Myxa_00080 Myxa_00080   Myxa_00100 Myxa_00100

Myxa_00090 : CDS information

close this sectionLocation

Organism
StrainSga15
Entry nameMyxalamid
Contig
Start / Stop / Direction48,170 / 41,064 / - [in whole cluster]
48,170 / 41,064 / - [in contig]
Locationcomplement(41064..48170) [in whole cluster]
complement(41064..48170) [in contig]
TypeCDS
Length7,107 bp (2,368 aa)
Click on the icon to see Genetic map.

close this sectionAnnotation

Category1.1 PKS
Productpolyketide synthase
Product (GenBank)MxaF
Gene
Gene (GenBank)mxaF
EC number
Keyword
Note
Note (GenBank)
  • PKS; ACP loading; contains KS; AT, DH, KR, and ACP regions
Reference
ACC
PmId
[11182319] Novel features in a combined polyketide synthase/non-ribosomal peptide synthetase: the myxalamid biosynthetic gene cluster of the myxobacterium Stigmatella aurantiaca Sga15. (Chem Biol. , 2001)
[17955482] Mutasynthesis-derived myxalamids and origin of the isobutyryl-CoA starter unit of myxalamid B. (Chembiochem. , 2007)
comment
[PMID: 11182319](2001)
myxalamid生合成gene clusterの報告。
MxaF: PKS domains (ACP-L, KS, AT-L, AT-1, DH, KR, ACP2)

mxaFはloading + module 1をコード。
mxaFのinactivationでmyxalamidsは産生されなくなる。

module 1 AT domainは2つある。
1つめのAT domain(AT-L)はmyxalamid A-Dの生合成のために異なるstarter unitを認識する。

myxalamid A: 2-methylbutyrate
myxalamid B: isobutyrate
myxalamid C: propionate
myxalamid D: acetate

これらを結合するのはloading moduleのACP-L.

--
[PMID:17955482](2007)
Myxococcus xanthus由来のmyxalamid生合成gene clusterの同定論文。

M. xanthus and Stigmatella aurantiacaのbkd mutantsからnew myxalamidsとmyxalamid Bを検出。
bkdは、isoleucine and valineから、myxalamid A and Bのstarter unitである2-methyl-butyryl-CoA and isobutyryl-CoAへの触媒をするbranched-chain ketoacid dehydrogenaseをコードする。

この結果からbkd mutantでのisobutyryl-CoAの起源を調査。
M. xanthus bkd mutantではvalineから生じるが、S. aurantiacaではiso-odd fatty acidsのalpha-oxidationに由来する。

close this sectionPKS/NRPS Module

0
1
2-methylbutyryl-CoA for Myxalamid A
isobutyryl-CoA for Myxalamid B
propionyl-CoA for Myxalamid C
acetyl-CoA for Myxalamid D
methylmalonyl-CoA
not conserved YASHS(Y->V)
ACP15..84
KS102..478
AT623..940
AT1060..1371
DH1426..1593
KR1967..2146
ACP2246..2315

