Rever_00100 Rever_00100   Rever_00120 Rever_00120

Rever_00110 : CDS information

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Organism
StrainSN-593
Entry nameReveromycin
Contig
Start / Stop / Direction12,672 / 28,304 / + [in whole cluster]
12,672 / 28,304 / + [in contig]
Location12672..28304 [in whole cluster]
12672..28304 [in contig]
TypeCDS
Length15,633 bp (5,210 aa)
Click on the icon to see Genetic map.

close this sectionAnnotation

Category1.1 PKS
Productpolyketide synthase
Product (GenBank)polyketide synthase
GenerevA
Gene (GenBank)revB
EC number
Keyword
Note
Note (GenBank)
Reference
ACC
PmId
[21642985] Reveromycin A biosynthesis uses RevG and RevJ for stereospecific spiroacetal formation. (Nat Chem Biol. , 2011)
comment
Reveromycinの4つのPKS(RevA,RevB,RevC,RevD)は１つのloading moduleと12のextension moduleからなり、これらが恐らく13回の脱炭酸縮合反応を触媒する。

ΔrevCΔrevDでは、Reveromycinが全く生合成されなくなった。ΔrevCΔrevDにReveromycinの推定中間体を与えると、Reveromycinの生合成能が復活した。
従って、revCとrevDはReveromycinの生合成に不可欠である。

revBと登録されているが、本論文のrevAに相当すると推測される。

close this sectionPKS/NRPS Module

4 butylmalonyl-CoA
isopentylmalonyl-CoA
pentylmalonyl-CoA
hexylmalonyl-CoA
5 malonyl-CoA
6 malonyl-CoA
KS37..413
AT578..900
KR1181..1361
ACP1462..1532
KS1554..1929
AT2122..2426
DH2474..2639
ER2953..3259
KR3269..3449
ACP3546..3620
KS3644..4020
AT4182..4488
KR4776..4956
ACP5052..5126

close this sectionSequence

selected fasta
>polyketide synthase [polyketide synthase]
MGAIVSDDKSFEYLKKVTSELKRTRNRLSEIESKSREPLAVVGMACRFPGGVAGPDDLWH
LVASGTDAVSLFPADRGWDVEQLYDPTGDRPHTSLTREGGFLAAAADFDAGFFGISPREA
QAMDPQQRLLLEVSWEALEHAGIDPRTLAGTSTGVFTGLMYHDYPASDQPDAAEGTGSAG
LGANGAVASGRVSYVLGLEGPAITVDTACSSSLVAMHWAGQALRSGECSLALAGGVTVMA
TPSTYVEFSRQGGAVSPDGRCRAFSEAADGTGFSEGVGILVLERLSDARRNGHEVLAVVR
SSAVNQDGASNGLTAPNGPSQQRVIRQALASAGLSPADVDAVEAHGTGTTLGDPIEAQAL
LSTYGQGRPDDQPLWLGSIKSNIGHTQAAAGVAGVIKMVQAMRHGVLPPTLHADLPSSHV
DWTAGQVRLLTEPQPWPDAGRPRRAGVSSFGVSGTNAHVIIEAAPETEAEPPAADRPGDE
DPGLFAPHTAMAWTLSARSAKALAGQAGRLLERVQDAPELDPADVGWSLLRSRALFEHRA
VVVGADRAELTAGLAALAAGEPAANVVTGAARSGGRAVFVFPGQGSHWEGMAKELLATSP
VFAAKVQECAEALDPLVDWSLLEVLRHPEESAELLSRIDVYHPVFFTMMVALAEVWRALG
VEPAAVVGHSQGEVAAAHVAGALSLSDAYRVVLVRGNIFENVLLGKGAIASVKLGQEAVE
EQIAGYERLSVAGVNSRSGVTVSGSMEDVKAYLAECEAAGVPARILGMAASHSPALEPLR
ERLLGELSFVRPRAGTIPMYSTVDAALVDTATLDAEYWYRNLRSPVLFEQTTRVLVDAGF
SAFVEASSHPVLTVPLQETLDTFYPDLAADAAVTGTLRRNEGGPARMLASAAHLFAHGVP
VVWDGLFAGRPPRRVELPTYAFQHRRFWNALPEPAAGRDPLDTLFWESVEGGRLAQSLGV
DDAVVSEVVPALLSWRERRQREAAADDWTYRQSWVPVDGLRQGPPAGRWLAVADRADDPW
TTGVAEALGPDTTVLARADATAERLAAPGYDGVVWLPPAGADGPAATLALVQALRASGQG
APLWVLTRAAVSARPGEPVSGMWQGGIWGLGRVAALELPDLWGGLVDLPEEFDAAVAARL
GGALSTAHGEDQLAVRASGVVARRLVRAAVHGTGEPWHTGGTALVTGGTGGLGAHVARWL
AERGAEHLVLLSRRGPDAPGAAELRAELEQAGARVSVHACDVADREAMTAIVTGLPDDLP
LRTVVHAAGVGSALVPVESLDAGQLEFELRVKAEGALLLDELTEGMDLDAFVLFSSGAAS
WGGSGQGGYAAGNACLDSLAEYRRARGRTATSLAWGGWAGPGLTDIDATFVDYLRRMGVL
AMQPDLAVAAMQRVLEQDETTVTVSDMDWTKFVPAFTLARPSRLFALLPEAAPAAAEPAD
DDGGDFAARVAAMSAAERRAYLTTLVRDHAAAVLGHGGGDEIDPGQAFREVGFDSLTAVE
LRNRLQTATGTGLPATLVFDYPSAARLAGYLAERFGDGAAAQPDLPALVQATDDPIAVVG
MACRYPGGVTGPDELWNLVATGTDAMSTFPDDRGWDLEALYDPAGYRPGASVTREGGFVD
SAVEFDAGFFGISPREALAMDPQQRLLLEVAWESLEHAGIDPAGLAGTATGVFVGAASSG
YLEAIDGLPETESHRMTSGLLSVISGRLSYSLGLEGPAVTVDTACSSSLVAMHWAGQALR
SGECSLAIAGGVNVLVSPVGFTEFSKQGGLAADGRVKAFAEAADGTSWSEGAGVVVLERL
SDARRNGHEVLAVVRSSAVNQDGASNGLTAPNGPSQQRVIRQALAAASLAPSDVDVVEAH
GTGTTLGDPIEAQALLATYGQGRPEDRPLWLGTIKSNIGHSQAAAGAAGVIKMVQAIRHG
SLPPTLNVDEPSTNVDWSEGRVRLLTEEQPWPETGRPRRAGVSSFGVSGTNAHVIIEAAP
EVEVEAAAEDTDTDPGPGTGAEAGPGTAAGTGEHPDGGNAGHPRGAALGTDDTVWVVSGR
