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遺伝子 : UDP-4-amino-4-deoxy-L-arabinose--oxoglutarate aminotransferase (ARNB)

遺伝子情報

ID NRULE_0133
遺伝子ID ARNB
作成日 2013/02/12
タンパク質名
Protein name
Full
UDP-4-amino-4-deoxy-L-arabinose--oxoglutarate aminotransferase
EC
EC 2.6.1.87
Synonym
Full
UDP-4-amino-4-deoxy-L-arabinose aminotransferase
UDP-(beta-L-threo-pentapyranosyl-4''-ulose diphosphate) aminotransferase
Short
UDP-Ara4O aminotransferase
遺伝子名 arnB
遺伝子条件 HAMAP; MF_01167; hit=1
参照
Gene Ontology
GO
GO:0005737, C:cytoplasm, NAS:EcoCyc
GO:0030170, F:pyridoxal phosphate binding, IDA:EcoCyc
GO:0008483, F:transaminase activity, IDA:EcoCyc
GO:0009245, P:lipid A biosynthetic process, IEA:UniProtKB-KW
GO:0009103, P:lipopolysaccharide biosynthetic process, IEA:UniProtKB-UniPathway
GO:0046677, P:response to antibiotic, IEA:UniProtKB-KW
Phylogenomic databases
KO
K07806, -
Family and domain databases
HAMAP
MF_01167, ArnB_transfer, 1, -
InterPro
IPR022850, ArnB_NH2Trfase
IPR000653, DegT/StrS_aminotransferase
Pfam
PF01041, DegT_DnrJ_EryC1, 1
配列の特徴
P77690 Escherichia coli (strain K12).
MOD_RES182N6-(pyridoxal phosphate)lysine (By similarity).
注釈
Function
Catalyzes the conversion of UDP-4-keto-arabinose (UDP- Ara4O) to UDP-4-amino-4-deoxy-L-arabinose (UDP-L-Ara4N). The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides (By similarity)
Catalytic activity
UDP-4-amino-4-deoxy-beta-L-arabinose + 2- oxoglutarate = UDP-beta-L-threo-pentapyranos-4-ulose + glutamate
Cofactor
Pyridoxal phosphate (By similarity)
Pathway
Nucleotide-sugar biosynthesis; UDP-4-deoxy-4-formamido- beta-L-arabinose biosynthesis; UDP-4-deoxy-4-formamido-beta-L- arabinose from UDP-alpha-D-glucuronate: step 2/3
Bacterial outer membrane biogenesis; lipopolysaccharide biosynthesis
Subunit structure
Homodimer (By similarity)
Sequence similarities
Belongs to the DegT/DnrJ/EryC1 family. ArnB subfamily
参考文献
P77690 Escherichia coli (strain K12).
12704196
Origin of lipid A species modified with 4-amino-4-deoxy-L-arabinose in polymyxin-resistant mutants of Escherichia coli. An aminotransferase (ArnB) that generates UDP-4-deoxyl-L-arabinose. (J Biol Chem. 2003)
17928292
An undecaprenyl phosphate-aminoarabinose flippase required for polymyxin resistance in Escherichia coli. (J Biol Chem. 2007)



関与する機能

機能名
Polymyxin resistance

該当CDS

データダウンロード
学名 NBRC番号 CDS タンパク質名
Edwardsiella tarda105688ET1_02_00770UDP-4-amino-4-deoxy-L-arabinose--oxoglutarate aminotransferase
Enterobacter aerogenes13534EAE_05700UDP-4-amino-4-deoxy-L-arabinose--oxoglutarate aminotransferase
Enterobacter cloacae subsp. cloacae13535ECL_04863UDP-4-amino-4-deoxy-L-arabinose--oxoglutarate aminotransferase
Escherichia coli3972EcolC_1396DegT/DnrJ/EryC1/StrS aminotransferase
Escherichia coli13500WFL_11960UDP-4-amino-4-deoxy-L-arabinose--oxoglutarate aminotransferase
Escherichia coli12713Y75_2256uridine 5'-(beta-1-threo-pentapyranosyl-4-ulose diphosphate) aminotransferase, PLP-dependent
Escherichia fergusonii102419EFER_0916uridine 5'-(beta-1-threo-pentapyranosyl-4-ulose diphosphate) aminotransferase, PLP-dependent
Escherichia hermannii105704EH105704_01_08430UDP-4-amino-4-deoxy-L-arabinose--oxoglutarate aminotransferase
Proteus mirabilis105697HMPREF0693_0616DegT/DnrJ/EryC1/StrS aminotransferase family protein
Providencia alcalifaciens105687PROVALCAL_02521DegT/DnrJ/EryC1/StrS aminotransferase family protein
Rahnella aquatilis105701Rahaq2_2853putative PLP-dependent enzyme possibly involved in cell wall biogenesis
Serratia odorifera102598HMPREF0758_3972DegT/DnrJ/EryC1/StrS aminotransferase family protein
Yersinia bercovieri105717yberc0001_21930UDP-4-amino-4-deoxy-L-arabinose--oxoglutarate aminotransferase
Yersinia rohdei105715yrohd0001_27840UDP-4-amino-4-deoxy-L-arabinose--oxoglutarate aminotransferase