close this sectionSequence

selected fasta
>polyketide synthase [MxaF]
MSAKDRVLKDGLAEVQARLAGVLSQRLGIEARKLDVRERFSRYGLDSIKVTAFIAEVGEV
LGRSLSPTLAFEYPTLEALARYLAGAEERPASQPVSQAARENEPIAIVGMACRYPQASDP
EAFWRLLAGGNHAITEIPPERWDINRLYDRDPAAAGKVTSRWGAYLDQVDGFDPLFFGIS
PKEALHMDPQQRLMLELTWEALEDAGIAAEGLQGSPTAVCFGVVWTDYEAMLQRMGLRRI
SSYTSSGSHHSIVANRVSYVLGLRGPSMAIDTACSSSLSAVHLACESLRRGESTMALVGG
VNLTIAPDSTVGLSKLGALSPDGRCYTFDARANGYVRGEGAGVAVLKPLSRAIADGDPIY
CVIRGSAINNNGGSNGLTAPNTQAQAEVIRQACARAGVAPTDVQYVEAHGTGTQLGDPME
ARALGEALGAGRPSDKPLHIGSCKTNIGHLEAAAGITGLIKVALSIKNRALPPSLHFETP
NPLIPFEDLRLEVQRTLSDWPEPDRKLVAGVSSFGFGGTNCHVVLEEVNAPQAELVRLSG
EAPEALRGAAQRLLERMDSGEWMPLPELLRSVADEVGDHPHRLAMTVRTRKDLRECLQSF
LAGETRAGMSVGQVEPEYPQKPVFIFSGHGSQWPGMGLALMRTEPVFRASMEQCDRLIQQ
NVGWSLLAMLGAKDAAAQLGRIDVTLPAIVALEISMTALWRSWGIEPAMVVGHSIGEVSA
AYAAGILGLEDAMRVVCHQSLLMSRLSGQGAMGIVGISWAQSAELLVGYEGRLCRAIDAG
SDSTVLSGEPKALDEIFAILQPRGVFCRRVDINVAVHSPQIDALSDELIEVLRGIRPSQA
RIPMVSTVTAALLEGEKADATHWVKNIAMPTLFTGALSHTLGEGHRVFVEVGPHTIVKHS
IESTLKHKGQQGLVVPTMRRQEDERGTMLDTLGVLFTRGQKAQWEAISTGGVDKGAQAAA
GEAPVRLLPLSARSPEALKSLAAACRDFLGGEGGAAGEAALDDVTYTAGARRSHLSHRLS
VVGGSRQEMVEALDAFARGEVRPGVSQGRVSPEGRAKVAFVFPGQGSQWLGMGRQLLREE
PVFRAAIEACEQAMRAHVDWSLTAELCADEQHSRLQEINVVQPVLFAMQVALAALWRSWG
MEPDAVVGHSMGEVAAAHVAGALSLEDAARIICLRSLLLRRMSGQGAMAVVELGLEQARE
ALAGYESRLSIGVSNSARSTVLSGDTEALEELLRRLEGQGVFCRRVKVNVASHSPQMDPL
KDDLLRALEGISPQRAPVSIYSTVTGQTSDGGDFHPSYWVSNLREPVLFHGAVERLLADG
YSVLLEVSPHPVLLAPIEETVRESKQEALALASLRRQAPERRSLLESLAAMYAWGCSVDW
KPLQPSGGRVVALPKYPWQRERYWLPDEAEADPRYGGAANEDRVGHPFLGSSLSSSVQPG
AHFWERAVSAEAFPYLADHCVWGDIVFPGAGYVEMALSAGAEVLGETGLVLENVSISEML
ALKAGESRRVQVVLNEEGTGQASFQISSRAEGDKSWRKHAAGSLRREENATLQLTAEPPE
LLRERLEVEISSEVHYQRRQDQGLVYGPTFQGLRQLWRSEREGLGRLELPEQVASDIGEY
