Chalc_00210 : CDS information

Location

Organism	Streptomyces bikiniensis
Strain	NRRL 2737
Entry name	Chalcomycin
Contig	AY509120
Start / Stop / Direction	23,622 / 36,947 / + [in whole cluster] 23,622 / 36,947 / + [in contig]
Location	23622..36947 [in whole cluster] 23622..36947 [in contig]
Type	CDS
Length	13,326 bp (4,441 aa)

Annotation

Category	1.1 PKS
Product	polyketide synthase
Product (GenBank)	polyketide synthase subunit
Gene
Gene (GenBank)	chmGI
EC number
Keyword
Note
Note (GenBank)	modules 0-2 KSq/AT/ACP/KS/AT/KR/ACP/KS/AT/DH/KR/ACP
Reference	ACC Q5SFB4 PmId [15561847] Chalcomycin biosynthesis gene cluster from Streptomyces bikiniensis: novel features of an unusual ketolide produced through expression of the chm polyketide synthase in Streptomyces fradiae. (Antimicrob Agents Chemother. , 2004) [15489173] Production of hybrid 16-membered macrolides by expressing combinations of polyketide synthase genes in engineered Streptomyces fradiae hosts. (Chem Biol. , 2004) comment [PMID:15561847](2004) Chalcomycin biosynthesis gene clusterに関する文献。 chmGI(4,441a.a.): PKS, module 0 to 2 tyl PKS genesを削除したS.fradiae K159-1でchm PKS genesを発現すると、5-O-mycaminosylchalcolactone産生。よって、これらgenesはchalcomycin PKSであり、同定したclusterはchalcomycin生合成clusterである。 -- [PMID:15489173](2004) hybrid PKS作成にchmGI, GIIが使用されている。

PKS/NRPS Module

0		malonyl-CoA not conserved HAFHS, conserved signature for methylmalonyl-CoA
1		methylmalonyl-CoA
2		malonyl-CoA not conserved HAFHS, conserved signature for methylmalonyl-CoA

