAGCTTCGCAACGGCGCCACGGAC
CATCCGCTGCTCGGGGCTCCATTGCTCGTCTCGGCGCGACCCGGAGCTCACTTGTGGGAG
CAAGCGCTGAGCGACGAGAGGCTATCCTACCTTTCGGAACATAGGGTCCATGGCGAAGCC
GTGTTGCCCAGCGCGGCGTATGTAGAGATGGCGCTCGCCGCCGGCGTAGATCTCTATGGC
ACGGCGACGCTGGTGCTGGAGCAGCTGGCGCTCGAGCGAGCCCTCGCCGTGCCCTCCGAA
GGCGGACGCATCGTGCAAGTGGCCCTCAGCGAAGAAGGTCCCGGTCGGGCCTCATTCCAG
GTATCGAGTCGTGAGGAGGCAGGTAGGAGCTGGGTGCGGCACGCCACGGGGCACGTGTGT
AGCGGCCAGAGCTCAGCGGTGGGAGCGTTGAAGGAAGCTCCGTGGGAGATTCAACGGCGA
TGTCCGAGCGTCCTGTCGTCGGAGGCGCTCTATCCGCTGCTCAACGAGCACGCCCTCGAC
TATGGTCCCTGCTTCCAGGGCGTGGAGCAGGTGTGGCTCGGCACGGGGGAGGTGCTCGGC
CGGGTACGCTTGCCAGGAGACATGGCATCCTCAAGTGGCGCCTACCGGATTCATCCCGCC
TTGTTGGATGCATGTTTTCAGGTGCTGACAGCGCTGCTCACCACGCCGGAATCCATCGAG
ATTCGGAGGCGGCTGACGGATCTCCACGAACCGGATCTCCCGCGGTCCAGGGCTCCGGTG
AATCAAGCGGTGAGTGACACCTGGCTGTGGGACGCCGCGCTGGACGGTGGACGGCGCCAG
AGCGCGAGCGTGCCCGTCGACCTGGTGCTCGGCAGCTTCCATGCGAAGTGGGAGGTCATG
GAGCGCCTCGCGCAGGCGTACATCATCGGCACTCTCCGCATATGGAACGTCTTCTGCGCT
GCTGGAGAGCGTCACACGATAGACGAGTTGCTCGTCAGGCTTCAAATCTCTGTCGTCTAC
AGGAAGGTCATCAAGCGATGGATGGAACACCTTGTCGCGATCGGCATCCTTGTAGGGGAC
GGAGAGCATTTTGTGAGCTCTCAGCCGCTGCCGGAGCCTGATTTGGCGGCGGTGCTCGAG
GAGGCCGGGAGGGTGTTCGCCGACCTCCCAGTCCTATTTGAGTGGTGCAAGTTTGCCGGG
GAACGGCTCGCGGACGTATTGACCGGTAAGACGCTCGCGCTCGAGATCCTCTTCCCTGGT
GGCTCGTTCGATATGGCGGAGCGAATCTATCGAGATTCGCCCATCGCCCGTTACTCGAAC
GGCATCGTGCGCGGTGTCGTCGAGTCGGCGGCGCGGGTGGTAGCACCGTCGGGAATGTTC
AGCATCTTGGAGATCGGAGCAGGGACGGGCGCGACCACCGCCGCCGTCCTCCCGGTGTTG
CTGCCTGACCGGACGGAGTACCATTTCACCGATGTTTCTCCGCTCTTCCTTGCTCGCGCG
GAGCAAAGATTTCGAGATTATCCATTCCTGAAGTATGGCATTCTGGATGTCGACCAGGAG
CCAGCTGGCCAGGGATACGCACATCAGAGGTTTGACGTCATCGTCGCGGCCAATGTCATC
CATGCGACCCGCGATATAAGAGCCACGGCGAAGCGTCTCCTGTCGTTGCTCGCGCCCGGA
GGCCTTCTGGTGCTGGTCGAGGGCACAGGGCATCCGATCTGGTTCGATATCACCACGGGA
TTGATTGAGGGGTGGCAGAAGTACGAAGATGATCTTCGTATCGACCATCCGCTCCTGCCT
GCTCGGACCTGGTGTGACGTCCTGCGCCGGGTAGGCTTTGCGGACGCCGTGAGTCTGCCA
GGCGACGGATCTCCGGCGGGGATCCTCGGACAGCACGTGATCCTCTCGCGCGCGCCGGGC
ATAGCAGGAGCCGCTTGTGACAGCTCCGGTGAGTCGGCGACCGAATCGCCGGCCGCGCGT
GCAGTACGGCAGGAATGGGCCGATGGCTCCGCTGACGTCGTCCATCGGATGGCGTTGGAG
AGGATGTACTTCCACCGCCGGCCGGGCCGGCAGGTTTGGGTCCACGGTCGATTGCGTACC