RLHPALLDASLQVAVELIAPMTGASTAAPTYVPVGLGRIRLFQKPGRAAWVWVKAVGEGA
SGERERSFDIRLLDDQGHVMLEIEELRLYRLEAGAAVRKELGEWIYQVDWESQPLAAELP
WPARSAGSWLILSDSSGVGQRLSSLLRARGETCVLVQPGEKYRSIGPGAYEVDPRNGEHL
RRLLGDAMGAGAPPCRGVVHLWSLDCASNDALTPQSLEASRRLGTTSVLHLVQALSRAGW
RDAPRLWLATRGARSVGKEPQRVNVAQAPLWGLGQVLSLEQPELRCTRVDLEGGADICAD
ALIREVSSTVFEDQAAWRAGTRLVARLSRAADALSTRDPATILRADGAYLITGGLGGLGL
EVARWLVSNGARHLLLLGRRAPSAEAEQTLAELRQAGAHVEPFQADVASPDDVARALARV
NETMPPLRGVFHAAGLLEDGLLINLTEERFASVMAPKVLGTWNLHTQTRHLPLDLFVLFS
SVASSLGTPGQANYSSANAFMDALAHARRAEGLPALSINWGTWTSVGLAAAQANRGERLE
ARGLRGMSPDKALMAFGMLLGQGRPQLSVMSFESRQWLGFYLAAAQSPFFTRLSQEQAGR
PSVEQGRSRIREQLEAARGSERRALLDGHLRELIGGVLRMEPSRIDPRTPLGSLGLDSLM
SMEIRNRLEASLGLKLSATVVWTYPTLAALTPYLAEKMELPLEDKGSELRLAAAPVSAPP
SAAPGSDIDDMSEEEVERLFAQRVAQGK
selected fasta
>polyketide synthase [MxaF]
GTGTCGGCAAAAGACAGAGTGCTGAAGGATGGTCTGGCTGAGGTACAGGCGCGTTTGGCC
GGTGTCCTCTCGCAGCGGTTGGGGATTGAGGCGCGCAAGCTGGATGTGCGCGAGCGCTTC
AGCCGGTATGGGCTTGACTCGATCAAGGTCACGGCCTTTATCGCCGAGGTGGGAGAGGTG
CTCGGGCGCTCGTTGTCGCCCACGCTCGCCTTCGAGTACCCGACCCTTGAAGCCCTGGCC
CGGTATCTGGCTGGAGCAGAGGAGCGTCCCGCCTCGCAGCCCGTGTCTCAGGCGGCCCGG
GAGAATGAGCCCATCGCCATTGTCGGCATGGCGTGCCGCTACCCCCAGGCCTCGGATCCC
GAGGCGTTCTGGCGTCTGCTCGCGGGAGGAAACCACGCGATCACGGAGATTCCTCCGGAG
CGGTGGGACATCAATCGCCTCTATGATCGTGACCCCGCCGCGGCCGGTAAGGTGACCTCC
CGTTGGGGAGCGTACCTGGACCAGGTGGACGGGTTCGATCCGCTCTTCTTTGGCATCTCG
CCCAAGGAGGCGCTCCACATGGATCCGCAGCAGCGGCTCATGTTGGAGCTGACGTGGGAG
GCGCTGGAGGACGCGGGGATCGCCGCGGAGGGCCTGCAGGGCTCGCCCACGGCGGTCTGC
TTCGGCGTGGTCTGGACGGACTACGAAGCCATGCTGCAGCGGATGGGTTTACGGCGCATT
TCCTCCTACACGTCGTCGGGGTCCCACCACAGCATCGTTGCCAACCGCGTCTCCTATGTC
CTGGGGCTCCGGGGACCCAGCATGGCCATCGACACGGCCTGCTCCTCCTCGCTCTCGGCG
GTGCATCTGGCCTGCGAGAGCCTGCGGCGTGGCGAGTCGACGATGGCCCTCGTGGGCGGC
