| ID |
NRULE_0099 |
| Rule name |
FOSB |
| Created |
2012-12-07 |
| Protein name |
Protein name
- Full
- Metallothiol transferase FosB
- EC
- EC 2.5.1.-
Synonym
- Full
- Fosfomycin resistance protein
|
| Gene name |
fosB |
| Rule Trigger |
HAMAP; MF_01512; hit=1 |
| Cross Reference |
Gene Ontology
- GO
- GO:0005737, C:cytoplasm, IEA:UniProtKB-SubCell
- GO:0046872, F:metal ion binding, IEA:UniProtKB-KW
- GO:0016765, F:transferase activity, transferring alkyl or aryl (other than methyl) groups, IEA:InterPro
- GO:0046677, P:response to antibiotic, IEA:UniProtKB-KW
Phylogenomic databases
- KO
- K11210, -
Family and domain databases
- HAMAP
- MF_01512, FosB, 1, -
- InterPro
- IPR004360, Glyas_Fos-R_dOase_dom
- IPR022858, Metallothiol_Trafse_FosB
- Pfam
- PF00903, Glyoxalase, 1
|
| Feature |
O31817 Bacillus subtilis (strain 168).
| METAL | 8 | Magnesium (By similarity). |
| METAL | 67 | Magnesium (By similarity). |
| METAL | 116 | Magnesium (By similarity). |
|
| General annotation |
- Function
- Metallothiol transferase which confers resistance to fosfomycin by catalyzing the addition of a thiol cofactor to fosfomycin. L-cysteine is probably the physiological thiol donor
- Cofactor
- Magnesium
- Subunit structure
- Homodimer
- Subcellular location
- Cytoplasm (By similarity)
- Sequence similarities
- Belongs to the fosfomycin resistance protein family. FosB subfamily
|
| Reference |
- O31817 Bacillus subtilis (strain 168).
- 11244082
- FosB, a cysteine-dependent fosfomycin resistance protein under the control of sigma(W), an extracytoplasmic-function sigma factor in Bacillus subtilis. (J Bacteriol. 2001)
- Q03377 Staphylococcus epidermidis.
- 2341025
- Nucleotide sequence of the fosB gene conferring fosfomycin resistance in Staphylococcus epidermidis. (FEMS Microbiol Lett. 1990)
|