GGTGGAGGCGCGTTCACGAAGGCGCTCGCTGGAGATCTGCTCCTGTTCGAAGACACCGGG
CAGGTCGTGGCAGAGGTTCAGGGGCTCCGCCTGCCGCAGCTCGAGGCTTCTGCTTTCGCG
CCGCGGGACCCGCGGGAAGAGTGGTTGTACGCTTTGGAATGGCAGCGCAAAGACCCTATA
CCAGAGGCTCCGGCAGCCGCGTCTTCTTCCTCCGCGGGGGCTTGGCTCGTGCTGATGGAC
CAGGGCGGGACAGGCGCTGCGCTCGTATCGCTGCTGGAAGGGCGAGGCGAGGCGTGCGTG
CGCGTCATCGCGGGTACGGCATACGCCTGCCTCGCGCCGGGGCTGTATCAAGTCGATCCG
GCGCAGCCAGATGGCTTTCATACCCTGCTCCGCGATGCATTCGGCGAGGACCGGATTTGT
CGCGCGGTAGTGCATATGTGGAGCCTTGATGCGACGGCAGCAGGGGAGAGGGCGACAGCG
GAGTCGCTTCAGGCCGATCAACTCCTGGGGAGCCTGAGCGCGCTTTCTCTGGTGCAGGCG
CTGGTGCGCCGGAGGTGGCGCAACATGCCGCGGCTTTGGCTCTTGACCCGCGCCGTGCAT
GCGGTGGGCGCGGAGGACGCAGCGGCCTCGGTGGCGCAGGCGCCGGTGTGGGGCCTCGGT
CGGACGCTCGCGCTCGAGCATCCAGAGCTGCGGTGCACGCTCGTGGACGTGAACCCGGCG
CCGTCTCCAGAGGACGCAGCCGCACTGGCGGTGGAGCTCGGGGCGAGCGACAGAGAGGAC
CAGGTCGCATTGCGCTCGGATGGCCGCTACGTGGCGCGCCTCGTGCGGAGCTCCTTTTCC
GGCAAGCCTGCTACGGATTGCGGCATCCGGGCGGACGGCAGCTATGTGATCACCGATGGC
ATGGGGAGAGTGGGGCTCTCGGTCGCGCAATGGATGGTGATGCAGGGGGCCCGCCATGTG
GTGCTCGTGGATCGCGGCGGCGCTTCCGAGGCATCCCGGGATGCCCTCCGGTCCATGGCC
GAGGCTGGCGCGGAGGTGCAGATCGTGGAGGCCGACGTGGCTCGGCGCGACGATGTCGCT
CGGCTCCTCTCGAAGATCGAACCGTCGATGCCGCCGCTTCGGGGGATCGTGTACGTGGAC
GGGACCTTCCAGGGCGACTCCTCGATGCTGGAGCTGGATGCCCGTCGCTTCAAGGAGTGG
ATGTATCCCAAGGTGCTCGGAGCGTGGAACCTGCACGCGCTGACCAGGGATAGATCGCTG
GACTTCTTCGTCCTGTATTCCTCGGGCACCTCGCTTCTGGGCTTGCCAGGACAGGGGAGC
CGCGCCGCCGGTGACGCCTTCTTGGACGCCATCGCGCATCACCGGTGCAAGGTGGGCCTT
ACAGCGATGAGCATCAACTGGGGATTGCTCTCCGAAGCATCATCGCCGGCGACCCCGAAC
GACGGCGGAGCACGGCTCGAATACCGGGGGATGGAAGGCCTCACGCTGGAGCAGGGAGCG
GCGGCGCTCGGGCGCTTGCTCGCACGACCCAGGGCGCAGGTAGGGGTGATGCGGCTGAAT
CTGCGCCAGTGGTTGGAGTTCTATCCCAACGCGGCCCGATTGGCGCTGTGGGCGGAGCTG
CTGAAGGAGCGTGACCGCGCCGACCGAGGCGCGTCGAACGCGTCGAACCTGCGCGAGGCG
CTGCAGAGCGCCAGGCCCGAAGATCGTCAGTTGATTCTGGAGAAGCACTTGAGCGAGCTG
TTGGGGCGGGGGCTGCGCCTTCCGCCGGAGAGGATCGAGCGGCACGTGCCGTTCAGCAAT
CTCGGCATGGACTCGCTGATAGGCCTGGAGCTCCGCAACCGCATCGAGGCCGCGCTCGGC
ATCACCGTGCCGGCGACCCTGCTATGGACCTACCCTAACGTAGCAGCTCTGAGCGGGAGC
TTGCTAGACATTCTGTTTCCGAATGCCGGCGCGACCCACGCTCCGGCCACCGAGCGGGAG