SADAVAGQAERLLERVEQDTGPDPVDVAHSLLTSRSLFEHRAVVVGADRSELVSGLRALA
AGEAAGNAVEGVARSGRRVAVLFTGQGAQRLGMGRELYEESPVFAAAFDEVVAELDRHLE
VPLREVVWGEDADALNSTGWAQPALFAVEVALFRLLESFGVRPDYLLGHSIGEVAAAYVA
GVFDLVDACRLVGARARLMQALPSGGAMVAIAASEDDVLPHLSDGVSVAAVNAPGSVVVS
GEESAVLAVGEHFKAVGVKTTRLRVSHAFHSVLMEPMLDDFLAAIADVSFSEPRIPVVSN
LTGEPADMTSPKYWAQQVRSAVRFADGLAWLTAQGVDAFVEAGPDAVLAGLVESDGATAV
AVQRRDRTGARTVLQALARLFAEGVPVDWDGLFAGRPPRRVELPTYAFQRRRYWPEGGTA
AADVAAAGLMAVEHPLLGAVVPSPEGGGVVFTSRLSVASQPWLADHAVQGVVLFPGTGFV
ELAVHAADAVGCGRVREVIVEAPLVLPERGGVQVQVVVGEPEDGRRPFTVYARPDTGGEQ
PWVRQASGAVDDAAGADAAGFEALAGVWPPAGADVLETDGIYERIAEQGFVYGPSFRGLA
RAWRRDGQVFAEVALPEAQSGRAGAFGLHPALLDAVMHALAFVDLEPAEFGRLPFSFGDV
ALHASGAGRVRACLTRTGPDSVAIAVADEAGDAVLSLGSLVVRPLTPQALSAAGGGRDEA
VLAPRWTALDTQDPALDDWESVAAAVVAGPGQRVDWLPGAVLHPHAGDVVSDAALPLVIA
VTGGDRPVEGAHEATRWMLDQLQTWQSGARELVVVTSGAVAAGPDESVTDLGAAAVWGLV
RSAQAENPGRITLVDTDAATGMTAGLLAAARATGEPQLAVRAGRLHAARLARADVGLVAP
ESGAWHLDSMAKGTLENLRLVPFPEAERALSDGEVRIEVRAAGLNFRDVLNALGMYPGEA
GPLGGEVAGVVTEVGAGVSDLRVGDRVMGLSDGGLGSVTVTDRRLVAPIPSGWSYTTAAS
VPTVFLTAYYGLVDLAGVRSGERVLVHAGAGGVGMAALQLVAHLGAEAYTTASEGKWPAL
RERGVEAARLASSRTLDFEEAFLRETGGRGVDVVLNSLTGEFIDASLRLMPGGGRFVEMG
KADLRTDEQIGAVHPGISYHTYDLVQAGPDRVQQMLLELVGLFESGVLVPLPVVEWDVRR
APEAFRFMSQARHVGKIVLTVGRRVVGEGAVLVTGGTGGLGGVVARHLVVEHGVRDLVLV
SRRGLGAPGAEELVAELSGRGARVEVVACDVSDREALAGVVAGMCASGVLAGVVHTAGVV
DDGLVSSLSGERLGPVLAPKVDAGWWLHELTRGLDLSLFAVFSSMSGLVGAPGQGNYAAA
NVFLDALVERRRSEGLPGVSMVWGPWTPEVGLTGALSEADLRRLHSSGTPPLSVEQGMRL
FDQAVLADAPVLALTRLDAAVLRGQADLPVMLRELVGARPRRAAAGARQQSGGLAGQLAG
LSAQQRDQHLLALVRDNVAVVLGHGGGQDVDPGQAFREAGFDSLTAVELRNRLQSATGLA
LPATLVFDYPNATRLAAFLAEQFGDAAEPAARPDLPALVSVTDDPIVVVGMACRFPGGVT
GPDDLWDLVASGTDAMSPFPADRGWDLDGLHDPTGTRPNTSVADEGGFLASAADFDAGFF
GISPREALAMDPQQRMVLEVAWEALEHAGIDPTGLGGTPAGVFVGSYHSGYSDLVVESGG
DAQAQLLTGAAQSVLSGRVSYVLGLEGPAVTVDTACSSSLVAMHLASQSLRSGESTLALA
GGVTVMATPGTFVEFSRQGGLAADGRCKAFAESADGTGWSEGAGIVVLERLSDAERNGHR
VLAVMRSSAVNQDGASNGLTAPNGPSQQRVIRQALAAAGLSPADVDAVEAHGTGTSLGDP
IEAQAVLAAYGQDRPEDRPLWLGSVKSNLGHTQAAAGVVGAIKMVQALRHGVLPRTLHVD
EPSTHVDWGQGRVRLLTESVPWPENGHPRRAGVSSFGISGTNAHVILEAAPAVESEVEAR
VEVAGEAGAESESGSGSVWVVSGRSEGALRAQAERLLSVAEGLDPVDVGGALLSRSVFEH
RAVVVGSGREELTAGLRALAAGEVAGNAVEGVARSGRRVAVLFAGQGAQRLGMGRRLHEE
SPVFAAAFDEVVAELDRHLEAPLREVLWGEDAEALNSTGWAQPALFAVEVALFRLLESFG
VTPDYLLGHSIGEVAAAYVAGVFDLVDACRLVAARARLMQQLPSGGAMVAIAASEDDVLP
LLSDGVSVAAVNAPGSVVVSGEEGAVLAVGEHFKALGVKTTRLRVSHAFHSALMEPMVDD
FLAAIAEVSFSEPRIPVVSNLTGEPADMTSPKYWAQQVRSAVRFADGLAWLTAQGVDVFV
DAGPDGVVAGLAQANASDAVAVALMRKDRGGLDTALLAAGDLFVHGVPVEWAGLVGGRGA
EWVELPTYAFQRRRYWPDAAVPTTGQEPGRDPLDALFWESVEHGRLAESLGVDDAAVSGV
VPALLDWRERRRREMAADDWRYDQRWVPVDGVPRGATADRRLVVVPAGADAWTRGVVDAL
GDGVTVLEAEAADADRLAAEGAECTAVVWLPPAEESGVAATLRLVQELRGAGVPAPLWVV
TRGAVAARPDDRVDGVWHGGVWGLGRVAALELPDLWGGLVDLPEEVDGTVAARLSGVLSG
GHGEDQLAVRASGVLARRLVHATGRDGAAEPWRTGGTAIVTGGTGGLGGRVARWLVDRGA
EHLVLLSRRGADAPGTADLTAGLEAAGARVTVVAGDVADRAVLAEAFAAVPADLPLRTVV
HAAGVGNAFTPLESMTPERLADELRVKAGGALLLDELTEGMDLDAFVLFSSGAASWGGSG
QGGYAAGNACLDSLAEYRRARGRTATSVAWGTWAEVGMAAGSSDGHDHLARLGVSAMAPD
LAIIALQRVIEDDAATATVSAMDWSTFAPAFTLARPSNLFALLPEAVPAAPDAAEADTGF
AQHLAALPDEERREELLALVREHTAAVLGHDSARDVDPAQAFRDAGFDSLTAVELRNRLQ
RRTGLALPATLVFDHPNPNRLVDHLAGELVGGGDAAGGLDELRDRLQTFAADPAVREDLE
AMLRQVLGAVEDATAAQRGDIDAASDEELFSMVDQGSSWMSDSSSTADHE
selected fasta
>polyketide synthase [polyketide synthase]
GTGGGAGCGATAGTGAGTGACGACAAGTCCTTCGAGTATCTGAAGAAAGTGACTTCGGAG
CTCAAGCGTACCCGGAACCGACTCTCGGAAATCGAGTCGAAATCCAGGGAGCCGCTCGCC
GTCGTCGGGATGGCGTGCCGCTTCCCCGGCGGGGTCGCCGGCCCCGACGACCTGTGGCAC