GTGAACCTGACCATCGCGCCCGATAGCACGGTGGGCTTGTCCAAGCTGGGGGCGCTTTCG
CCGGATGGGCGTTGCTACACCTTTGATGCACGTGCCAACGGGTATGTGCGGGGCGAGGGA
GCCGGCGTGGCGGTGCTCAAGCCCCTGTCGCGGGCCATCGCGGACGGCGATCCCATCTAC
TGTGTCATCCGCGGCAGCGCCATCAACAACAATGGTGGAAGCAACGGCCTCACCGCGCCC
AACACCCAGGCTCAGGCGGAGGTGATTCGCCAAGCGTGCGCCCGCGCGGGCGTCGCGCCG
ACCGACGTGCAGTACGTCGAGGCGCATGGCACCGGCACGCAGCTCGGGGACCCCATGGAG
GCTCGGGCCTTGGGCGAGGCGCTCGGCGCCGGGCGGCCCTCCGACAAGCCGCTGCACATC
GGCTCCTGCAAGACCAACATCGGGCACCTGGAAGCCGCCGCGGGCATCACGGGGCTGATC
AAGGTCGCGCTGTCCATCAAGAACCGGGCGCTGCCGCCGAGCCTCCACTTCGAGACGCCC
AATCCGCTCATCCCCTTCGAGGATCTGCGTCTGGAAGTCCAGCGCACCCTCAGTGACTGG
CCCGAGCCGGACAGGAAGCTCGTCGCGGGGGTCAGCTCCTTTGGATTCGGTGGCACGAAC
TGCCACGTGGTGCTCGAGGAAGTGAACGCGCCCCAGGCGGAACTCGTGCGTTTGTCGGGT
GAGGCTCCCGAGGCGCTCCGAGGGGCGGCACAGCGGCTGCTCGAGCGCATGGACTCCGGG
GAGTGGATGCCCCTGCCCGAGCTGCTCCGCTCGGTGGCGGATGAGGTGGGCGATCACCCA
CATCGCTTGGCGATGACCGTCCGGACTCGGAAGGACCTTCGGGAGTGCCTCCAGAGCTTC
TTGGCGGGGGAGACCCGGGCGGGGATGTCGGTGGGACAGGTGGAGCCCGAGTATCCTCAG
AAGCCGGTCTTCATCTTCTCGGGGCATGGTTCGCAGTGGCCCGGCATGGGGCTTGCCCTC
ATGCGGACCGAGCCGGTGTTCCGGGCGTCGATGGAGCAGTGCGATCGGCTCATCCAGCAG
AACGTGGGTTGGTCGCTGCTGGCCATGTTGGGCGCCAAGGACGCGGCGGCGCAGCTTGGC
CGGATCGACGTCACGCTGCCGGCGATCGTGGCCCTGGAGATCTCCATGACGGCGCTCTGG
CGCTCCTGGGGGATCGAGCCCGCCATGGTGGTGGGTCACAGCATCGGCGAGGTCTCGGCG
GCGTACGCCGCGGGCATCCTGGGGCTCGAAGACGCCATGCGCGTCGTCTGCCACCAGAGT
CTGCTGATGAGTCGGCTGAGCGGCCAGGGCGCGATGGGGATCGTGGGGATCTCTTGGGCG
CAGTCCGCCGAGTTGTTGGTGGGCTACGAGGGTCGGCTGTGCCGCGCCATCGATGCCGGC
TCGGACTCGACGGTGCTGTCCGGTGAGCCGAAGGCGCTTGACGAGATATTCGCGATCTTG
CAGCCGCGCGGAGTGTTCTGCCGCCGGGTGGATATCAACGTCGCGGTGCACAGCCCCCAG
ATCGATGCGCTGAGCGATGAGCTGATCGAGGTTCTGCGGGGGATCCGTCCAAGCCAGGCT
CGCATTCCCATGGTGTCCACGGTCACCGCCGCGCTGCTCGAGGGCGAGAAGGCCGATGCC
ACCCACTGGGTGAAGAACATCGCGATGCCCACGCTCTTCACGGGCGCGCTCTCCCACACG