KSQ	68..420

AT	580..896

ACP	972..1042

KS	1062..1438

AT	1591..1907

KR	2179..2354

ACP	2457..2531

KS	2559..2934

AT	3092..3408

DH	3458..3624

KR	3972..4152

ACP	4273..4343

Sequence

>polyketide synthase [polyketide synthase subunit]
MRAPYGNRQVNRRFLREFRAKRPHCVSPLHFLAEFSESRQTTGSAGVTAPIDRPGVSMAP
KSGAQRSSDIAVVGMSCRLPGAPGIDEFWHLLTTGGSAIERRADGTWRGSLDGAADFDAA
FFDMTPRQAAAADPQQRLMLELGWTALENAGIVPGSLAGTDTGVFVGIAADDYAALLHRS
ATPVSGHTATGLSRGMAANRLSYLLGLRGPSLAVDSAQSSSLVAVHLACESLRRGESDLA
IVGGVSLILAEDSTAGMELMGALSPDGRCHTFDARANGYVRGEGGACVVLKPLERALADG
DRVHCVVRGSAVNNDGGGSTLTTPHREAQAAVLRAAYERAGVGPDQVSYVELHGTGTPVG
DPVEAAALGAVLGTAHGRNAPLSVGSVKTNVGHLEAAAGLVGFVKAALCVREGVVPPSLN
HATPNPAIPMDRLNLRVPTRLEPWPHPDDRATGRLRLAGVSSFGMGGTNAHVVVEEAPLP
EAGEPVGAGVPLAVVPVVVSGRSAGAVAELASRLNESVRSDRLVDVGLSSVVSRSVFEHR
SVVLAGDSAELSAGLDALAADGVSPVLVSGVASVGGGRSVFVFPGAGVKWAGMALGLWAE
SAVFAESMARCEAAFAGLVEWRLADVLGDGAALEREDVVQPASFAVMVSLAALWRSLGVV
PDAVVGHSQGEIAAAVVAGGLSLEDGARVVVLRARVAEEVLSGGGIASVRLSRAEVEERL
AGGGGGLSVAVVNAPSSTVVAGELGDLDRFVAACEAEGVRARRLEFGYASHSRFVEPVRE
RLLEGLADVRPVRGRIPFYSTVEAAEFDTAGLDAEYWFGNLRRPVRFQETVERLLADGFR
VFVECGAHPVLTGAVQETAETAGREICSVGSLRRDEGGLRRFLTSAAEAFVQGVEVSWPV
LFDGTGARTVDLPTYPFQRRHHWAPDGSASAAPTRDIRPDETAAVPADTMDLAGQLRADV
ASLPTTEQIARLLDQVRDGVATVLGLDARDEVRAEATFKELGVESLTGVELKNHLRARTG
LHVPTSLIYDCPTPLAAAHYLRDELLGRPAEQAVVPAGIPVDEPIAIVGMGCRLPGGVSS
PEGLWDLVASGVDAVSPFPTDRGWDVGGLFDPEPGVPGRSYVREGGFLHEAGEFDAGFFG
ISPREALAMDPQQRLLLETSWEALERAGIDPHTLRGSRTGVYAGVMAQEYGPRLHEGADG
YEGYLLTGSSSSVASGRISYVLGLEGPAVTVDTACSSSLVALHLAVRALRSGECDLALAG
GATVMAEPGMFVEFSRQRGLSAHGRCKAYSDSADGTGWAEGAGVLLVERLSDAVRHGRRV
LAVVRGSAVNQDGASNGLTAPNGRSQSRLIRQALADARLGVADVDVVEGHGTGTRLGDPI
EAQALLATYGQRDAGRPLRLGSLKSNVGHTQAAAGVAGVIKMVMAMRHGVLPKTLHVDEP
TAEVDWSAGAVSLLREQEAWPRGERVRRAGVSSFGVSGTNAHVVVEEAPVPEDGEAIEGG
APLAVVPVVVSGRSAGAVAELAGRVSEVAGSGRLVDVGLSSVVSRSVFEHRSVVLAGDSA
ELNAGLDALAADGVSPVLVSGVASGEGGRSVFVFPGQGTQWAGMALGLWAESAVFAESMA
RCEAAFAGLVEWRLADVLGDGSALERVDVVQPASFAVMVSLAELWRSLGVVPDAVVGHSQ
GEIAAAVVAGGLSLEDGARVVVLRARLIGRELAGRGGMASVALPVAVVEERLAGWAGRLG
VAVVNGPSATVVAGDVDAVGEFVTACEVEGVRARVLPVDYASHSAHVEDLKAELEQILAG
IGPVTGGIPFYSTSEAAQIDTAGLDAGYWFGNLRRPVRFQETVERLLADGFRVFVECGAH
PVLTGAVQETAESTGRQVCAVGSLRRDEGGLRRFLTSAAEAFVQGVGVSWPALFDGTGAR
TVDLPTYPFQRRRYWLESRPPAAVVPSGVQDGLSYEVVWKSLPVRESSRLDGRWLLVVPE
TLDADGTRIAHDLQHALTTHGATVSRVSVDVTTIDRADLSARLTTSAAEDQEPLGRVVSL
LGWAEGVRAHGPNVPTSVAASLALVQAVGDAGFGVPVWAVTRGAVSVVPGEVPETAGAQL
WALGRVAGLELPDRWGGLIDLPADADARTAGLAVRALAAGIADGEDQVAVRPSGAYGRRV
VQAAHREPSGAKTEWRPRGTVLVTGGMGAIGTRVARWLARNGAEHLVLTGRRGAGTPGAD
ELAGELRASGVQVTLAACDVSDRAALAALLDAHPPTAVFHTAGVLNDGTVDTLTPAHLDG
VLSPKATAAVHLHELTAHLDLDAFVLFASVTGVWGNGGQAGYAMANAALDALAEQRRAGG
LAATSISWGLWGGGGMAEGDGEVSLNRRGIRALEPATGIEALQRTLDQGATCRTVVDVDW
GQFAPRTAALRRGRLFADLPEVRRVLESEGVAREDAGTVEPGAVLAERLASRSEAEQRRM
LVELVRAEAAAVLRHDTTDLLAPRRSFKDAGFDSLTALELRNRLNTATGVVLPVTVVFDH
PNPGALADFLYGEALGLSAARSSASDTADTTRPAAAPEEPIAIVGMACRYPGEARSPEEL
WKLLIDERDVIGPMPTDRGWDVGGLFDPEPGVPGRSYVREGGFLHEAGEFDAGFFGISPR
EALAMDPQQRLLLETSWEALERAGIDPHTLRGSQTGVYAGMFHQEYATRLHEAPVEFEGH
LLTGTSGSVASGRISYVLGLEGPAVTVDTACSSSLVALHLAVRALRSGECDLALAGGVTV
MAEPGVFVEFSRQRGLAADGRCKAFAAAADGTGWAEGVGVLAVERLSDAVRHGRRVLAVV
RGSAVNQDGASNGLTAPNGPSQQRVIRQALADARLGVADVDVVEGHGTGTRLGDPIEAQA
LLATYGQRDAGRPLRLGSLKSNVGHTQAAAGVAGVIKMVMAMRHGVLPKTLHVDEVSPHV
DWSAGAVSLLTEQEPWPRGERVRRAGVSAFGVSGTNAHVVVEEAPASEAPVAVEPVEPGA
VGLLPVVPVVVSGRSAGAVAELASRLNESVRSDRLVDVGLSSVVSRSVFEHRSVVLAGDS
AELSAGLDALAADGVSPVLVSGVASVGGGRSVFVFPGAGVKWAGMALGLWAESAVFAESM
ARCEAAFAGLVEWRLADVLGDGAALEREDVVQPASFAVMVSLAALWRSLGVVPDAVVGHS
QGEIAAAVVAGGLSLEDGARVVVLRARVAEEVLSGGGIASVRLSRAEVEERLAGGGGGLS
VAVVNAPSSTVVAGELGELDRFVAACEAEGVRARRLEFGYASHSRFVEPVRERLLEGLAD
VRPVRGRIPFYSTVEAGEFDTAGLDAEYWFGNLRRPVRFQETVERLLADGFRVFVECGAH
PVLTGAVQETAETAGREVCAVGSLRRDEGGLRRFLTSAAEAFVQGVEVSWPVLFDGTGAR
TVDLPTYPFQRRHYWAQSSPAGAGSSAAARFGMTWEEHPLLGGALPLADSGELLLVGRIS
PASHSWIADHTVAGTALLPGTAFVDMALHAAAVAGCAGVEELSIEAPLPVHGGIRLQVVI
DEPDSSARRRVSVFARPEEEDGDAGRWTRHATGVLTPDVAPEPGRPQWCRQAWPPSGSVR
VEASELYDRFSALGYDYGEVFAGVEAVWLREGEAFAEVRLPTGAAPDAERFGVHPGLLDA
ALHPWLLGDFLSRPDGGSVLLPFAWRGITLHTAGADALRVRLGPAGEGALSLEAVDLSGA
PVLSMDALVLRPLAQDRLAELVGGTTSTPLYRVDWQRSPIARTAPSATGLFGSLPSGAVR
RWAVVGQGGVAARYATAEPGTGCVGVFPDLDALRTTLDSGADGPDIVLADFGARPGDAAP
HGTDPADGARDTVRRGLALIQGWLSDERFAAARLAVLTEHAVATEADTRRTDLAGSALWG
LMRSAQTEHPDRFVLVDHDGQDASYRTLPTALDSEIPQLALRAGETLAPELAVLPSPADG
GPATSAAFDPEGTVLVTGATGTLGSLLARHLVTAHGVRHLLLLSRSGREAAGAAELEREL
RQRGAEFQLLSCDATDRAALKEALATVPAAHPLTAVIHTAGVLDDGVVEALTPERLDRVL
RPKADAALNLHDLTEGMPLKAFVLYSGAVGLLGGAGQANYAAANAFLDGLAQHRHAQGLP
AVSLAWGLWSATSTFTDHLGEVDLRRMERSGITPLTDEQGLDLFDRALGAAVDAPQLCVM
GLDTAALRRQAAEHGPTSMPPLLRTLAAPPVRRGAGRSGRGGRAASATDAPSRAQALRER
LTGLDAAARRDELLVLSQAQLADVLGFADKTAVDPVRSFREIGLDSLTAVELRNRLGVVT
GLRLPPALVFDHPNLDALAAHLAELLAAEGRDDAGAAALSGIDALDRAVREMAADDTRRD
AVRRRLAELLAVVGDAPRDGGRAPRAAADAGGRDAQADPDLLGRLDSASDDDLFAFIEDQ
L

