遺伝子 : Undecaprenyl-phosphate 4-deoxy-4-formamido-L-arabinose transferase (ARNC)

遺伝子情報

ID	NRULE_0134
遺伝子ID	ARNC
作成日	2013/02/12
タンパク質名	Protein name Full Undecaprenyl-phosphate 4-deoxy-4-formamido-L-arabinose transferase EC EC 2.7.8.30 Synonym Full Undecaprenyl-phosphate Ara4FN transferase Short Ara4FN transferase
遺伝子名	arnC
遺伝子条件	HAMAP; MF_01164; hit=1
参照	Gene Ontology GO GO:0016780, F:phosphotransferase activity, for other substituted phosphate groups, IDA:EcoCyc GO:0016757, F:transferase activity, transferring glycosyl groups, IEA:UniProtKB-KW GO:0036108, P:4-amino-4-deoxy-alpha-L-arabinopyranosyl undecaprenyl phosphate biosynthetic process, IEA:UniProtKB-UniPathway GO:0009245, P:lipid A biosynthetic process, IEA:UniProtKB-KW GO:0009103, P:lipopolysaccharide biosynthetic process, IEA:UniProtKB-UniPathway GO:0046677, P:response to antibiotic, IEA:UniProtKB-KW Phylogenomic databases KO K10012, - Family and domain databases HAMAP MF_01164, ArnC_transfer, 1, - InterPro IPR022857, ArnC_tfrase IPR001173, Glyco_trans_2 Pfam PF00535, Glycos_transf_2, 1
配列の特徴	該当データなし
注釈	Function Catalyzes the transfer of 4-deoxy-4-formamido-L- arabinose from UDP to undecaprenyl phosphate. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides (By similarity) Catalytic activity UDP-4-deoxy-4-formamido-beta-L-arabinose + di- trans,octa-cis-undecaprenyl phosphate = UDP + 4-deoxy-4-formamido- alpha-L-arabinose di-trans,octa-cis-undecaprenyl phosphate Pathway Glycolipid biosynthesis; 4-amino-4-deoxy-alpha-L- arabinose undecaprenyl phosphate biosynthesis; 4-amino-4-deoxy- alpha-L-arabinose undecaprenyl phosphate from UDP-4-deoxy-4- formamido-beta-L-arabinose and undecaprenyl phosphate: step 1/2 Bacterial outer membrane biogenesis; lipopolysaccharide biosynthesis Sequence similarities Belongs to the glycosyltransferase 2 family
参考文献	P77757 Escherichia coli (strain K12). 15695810 A formyltransferase required for polymyxin resistance in Escherichia coli and the modification of lipid A with 4-Amino-4-deoxy-L-arabinose. Identification and function oF UDP-4-deoxy-4-formamido-L-arabinose. (J Biol Chem. 2005) 17928292 An undecaprenyl phosphate-aminoarabinose flippase required for polymyxin resistance in Escherichia coli. (J Biol Chem. 2007)

関与する機能

機能名
Polymyxin resistance

該当CDS

学名	NBRC番号	CDS	タンパク質名
Edwardsiella tarda	105688	ET1_02_00780	undecaprenyl-phosphate 4-deoxy-4-formamido-L-arabinose transferase
Enterobacter aerogenes	13534	EAE_05695	undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase
Enterobacter cloacae subsp. cloacae	13535	ECL_04862	undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase
Escherichia coli	3972	EcolC_1395	glycosyl transferase family 2
Escherichia coli	13500	WFL_11965	undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase
Escherichia coli	12713	Y75_2257	undecaprenyl phosphate-L-Ara4FN transferase
Escherichia fergusonii	102419	EFER_0915	undecaprenyl phosphate-L-Ara4FN transferase
Escherichia hermannii	105704	EH105704_01_08420	undecaprenyl-phosphate 4-deoxy-4-formamido-L-arabinose transferase
Klebsiella pneumoniae	14438	KPR_5071
Klebsiella pneumoniae subsp. rhinoscleromatis	105682	HMPREF0484_0803	undecaprenyl-phosphate 4-deoxy-4-formamido-L-arabinose transferase
Proteus mirabilis	105697	HMPREF0693_0617	glycosyltransferase, group 2 family protein
Providencia alcalifaciens	105687	PROVALCAL_02522	glycosyltransferase, group 2 family protein
Rahnella aquatilis	105701	Rahaq2_2852	glycosyl transferase
Serratia odorifera	102598	HMPREF0758_3971	glycosyltransferase, group 2 family protein
Shimwellia blattae	105725	EB105725_04_02070	undecaprenyl-phosphate 4-deoxy-4-formamido-L-arabinose transferase
Yersinia bercovieri	105717	yberc0001_21940	Undecaprenyl-phosphate 4-deoxy-4-formamido-L-arabinose transferase