Calm_00470 Calm_00470   Calm_00490 Calm_00490

Calm_00480 : CDS information

close this sectionLocation

Organism
StrainNRRL 15839
Entry nameCalicheamicin
Contig
Start / Stop / Direction56,411 / 56,959 / + [in whole cluster]
56,411 / 56,959 / + [in contig]
Location56411..56959 [in whole cluster]
56411..56959 [in contig]
TypeCDS
Length549 bp (182 aa)
Click on the icon to see Genetic map.

close this sectionAnnotation

Category4.4 resistance
Productcalicheamicin resistance protein
Product (GenBank)CalU16
Gene
Gene (GenBank)calU16
EC number
Keyword
Note
Note (GenBank)
Reference
ACC
PmId
[12183629] The calicheamicin gene cluster and its iterative type I enediyne PKS. (Science. , 2002)
[25079510] Structure-guided functional characterization of enediyne self-sacrifice resistance proteins, CalU16 and CalU19. (ACS Chem Biol. , 2014)
comment
[PMID: 12183629](2002)
calicheamicin生合成遺伝子クラスターの報告

このORFは、Fig2の生合成clusterにて、unknown function(U1 to U22)と示されているのみ。本文中では特にふれていない。

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[PMID: 25079510](2014)
構造ゲノム科学と生化学的特徴づけを用いたCalU16 と CalU19の機能解明。
CalCと類似した構造であり、同様に自己犠牲となるenediyne耐性タンパクである。

close this sectionSequence

selected fasta
>calicheamicin resistance protein [CalU16]
MASGQATERALGRRTIPAGEARSIIIRQRYDAPVDEVWSACTDPNRINRWFIEPKGDLRE
GGNFALQGNASGDILRCEPPRRLTISWVYEGKPDSEVELRLSEEGDGTLLELEHATTSEQ
MLVEVGVGWEMALDFLGMFIRGDLPGGPVPEDAAEEFEPSPEMMRISQERGEAWAALVHS
GS
selected fasta
>calicheamicin resistance protein [CalU16]
GTGGCGTCAGGTCAGGCGACGGAGCGTGCCCTCGGCCGGCGCACCATCCCGGCCGGCGAG
GCCCGCAGCATCATCATCCGGCAACGGTACGACGCGCCCGTCGACGAGGTCTGGAGCGCC
TGCACCGACCCGAACCGCATCAACCGCTGGTTCATCGAGCCCAAGGGCGACCTCCGCGAG
GGTGGCAACTTCGCCCTGCAGGGCAACGCCAGCGGCGACATCCTGCGCTGCGAGCCACCG
CGCCGGCTCACCATCAGCTGGGTGTACGAGGGCAAGCCGGACAGCGAGGTGGAGCTGCGG
CTGAGCGAGGAGGGCGACGGCACCCTGCTGGAGCTGGAGCACGCCACGACCTCGGAGCAG
ATGCTCGTGGAGGTCGGCGTCGGCTGGGAGATGGCGCTCGACTTCCTCGGTATGTTCATC
CGGGGCGACCTGCCGGGCGGCCCGGTCCCGGAGGACGCGGCCGAGGAGTTCGAGCCGAGC
CCCGAGATGATGCGGATCTCGCAGGAGCGCGGCGAGGCCTGGGCCGCGCTGGTCCACTCC
GGCTCGTAG

close this sectionFeature

BLASTP
Database:UniProtKB:2011_09 		show BLAST table
InterPro
Database:interpro:38.0
IPR013538 Activator of Hsp90 ATPase homologue 1-like (Family)
[31-137] 1.8e-22 PF08327
PF08327   AHSA1
IPR023393 START-like domain (Domain)
[20-140] 1.99999999999999e-31 G3DSA:3.30.530.20
G3DSA:3.30.530.20   G3DSA:3.30.530.20
SignalP No significant hit
TMHMM No significant hit
Calm_00470 Calm_00470   Calm_00490 Calm_00490
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