CTGGTCGCCTCGGGCACCGACGCGGTGTCGCTCTTCCCCGCCGACCGCGGCTGGGACGTC
GAGCAGCTCTACGACCCCACCGGCGACCGCCCCCACACCTCGCTCACCCGCGAGGGCGGA
TTCCTGGCCGCCGCCGCCGACTTCGACGCCGGGTTCTTCGGGATCTCCCCGCGCGAGGCG
CAGGCGATGGACCCGCAGCAGCGGCTGCTGCTGGAGGTGTCGTGGGAGGCGCTGGAGCAC
GCCGGCATCGACCCGCGCACCCTCGCCGGCACCTCCACCGGCGTGTTCACCGGCCTGATG
TACCACGACTACCCGGCCTCCGACCAACCGGACGCCGCCGAGGGCACCGGCTCGGCCGGC
CTCGGCGCCAACGGCGCCGTCGCCTCCGGCCGGGTCTCCTACGTGCTGGGCCTGGAGGGC
CCGGCCATCACCGTGGACACCGCCTGCTCCTCGTCGCTGGTCGCCATGCACTGGGCCGGG
CAGGCGCTGCGCTCGGGCGAGTGCTCGCTCGCCCTGGCCGGCGGCGTGACCGTGATGGCG
ACCCCCAGCACGTACGTGGAGTTCAGCCGCCAGGGCGGCGCCGTGTCACCCGACGGCCGC
TGCCGGGCGTTCTCCGAGGCGGCCGACGGCACCGGGTTCAGCGAGGGCGTCGGCATCCTC
GTGCTGGAGCGGTTGTCGGACGCGCGGCGCAACGGGCACGAGGTGCTGGCCGTGGTCCGG
TCGAGTGCGGTGAACCAGGACGGCGCGTCCAACGGCCTGACGGCGCCGAACGGTCCGTCG
CAGCAGCGCGTGATCCGCCAGGCGCTGGCGTCGGCCGGACTGTCGCCGGCCGACGTGGAC
GCCGTGGAGGCGCACGGCACGGGCACGACCCTGGGCGACCCGATCGAGGCGCAGGCGCTG
CTGTCCACCTACGGCCAGGGCCGCCCCGACGACCAGCCGCTGTGGCTCGGCTCGATCAAG
TCCAACATCGGCCACACCCAGGCCGCCGCCGGCGTCGCCGGCGTCATCAAGATGGTGCAG
GCGATGCGGCACGGCGTGCTGCCCCCCACCCTGCACGCCGACCTGCCCAGCTCGCACGTC
GACTGGACGGCCGGCCAGGTCCGGCTGCTCACCGAGCCGCAGCCCTGGCCCGACGCCGGC
CGCCCGCGCCGGGCCGGCGTGTCCTCCTTCGGCGTGTCCGGCACCAACGCGCACGTCATC
ATCGAAGCCGCCCCCGAGACCGAGGCCGAACCCCCCGCCGCGGACCGGCCCGGCGACGAG
GACCCCGGACTGTTCGCCCCGCACACCGCGATGGCGTGGACCCTGTCCGCACGCAGCGCC
AAGGCACTGGCCGGCCAGGCGGGACGCCTGCTGGAGCGTGTGCAGGACGCCCCGGAACTC
GACCCCGCCGACGTGGGCTGGTCGCTGCTGCGCTCCCGCGCGCTGTTCGAGCACCGCGCC
GTCGTCGTCGGCGCCGACCGGGCCGAGCTGACGGCCGGCCTGGCCGCGCTCGCCGCGGGC
GAACCCGCCGCGAACGTCGTCACCGGCGCCGCCCGCTCCGGCGGCCGGGCCGTCTTCGTC
TTCCCCGGCCAGGGCTCGCACTGGGAGGGCATGGCCAAGGAACTCCTCGCCACCTCACCG
GTCTTCGCCGCGAAGGTCCAGGAGTGCGCCGAGGCGCTCGACCCGCTCGTCGACTGGTCG
CTGCTGGAAGTGCTGCGCCACCCCGAGGAGTCCGCGGAGCTGCTGAGCCGCATCGACGTC
TACCACCCGGTCTTCTTCACCATGATGGTGGCGCTGGCCGAGGTCTGGCGCGCCCTGGGC
GTCGAGCCCGCGGCCGTCGTCGGGCACTCCCAGGGCGAGGTCGCCGCCGCCCACGTGGCC
GGCGCGCTGTCCCTCAGCGACGCCTACCGCGTGGTCCTGGTGCGCGGCAACATCTTCGAG
AACGTGCTGCTCGGCAAGGGCGCCATCGCCTCGGTCAAGCTGGGCCAGGAAGCGGTCGAG
GAACAGATCGCCGGGTACGAACGGCTCTCCGTCGCCGGCGTCAACTCCCGCTCCGGGGTG
ACCGTCTCCGGCAGCATGGAGGACGTCAAGGCGTACCTCGCCGAGTGCGAGGCCGCCGGC
GTCCCCGCCCGCATCCTCGGCATGGCCGCCTCCCACTCGCCCGCCCTGGAACCGCTGCGC
GAGCGGCTGCTCGGCGAGCTGTCCTTCGTCCGCCCCCGGGCCGGCACCATCCCCATGTAC
TCCACCGTCGACGCCGCCCTGGTCGACACCGCCACCCTGGACGCCGAGTACTGGTACCGC
AACCTGCGCTCACCGGTGCTGTTCGAGCAGACCACGCGCGTCCTGGTCGACGCCGGCTTC
AGCGCCTTCGTCGAGGCCAGCTCGCACCCGGTGCTGACCGTGCCGCTCCAGGAGACCCTC
GACACCTTCTACCCCGACCTCGCGGCCGACGCGGCGGTCACCGGGACGCTGCGCCGCAAC
GAGGGCGGCCCGGCCCGGATGCTGGCGTCCGCGGCCCACCTGTTCGCGCACGGCGTGCCG
GTCGTCTGGGACGGCCTGTTCGCGGGCCGCCCGCCGCGCCGGGTCGAGCTGCCCACCTAC
GCCTTCCAGCACCGGCGGTTCTGGAACGCGCTCCCGGAGCCCGCGGCCGGCCGCGACCCG
CTGGACACCCTGTTCTGGGAGTCCGTCGAGGGCGGACGGCTGGCCCAGTCCCTGGGTGTG
GACGACGCGGTCGTCTCCGAGGTCGTGCCGGCCCTGCTGAGCTGGCGCGAGCGCCGGCAG
CGGGAGGCGGCCGCCGACGACTGGACCTACCGCCAGTCCTGGGTGCCGGTCGACGGACTG
CGGCAGGGCCCGCCCGCCGGCCGCTGGCTGGCCGTCGCGGACCGCGCCGACGACCCCTGG
ACCACCGGCGTCGCCGAGGCCCTCGGCCCCGACACGACCGTCCTCGCCCGGGCCGACGCG
ACCGCCGAACGGCTCGCCGCCCCCGGCTACGACGGCGTCGTCTGGCTGCCGCCCGCCGGT
GCGGACGGCCCGGCGGCGACCCTCGCCCTGGTCCAGGCGCTGCGCGCGTCCGGGCAGGGC
GCGCCGCTGTGGGTGCTCACCCGGGCCGCGGTGTCCGCCCGGCCCGGCGAACCCGTCAGC
GGCATGTGGCAGGGCGGCATCTGGGGCCTCGGCCGCGTCGCCGCCCTGGAACTGCCGGAC
CTGTGGGGCGGGTTGGTCGACCTGCCCGAGGAGTTCGACGCCGCCGTCGCGGCCCGCCTG
GGCGGCGCGCTGTCCACCGCCCACGGCGAGGACCAGCTCGCGGTCCGCGCCTCGGGCGTC
GTGGCCCGCCGCCTCGTGCGCGCCGCCGTCCACGGCACCGGCGAGCCCTGGCACACCGGC
GGGACCGCCCTGGTCACCGGCGGCACCGGCGGCCTCGGGGCGCACGTCGCCCGCTGGCTG
GCGGAGCGCGGCGCCGAGCACCTGGTGCTGCTGTCGCGCCGCGGCCCGGACGCCCCGGGC