>polyketide synthase [polyketide synthase subunit]
ATGCGCGCACCCTACGGAAATCGGCAGGTCAACCGGCGATTCCTGCGGGAATTCCGAGCG
AAACGGCCTCACTGTGTTTCCCCGCTGCATTTCCTCGCTGAATTCAGCGAATCCCGGCAG
ACGACCGGCTCTGCCGGCGTGACAGCCCCTATCGATCGACCAGGAGTTTCGATGGCCCCG
AAGAGTGGTGCGCAGCGTTCGAGCGACATAGCCGTCGTCGGCATGTCCTGCCGCCTTCCG
GGGGCACCGGGCATCGATGAGTTCTGGCATCTGCTGACCACCGGAGGCAGCGCGATCGAG
CGTCGCGCCGACGGCACCTGGCGCGGCTCCCTGGACGGAGCCGCCGACTTCGACGCCGCC
TTCTTCGACATGACCCCCCGCCAGGCCGCCGCCGCCGACCCGCAGCAACGACTCATGCTG
GAACTCGGCTGGACGGCCCTGGAGAACGCCGGGATCGTCCCCGGCAGCCTCGCCGGCACG
GACACCGGCGTCTTCGTCGGCATCGCGGCCGACGACTACGCGGCACTCCTGCACCGGTCC
GCCACCCCCGTCAGCGGGCACACCGCGACGGGCCTGAGCCGGGGCATGGCCGCCAACCGC
CTCTCCTACCTCCTGGGCCTGCGCGGTCCCAGCCTCGCGGTGGACAGCGCGCAGTCCTCC
TCGCTCGTCGCGGTCCACCTGGCCTGCGAGAGCCTGCGCCGCGGCGAGTCCGACCTCGCG
ATCGTCGGCGGCGTCAGCCTGATCCTCGCCGAGGACAGCACGGCGGGCATGGAGCTCATG
GGCGCGCTCTCGCCGGACGGCCGCTGCCACACCTTCGACGCACGCGCCAACGGCTACGTA
CGCGGTGAGGGCGGAGCCTGCGTCGTCCTCAAGCCCCTGGAGCGGGCACTGGCCGACGGG
GACCGCGTCCACTGCGTCGTCCGAGGAAGCGCGGTCAACAACGACGGCGGCGGCTCCACC
CTGACCACCCCCCACCGCGAGGCCCAGGCCGCCGTCCTGCGGGCGGCGTACGAACGGGCC
GGGGTCGGCCCGGACCAGGTGTCCTACGTCGAACTGCACGGTACGGGGACGCCGGTCGGC
GACCCCGTCGAGGCGGCGGCTCTCGGCGCGGTCCTCGGCACGGCCCACGGCCGTAACGCC
CCGCTGTCCGTGGGATCGGTCAAGACGAACGTCGGCCACCTGGAGGCGGCCGCGGGCCTC
GTGGGATTCGTGAAGGCAGCCCTGTGCGTCCGCGAGGGCGTGGTGCCGCCGAGCCTGAAC
CACGCGACGCCCAACCCTGCCATCCCCATGGACCGGCTAAACCTGCGCGTACCCACGCGA
CTGGAGCCCTGGCCGCACCCGGACGACCGAGCGACCGGCCGGCTGCGACTGGCCGGCGTC
TCGTCCTTCGGCATGGGTGGGACGAACGCGCATGTGGTGGTGGAGGAGGCGCCGCTTCCG
GAGGCCGGGGAGCCGGTCGGGGCCGGTGTGCCTTTGGCTGTGGTGCCGGTGGTGGTGTCG
GGTCGTTCTGCGGGTGCGGTGGCTGAACTGGCCTCCCGCTTGAACGAGTCGGTTCGTTCG
GATCGGTTGGTGGATGTGGGGTTGTCGTCGGTGGTGTCGCGGTCGGTGTTCGAGCATCGG
TCCGTGGTTCTGGCGGGGGACTCTGCCGAGCTGAGTGCCGGTTTGGATGCTCTGGCCGCT
GACGGAGTGTCTCCTGTCCTGGTGTCGGGTGTGGCGTCGGTCGGGGGTGGCCGGTCGGTG
TTCGTGTTCCCGGGTGCGGGGGTGAAGTGGGCGGGGATGGCGCTCGGGTTGTGGGCGGAG
TCTGCTGTGTTTGCGGAGTCGATGGCGCGGTGTGAGGCGGCGTTCGCCGGGTTGGTGGAG
TGGCGTCTGGCGGATGTGCTGGGTGATGGGGCTGCGTTGGAGCGTGAGGACGTGGTGCAG
CCGGCGTCGTTCGCGGTGATGGTGTCGTTGGCGGCGTTGTGGCGGTCGTTGGGTGTGGTG
CCGGATGCGGTGGTGGGGCATTCGCAGGGGGAGATCGCTGCTGCGGTGGTGGCGGGTGGT
CTGTCGTTGGAGGACGGGGCGCGTGTGGTGGTGTTGCGTGCGCGGGTGGCTGAGGAGGTT
TTGTCGGGTGGGGGGATTGCTTCGGTGCGTCTTTCGCGGGCCGAGGTGGAGGAGCGGTTG
GCGGGTGGGGGTGGTGGGTTGAGTGTGGCGGTGGTGAATGCGCCGTCGTCGACGGTGGTG
GCGGGTGAGTTGGGGGATTTGGATCGGTTTGTTGCGGCGTGTGAGGCGGAGGGGGTGCGG
GCGCGTCGGCTGGAGTTCGGGTATGCGTCGCATTCGAGGTTCGTGGAGCCGGTGCGTGAG
CGGTTGTTGGAGGGGTTGGCCGATGTCCGTCCGGTGAGGGGGCGGATTCCGTTCTATTCG
ACGGTGGAGGCTGCGGAGTTCGATACGGCTGGTCTGGATGCGGAGTACTGGTTCGGGAAT
CTGCGTCGGCCGGTTCGCTTCCAGGAGACGGTCGAGCGGCTGTTGGCGGATGGTTTCCGG
GTGTTCGTGGAGTGCGGCGCGCATCCGGTGCTGACCGGGGCGGTGCAGGAGACCGCGGAG
ACTGCGGGCCGGGAGATCTGCTCCGTCGGATCCCTGCGTCGTGACGAGGGTGGACTGCGT