CTCGGCGAGGGCCACCGCGTCTTCGTGGAAGTCGGCCCGCACACGATCGTCAAGCACTCC
ATTGAGTCGACGCTGAAGCACAAGGGGCAGCAGGGGCTCGTTGTCCCCACCATGCGTCGG
CAGGAGGACGAGCGCGGCACGATGCTCGATACCCTGGGCGTCCTCTTCACGCGGGGCCAG
AAGGCCCAGTGGGAGGCGATCTCCACGGGAGGGGTGGACAAGGGAGCGCAGGCTGCCGCC
GGTGAGGCACCGGTGCGGTTGTTGCCCCTGTCGGCCCGCAGCCCCGAGGCGCTGAAGTCG
CTGGCGGCGGCTTGCCGTGACTTCCTGGGGGGAGAGGGCGGTGCGGCGGGGGAAGCGGCG
CTCGACGACGTCACCTACACGGCCGGAGCGCGGCGGAGCCATCTCTCCCACCGTCTGTCG
GTGGTGGGCGGTTCGCGGCAGGAGATGGTCGAGGCGCTGGATGCCTTCGCGAGGGGCGAA
GTCCGTCCAGGGGTGAGCCAGGGCCGGGTGAGCCCCGAGGGGCGGGCCAAGGTGGCGTTC
GTCTTCCCGGGACAGGGTTCGCAGTGGCTCGGCATGGGTCGTCAGCTCCTGCGCGAGGAG
CCTGTCTTCCGGGCGGCGATCGAGGCCTGCGAGCAGGCGATGCGGGCCCACGTGGACTGG
TCCCTCACGGCGGAACTCTGCGCGGATGAGCAGCACTCGCGCCTGCAAGAGATCAACGTC
GTGCAGCCGGTGCTGTTCGCGATGCAGGTGGCGCTGGCGGCGCTGTGGCGCTCGTGGGGC
ATGGAGCCGGATGCCGTGGTGGGCCACAGCATGGGTGAGGTGGCTGCGGCACACGTGGCG
GGCGCCCTCAGCCTGGAGGACGCGGCCCGTATCATCTGCCTTCGCAGCTTGCTGCTGCGC
CGCATGAGCGGGCAGGGGGCGATGGCCGTGGTGGAACTGGGCCTGGAGCAGGCCCGCGAA
GCGCTGGCTGGCTACGAGTCGCGGCTCTCCATCGGCGTGAGCAACAGCGCGCGCTCGACG
GTGCTCTCCGGAGACACCGAAGCCCTGGAGGAACTGCTGCGTCGGCTCGAAGGCCAGGGG
GTCTTCTGCCGCCGGGTCAAGGTGAATGTTGCTTCCCACAGCCCGCAGATGGATCCGCTG
AAGGATGACCTCCTGCGCGCACTGGAGGGGATTTCTCCCCAGCGTGCGCCGGTCTCCATC
TACTCCACGGTCACGGGGCAGACGAGCGACGGGGGCGACTTCCATCCGTCCTACTGGGTC
AGCAACCTGCGCGAGCCCGTGTTGTTCCACGGCGCCGTCGAGCGGCTCCTGGCGGATGGC
TACAGCGTGCTCCTCGAGGTGAGTCCGCATCCCGTGCTGCTCGCCCCCATCGAAGAGACG
GTGCGCGAGTCGAAGCAGGAAGCGCTCGCGCTCGCCTCGCTGCGGCGTCAGGCGCCGGAG
CGGCGGAGCCTGCTGGAGTCACTCGCGGCGATGTATGCGTGGGGCTGCTCCGTCGACTGG
AAGCCGTTGCAGCCTTCGGGCGGGCGCGTCGTCGCGCTGCCCAAGTACCCGTGGCAGCGG
GAGCGGTACTGGCTCCCGGATGAGGCGGAGGCGGATCCCCGGTACGGGGGCGCCGCGAAC
GAGGACCGTGTGGGTCATCCGTTCCTCGGCAGCTCGCTCTCTTCGTCCGTGCAGCCGGGG