GCGGCCGAACTGCGGGCCGAACTGGAACAGGCCGGCGCGCGTGTCAGCGTGCACGCCTGC
GACGTGGCCGACCGCGAGGCCATGACCGCGATCGTCACCGGTCTGCCGGACGACCTGCCG
CTGCGCACGGTGGTGCACGCCGCCGGCGTCGGCAGCGCACTCGTGCCGGTCGAGTCCCTG
GACGCCGGCCAGTTGGAGTTCGAGCTGCGGGTCAAGGCCGAGGGCGCCCTGCTGCTGGAC
GAGTTGACCGAGGGCATGGACCTGGACGCGTTCGTGCTGTTCTCGTCGGGGGCGGCGTCC
TGGGGCGGCAGCGGGCAGGGCGGTTACGCGGCGGGCAACGCCTGCCTGGACAGCCTGGCC
GAGTACCGCCGGGCGCGGGGGCGTACCGCCACCTCCCTCGCCTGGGGCGGCTGGGCCGGC
CCTGGCCTGACCGACATCGACGCCACCTTCGTGGACTACCTGCGGCGCATGGGCGTGCTC
GCCATGCAGCCCGACCTCGCCGTCGCGGCCATGCAACGCGTCCTGGAACAGGACGAGACC
ACCGTCACCGTCTCCGACATGGACTGGACGAAGTTCGTCCCCGCGTTCACCCTGGCCCGC
CCCAGCCGCCTGTTCGCCCTGCTCCCCGAAGCGGCCCCGGCCGCCGCCGAGCCGGCCGAC
GACGACGGCGGCGACTTCGCCGCCCGGGTGGCCGCCATGTCCGCGGCCGAGCGGCGCGCC
TACCTGACCACCCTGGTCCGCGACCACGCCGCCGCCGTCCTCGGGCACGGCGGCGGCGAC
GAGATCGACCCCGGCCAGGCGTTCCGCGAGGTCGGCTTCGACTCGCTGACGGCGGTGGAA
CTGCGCAACCGGCTCCAGACCGCGACCGGCACCGGCCTGCCCGCCACCCTGGTCTTCGAC
TACCCGAGTGCGGCCCGGCTGGCCGGTTACCTCGCCGAGCGGTTCGGCGACGGCGCGGCG
GCGCAACCGGACCTGCCCGCGCTGGTGCAGGCCACCGACGACCCGATCGCCGTGGTCGGC
ATGGCCTGCCGCTACCCCGGCGGGGTGACCGGCCCCGACGAGCTGTGGAACCTGGTCGCC
ACCGGCACGGACGCGATGAGCACCTTCCCGGACGACCGCGGCTGGGACCTGGAGGCGCTG
TACGACCCGGCGGGCTACCGGCCGGGCGCGTCGGTCACCCGCGAGGGCGGCTTCGTGGAC
TCCGCGGTGGAGTTCGACGCGGGGTTCTTCGGGATCTCCCCGCGTGAGGCGCTGGCGATG
GACCCGCAGCAGCGGCTGCTGCTGGAGGTGGCCTGGGAGTCGCTGGAGCACGCCGGCATC
GATCCGGCGGGGCTCGCCGGGACGGCCACCGGCGTCTTCGTCGGCGCCGCGTCGTCCGGC
TACCTGGAGGCCATCGACGGCCTGCCCGAGACCGAGAGCCACCGGATGACCAGCGGGCTG
CTGTCCGTCATCTCCGGCCGGCTCTCCTACAGCCTGGGCCTGGAGGGCCCGGCGGTGACG
GTGGACACCGCGTGCTCGTCGTCGCTGGTGGCCATGCACTGGGCCGGCCAGGCGCTGCGC
TCGGGCGAGTGCTCGCTCGCCATCGCCGGCGGCGTGAACGTGCTCGTCAGCCCGGTCGGG
TTCACCGAGTTCAGCAAGCAGGGCGGCCTCGCCGCCGACGGCCGCGTCAAGGCGTTCGCC
GAGGCCGCCGACGGGACCAGTTGGTCCGAGGGCGCCGGCGTCGTGGTGCTGGAGCGGTTG
TCGGACGCGCGCCGCAACGGGCACGAGGTGCTGGCCGTGGTCCGGTCGAGTGCGGTGAAC
CAGGACGGCGCGTCGAACGGGTTGACGGCGCCGAACGGTCCGTCGCAGCAGCGGGTGATC
CGCCAGGCGCTGGCGGCGGCCTCCCTGGCACCGTCCGACGTGGACGTGGTGGAGGCGCAC
GGCACGGGCACGACACTGGGCGACCCGATCGAGGCGCAGGCGCTGCTGGCGACCTACGGC
CAGGGCCGCCCCGAGGACCGGCCGTTGTGGCTGGGCACGATCAAGTCCAACATCGGCCAC
TCGCAGGCCGCCGCCGGTGCGGCCGGCGTCATCAAGATGGTGCAGGCCATCCGCCACGGC
TCGCTGCCGCCCACCCTCAACGTGGACGAGCCGAGCACGAACGTGGACTGGAGCGAGGGC
CGGGTGCGGCTGCTGACCGAGGAGCAGCCGTGGCCGGAGACCGGCCGCCCGCGCCGCGCG
GGCGTGTCCTCCTTCGGCGTGTCCGGCACCAACGCGCACGTCATCATCGAGGCCGCGCCC
GAGGTTGAGGTCGAGGCCGCCGCCGAGGACACGGACACGGACCCGGGCCCGGGAACGGGC
GCGGAGGCGGGCCCCGGGACTGCCGCGGGAACGGGCGAGCACCCGGACGGCGGGAACGCC
GGGCACCCGCGGGGCGCCGCACTCGGCACGGACGACACCGTGTGGGTCGTCTCCGGGCGC
TCGGCGGACGCCGTGGCCGGCCAGGCGGAACGGCTGCTGGAGCGCGTCGAGCAGGACACG
GGTCCGGACCCCGTGGACGTGGCCCACTCGCTGCTGACGTCCCGTTCCCTCTTCGAGCAC
CGTGCGGTGGTGGTGGGTGCGGATCGCTCGGAACTCGTCTCCGGGTTGCGGGCGTTGGCG
GCCGGTGAGGCGGCGGGGAACGCGGTGGAGGGTGTGGCGCGGAGCGGCCGCCGGGTGGCG
GTGTTGTTCACCGGTCAGGGTGCGCAGCGGCTGGGGATGGGGCGGGAGTTGTATGAAGAG
TCGCCGGTGTTCGCGGCGGCCTTCGACGAGGTGGTGGCGGAGTTGGACCGGCATCTTGAG
GTGCCGTTGCGGGAGGTGGTGTGGGGTGAGGACGCCGACGCGTTGAACTCCACCGGTTGG
GCGCAGCCGGCGTTGTTCGCGGTCGAGGTGGCGTTGTTCCGGCTGTTGGAGTCGTTCGGG
GTGAGGCCGGATTACCTGTTGGGGCACTCCATTGGTGAGGTGGCTGCGGCTTACGTTGCC
GGGGTTTTCGATCTGGTGGATGCGTGCCGGTTGGTGGGGGCGCGGGCGCGTTTGATGCAG
GCGCTTCCCTCGGGTGGGGCGATGGTGGCCATCGCCGCTTCCGAGGACGACGTGCTGCCG
CATCTGTCCGACGGGGTGTCGGTGGCGGCGGTGAACGCGCCGGGTTCGGTGGTGGTCTCC
GGTGAGGAGTCCGCTGTGCTCGCGGTCGGTGAGCATTTCAAGGCGGTGGGGGTGAAGACG
ACCCGGCTGCGCGTCTCGCACGCCTTCCACTCGGTCCTGATGGAGCCGATGCTGGACGAC
TTCCTGGCCGCGATCGCGGATGTGTCGTTCTCCGAGCCTCGGATCCCGGTGGTGTCGAAC
CTGACGGGTGAGCCGGCGGACATGACGTCGCCGAAGTACTGGGCACAGCAGGTGCGTTCG