CGCTTCCTGACCTCTGCGGCGGAGGCGTTCGTCCAGGGGGTGGAGGTGTCCTGGCCGGTG
CTGTTCGACGGCACCGGCGCCCGGACGGTCGACCTGCCCACCTACCCCTTCCAACGCCGG
CACCACTGGGCACCCGACGGCTCCGCGTCGGCGGCGCCCACACGGGACATCCGACCGGAC
GAGACCGCCGCGGTTCCAGCGGACACGATGGACCTCGCGGGACAACTTCGCGCGGACGTG
GCGTCGTTGCCCACCACCGAGCAGATCGCGCGGTTGCTCGACCAGGTACGCGACGGTGTC
GCCACGGTCCTCGGACTGGACGCCCGGGACGAGGTGCGCGCGGAGGCGACGTTCAAGGAA
CTGGGCGTCGAATCGCTGACCGGCGTCGAGCTGAAGAACCACCTCCGTGCCCGGACCGGA
CTGCACGTCCCCACCTCGCTGATCTACGACTGCCCGACTCCCCTCGCCGCCGCTCACTAC
CTCCGCGACGAGCTCTTGGGCCGACCCGCGGAGCAGGCCGTCGTCCCCGCCGGCATCCCG
GTCGACGAACCGATCGCGATCGTGGGGATGGGGTGCCGTCTGCCGGGTGGGGTGTCGTCG
CCGGAGGGGTTGTGGGATCTGGTGGCGTCGGGGGTGGATGCGGTTTCTCCGTTCCCCACG
GATCGGGGTTGGGATGTGGGGGGTCTGTTCGATCCGGAGCCGGGGGTGCCGGGGCGTTCG
TATGTGCGTGAGGGCGGGTTCCTTCATGAGGCGGGGGAGTTCGACGCGGGGTTCTTCGGT
ATCTCTCCGCGTGAGGCGTTGGCGATGGATCCGCAGCAGCGGTTGTTGCTGGAGACGTCG
TGGGAGGCGTTGGAGCGGGCGGGCATCGATCCGCACACGCTTCGCGGTTCACGGACCGGC
GTCTACGCCGGAGTGATGGCCCAGGAATACGGCCCCCGACTCCACGAAGGCGCAGACGGA
TACGAGGGCTATCTGCTGACCGGATCCTCCAGCAGTGTCGCCTCGGGTCGTATCTCGTAC
GTGCTGGGTCTGGAAGGGCCGGCGGTGACGGTGGACACCGCGTGCTCGTCGTCGCTGGTC
GCGCTGCACCTGGCCGTGCGGGCGCTGCGCAGCGGTGAGTGCGACCTCGCCCTCGCCGGC
GGCGCGACCGTCATGGCCGAACCCGGCATGTTCGTGGAGTTCTCACGGCAGCGCGGGCTG
TCTGCCCACGGACGGTGCAAGGCGTACTCGGACTCGGCCGATGGCACGGGCTGGGCCGAG
GGGGCGGGTGTGCTGCTCGTCGAGCGGTTGTCGGATGCGGTACGTCATGGGCGTCGGGTG
CTGGCGGTCGTGCGTGGTTCCGCGGTCAACCAGGACGGTGCGAGCAACGGACTGACGGCG
CCGAACGGGCGGTCCCAGTCGCGTTTGATCCGTCAGGCGTTGGCGGATGCGCGGTTGGGT
GTGGCTGATGTGGATGTGGTGGAGGGCCACGGCACGGGGACGCGTCTGGGTGATCCGATC
GAGGCGCAGGCGTTGTTGGCGACGTATGGGCAGCGGGATGCGGGTCGGCCTCTGCGGCTT
GGTTCGCTGAAGTCGAACGTGGGGCATACGCAGGCGGCTGCCGGTGTGGCGGGCGTGATC
AAGATGGTCATGGCGATGCGGCACGGTGTCCTGCCGAAGACGCTGCACGTGGATGAGCCG
ACGGCGGAGGTGGACTGGTCGGCCGGCGCGGTGTCCCTGCTGAGGGAGCAGGAGGCGTGG
CCGCGTGGCGAGCGTGTGCGGCGGGCCGGAGTCTCCTCGTTCGGCGTGAGTGGGACGAAC
GCGCATGTGGTGGTCGAGGAGGCGCCGGTTCCGGAGGACGGGGAGGCGATCGAGGGCGGT
GCGCCTTTGGCTGTGGTGCCGGTGGTGGTGTCGGGTCGTTCTGCGGGTGCGGTGGCGGAG
CTGGCGGGCCGGGTCAGCGAGGTCGCTGGGTCTGGTCGGTTGGTGGATGTGGGGTTGTCG
TCGGTGGTGTCGCGGTCGGTGTTCGAGCACCGGTCCGTGGTGCTGGCGGGGGACTCTGCC
GAGCTGAATGCCGGTCTGGATGCTCTGGCCGCTGACGGAGTGTCTCCTGTCCTGGTGTCG
GGTGTGGCGTCGGGTGAGGGTGGCCGGTCGGTGTTCGTGTTCCCTGGTCAGGGGACGCAG
TGGGCGGGGATGGCGCTCGGGTTGTGGGCGGAGTCGGCGGTGTTCGCGGAGTCGATGGCG
CGGTGTGAGGCGGCGTTCGCCGGGTTGGTGGAGTGGCGTCTGGCGGATGTGCTGGGTGAC
GGGTCTGCGTTGGAGCGGGTCGATGTGGTGCAGCCGGCGTCGTTCGCGGTGATGGTGTCG
CTGGCGGAGTTGTGGCGGTCGTTGGGTGTGGTGCCGGATGCGGTGGTGGGGCATTCGCAG
GGGGAGATCGCTGCTGCGGTGGTGGCGGGTGGTCTCTCGCTGGAGGATGGCGCGCGTGTG
GTGGTGTTGCGTGCGCGGTTGATAGGCCGTGAGCTGGCCGGGCGCGGTGGGATGGCGTCG
GTGGCGCTGCCGGTCGCGGTGGTGGAGGAGCGTCTGGCGGGGTGGGCGGGGCGTCTGGGT
GTGGCGGTGGTCAACGGACCCTCCGCCACGGTCGTCGCGGGTGATGTGGATGCGGTGGGG
