遺伝子 : 4-hydroxyphenylacetate 3-monooxygenase reductase component (HPAC)

遺伝子情報

ID	NRULE_0102
遺伝子ID	HPAC
作成日	2012/11/30
タンパク質名	Protein name Full 4-hydroxyphenylacetate 3-monooxygenase reductase component EC EC 1.5.1.36 Synonym Full 4-HPA 3-monooxygenase small component NADH-dependent flavin reductase
遺伝子名	hpaC
遺伝子条件	TIGRFAMs; TIGR02296; hit=1
参照	Gene Ontology GO GO:0010181, F:FMN binding, IEA:InterPro GO:0051287, F:NAD binding, IEA:InterPro GO:0016651, F:oxidoreductase activity, acting on NADH or NADPH, IEA:InterPro GO:0042602, F:riboflavin reductase (NADPH) activity, IEA:InterPro GO:0019439, P:aromatic compound catabolic process, IEA:UniProtKB-KW GO:0042537, P:benzene-containing compound metabolic process, IEA:InterPro Phylogenomic databases KO K00484, - Enzyme and pathway databases UniPathway UPA00208, UER00416 Family and domain databases InterPro IPR002563, Flavin_Rdtase_FMN-bd IPR011982, HPA_mOase_red IPR012349, Split_barrel_FMN-bd IPR009002, Split_barrel_FMN-bd-related Pfam PF01613, Flavin_Reduct, 1 SMART SM00903, Flavin_Reduct, 1 TIGRFAMs TIGR02296, HpaC, 1
配列の特徴	該当データなし
注釈	Function Catalyzes the reduction of free flavins (FMN, FAD and riboflavin) by NADH. Subsequently, the reduced flavins diffuse to the large HpaB component or to other electron acceptors such as cytochrome c and Fe(3+) ion Catalytic activity Reduced flavin + NAD(+) = flavin + NADH Pathway Aromatic compound metabolism; 4-hydroxyphenylacetate degradation; pyruvate and succinate semialdehyde from 4-hydroxyphenylacetate: step 1/7 Subunit structure Homodimer (Probable). 4-HPA 3-monooxygenase consists of a reductase component HpaC and an oxygenase component HpaB Sequence similarities Belongs to the non-flavoprotein flavin reductase family. HpaC subfamily
参考文献	Q57501 Escherichia coli. 8077235 Molecular characterization of 4-hydroxyphenylacetate 3-hydroxylase of Escherichia coli. A two-protein component enzyme. (J Biol Chem. 1994) 10633095 Functional analysis of the small component of the 4-hydroxyphenylacetate 3-monooxygenase of Escherichia coli W: a prototype of a new Flavin:NAD(P)H reductase subfamily. (J Bacteriol. 2000)

関与する機能

機能名
4-hydroxyphenylacetate degradation

該当CDS

学名	NBRC番号	CDS	タンパク質名
Enterobacter aerogenes	13534	EAE_10310	4-hydroxyphenylacetate 3-monooxygenase reductase subunit
Enterobacter cloacae subsp. cloacae	13535	ECL_00749	4-hydroxyphenylacetate-3-hydroxylase small chain
Enterobacter hormaechei	105718	HMPREF9086_1895	4-hydroxyphenylacetate 3-monooxygenase reductase component
Escherichia coli	3972	EcolC_3711	4-hydroxyphenylacetate 3-monooxygenase, reductase subunit
Escherichia coli	13500	WFL_22915	4-hydroxyphenylacetate 3-monooxygenase reductase subunit
Escherichia fergusonii	102419	EFER_3071	4-hydroxyphenylacetate 3-monooxygenase small component, Flavin:NADH reductase
Klebsiella pneumoniae	14438	KPR_0856
Klebsiella pneumoniae subsp. rhinoscleromatis	105682	HMPREF0484_5100	4-hydroxyphenylacetate 3-monooxygenase, reductase component
Proteus mirabilis	105697	HMPREF0693_3207	4-hydroxyphenylacetate 3-monooxygenase, reductase component
Providencia alcalifaciens	105687	PROVALCAL_00323	4-hydroxyphenylacetate 3-monooxygenase, reductase component
Rhodococcus opacus	108011	ROP_25720	putative 4-hydroxyphenylacetate 3-hydroxylase reductase component
Serratia odorifera	102598	HMPREF0758_0648	4-hydroxyphenylacetate 3-monooxygenase, reductase component
Shimwellia blattae	105725	EB105725_26_00220	flavin reductase RutF