GCGGTCCGCTTCGCGGACGGACTGGCATGGCTGACGGCGCAGGGCGTGGACGCCTTCGTC
GAGGCGGGACCGGACGCGGTGCTGGCCGGACTGGTGGAGTCCGACGGCGCCACCGCGGTG
GCCGTGCAGCGCCGCGACCGCACCGGGGCCCGGACCGTCCTCCAGGCGCTGGCACGGTTG
TTCGCGGAGGGCGTGCCGGTCGACTGGGACGGCCTGTTCGCGGGCCGCCCGCCGCGCCGG
GTCGAGCTGCCCACGTACGCCTTCCAGCGGCGCCGTTACTGGCCGGAGGGCGGCACGGCC
GCCGCCGACGTGGCGGCCGCCGGCCTGATGGCGGTCGAACACCCGCTGCTGGGCGCGGTG
GTGCCGTCGCCCGAGGGCGGCGGGGTGGTGTTCACCTCGCGGCTGTCGGTCGCGTCGCAG
CCGTGGCTGGCCGACCACGCCGTGCAGGGTGTGGTGCTCTTCCCGGGCACCGGTTTCGTG
GAACTCGCGGTGCACGCCGCGGACGCGGTCGGCTGCGGCCGGGTCCGCGAGGTGATCGTG
GAGGCGCCGCTGGTGCTGCCGGAGCGCGGCGGCGTGCAGGTCCAGGTGGTCGTCGGCGAA
CCCGAGGACGGCCGGCGCCCGTTCACGGTGTACGCGCGCCCCGACACGGGCGGCGAGCAG
CCCTGGGTCCGGCAGGCCAGCGGTGCCGTGGACGACGCGGCCGGGGCCGACGCGGCCGGG
TTCGAGGCGCTGGCCGGCGTGTGGCCCCCGGCGGGCGCGGACGTGCTGGAGACCGACGGG
ATCTACGAGCGGATCGCCGAGCAGGGCTTCGTGTACGGCCCCTCGTTCCGCGGCCTGGCC
CGCGCCTGGCGCCGCGACGGGCAGGTCTTCGCCGAAGTGGCGCTGCCCGAGGCGCAGTCG
GGCCGGGCGGGCGCTTTCGGCCTGCACCCGGCGCTGCTGGACGCGGTGATGCACGCGCTG
GCCTTCGTGGACCTGGAGCCGGCGGAGTTCGGCCGGCTGCCGTTCAGCTTCGGCGACGTG
GCGCTGCACGCCTCCGGCGCGGGGCGGGTGCGCGCCTGCCTGACGCGGACCGGACCCGAC
TCGGTGGCGATCGCCGTGGCCGACGAGGCCGGTGACGCGGTGCTGTCGCTGGGCTCGCTG
GTGGTACGCCCGCTGACCCCGCAGGCGCTGAGCGCCGCGGGCGGCGGCCGGGACGAGGCC
GTCCTGGCCCCGCGGTGGACTGCGCTGGACACGCAGGACCCGGCGCTGGACGACTGGGAG
AGCGTGGCCGCCGCAGTCGTGGCGGGGCCCGGCCAGCGCGTGGACTGGCTGCCGGGCGCG
GTGCTGCACCCGCACGCCGGGGACGTGGTGTCGGACGCGGCACTGCCGCTGGTGATCGCC
GTGACCGGTGGCGACCGCCCGGTCGAGGGGGCCCACGAGGCCACCCGGTGGATGCTGGAC
CAGCTCCAGACCTGGCAGTCCGGGGCCCGGGAGCTCGTCGTGGTGACCTCGGGCGCGGTG
GCCGCCGGCCCCGACGAGTCGGTCACCGACCTGGGCGCCGCCGCGGTATGGGGCCTGGTG
CGTTCGGCGCAGGCGGAGAACCCCGGCCGGATCACCCTGGTCGACACCGACGCCGCCACC
GGCATGACGGCCGGCCTGCTGGCCGCCGCGCGCGCCACCGGGGAGCCGCAACTCGCGGTA
CGGGCGGGCCGGTTGCACGCGGCGCGGTTGGCGCGTGCGGATGTCGGGCTGGTGGCGCCG
GAGTCGGGTGCCTGGCACCTGGACTCCATGGCGAAGGGGACGTTGGAGAACCTGCGGTTG
GTGCCGTTCCCGGAGGCGGAGCGGGCGTTGTCCGACGGTGAGGTGCGGATCGAGGTGCGG
GCGGCGGGGTTGAACTTCCGCGACGTCCTCAACGCCCTGGGCATGTACCCGGGCGAGGCG
GGCCCGTTGGGCGGCGAGGTGGCCGGCGTGGTGACCGAGGTCGGCGCGGGCGTGTCCGAC
CTGCGGGTCGGCGACCGCGTCATGGGCCTGAGCGACGGCGGTCTCGGCTCCGTCACCGTG
ACCGACCGGCGGCTGGTCGCGCCGATCCCGTCGGGCTGGTCGTACACGACGGCCGCGTCG
GTGCCGACGGTCTTCCTGACCGCGTACTACGGACTGGTGGACCTGGCCGGGGTGCGGTCG
GGCGAGCGGGTGCTGGTGCACGCGGGCGCCGGCGGCGTCGGCATGGCCGCGCTGCAACTC
GTCGCGCACCTGGGCGCCGAGGCGTACACGACCGCGAGCGAGGGCAAGTGGCCGGCGCTG
CGGGAGCGGGGGGTGGAGGCGGCGCGTCTGGCGTCGTCGCGGACGCTGGACTTCGAGGAG
GCGTTCCTGCGGGAGACCGGGGGGCGCGGGGTGGACGTGGTGCTGAACTCCCTGACGGGG
GAGTTCATCGACGCGTCGCTGCGGTTGATGCCGGGTGGCGGCCGCTTCGTCGAGATGGGC
AAGGCCGACCTCCGCACCGACGAGCAGATCGGCGCCGTGCACCCGGGCATCAGCTACCAC
ACCTACGACCTGGTGCAGGCCGGGCCCGACCGGGTCCAGCAGATGTTGCTGGAGTTGGTG
GGGTTGTTCGAGTCGGGTGTGTTGGTGCCGTTGCCGGTGGTGGAGTGGGATGTGCGGCGG
GCGCCGGAGGCGTTCCGGTTCATGAGTCAGGCGCGGCATGTGGGCAAGATCGTGTTGACG
GTGGGTCGGCGGGTGGTGGGTGAGGGGGCGGTTCTGGTCACTGGGGGGACTGGTGGTCTG
GGGGGTGTGGTGGCGAGGCATCTGGTGGTGGAGCACGGGGTGCGGGATCTGGTGTTGGTG
TCGCGTCGGGGGTTGGGGGCGCCGGGTGCGGAGGAGTTGGTGGCGGAGCTTTCGGGTCGG
GGTGCTCGGGTGGAGGTGGTGGCGTGTGATGTGAGTGATCGTGAGGCGTTGGCGGGGGTG
GTGGCGGGGATGTGTGCGTCGGGTGTGTTGGCGGGTGTGGTGCATACGGCGGGTGTGGTG
GATGACGGGTTGGTGTCGTCGTTGTCGGGGGAGCGGTTGGGTCCGGTGTTGGCGCCGAAG
GTGGATGCGGGGTGGTGGCTGCATGAGTTGACGCGGGGGTTGGATCTGTCGTTGTTCGCG
GTGTTCTCGTCGATGTCGGGTCTGGTGGGGGCTCCGGGGCAGGGCAACTACGCGGCGGCG
AACGTGTTCCTGGACGCGTTGGTGGAGCGGCGTCGGAGTGAGGGGCTGCCGGGCGTGTCG
ATGGTCTGGGGTCCGTGGACCCCCGAGGTCGGCCTCACCGGCGCCCTGTCCGAGGCCGAT
CTCCGCCGGCTGCACAGCTCCGGTACGCCGCCGTTGTCGGTGGAGCAGGGCATGCGGCTG
TTCGACCAGGCCGTGCTCGCGGACGCGCCCGTCCTCGCGCTCACCCGCCTCGACGCCGCC