GAGTTTGTGACCGCGTGCGAGGTGGAGGGGGTTCGGGCGCGTGTTCTGCCGGTGGACTAC
GCCTCGCACTCGGCGCACGTGGAGGACCTGAAAGCCGAGCTTGAACAGATTCTGGCCGGC
ATCGGCCCGGTGACCGGTGGCATCCCGTTCTATTCGACGTCCGAAGCCGCGCAGATCGAC
ACGGCTGGTCTGGACGCGGGGTACTGGTTCGGGAATCTGCGTCGGCCGGTGCGGTTCCAG
GAGACGGTCGAGCGGTTGCTGGCGGATGGTTTCCGGGTGTTCGTGGAGTGTGGCGCGCAT
CCGGTGCTGACGGGGGCGGTGCAGGAGACCGCGGAATCCACCGGTCGCCAGGTGTGTGCG
GTCGGATCCCTGCGTCGTGACGAGGGAGGTCTGCGCCGCTTCCTGACCTCTGCGGCGGAG
GCGTTCGTCCAGGGGGTCGGGGTGTCCTGGCCGGCACTGTTCGACGGCACCGGCGCCCGC
ACGGTCGACCTGCCCACCTATCCCTTCCAGCGTCGGCGTTACTGGCTGGAGTCACGTCCT
CCTGCGGCGGTTGTTCCGTCGGGGGTCCAGGACGGATTGTCGTATGAGGTGGTGTGGAAG
AGCCTGCCGGTACGGGAGTCGTCGCGTCTTGACGGCCGGTGGCTGCTCGTCGTGCCCGAA
ACCCTGGACGCCGACGGCACGCGGATCGCCCACGACCTCCAGCACGCCCTCACCACCCAC
GGCGCCACGGTCTCCCGTGTGTCGGTCGACGTGACGACGATCGACCGCGCCGACCTGTCG
GCGCGGCTCACCACGAGCGCGGCCGAAGACCAGGAACCGCTTGGGCGAGTGGTGTCCCTC
CTGGGGTGGGCCGAGGGAGTACGGGCCCATGGCCCGAACGTACCGACTTCCGTCGCCGCC
TCCCTGGCACTCGTGCAGGCTGTCGGCGATGCCGGGTTCGGTGTTCCGGTGTGGGCGGTG
ACGCGGGGTGCGGTGTCCGTGGTGCCTGGTGAGGTGCCGGAGACGGCGGGTGCGCAACTG
TGGGCGCTCGGCCGGGTCGCCGGTCTCGAACTTCCCGACCGTTGGGGTGGTCTGATCGAT
CTTCCGGCGGATGCCGATGCGCGTACGGCGGGGCTTGCGGTGCGGGCCCTGGCCGCCGGG
ATCGCCGATGGTGAGGACCAGGTGGCGGTGCGCCCCTCGGGTGCCTACGGCCGGCGTGTA
GTTCAGGCAGCCCACCGGGAGCCGTCGGGAGCGAAGACGGAGTGGCGACCGCGTGGCACC
GTGCTCGTCACCGGGGGAATGGGCGCCATCGGCACTCGGGTGGCCCGCTGGCTGGCCCGG
AACGGAGCCGAACACCTGGTGCTGACCGGCCGCCGCGGTGCCGGGACCCCCGGCGCGGAC
GAGCTGGCGGGAGAGCTGAGGGCGTCCGGAGTCCAGGTCACGCTCGCCGCCTGCGACGTG
TCCGATCGTGCCGCGCTGGCCGCGCTGCTCGACGCGCATCCGCCGACCGCCGTCTTCCAC
ACGGCCGGTGTACTGAACGACGGAACGGTCGACACGCTCACTCCCGCTCACCTGGACGGG
GTCCTGAGCCCCAAGGCGACGGCCGCCGTTCACCTGCACGAGCTCACCGCCCACCTGGAC
CTGGACGCCTTCGTCCTCTTCGCCTCCGTCACCGGCGTATGGGGTAACGGCGGCCAGGCC
GGGTACGCCATGGCCAACGCGGCTCTGGACGCGCTCGCCGAGCAGCGCCGTGCCGGCGGA
CTTGCGGCGACCTCCATCAGTTGGGGCCTCTGGGGTGGCGGCGGCATGGCCGAGGGTGAC
GGCGAGGTGAGCCTCAACCGTCGTGGAATCCGCGCTCTTGAGCCCGCCACCGGCATCGAG
GCGCTGCAGCGGACGCTCGACCAGGGCGCCACCTGCCGCACCGTCGTCGACGTGGACTGG
GGTCAGTTCGCTCCTCGTACGGCGGCGCTGCGGCGCGGGCGGCTCTTCGCGGATCTGCCC
GAGGTGCGGCGTGTCCTGGAGTCCGAGGGGGTTGCACGGGAGGACGCCGGAACCGTCGAG
CCCGGCGCCGTGCTCGCCGAGCGCCTCGCATCGCGCTCCGAGGCCGAACAGCGACGCATG
CTCGTCGAGTTGGTACGAGCCGAAGCGGCTGCCGTCCTGCGTCACGACACGACGGACCTC
CTGGCGCCGCGCAGGTCGTTCAAGGACGCCGGGTTCGACTCCTTGACCGCGCTGGAGCTC
CGTAACCGGCTGAACACCGCCACCGGTGTCGTCCTTCCCGTCACCGTCGTCTTCGACCAC
CCGAACCCCGGTGCACTGGCGGACTTCCTGTACGGCGAAGCACTGGGCCTGTCCGCGGCC
AGGTCTTCCGCGAGCGATACGGCCGACACGACCCGCCCGGCCGCCGCCCCCGAAGAGCCG
ATCGCGATCGTCGGAATGGCCTGCCGCTACCCGGGCGAGGCCCGTTCCCCCGAGGAACTG
TGGAAGTTGCTCATCGACGAACGGGACGTCATCGGCCCCATGCCCACGGATCGGGGTTGG
GATGTGGGGGGTCTGTTCGATCCGGAGCCGGGGGTGCCGGGGCGTTCGTATGTGCGTGAG
GGCGGGTTCCTTCATGAGGCGGGGGAGTTCGACGCGGGGTTCTTCGGTATTTCTCCGCGT
GAGGCGTTGGCGATGGATCCGCAGCAGCGGTTGTTGCTGGAGACGTCGTGGGAGGCGTTG
