遺伝子 : 4-hydroxyphenylacetate 3-monooxygenase oxygenase component (HPAB2)

遺伝子情報

ID	NRULE_0086
遺伝子ID	HPAB2
作成日	2012/11/21
タンパク質名	Protein name Full 4-hydroxyphenylacetate 3-monooxygenase oxygenase component EC EC 1.14.14.9 Synonym Full 4-HPA 3-hydroxylase 4-HPA 3-monooxygenase large component
遺伝子名	hpaB
遺伝子条件	TIGRFAMs; TIGR02309; hit=1
参照	Gene Ontology GO GO:0052881, F:4-hydroxyphenylacetate 3-monooxygenase activity, IEA:EC GO:0003995, F:acyl-CoA dehydrogenase activity, IEA:InterPro GO:0050660, F:flavin adenine dinucleotide binding, IEA:InterPro GO:0010124, P:phenylacetate catabolic process, IEA:InterPro Phylogenomic databases eggNOG COG2368, - HOGENOM HOG000145842, - KO K00483, - Enzyme and pathway databases UniPathway UPA00208, UER00416 Family and domain databases InterPro IPR006091, Acyl-CoA_Oxase/DH_cen-dom IPR009075, AcylCo_DH/oxidase_C IPR009100, AcylCoA_DH/oxidase IPR004925, HpaB/PvcC/4-BUDH IPR024719, HpaB/PvcC/4-BUDH_C IPR024674, HpaB/PvcC/4-BUDH_N IPR012687, HpaB_Deino-type Pfam PF03241, HpaB, 1 PF11794, HpaB_N, 1 TIGRFAMs TIGR02309, HpaB-1, 1
配列の特徴	該当データなし
注釈	Function Utilizes FADH(2) supplied by hpaC, to catalyze the hydroxylation of 4-hydroxyphenylacetic acid, leading to the production of 3,4-dihydroxyphenylacetic acid (DHPA) Catalytic activity 4-hydroxyphenylacetate + FADH(2) + O(2) = 3,4-dihydroxyphenylacetate + FAD + H(2)O Pathway Aromatic compound metabolism; 4-hydroxyphenylacetate degradation; pyruvate and succinate semialdehyde from 4-hydroxyphenylacetate: step 1/7 Subunit structure 4-HPA 3-monooxygenase consists of a reductase component HpaC and an oxygenase component HpaB Sequence similarities Belongs to the FADH(2)-utilizing monooxygenase family
参考文献	Q5SJP8 Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579). 17804419 Crystal structure of the oxygenase component (HpaB) of the 4-hydroxyphenylacetate 3-monooxygenase from Thermus thermophilus HB8. (J Biol Chem. 2007) Q4L1M7 Geobacillus sp. (strain PA-9). 17805928 Cloning and characterization of a 4-hydroxyphenylacetate 3-hydroxylase from the thermophile Geobacillus sp. PA-9. (Curr Microbiol. 2007)

関与する機能

機能名
4-hydroxyphenylacetate degradation

該当CDS

学名	NBRC番号	CDS	タンパク質名
Acaricomes phytoseiuli	107788	C501_01025	MFS transporter
Alicyclobacillus acidocaldarius subsp. acidocaldarius	15652	Aaci_0339	4-hydroxyphenylacetate 3-monooxygenase, oxygenase subunit
Amycolatopsis azurea	14573	C791_5126	4-hydroxyphenylacetate 3-monooxygenase
Arthrobacter globiformis	12137	ARGLB_096_00280	4-hydroxyphenylacetate-3-hydroxylase
Bacillus amyloliquefaciens	15535	BAMF_0207	putative 4-hydroxyphenylacetate-3-hydroxylase
Bacillus psychrosaccharolyticus	101233	WYK_156_00320	4-hydroxyphenylacetate-3-hydroxylase
Bacillus subtilis	3134	BSU6633_05964	putative 4-hydroxyphenylacetate-3-hydroxylase
Bacillus subtilis subsp. subtilis	13719	BSU18620	putative 4-hydroxyphenylacetate-3-hydroxylase
Beutenbergia cavernae	16432	Bcav_0870	4-hydroxyphenylacetate 3-monooxygenase, oxygenase subunit
Deinococcus proteolyticus	101906	Deipr_2619	4-hydroxyphenylacetate 3-monooxygenase, oxygenase subunit
Halobacillus halophilus	102448	HBHAL_2383	4-hydroxyphenylacetate-3-hydroxylase
		HBHAL_3970	4-hydroxyphenylacetate-3-hydroxylase
Kyrpidia tusciae	15312	Btus_1571	4-hydroxyphenylacetate 3-monooxygenase, oxygenase subunit
Meiothermus ruber	106122	Mrub_1332	4-hydroxyphenylacetate 3-monooxygenase, oxygenase subunit
Meiothermus silvanus	106475	Mesil_2312	4-hydroxyphenylacetate 3-monooxygenase, oxygenase subunit
Thermus thermophilus	101084	TTHA0960	4-hydroxyphenylacetate-3-hydroxylase
Thermus thermophilus	101085	TT_C0594	4-hydroxyphenylacetate 3-monooxygenase