GTGCTGCGCGGCCAGGCCGACCTGCCCGTGATGCTCCGGGAACTGGTCGGGGCCAGGCCG
CGGCGGGCCGCGGCCGGCGCACGGCAGCAGTCCGGGGGCCTCGCGGGGCAGTTGGCCGGG
CTCAGTGCCCAGCAGCGCGACCAGCACCTGCTGGCCCTGGTCCGCGACAACGTCGCGGTC
GTCCTCGGCCACGGCGGCGGTCAGGACGTCGATCCCGGCCAGGCGTTCCGGGAGGCGGGC
TTCGACTCGCTGACGGCCGTGGAACTGCGCAACCGCCTCCAGAGCGCGACCGGCCTCGCA
CTGCCGGCCACGCTCGTCTTCGACTACCCCAACGCGACCCGGCTCGCCGCCTTCCTCGCC
GAGCAGTTCGGCGACGCCGCCGAGCCCGCCGCCCGGCCGGACCTGCCCGCGCTGGTCTCG
GTGACCGACGACCCGATCGTCGTCGTGGGCATGGCCTGCCGCTTCCCCGGCGGTGTGACC
GGCCCCGACGACCTGTGGGACCTGGTCGCCTCCGGCACGGACGCGATGTCCCCCTTCCCG
GCGGACCGCGGCTGGGACCTGGACGGCCTCCACGACCCGACGGGCACCCGCCCGAACACG
TCCGTGGCCGACGAGGGCGGGTTCCTGGCCTCCGCCGCCGACTTCGACGCCGGGTTCTTC
GGGATCTCCCCGCGCGAGGCGCTGGCGATGGACCCGCAGCAGCGCATGGTCCTCGAAGTG
GCCTGGGAGGCGCTGGAGCACGCGGGCATCGACCCGACCGGACTCGGCGGCACCCCGGCC
GGCGTCTTCGTCGGCAGCTACCACTCCGGCTACAGCGACCTCGTCGTGGAGTCCGGCGGC
GACGCGCAGGCCCAACTGCTCACCGGCGCCGCGCAGAGCGTGCTGTCCGGGCGGGTCTCC
TACGTCCTCGGGCTGGAGGGCCCGGCGGTGACGGTGGACACCGCGTGCTCGTCGTCGCTC
GTCGCGATGCACCTGGCGAGCCAGTCGCTGCGCTCGGGCGAGAGCACGCTCGCGCTGGCG
GGCGGCGTGACCGTGATGGCCACCCCCGGGACGTTCGTGGAGTTCAGCCGGCAGGGCGGG
CTCGCGGCCGACGGGCGCTGCAAGGCGTTCGCCGAGTCCGCCGACGGCACCGGCTGGTCC
GAGGGCGCGGGCATCGTGGTGCTGGAGCGGTTGTCGGACGCGGAGCGGAACGGGCATCGG
GTGCTGGCGGTCATGCGCTCCAGCGCGGTGAACCAGGACGGTGCGTCGAACGGGTTGACG
GCGCCGAACGGTCCGTCGCAGCAGCGGGTGATCCGCCAGGCGCTGGCCGCCGCGGGGCTC
TCACCGGCCGACGTGGACGCCGTGGAGGCGCACGGCACCGGCACCTCGCTGGGCGACCCG
ATCGAGGCACAGGCGGTGCTGGCCGCCTACGGACAGGACCGCCCCGAGGACCGGCCGCTC
TGGCTCGGCTCGGTCAAGTCCAACCTGGGCCACACGCAGGCGGCGGCCGGTGTCGTGGGC
GCCATCAAGATGGTGCAGGCGCTGCGTCACGGGGTGCTGCCCCGGACCCTGCACGTGGAC
GAGCCGAGCACGCACGTGGACTGGGGCCAGGGCCGGGTGCGGTTGCTGACGGAGTCGGTG
CCGTGGCCGGAGAACGGGCACCCGCGGCGGGCGGGTGTCTCCTCGTTCGGGATCTCGGGG
ACGAACGCGCACGTGATCTTGGAGGCGGCTCCCGCGGTGGAGTCCGAGGTCGAGGCGCGG
GTCGAGGTCGCGGGAGAGGCTGGGGCCGAGTCCGAGTCCGGGTCGGGGTCGGTGTGGGTG
GTGTCGGGTCGTTCGGAGGGGGCGTTGCGGGCGCAGGCGGAGCGGTTGTTGTCTGTGGCC
GAGGGGCTGGATCCGGTGGATGTGGGTGGGGCGTTGTTGTCGCGGTCGGTGTTCGAGCAC
CGTGCGGTGGTGGTGGGCAGTGGGCGTGAGGAACTGACGGCGGGGTTGCGGGCGTTGGCG
GCCGGTGAGGTGGCGGGCAACGCGGTGGAGGGTGTGGCGCGGAGCGGCCGCCGGGTGGCG
GTGTTGTTCGCGGGTCAGGGTGCGCAGCGGCTGGGAATGGGCCGCCGGCTGCACGAGGAG
TCGCCGGTGTTCGCGGCGGCCTTCGACGAGGTGGTGGCGGAGTTGGACCGGCACCTCGAG
GCGCCGTTGCGGGAGGTGCTGTGGGGCGAGGACGCCGAGGCGTTGAACTCCACCGGTTGG
GCGCAGCCGGCGTTGTTCGCCGTGGAAGTGGCGCTGTTCCGGCTGCTCGAATCCTTCGGC
GTCACACCGGATTACCTGCTGGGGCACTCCATCGGTGAGGTGGCCGCGGCTTACGTCGCC
GGGGTGTTCGATCTGGTGGATGCGTGCCGGTTGGTGGCCGCGCGGGCCCGTTTGATGCAG
CAGCTTCCCTCGGGTGGGGCGATGGTGGCCATCGCCGCTTCCGAGGACGACGTGCTGCCG
CTCTTGTCGGACGGGGTCTCTGTCGCGGCGGTGAACGCGCCGGGTTCGGTGGTGGTCTCC
GGTGAGGAGGGCGCTGTGCTCGCGGTCGGTGAGCATTTCAAGGCGTTGGGGGTGAAGACG
ACCCGGCTGCGGGTGTCGCACGCCTTCCATTCGGCGTTGATGGAGCCGATGGTGGACGAC
TTCCTGGCGGCGATCGCGGAGGTGTCGTTCTCCGAGCCGCGGATCCCGGTGGTGTCGAAT
CTGACGGGTGAGCCGGCGGACATGACGTCGCCGAAGTACTGGGCGCAGCAGGTGCGTTCG
GCGGTCCGCTTCGCGGACGGACTGGCGTGGCTGACCGCGCAGGGTGTGGACGTGTTCGTG
GATGCGGGTCCTGATGGTGTGGTGGCGGGTCTGGCGCAGGCGAACGCGTCGGATGCGGTG
GCGGTGGCGTTGATGCGCAAGGACCGTGGGGGTCTGGACACGGCGTTGCTGGCCGCTGGT
GACCTGTTCGTGCACGGGGTGCCGGTGGAGTGGGCGGGTCTGGTCGGTGGGCGGGGGGCG
GAGTGGGTCGAGCTGCCGACGTACGCCTTCCAGCGCCGCCGCTACTGGCCCGACGCGGCT
GTTCCGACGACGGGTCAGGAGCCGGGCCGCGACCCGCTGGACGCGCTGTTCTGGGAATCC
GTCGAGCACGGGCGGCTGGCCGAGTCGCTGGGTGTCGACGACGCCGCGGTCTCGGGCGTC
GTGCCCGCCCTGCTGGACTGGCGCGAGCGGCGCCGCCGCGAGATGGCGGCCGACGACTGG
CGCTACGACCAGCGCTGGGTCCCGGTCGACGGTGTCCCGCGCGGCGCCACGGCGGACCGC
CGGCTGGTGGTCGTGCCCGCCGGGGCGGACGCCTGGACCCGCGGAGTCGTGGACGCGCTG
GGCGACGGCGTGACCGTCCTGGAGGCCGAGGCGGCGGACGCGGACCGGCTGGCCGCCGAG