GAGCGGGCGGGCATCGATCCGCACACGCTCCGCGGCTCACAGACCGGCGTCTACGCGGGG
ATGTTCCACCAGGAGTACGCGACCCGGCTGCACGAGGCACCCGTGGAGTTCGAAGGCCAC
TTGCTGACGGGGACGTCCGGGAGTGTGGCTTCGGGTCGTATCTCGTATGTGCTGGGTCTG
GAGGGGCCGGCGGTGACGGTGGACACGGCGTGTTCGTCGTCGTTGGTGGCGCTGCATCTG
GCGGTGCGGGCGTTGCGGAGTGGTGAGTGTGACCTTGCTCTTGCGGGTGGGGTGACGGTG
ATGGCGGAGCCGGGTGTGTTCGTGGAGTTCTCGCGGCAGCGGGGGTTGGCTGCGGACGGG
CGGTGCAAGGCGTTCGCGGCTGCTGCCGATGGCACGGGCTGGGCCGAGGGTGTGGGCGTG
CTGGCGGTGGAGCGGTTGTCGGATGCGGTGCGTCATGGGCGTCGGGTGCTGGCGGTGGTG
CGTGGCTCGGCGGTGAATCAGGACGGTGCGAGCAATGGGTTGACGGCTCCGAACGGTCCG
TCGCAGCAGCGGGTGATTCGTCAGGCGTTGGCGGATGCGCGGTTGGGTGTGGCTGATGTG
GATGTGGTGGAGGGGCATGGGACGGGGACGCGTCTGGGTGATCCGATCGAGGCGCAGGCG
TTGTTGGCGACGTATGGGCAGCGGGATGCGGGTCGGCCTCTGCGGCTTGGTTCGCTGAAG
TCGAATGTGGGGCATACGCAGGCGGCTGCCGGTGTGGCGGGCGTGATCAAGATGGTCATG
GCGATGCGGCACGGGGTCCTGCCGAAGACGCTGCACGTCGATGAGGTCTCTCCGCACGTC
GACTGGTCGGCGGGCGCGGTGTCCCTGCTGACGGAGCAGGAGCCGTGGCCCCGTGGTGAG
CGCGTACGGCGGGCTGGTGTCTCCGCGTTCGGTGTGAGTGGGACGAACGCGCATGTGGTG
GTGGAGGAGGCACCTGCTTCGGAGGCGCCGGTCGCGGTGGAGCCGGTGGAGCCGGGGGCT
GTGGGGCTTCTTCCGGTGGTGCCCGTGGTGGTGTCGGGTCGTTCTGCGGGTGCGGTGGCT
GAACTGGCCTCCCGCTTGAACGAGTCGGTTCGTTCGGATCGGTTGGTGGATGTGGGGTTG
TCGTCGGTGGTGTCGCGGTCGGTGTTCGAGCATCGGTCCGTGGTTCTGGCGGGGGACTCT
GCCGAGCTGAGTGCCGGTTTGGATGCTCTGGCCGCTGACGGAGTGTCTCCTGTCCTGGTG
TCGGGTGTGGCGTCGGTCGGGGGTGGCCGGTCGGTGTTCGTGTTCCCGGGTGCGGGGGTG
AAGTGGGCGGGGATGGCGCTCGGGTTGTGGGCGGAGTCTGCTGTGTTTGCGGAGTCGATG
GCGCGGTGTGAGGCGGCGTTCGCCGGGTTGGTGGAGTGGCGTCTGGCGGATGTGCTGGGT
GATGGGGCTGCGTTGGAGCGTGAGGACGTGGTGCAGCCGGCGTCGTTCGCGGTGATGGTG
TCGTTGGCGGCGTTGTGGCGGTCGTTGGGTGTGGTGCCGGATGCGGTGGTGGGGCATTCG
CAGGGGGAGATCGCTGCTGCGGTGGTGGCGGGTGGTCTGTCGTTGGAGGACGGGGCGCGT
GTGGTGGTGTTGCGGGCGCGGGTGGCTGAGGAGGTTTTGTCGGGTGGGGGGATTGCTTCG
GTGCGTCTTTCGCGGGCCGAGGTGGAGGAGCGGTTGGCGGGTGGGGGTGGTGGGTTGAGT
GTGGCGGTGGTGAATGCGCCGTCGTCGACGGTGGTGGCGGGTGAGTTGGGGGAGTTGGAT
CGGTTTGTTGCGGCGTGTGAGGCGGAGGGGGTGCGGGCGCGTCGGCTGGAGTTCGGGTAT
GCGTCGCATTCGAGGTTCGTGGAGCCGGTGCGTGAGCGGTTGTTGGAGGGGTTGGCCGAT
GTCCGTCCGGTGAGGGGGCGGATTCCGTTCTATTCGACGGTGGAGGCTGGGGAGTTCGAT
ACGGCTGGTCTGGATGCGGAGTACTGGTTCGGGAATCTGCGTCGGCCGGTTCGGTTCCAG
GAGACGGTCGAGCGGTTGTTGGCGGATGGTTTCCGGGTGTTCGTGGAGTGTGGTGCGCAT
CCGGTGCTGACCGGGGCGGTGCAGGAGACCGCGGAGACTGCGGGCCGGGAGGTGTGTGCG
GTTGGTTCGCTGCGTCGTGACGAGGGAGGTCTCCGTCGCTTCCTGACCTCTGCGGCGGAG
GCGTTCGTCCAGGGGGTGGAGGTGTCCTGGCCGGTGCTGTTCGACGGCACCGGCGCCCGC
ACGGTCGACCTGCCCACCTACCCCTTCCAACGCCGCCACTACTGGGCACAGTCCTCGCCC
GCCGGCGCCGGCAGCTCTGCTGCGGCCCGCTTCGGTATGACCTGGGAGGAGCATCCGCTC
CTCGGCGGCGCGCTGCCGCTCGCGGACTCCGGCGAGCTGCTGCTCGTCGGGAGGATCTCC
CCGGCCTCCCACTCCTGGATCGCCGACCACACCGTGGCCGGGACCGCCCTGCTGCCCGGG
ACGGCCTTCGTCGACATGGCACTGCACGCCGCCGCGGTCGCGGGCTGTGCGGGTGTGGAG
GAGCTGAGCATCGAGGCCCCGCTGCCGGTGCACGGCGGGATCCGGCTCCAGGTGGTGATC
GACGAGCCCGACTCCTCCGCGCGGCGCCGCGTGAGCGTGTTCGCGAGGCCGGAAGAGGAA