GCCCACTTCTGGGAACGGGCCGTGAGCGCGGAGGCGTTCCCGTACCTCGCCGATCACTGC
GTGTGGGGAGACATCGTCTTCCCAGGGGCAGGGTACGTGGAGATGGCCCTTTCGGCCGGA
GCAGAGGTGCTGGGAGAGACGGGGCTCGTGCTCGAGAACGTCTCGATCAGCGAGATGCTC
GCGCTCAAGGCAGGAGAATCCAGGCGCGTCCAGGTGGTGCTGAACGAGGAGGGGACGGGC
CAGGCCTCCTTCCAGATCTCCAGCCGAGCTGAGGGAGACAAGTCCTGGCGCAAGCATGCG
GCGGGAAGCTTGCGCCGCGAGGAGAACGCGACCCTGCAGCTCACCGCGGAGCCGCCCGAG
CTGCTCCGGGAACGCCTGGAAGTGGAGATCTCCTCCGAGGTGCACTACCAGCGCAGGCAG
GATCAGGGGCTCGTGTACGGCCCCACGTTCCAAGGGCTGCGGCAGCTCTGGCGGAGTGAG
CGAGAGGGGTTGGGGCGCCTGGAGCTTCCCGAGCAGGTGGCTTCCGATATTGGAGAGTAC
CGGCTTCACCCCGCGCTGCTGGATGCGAGCCTCCAGGTCGCGGTGGAGCTGATTGCTCCC
ATGACAGGGGCATCGACCGCGGCGCCGACCTACGTGCCGGTGGGGCTGGGTCGGATCCGG
CTCTTCCAGAAGCCTGGGCGTGCGGCCTGGGTGTGGGTGAAGGCCGTGGGCGAGGGGGCC
TCGGGCGAACGGGAGCGCTCCTTCGACATCCGGCTCCTGGATGACCAGGGCCACGTGATG
CTGGAGATCGAGGAGCTGCGCCTCTACAGGCTCGAGGCGGGCGCCGCGGTCCGCAAGGAG
CTCGGCGAGTGGATCTACCAGGTGGACTGGGAGTCGCAGCCCCTGGCGGCGGAACTGCCA
TGGCCCGCGCGCTCGGCGGGGAGCTGGTTGATTCTCAGCGATAGCAGTGGTGTGGGTCAG
CGGCTGTCCTCGCTGCTGAGGGCGCGTGGCGAGACCTGCGTGCTCGTTCAGCCGGGGGAG
AAGTACCGGTCCATCGGCCCGGGGGCGTACGAGGTGGATCCCCGCAACGGGGAGCACCTG
CGTCGGCTGCTCGGGGATGCGATGGGGGCAGGGGCGCCTCCGTGCCGTGGGGTGGTGCAC
CTGTGGAGCCTCGATTGCGCCTCGAATGACGCGCTCACGCCTCAGTCGCTGGAGGCCTCG
CGGCGTCTGGGGACCACCAGCGTGCTGCACCTCGTGCAGGCGCTTTCCCGGGCGGGTTGG
AGAGATGCGCCTCGGCTCTGGTTGGCCACGCGCGGCGCGCGTTCCGTCGGCAAAGAGCCC
CAGCGGGTCAATGTGGCCCAGGCTCCGCTCTGGGGATTGGGGCAGGTGCTGTCCCTGGAG
CAGCCCGAGCTGCGCTGCACGCGAGTGGATCTCGAAGGCGGCGCGGACATTTGCGCCGAT
GCGTTGATCCGAGAGGTGTCGTCGACGGTGTTCGAGGATCAGGCCGCGTGGCGTGCTGGC
ACGCGGCTCGTGGCTCGGCTGTCGCGGGCGGCGGACGCTCTGTCCACCCGGGATCCGGCG
ACGATTCTCCGCGCCGATGGTGCCTACCTCATCACGGGTGGGCTCGGTGGATTGGGTCTC
GAGGTCGCGCGCTGGCTTGTGTCGAATGGGGCGCGTCACCTGCTTCTGCTGGGACGCCGT
