Reveromycin : Cluster information
Compound
| Entry name | Reveromycin |
|---|---|
| PKS Type | TypeI modular |
| Starter Unit | methylmalonyl-CoA |
| Chain Length | 13 |
| Sugar Unit | none |
| Classification | Spiroacetal structure |
| Activity | Antifungal Antiosteoclastic |
| Composition | reveromycin A: C36H52O11 |
Original source
| Organism | Streptomyces sp. |
|---|---|
| Strain | SN-593 |
| Contig | AB568601 |
PKS/NRPS Module
| Rever_00230 revC | 0 |  | methylmalonyl-CoA |
| 1 |  | malonyl-CoA | |
| 2 |  | methylmalonyl-CoA | |
| 3 | | malonyl-CoA | |
| Rever_00110 revA | 4 |  | butylmalonyl-CoA isopentylmalonyl-CoA pentylmalonyl-CoA hexylmalonyl-CoA |
| 5 |  | malonyl-CoA | |
| 6 | | malonyl-CoA | |
| Rever_00120 revB | 7 | | methylmalonyl-CoA |
| 8 | | malonyl-CoA | |
| Rever_00240 revD | 9 | | methylmalonyl-CoA |
| 10 | | malonyl-CoA | |
| 11 | | methylmalonyl-CoA | |
| 12 |  | malonyl-CoA |
Reference
- Reveromycin A biosynthesis uses RevG and RevJ for stereospecific spiroacetal formation.
- Takahashi S, Toyoda A, Sekiyama Y, Takagi H, Nogawa T, Uramoto M, Suzuki R, Koshino H, Kumano T, Panthee S, Dairi T, Ishikawa J, Ikeda H, Sakaki Y, Osada H[PMID: 21642985]Nat Chem Biol. 7 (2011) 461-8
- Structure-function analyses of cytochrome P450revI involved in reveromycin A biosynthesis and evaluation of the biological activity of its substrate, reveromycin T.
- Takahashi S, Nagano S, Nogawa T, Kanoh N, Uramoto M, Kawatani M, Shimizu T, Miyazawa T, Shiro Y, Osada H[PMID: 25258320]J Biol Chem. 289 (2014) 32446-58
- Chemical and biological studies of reveromycin A.
- Osada H[PMID: 27270304]J Antibiot (Tokyo). 69 (2016) 723-730
Data download
| Compound name | Genomic nucleotide sequence |
Nucleotide sequences of the coding regions | Translation of the coding sequences | List of genes/ORFs | GBK | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
 Reveromycin |
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History
- 2016-12-27[Update]
- 2016-01-27[Update]
- 2013-09-04[Release]
