遺伝子 : 4-hydroxyphenylacetate 3-monooxygenase oxygenase component (HPAB1)

遺伝子情報

ID	NRULE_0085
遺伝子ID	HPAB1
作成日	2012/11/21
タンパク質名	Protein name Full 4-hydroxyphenylacetate 3-monooxygenase oxygenase component EC EC 1.14.14.9 Synonym Full 4-HPA 3-hydroxylase 4-HPA 3-monooxygenase large component
遺伝子名	hpaB
遺伝子条件	TIGRFAMs; TIGR02310; hit=1
参照	Gene Ontology GO GO:0052881, F:4-hydroxyphenylacetate 3-monooxygenase activity, IEA:EC GO:0003995, F:acyl-CoA dehydrogenase activity, IEA:InterPro GO:0050660, F:flavin adenine dinucleotide binding, IEA:InterPro GO:0010124, P:phenylacetate catabolic process, IEA:InterPro Phylogenomic databases KO K00483, - Enzyme and pathway databases UniPathway UPA00208, UER00416 Family and domain databases InterPro IPR006091, Acyl-CoA_Oxase/DH_cen-dom IPR009075, AcylCo_DH/oxidase_C IPR009100, AcylCoA_DH/oxidase IPR024677, HpaB/PvcC IPR004925, HpaB/PvcC/4-BUDH IPR024719, HpaB/PvcC/4-BUDH_C IPR024674, HpaB/PvcC/4-BUDH_N IPR012688, HpaB_gammaproteobact Pfam PF03241, HpaB, 1 PF11794, HpaB_N, 1 TIGRFAMs TIGR02310, HpaB-2, 1
配列の特徴	該当データなし
注釈	Function Utilizes FADH(2) supplied by HpaC or by another flavin reductase, to catalyze the hydroxylation of 4-hydroxyphenylacetic acid, leading to the production of 3,4-DHPA. Can also oxidize phenol to catechol, and hydroxylate other phenol derivatives Catalytic activity 4-hydroxyphenylacetate + FADH(2) + O(2) = 3,4-dihydroxyphenylacetate + FAD + H(2)O Pathway Aromatic compound metabolism; 4-hydroxyphenylacetate degradation; pyruvate and succinate semialdehyde from 4-hydroxyphenylacetate: step 1/7 Subunit structure 4-HPA 3-monooxygenase consists of a reductase component HpaC and an oxygenase component HpaB Sequence similarities Belongs to the FADH(2)-utilizing monooxygenase family
参考文献	Q57160 Escherichia coli. 8077235 Molecular characterization of 4-hydroxyphenylacetate 3-hydroxylase of Escherichia coli. A two-protein component enzyme. (J Biol Chem. 1994) 8550403 Molecular characterization of the 4-hydroxyphenylacetate catabolic pathway of Escherichia coli W: engineering a mobile aromatic degradative cluster. (J Bacteriol. 1996) 10653707 Characterization of 4-hydroxyphenylacetate 3-hydroxylase (HpaB) of Escherichia coli as a reduced flavin adenine dinucleotide-utilizing monooxygenase. (Appl Environ Microbiol. 2000)

関与する機能

機能名
4-hydroxyphenylacetate degradation

該当CDS

学名	NBRC番号	CDS	タンパク質名
Enterobacter aerogenes	13534	EAE_10315	4-hydroxyphenylacetate 3-monooxygenase, oxygenase subunit
Enterobacter cloacae subsp. cloacae	13535	ECL_00750	4-hydroxyphenylacetate-3-hydroxylase large chain
Enterobacter hormaechei	105718	HMPREF9086_1894	4-hydroxyphenylacetate 3-monooxygenase oxygenase component
Escherichia coli	3972	EcolC_3710	4-hydroxyphenylacetate 3-monooxygenase, oxygenase subunit
Escherichia coli	13500	WFL_22920	4-hydroxyphenylacetic hydroxylase
Escherichia fergusonii	102419	EFER_3070	4-hydroxyphenylacetate 3-monooxygenase large component
Providencia alcalifaciens	105687	PROVALCAL_00324	4-hydroxyphenylacetate 3-monooxygenase, oxygenase component
Serratia odorifera	102598	HMPREF0758_0649	4-hydroxyphenylacetate 3-monooxygenase, oxygenase component
Shimwellia blattae	105725	EB105725_26_00210	putative 4-hydroxyphenylacetate 3-monooxygenase oxygenase component