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Rule : Metallothiol transferase FosB (FOSB)

Rule Description

ID NRULE_0099
Rule name FOSB
Created 2012-12-07
Protein name
Protein name
Full
Metallothiol transferase FosB
EC
EC 2.5.1.-
Synonym
Full
Fosfomycin resistance protein
Gene name fosB
Rule Trigger HAMAP; MF_01512; hit=1
Cross Reference
Gene Ontology
GO
GO:0005737, C:cytoplasm, IEA:UniProtKB-SubCell
GO:0046872, F:metal ion binding, IEA:UniProtKB-KW
GO:0016765, F:transferase activity, transferring alkyl or aryl (other than methyl) groups, IEA:InterPro
GO:0046677, P:response to antibiotic, IEA:UniProtKB-KW
Phylogenomic databases
KO
K11210, -
Family and domain databases
HAMAP
MF_01512, FosB, 1, -
InterPro
IPR004360, Glyas_Fos-R_dOase_dom
IPR022858, Metallothiol_Trafse_FosB
Pfam
PF00903, Glyoxalase, 1
Feature
O31817 Bacillus subtilis (strain 168).
METAL8Magnesium (By similarity).
METAL67Magnesium (By similarity).
METAL116Magnesium (By similarity).
General annotation
Function
Metallothiol transferase which confers resistance to fosfomycin by catalyzing the addition of a thiol cofactor to fosfomycin. L-cysteine is probably the physiological thiol donor
Cofactor
Magnesium
Subunit structure
Homodimer
Subcellular location
Cytoplasm (By similarity)
Sequence similarities
Belongs to the fosfomycin resistance protein family. FosB subfamily
Reference
O31817 Bacillus subtilis (strain 168).
11244082
FosB, a cysteine-dependent fosfomycin resistance protein under the control of sigma(W), an extracytoplasmic-function sigma factor in Bacillus subtilis. (J Bacteriol. 2001)
Q03377 Staphylococcus epidermidis.
2341025
Nucleotide sequence of the fosB gene conferring fosfomycin resistance in Staphylococcus epidermidis. (FEMS Microbiol Lett. 1990)



Related Function

Function name
Fosfomycin resistance

CDS

Data Download
Scientific name NBRC No. CDS Product name
Bacillus amyloliquefaciens15535BAMF_1189metallothiol transferase
Bacillus atrophaeus13721BATRMS_01_00220fosfomycin resistance protein FosB
Bacillus cereus15305BC_2027Fosfomycin resistance protein
Bacillus licheniformis12200BL03635putative metallothiol transferase Fosfomycin resistance protein
Bacillus licheniformis12195BLi01518metallothiol transferase FosB
Bacillus mojavensis15718GYU_26_00500fosfomycin resistance protein FosB
Bacillus mycoides101228bmyco0001_18180Metallothiol transferase fosB
Bacillus pseudomycoides101232bpmyx0001_18210Metallothiol transferase fosB
Bacillus psychrosaccharolyticus101233WYK_032_00110fosfomycin resistance protein FosB
Bacillus subtilis3134BSU6633_07851fosfomycin resistance protein FosB
Bacillus subtilis subsp. subtilis13719BSU17840metallothiol transferase
Bacillus vallismortis101236BvalD_010100016312fosfomycin resistance protein FosB
Brevibacillus brevis100599BBR47_44100probable fosfomycin resistance protein
Halobacillus halophilus102448HBHAL_1577fosfomycin resistance protein FosB
Paenibacillus alvei3343PAV_6c03910metallothiol transferase FosB
Paenibacillus polymyxa15309PPT_11120fosmidomycin resistance protein
Staphylococcus epidermidis12993SE_0231fosfomycin resistance protein fofB
Staphylococcus saprophyticus subsp. saprophyticus102446SSP1926fosfomycin resistance protein