GGCGCGGAGTGCACCGCCGTGGTGTGGCTGCCGCCCGCCGAGGAGTCCGGGGTCGCGGCG
ACGCTGCGCCTGGTCCAGGAACTGCGCGGGGCCGGGGTGCCGGCTCCCCTGTGGGTGGTC
ACCCGCGGCGCGGTCGCCGCCCGGCCGGACGACCGGGTCGACGGCGTCTGGCACGGCGGT
GTCTGGGGCCTCGGCCGTGTCGCGGCCCTCGAACTGCCCGACCTGTGGGGCGGGTTGGTG
GACCTGCCCGAGGAGGTGGACGGGACGGTGGCAGCCCGGCTGTCGGGCGTGCTGTCCGGC
GGCCACGGCGAGGACCAGCTCGCCGTCCGTGCCTCGGGCGTCCTCGCCCGCCGACTGGTC
CACGCGACCGGCCGGGACGGCGCCGCGGAGCCGTGGCGTACCGGCGGGACGGCGATCGTC
ACCGGCGGGACCGGCGGTCTGGGCGGCCGCGTGGCCCGCTGGCTGGTGGACCGCGGCGCC
GAGCACCTGGTGCTGCTCTCGCGCCGGGGCGCCGACGCCCCCGGGACCGCGGACCTCACG
GCGGGGCTCGAAGCCGCGGGCGCCCGGGTCACGGTGGTCGCCGGCGACGTGGCCGACCGG
GCGGTGCTGGCCGAGGCGTTCGCCGCGGTGCCGGCGGACCTGCCGCTGCGGACGGTGGTG
CACGCCGCGGGCGTGGGCAACGCGTTCACGCCGTTGGAGTCCATGACGCCCGAGCGGCTC
GCGGACGAGCTGCGGGTCAAGGCCGGCGGCGCGCTGCTGCTGGACGAGTTGACCGAGGGC
ATGGACCTGGACGCGTTCGTGCTGTTCTCGTCGGGTGCGGCGTCCTGGGGCGGCAGCGGG
CAGGGCGGTTACGCGGCGGGCAACGCCTGCCTGGACAGCCTGGCCGAGTACCGGCGGGCC
CGGGGCCGTACCGCCACGTCGGTGGCCTGGGGCACCTGGGCCGAGGTCGGGATGGCCGCG
GGCAGTTCCGACGGCCACGACCACCTGGCGCGCCTGGGCGTCTCCGCCATGGCGCCCGAC
CTCGCGATCATCGCTCTGCAACGGGTGATCGAGGACGACGCGGCCACGGCCACCGTCTCC
GCCATGGACTGGTCCACCTTCGCCCCGGCGTTCACCCTGGCGCGCCCCAGCAACCTCTTC
GCCCTGCTTCCCGAGGCCGTCCCGGCGGCCCCGGACGCGGCCGAGGCGGACACCGGGTTC
GCTCAGCACCTCGCGGCGCTGCCGGACGAGGAGCGGCGCGAGGAACTGCTCGCCCTGGTC
CGGGAGCACACCGCGGCCGTGCTCGGCCACGACAGCGCCAGGGACGTCGATCCCGCCCAG
GCGTTCCGCGACGCCGGGTTCGACTCGCTCACCGCGGTCGAGCTGCGCAACCGGTTGCAG
CGGCGTACCGGGCTCGCGCTCCCCGCGACGCTCGTCTTCGACCACCCGAACCCGAACCGG
CTCGTCGACCACCTGGCCGGGGAACTGGTCGGCGGCGGGGACGCGGCGGGCGGACTGGAC
GAGCTGAGGGACCGGTTGCAGACGTTCGCCGCCGACCCGGCGGTCCGCGAGGACCTGGAG
GCGATGCTGCGCCAGGTGCTCGGCGCCGTCGAGGACGCGACCGCCGCGCAGCGCGGCGAC
ATCGACGCCGCCTCCGACGAGGAGCTGTTCTCCATGGTCGACCAGGGGAGCAGTTGGATG
TCCGATTCTTCGTCGACCGCCGACCACGAGTGA
[4] KS37..413
[4] AT578..900
[4] butylmalonyl-CoA isopentylmalonyl-CoA pentylmalonyl-CoA hexylmalonyl-CoA769..773
[4] KR1181..1361
[4] ACP1462..1532
[5] KS1554..1929
[5] AT2122..2426
[5] malonyl-CoA2307..2311
[5] DH2474..2639
[5] ER2953..3259
[5] KR3269..3449
[5] ACP3546..3620
[6] KS3644..4020
[6] AT4182..4488
[6] malonyl-CoA4367..4371
[6] KR4776..4956
[6] ACP5052..5126
[4] KS109..1239
[4] AT1732..2700
[4] butylmalonyl-CoA isopentylmalonyl-CoA pentylmalonyl-CoA hexylmalonyl-CoA2305..2319
[4] KR3541..4083
[4] ACP4384..4596
[5] KS4660..5787
[5] AT6364..7278
[5] malonyl-CoA6919..6933
[5] DH7420..7917
[5] ER8857..9777
[5] KR9805..10347
[5] ACP10636..10860
[6] KS10930..12060
[6] AT12544..13464
[6] malonyl-CoA13099..13113
[6] KR14326..14868
[6] ACP15154..15378

close this sectionFeature

BLASTP
Database:UniProtKB:2011_09 		show BLAST table
InterPro
Database:interpro:38.0
IPR001227 Acyl transferase domain (Domain)
[567-702] G3DSA:3.40.366.10 [769-889] G3DSA:3.40.366.10 [2110-2242] G3DSA:3.40.366.10 [2307-2416] G3DSA:3.40.366.10 [4170-4302] G3DSA:3.40.366.10 [4367-4476] G3DSA:3.40.366.10
G3DSA:3.40.366.10   Ac_transferase_reg
IPR006162 Phosphopantetheine attachment site (PTM)
[1490-1505] PS00012 [3578-3593] PS00012 [5084-5099] PS00012
PS00012   PHOSPHOPANTETHEINE
IPR009081 Acyl carrier protein-like (Domain)
[1462-1536] 7.40000000000007e-68 G3DSA:1.10.1200.10 [3548-3624] 7.40000000000007e-68 G3DSA:1.10.1200.10 [5053-5129] 7.40000000000007e-68 G3DSA:1.10.1200.10
G3DSA:1.10.1200.10   ACP_like
[1462-1532] PS50075 [3546-3620] PS50075 [5052-5126] PS50075
PS50075   ACP_DOMAIN
[1466-1531] 1.2e-11 PF00550 [3554-3619] 1.4e-09 PF00550 [5060-5125] 1.1e-13 PF00550
PF00550   PP-binding
[1455-1570] 7.10001443313147e-29 SSF47336 [3543-3660] 2.39999798157265e-26 SSF47336 [5047-5133] 9.00000407957274e-25 SSF47336