AAGAGCTTCGAGAACGATGCCGCAGATCTCGAGGCTCTGCGGGGCATGACGGACGAGCAG
AAGGACGCGTTGCTCGCCGAAAAGCTGGCGCAGCTCGCGCAGATCGTTGGTGAGTAA
[7] KS35..405
[7] AT560..876
[7] methylmalonyl-CoA not conserved YASHS(Y->V)751..755
[7] KR1145..1334
[7] ACP1430..1500
[8] KS1522..1896
[8] AT2052..2368
[8] methylmalonyl-CoA not conserved YASHS(Y->V)2243..2247
[8] dh2421..2588
[8] MT2863..2963
[8] kr3393..3573
[8] ACP3669..3742
[7] KS103..1215
[7] AT1678..2628
[7] methylmalonyl-CoA not conserved YASHS(Y->V)2251..2265
[7] KR3433..4002
[7] ACP4288..4500
[8] KS4564..5688
[8] AT6154..7104
[8] methylmalonyl-CoA not conserved YASHS(Y->V)6727..6741
[8] dh7261..7764
[8] MT8587..8889
[8] kr10177..10719
[8] ACP11005..11226

close this sectionFeature

BLASTP
Database:UniProtKB:2011_09 		show BLAST table
InterPro
Database:interpro:38.0
IPR001227 Acyl transferase domain (Domain)
[554-683] G3DSA:3.40.366.10 [751-868] G3DSA:3.40.366.10 [2046-2175] G3DSA:3.40.366.10 [2243-2360] G3DSA:3.40.366.10
G3DSA:3.40.366.10   Ac_transferase_reg
IPR009081 Acyl carrier protein-like (Domain)
[1427-1501] 5.69999999999998e-36 G3DSA:1.10.1200.10 [3673-3741] 5.69999999999998e-36 G3DSA:1.10.1200.10
G3DSA:1.10.1200.10   ACP_like
[1423-1538] 3.69999438558106e-26 SSF47336 [3666-3762] 2.70000183580794e-17 SSF47336
SSF47336   ACP_like
[1430-1500] PS50075 [3669-3742] PS50075
PS50075   ACP_DOMAIN
[1433-1499] 4.3e-13 PF00550 [3677-3738] 7.59999999999999e-10 PF00550
PF00550   PP-binding
IPR013217 Methyltransferase type 12 (Domain)
[2863-2963] 1.2e-18 PF08242
PF08242   Methyltransf_12
IPR013968 Polyketide synthase, KR (Domain)
[1145-1333] 4.2e-69 PF08659 [3393-3572] 3.5e-59 PF08659
PF08659   KR
IPR014030 Beta-ketoacyl synthase, N-terminal (Domain)
[35-280] 1.29999999999998e-89 PF00109 [1522-1772] 7.90000000000016e-89 PF00109
PF00109   ketoacyl-synt
IPR014031 Beta-ketoacyl synthase, C-terminal (Domain)
[289-405] 1.29999999999998e-38 PF02801 [1780-1896] 1.09999999999999e-41 PF02801
PF02801   Ketoacyl-synt_C
IPR014043 Acyl transferase (Domain)
[560-876] 7.99999999999993e-101 PF00698 [2052-2368] 7.99999999999993e-101 PF00698
PF00698   Acyl_transf_1
IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase (Domain)
[558-862] 4.69998262513189e-69 SSF52151 [2050-2354] 4.69998262513189e-69 SSF52151
SSF52151   Acyl_Trfase/lysoPlipase
IPR016036 Malonyl-CoA ACP transacylase, ACP-binding (Domain)
[685-750] 5.39999384454126e-17 SSF55048 [2177-2242] 5.39999384454126e-17 SSF55048
SSF55048   Malonyl_transacylase_ACP-bd
IPR016038 Thiolase-like, subgroup (Domain)
[35-291] G3DSA:3.40.47.10 [292-458] 2.70000000000002e-123 G3DSA:3.40.47.10 [1521-1783] G3DSA:3.40.47.10 [1786-1950] 2.70000000000002e-123 G3DSA:3.40.47.10
G3DSA:3.40.47.10   Thiolase-like_subgr
IPR016039 Thiolase-like (Domain)
[27-402] 4.89996723796399e-95 SSF53901 [1514-1894] 7.80005155399507e-99 SSF53901
SSF53901   Thiolase-like
IPR016040 NAD(P)-binding domain (Domain)
[1146-1340] 1.10000000000001e-66 G3DSA:3.40.50.720 [3394-3573] 1.10000000000001e-66 G3DSA:3.40.50.720
G3DSA:3.40.50.720   NAD(P)-bd
IPR018201 Beta-ketoacyl synthase, active site (Active_site)
[193-209] PS00606 [1685-1701] PS00606
PS00606   B_KETOACYL_SYNTHASE
IPR020801 Polyketide synthase, acyl transferase domain (Domain)
[562-859] 1.19999063421924e-118 SM00827 [2054-2351] 1.19999063421924e-118 SM00827
SM00827   PKS_AT
IPR020803 Polyketide synthase, methyltransferase domain (Domain)
[2704-2878] 6.60002751141562e-49 SM00828
SM00828   PKS_MT
IPR020806 Polyketide synthase, phosphopantetheine-binding domain (Domain)
[1431-1503] 1.20000117458134e-27 SM00823 [3673-3745] 1.39999892049878e-18 SM00823
SM00823   PKS_PP
IPR020807 Polyketide synthase, dehydratase domain (Domain)
[2421-2588] 8.39998014024981e-50 SM00826
SM00826   PKS_DH
IPR020841 Polyketide synthase, beta-ketoacyl synthase domain (Domain)
[37-458] SM00825 [1524-1950] SM00825
SM00825   PKS_KS
IPR020842 Polyketide synthase/Fatty acid synthase, KR (Domain)
[1145-1334] 3.49999466863949e-57 SM00822 [3393-3573] 2.9000035467798e-34 SM00822
SM00822   PKS_KR
SignalP No significant hit
TMHMM No significant hit
Epoth_00090 Epoth_00090   Epoth_00110 Epoth_00110
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