GCCCCGTCCGCGGAGGCCGAACAGACGCTCGCGGAACTGCGTCAGGCGGGCGCCCACGTG
GAGCCTTTCCAGGCCGATGTCGCGAGCCCAGACGATGTGGCGCGCGCACTGGCCCGGGTG
AACGAGACCATGCCGCCGCTGCGCGGTGTGTTCCACGCGGCAGGCCTCCTCGAGGACGGC
TTGCTGATCAACCTCACGGAGGAGCGCTTCGCCTCGGTGATGGCACCCAAGGTCCTAGGC
ACTTGGAATCTGCACACCCAGACGCGCCATCTGCCGCTGGATCTCTTCGTGCTCTTCTCC
AGCGTGGCCTCGTCGTTGGGGACGCCGGGCCAGGCGAACTACTCCTCGGCCAACGCGTTC
ATGGATGCGCTGGCGCATGCCCGCCGGGCGGAAGGCTTGCCCGCGCTGAGCATCAACTGG
GGAACCTGGACGAGCGTCGGCCTCGCGGCGGCACAGGCCAACCGAGGCGAGCGCCTCGAG
GCGCGGGGCCTGCGTGGCATGTCGCCGGACAAGGCCCTGATGGCGTTCGGAATGCTGCTG
GGACAGGGGCGGCCGCAGCTCAGCGTGATGTCGTTCGAGTCCAGGCAGTGGCTGGGGTTC
TACTTGGCCGCGGCGCAGTCGCCCTTCTTCACGCGGCTGTCTCAGGAGCAGGCGGGTCGG
CCCTCCGTGGAGCAGGGGCGGAGCCGGATCCGCGAGCAACTCGAGGCCGCCCGCGGCTCC
GAGCGTCGCGCCCTGCTCGATGGTCACCTGCGAGAGCTGATCGGCGGGGTGCTGCGGATG
GAGCCCTCGCGGATTGATCCGCGGACTCCCCTGGGGAGCCTGGGGCTCGACTCGCTGATG
AGCATGGAGATCCGCAATCGCCTGGAGGCATCGCTCGGTCTGAAGCTCAGCGCGACGGTG
GTGTGGACCTACCCGACCCTTGCCGCGCTCACGCCGTATCTGGCAGAAAAGATGGAGCTC
CCGCTCGAGGACAAGGGCAGTGAGCTTCGGCTGGCAGCAGCCCCCGTGTCGGCACCGCCG
AGTGCCGCGCCGGGCAGTGACATCGACGACATGTCGGAAGAAGAAGTCGAGAGGTTGTTC
GCTCAAAGGGTGGCGCAGGGCAAATGA
[0] ACP15..84
[1] KS102..478
[1] AT623..940
[1] 2-methylbutyryl-CoA for Myxalamid A isobutyryl-CoA for Myxalamid B propionyl-CoA for Myxalamid C acetyl-CoA for Myxalamid D814..818
[1] AT1060..1371
[1] methylmalonyl-CoA not conserved YASHS(Y->V)1250..1254
[1] DH1426..1593
[1] KR1967..2146
[1] ACP2246..2315
[0] ACP43..252
[1] KS304..1434
[1] AT1867..2820
[1] 2-methylbutyryl-CoA for Myxalamid A isobutyryl-CoA for Myxalamid B propionyl-CoA for Myxalamid C acetyl-CoA for Myxalamid D2440..2454
[1] AT3178..4113
[1] methylmalonyl-CoA not conserved YASHS(Y->V)3748..3762
[1] DH4276..4779
[1] KR5899..6438
[1] ACP6736..6945