GACGGGGACGCCGGCCGCTGGACCCGACACGCCACCGGCGTGCTGACCCCCGACGTCGCC
CCCGAGCCGGGCCGGCCGCAGTGGTGCCGGCAGGCCTGGCCGCCGAGCGGCTCCGTCCGG
GTGGAGGCGTCGGAGCTCTACGACCGGTTCTCCGCGCTGGGATACGACTACGGCGAGGTC
TTCGCCGGGGTCGAGGCCGTCTGGCTGCGCGAGGGCGAGGCCTTCGCCGAGGTCCGCCTG
CCCACGGGCGCGGCGCCCGACGCCGAGCGGTTCGGGGTGCACCCCGGCCTCCTCGACGCG
GCTCTGCACCCCTGGCTGCTGGGCGACTTCCTGTCGCGGCCCGACGGCGGATCCGTACTG
CTGCCGTTCGCGTGGCGCGGCATCACGCTCCACACGGCCGGTGCCGACGCGCTGCGGGTC
CGTCTCGGACCGGCCGGAGAAGGCGCTCTGTCGCTCGAAGCCGTCGACCTCTCCGGTGCC
CCGGTGCTGTCGATGGACGCACTGGTGCTGCGTCCGCTCGCCCAGGACCGCCTGGCGGAA
CTGGTCGGCGGCACGACCTCCACCCCGCTGTACCGCGTGGACTGGCAGCGGAGCCCGATC
GCGAGGACGGCGCCGTCGGCCACGGGGCTCTTCGGCTCCCTCCCGTCCGGTGCCGTCCGC
CGCTGGGCGGTCGTCGGGCAGGGCGGTGTCGCCGCACGGTACGCGACGGCGGAACCCGGC
ACGGGGTGCGTCGGGGTCTTCCCCGACCTGGACGCACTGCGTACGACGCTGGACTCCGGA
GCGGACGGCCCCGACATCGTCCTCGCCGACTTCGGGGCCCGGCCAGGCGACGCCGCGCCG
CACGGGACGGATCCGGCCGACGGCGCACGCGACACGGTCCGGCGGGGGCTCGCCCTCATA
CAGGGCTGGCTGTCCGACGAGCGCTTCGCCGCCGCGCGTCTCGCCGTGCTCACCGAGCAC
GCCGTCGCCACCGAGGCGGACACCCGCCGGACGGACCTCGCGGGCTCGGCACTGTGGGGG
CTGATGCGTTCGGCGCAGACCGAGCACCCCGACCGCTTCGTCCTCGTCGACCACGACGGG
CAGGACGCCTCGTACCGGACGCTGCCCACCGCGCTCGACAGCGAAATCCCGCAACTGGCG
CTCCGAGCCGGGGAGACGCTGGCCCCCGAACTGGCGGTCCTGCCGAGTCCGGCCGACGGG
GGGCCCGCGACAAGCGCGGCGTTCGATCCCGAAGGCACGGTACTCGTCACCGGAGCCACC
GGCACCCTCGGCAGCCTGCTGGCCCGGCACCTGGTCACGGCACACGGCGTACGGCATCTG
CTGCTGCTCAGCCGCAGCGGACGCGAAGCCGCGGGGGCCGCCGAACTGGAGCGTGAACTC
CGTCAACGGGGAGCCGAGTTCCAGCTCCTCTCCTGTGACGCGACGGACCGGGCAGCGCTG
AAGGAGGCCCTCGCCACCGTCCCCGCCGCCCACCCGCTGACCGCGGTGATCCACACGGCC
GGCGTCCTCGACGACGGCGTCGTCGAGGCGCTGACCCCCGAACGGCTGGACCGCGTGCTG
CGCCCCAAGGCGGACGCCGCGCTGAACCTGCACGACCTGACCGAGGGAATGCCGCTGAAG
GCGTTCGTCCTGTACTCCGGGGCGGTCGGACTGCTGGGTGGAGCGGGCCAGGCCAACTAC
GCGGCAGCCAACGCGTTCCTGGACGGCCTGGCCCAACACCGGCACGCGCAAGGGCTGCCC
GCGGTGTCCCTGGCATGGGGACTCTGGAGCGCCACCAGCACGTTCACCGACCATCTCGGC
GAGGTGGACCTGCGGCGCATGGAGCGGTCCGGCATCACGCCGCTCACGGACGAGCAGGGC
CTTGACCTGTTCGACCGGGCCCTCGGCGCCGCGGTGGACGCGCCGCAGCTCTGCGTGATG
GGGCTGGACACGGCGGCGCTGCGCCGGCAGGCGGCCGAGCACGGGCCGACTTCGATGCCT
CCTCTGCTGCGTACGCTGGCGGCGCCTCCCGTACGGCGCGGCGCGGGGCGCTCCGGCCGG
GGCGGACGGGCGGCGTCCGCCACGGACGCGCCGAGCCGGGCGCAGGCCCTGCGCGAGCGA
CTGACGGGCCTGGACGCGGCGGCACGGCGGGACGAACTCCTGGTCCTGTCGCAGGCGCAG
TTGGCCGATGTGCTGGGCTTCGCCGACAAGACCGCGGTGGACCCCGTTCGTTCCTTCCGC
GAGATCGGTCTGGACTCGCTGACCGCCGTCGAGCTGCGCAACCGGCTCGGTGTCGTCACC
GGACTGCGGCTGCCGCCGGCGCTGGTCTTCGACCACCCCAACCTCGACGCGCTCGCGGCC
CACCTGGCGGAGCTCCTCGCGGCTGAGGGCCGGGACGACGCGGGCGCCGCGGCGCTCTCG
GGAATCGACGCCCTGGACCGGGCGGTCCGGGAGATGGCGGCCGACGACACGCGCCGTGAC
GCCGTCCGCCGACGCCTCGCGGAACTGCTGGCGGTGGTCGGCGACGCCCCGCGGGACGGC
GGCCGCGCCCCACGGGCGGCCGCCGACGCGGGAGGCCGCGACGCTCAAGCGGACCCCGAC
CTGCTGGGCCGGCTGGACTCCGCCTCCGACGACGATCTGTTCGCGTTCATCGAAGACCAG
CTGTGA

