Avil_00340 Avil_00340   Avil_00360 Avil_00360

Avil_00350 : CDS information

close this sectionLocation

Organism
StrainTü57
Entry nameAvilamycin
Contig
Start / Stop / Direction34,188 / 35,159 / + [in whole cluster]
34,188 / 35,159 / + [in contig]
Location34188..35159 [in whole cluster]
34188..35159 [in contig]
TypeCDS
Length972 bp (323 aa)
Click on the icon to see Genetic map.

close this sectionAnnotation

Category4.3 transport
Productavilamycin resistance ABC transporter ATP-binding protein
Product (GenBank)putative ATP binding protein
Gene
Gene (GenBank)aviABC1
EC number
Keyword
Note
Note (GenBank)
  • AviABC1
Reference
ACC
PmId
[11410376] Biosynthesis of the orthosomycin antibiotic avilamycin A: deductions from the molecular analysis of the avi biosynthetic gene cluster of Streptomyces viridochromogenes Tu57 and production of new antibiotics. (Chem Biol. , 2001)
[11181344] An ATP-binding cassette transporter and two rRNA methyltransferases are involved in resistance to avilamycin in the producer organism Streptomyces viridochromogenes Tu57. (Antimicrob Agents Chemother. , 2001)
comment
[PMID:11181344]
avilamycin耐性遺伝子(aviABC1,aviABC2,aviRa,aviRb)のクローニングと機能解析の報告。

aviABC1,aviABC2はそれぞれATP-bindingとmembrane proteinをコードする独立した遺伝子でtype I transporterに属すると推定している。
S. lividans TK66にaviABC1 plus aviABC2を導入した株は5mg/ml avilamycin containing platesで生育が可能であった。


[PMID:11410376]
avilamycin A生合成遺伝子クラスターの報告。

AviABC1:DrrA from S. peucetius [Proposed function:Antibiotic transport]

close this sectionSequence

selected fasta
>avilamycin resistance ABC transporter ATP-binding protein [putative ATP binding protein]
MSGSAKAALVAEGLRKTYGSETALDGFDLVVPEGTVCALLGPNGAGKTTAVRILSTLLKP
DGGRALVAGLDVTREAAEVRRNIGVTGQYPAVEEILTGRENLEMWGRLYHVGRREAQRRT
EELLEQFDLTEAADKRLKHYSGGMRRRLDLAAGFFTVPKVLFLDEPTTGLDPRNRNEVWK
MVRSMVEQGTTVLLTTQYLEEADRLADQISVIDAGRGVVEGTPETLKSLVGGDRIVVTLA
ATEDLSAAAAQVARFTGTEPEVDAEARRIDAPVRDRVGDLVEIVQLLRGQGHGVVDVSLR
RPTLDDVFLHATNRAGRRKEPVG
selected fasta
>avilamycin resistance ABC transporter ATP-binding protein [putative ATP binding protein]
ATGAGCGGGTCGGCGAAAGCTGCCCTGGTTGCCGAGGGGCTGCGCAAGACCTACGGATCC
GAGACGGCGCTGGACGGGTTCGACCTCGTCGTGCCCGAGGGCACCGTGTGCGCCCTGCTC
GGTCCCAACGGCGCGGGCAAGACCACCGCCGTACGCATCCTGAGCACCCTGCTCAAGCCG
GACGGCGGCCGTGCCCTGGTGGCCGGCCTCGATGTGACCCGCGAGGCCGCCGAGGTGCGC
CGGAACATCGGCGTCACCGGCCAGTACCCGGCGGTCGAGGAGATCCTGACCGGCCGCGAG
AACCTGGAGATGTGGGGCCGCCTCTACCACGTGGGCCGCAGGGAGGCGCAGCGCCGTACG
GAAGAACTGCTGGAGCAGTTCGACCTGACCGAGGCCGCCGACAAGCGGCTCAAGCACTAC
TCGGGCGGTATGCGGCGCAGGCTCGACCTGGCCGCCGGATTCTTCACCGTGCCCAAGGTG
CTCTTCCTGGACGAGCCCACCACCGGCCTCGACCCGCGCAACCGCAACGAGGTCTGGAAG
ATGGTCCGTTCGATGGTCGAGCAGGGCACCACCGTGCTGCTCACCACGCAGTACCTGGAG
GAGGCCGACCGGCTCGCCGACCAGATCTCGGTGATCGACGCGGGCCGCGGGGTCGTCGAG
GGCACCCCCGAGACCCTGAAGTCCCTGGTGGGCGGCGACCGGATCGTGGTGACCCTGGCG
GCCACCGAGGACCTGTCGGCCGCCGCGGCTCAGGTCGCCCGCTTCACGGGGACCGAGCCC
GAGGTGGACGCCGAGGCCCGCCGTATCGACGCGCCGGTACGCGACCGGGTCGGCGACCTC
GTGGAGATCGTGCAGCTGCTGCGCGGGCAGGGCCACGGCGTGGTCGATGTGTCGCTGCGC
CGCCCGACGCTGGATGACGTGTTCCTGCACGCGACCAACCGTGCCGGTCGAAGGAAGGAG
CCGGTCGGATGA

close this sectionFeature

BLASTP
Database:UniProtKB:2011_09 		show BLAST table
InterPro
Database:interpro:38.0
IPR003439 ABC transporter-like (Domain)
[48-168] 3.8e-17 PF00005
PF00005   ABC_tran
[9-239] PS50893
PS50893   ABC_TRANSPORTER_2
IPR003593 AAA+ ATPase domain (Domain)
[33-216] 2.2999993566538e-14 SM00382
SM00382   AAA
IPR005894 Daunorubicin resistance ABC transporter ATP-binding subunit (Family)
[16-312] 5.59999999999999e-105 TIGR01188
TIGR01188   DrrA
IPR017871 ABC transporter, conserved site (Conserved_site)
[140-154] PS00211
PS00211   ABC_TRANSPORTER_1
SignalP
[1-19] 0.136 Signal
Eukaryota   
TMHMM No significant hit
Avil_00340 Avil_00340   Avil_00360 Avil_00360
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