close this sectionFeature

BLASTP
Database:UniProtKB:2011_09 		show BLAST table
InterPro
Database:interpro:38.0
IPR001227 Acyl transferase domain (Domain)
[619-746] G3DSA:3.40.366.10 [814-931] G3DSA:3.40.366.10 [1057-1179] G3DSA:3.40.366.10 [1247-1358] G3DSA:3.40.366.10
G3DSA:3.40.366.10   Ac_transferase_reg
IPR002198 Short-chain dehydrogenase/reductase SDR (Family)
[1967-2133] 6.19999999999995e-64 PF00106
PF00106   adh_short
IPR006162 Phosphopantetheine attachment site (PTM)
[2273-2288] PS00012
PS00012   PHOSPHOPANTETHEINE
IPR009081 Acyl carrier protein-like (Domain)
[15-84] PS50075 [2246-2315] PS50075
PS50075   ACP_DOMAIN
[14-109] 1e-33 G3DSA:1.10.1200.10 [2249-2318] 3.09999999999998e-33 G3DSA:1.10.1200.10
G3DSA:1.10.1200.10   ACP_like
[18-83] 1.5e-10 PF00550 [2250-2311] 5.40000000000001e-12 PF00550
PF00550   PP-binding
[8-119] 2.70000183580794e-22 SSF47336 [2239-2317] 5.20000089003336e-19 SSF47336
SSF47336   ACP_like
IPR014030 Beta-ketoacyl synthase, N-terminal (Domain)
[102-352] 4.40000000000003e-95 PF00109
PF00109   ketoacyl-synt
IPR014031 Beta-ketoacyl synthase, C-terminal (Domain)
[360-478] 5.49999999999995e-44 PF02801
PF02801   Ketoacyl-synt_C
IPR014043 Acyl transferase (Domain)
[623-940] 1.60000000000002e-84 PF00698 [1060-1371] 6.7999999999999e-101 PF00698
PF00698   Acyl_transf_1
IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase (Domain)
[621-925] 4.19999771339582e-62 SSF52151 [1057-1359] 4.60000044330866e-72 SSF52151
SSF52151   Acyl_Trfase/lysoPlipase
IPR016036 Malonyl-CoA ACP transacylase, ACP-binding (Domain)
[748-813] 3.00000067992871e-12 SSF55048 [1184-1249] 7.69998480533694e-17 SSF55048
SSF55048   Malonyl_transacylase_ACP-bd
IPR016038 Thiolase-like, subgroup (Domain)
[110-363] 5.90000000000008e-102 G3DSA:3.40.47.10 [364-529] 5.10000000000004e-63 G3DSA:3.40.47.10
G3DSA:3.40.47.10   Thiolase-like_subgr
IPR016039 Thiolase-like (Domain)
[95-530] 3.699978135861e-103 SSF53901
SSF53901   Thiolase-like
IPR016040 NAD(P)-binding domain (Domain)
[1967-2161] 7.59999999999998e-47 G3DSA:3.40.50.720
G3DSA:3.40.50.720   NAD(P)-bd
IPR018201 Beta-ketoacyl synthase, active site (Active_site)
[265-281] PS00606
PS00606   B_KETOACYL_SYNTHASE
IPR020801 Polyketide synthase, acyl transferase domain (Domain)
[625-922] 1.79999754022378e-93 SM00827 [1061-1358] 1.50000965748778e-125 SM00827
SM00827   PKS_AT
IPR020806 Polyketide synthase, phosphopantetheine-binding domain (Domain)
[16-87] 1.70000295590054e-17 SM00823 [2247-2318] 2.19999900980708e-23 SM00823
SM00823   PKS_PP
IPR020807 Polyketide synthase, dehydratase domain (Domain)
[1426-1593] 1.10000150671643e-55 SM00826
SM00826   PKS_DH
IPR020841 Polyketide synthase, beta-ketoacyl synthase domain (Domain)
[105-530] SM00825
SM00825   PKS_KS
IPR020842 Polyketide synthase/Fatty acid synthase, KR (Domain)
[1967-2146] 5.10003242202156e-67 SM00822
SM00822   PKS_KR
SignalP No significant hit
TMHMM No significant hit
Myxa_00080 Myxa_00080   Myxa_00100 Myxa_00100
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