[0] KSQ	68..420

[0] AT	580..896

[0] malonyl-CoA not conserved HAFHS, conserved signature for methylmalonyl-CoA	768..772

[0] ACP	972..1042

[1] KS	1062..1438

[1] AT	1591..1907

[1] methylmalonyl-CoA	1780..1784

[1] KR	2179..2354

[1] ACP	2457..2531

[2] KS	2559..2934

[2] AT	3092..3408

[2] malonyl-CoA not conserved HAFHS, conserved signature for methylmalonyl-CoA	3280..3284

[2] DH	3458..3624

[2] KR	3972..4152

[2] ACP	4273..4343

[0] KSQ	202..1260

[0] AT	1738..2688

[0] malonyl-CoA not conserved HAFHS, conserved signature for methylmalonyl-CoA	2302..2316

[0] ACP	2914..3126

[1] KS	3184..4314

[1] AT	4771..5721

[1] methylmalonyl-CoA	5338..5352

[1] KR	6535..7062

[1] ACP	7369..7593

[2] KS	7675..8802

[2] AT	9274..10224

[2] malonyl-CoA not conserved HAFHS, conserved signature for methylmalonyl-CoA	9838..9852

[2] DH	10372..10872

[2] KR	11914..12456

[2] ACP	12817..13029

Feature

BLASTP Database:UniProtKB:2011_09	show BLAST table
InterPro Database:interpro:38.0	IPR001227 Acyl transferase domain (Domain) G3DSA:3.40.366.10 Ac_transferase_reg IPR006162 Phosphopantetheine attachment site (PTM) PS00012 PHOSPHOPANTETHEINE IPR009081 Acyl carrier protein-like (Domain) SSF47336 ACP_like PF00550 PP-binding PS50075 ACP_DOMAIN G3DSA:1.10.1200.10 ACP_like IPR013968 Polyketide synthase, KR (Domain) PF08659 KR IPR014030 Beta-ketoacyl synthase, N-terminal (Domain) PF00109 ketoacyl-synt IPR014031 Beta-ketoacyl synthase, C-terminal (Domain) PF02801 Ketoacyl-synt_C IPR014043 Acyl transferase (Domain) PF00698 Acyl_transf_1 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase (Domain) SSF52151 Acyl_Trfase/lysoPlipase IPR016036 Malonyl-CoA ACP transacylase, ACP-binding (Domain) SSF55048 Malonyl_transacylase_ACP-bd IPR016038 Thiolase-like, subgroup (Domain) G3DSA:3.40.47.10 Thiolase-like_subgr IPR016039 Thiolase-like (Domain) SSF53901 Thiolase-like IPR016040 NAD(P)-binding domain (Domain) G3DSA:3.40.50.720 NAD(P)-bd IPR018201 Beta-ketoacyl synthase, active site (Active_site) PS00606 B_KETOACYL_SYNTHASE IPR020801 Polyketide synthase, acyl transferase domain (Domain) SM00827 PKS_AT IPR020806 Polyketide synthase, phosphopantetheine-binding domain (Domain) SM00823 PKS_PP IPR020807 Polyketide synthase, dehydratase domain (Domain) SM00826 PKS_DH IPR020841 Polyketide synthase, beta-ketoacyl synthase domain (Domain) SM00825 PKS_KS IPR020842 Polyketide synthase/Fatty acid synthase, KR (Domain) SM00822 PKS_KR
SignalP	No significant hit
TMHMM	No significant hit

Chalc_00200 Chalc_00220