SSF47336   ACP_like
IPR011032 GroES-like (Domain)
[2947-3099] 1.39999892049878e-32 SSF50129
SSF50129   GroES_like
IPR013154 Alcohol dehydrogenase GroES-like (Domain)
[2973-3028] 3.3e-07 PF08240
PF08240   ADH_N
IPR013968 Polyketide synthase, KR (Domain)
[1181-1360] 2.70000000000002e-58 PF08659 [3269-3447] 1.70000000000001e-58 PF08659 [4776-4956] 1.80000000000002e-58 PF08659
PF08659   KR
IPR014030 Beta-ketoacyl synthase, N-terminal (Domain)
[37-288] 1.69999999999998e-93 PF00109 [1554-1803] 2.39999999999997e-89 PF00109 [3644-3894] 2.70000000000002e-93 PF00109
PF00109   ketoacyl-synt
IPR014031 Beta-ketoacyl synthase, C-terminal (Domain)
[296-413] 3.5e-50 PF02801 [1811-1929] 1.70000000000001e-47 PF02801 [3902-4020] 1.2e-47 PF02801
PF02801   Ketoacyl-synt_C
IPR014043 Acyl transferase (Domain)
[578-900] 2.70000000000002e-89 PF00698 [2122-2426] 1e-61 PF00698 [4182-4488] 7.79999999999999e-62 PF00698
PF00698   Acyl_transf_1
IPR015083 Polyketide synthase, docking (Domain)
[7-30] 5.39999999999999e-05 PF08990
PF08990   Docking
IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase (Domain)
[576-862] 3.70001063537244e-63 SSF52151 [2117-2421] 1.59998835313644e-72 SSF52151 [4177-4481] 1.3000049540733e-70 SSF52151
SSF52151   Acyl_Trfase/lysoPlipase
IPR016036 Malonyl-CoA ACP transacylase, ACP-binding (Domain)
[705-769] 2.59999946718995e-12 SSF55048 [2244-2306] 4.60000044330862e-17 SSF55048 [4304-4366] 2.70000183580794e-17 SSF55048
SSF55048   Malonyl_transacylase_ACP-bd
IPR016038 Thiolase-like, subgroup (Domain)
[36-299] G3DSA:3.40.47.10 [302-467] G3DSA:3.40.47.10 [1553-1814] G3DSA:3.40.47.10 [1817-1981] G3DSA:3.40.47.10 [3643-3905] G3DSA:3.40.47.10 [3908-4072] G3DSA:3.40.47.10
G3DSA:3.40.47.10   Thiolase-like_subgr
IPR016039 Thiolase-like (Domain)
[29-412] 3.30001976117415e-101 SSF53901 [1546-1981] 3.99998544139406e-101 SSF53901 [3636-4018] 1.50000965748778e-102 SSF53901
SSF53901   Thiolase-like
IPR016040 NAD(P)-binding domain (Domain)
[1179-1401] 1.29999999999998e-102 G3DSA:3.40.50.720 [3089-3183] 4.2e-16 G3DSA:3.40.50.720 [3270-3485] 1.29999999999998e-102 G3DSA:3.40.50.720 [4774-5000] 1.29999999999998e-102 G3DSA:3.40.50.720
G3DSA:3.40.50.720   NAD(P)-bd
IPR018201 Beta-ketoacyl synthase, active site (Active_site)
[200-216] PS00606 [1716-1732] PS00606 [3807-3823] PS00606
PS00606   B_KETOACYL_SYNTHASE
IPR020801 Polyketide synthase, acyl transferase domain (Domain)
[580-881] 1.90000694315261e-88 SM00827 [2122-2407] 4.60000044330866e-120 SM00827 [4182-4469] 2.39999798157263e-117 SM00827
SM00827   PKS_AT
IPR020806 Polyketide synthase, phosphopantetheine-binding domain (Domain)
[1463-1535] 7.40000780398342e-35 SM00823 [3551-3623] 4.10001399699315e-33 SM00823 [5057-5129] 4.50001022902825e-36 SM00823
SM00823   PKS_PP
IPR020807 Polyketide synthase, dehydratase domain (Domain)
[2474-2639] 6.80004680300024e-82 SM00826
SM00826   PKS_DH
IPR020841 Polyketide synthase, beta-ketoacyl synthase domain (Domain)
[39-466] SM00825 [1556-1981] SM00825 [3646-4072] SM00825
SM00825   PKS_KS
IPR020842 Polyketide synthase/Fatty acid synthase, KR (Domain)
[1181-1361] 7.79998304125571e-50 SM00822 [3269-3449] 1.10000150671643e-55 SM00822 [4776-4956] 5.20000089003336e-49 SM00822
SM00822   PKS_KR
IPR020843 Polyketide synthase, enoylreductase (Domain)
[2953-3259] SM00829
SM00829   PKS_ER
SignalP No significant hit
TMHMM No significant hit
Rever_00100 Rever_00100   Rever_00120 Rever_00120
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