遺伝子 : Probable 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD (ARND)

遺伝子情報

ID	NRULE_0135
遺伝子ID	ARND
作成日	2013/02/12
タンパク質名	Protein name Full Probable 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD EC EC 3.5.1.n3
遺伝子名	arnD
遺伝子条件	HAMAP; MF_01870; hit=1
参照	Gene Ontology GO GO:0016811, F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides, IEA:EC GO:0036108, P:4-amino-4-deoxy-alpha-L-arabinopyranosyl undecaprenyl phosphate biosynthetic process, IEA:UniProtKB-UniPathway GO:0009245, P:lipid A biosynthetic process, IEA:UniProtKB-KW GO:0009103, P:lipopolysaccharide biosynthetic process, IEA:UniProtKB-UniPathway GO:0046677, P:response to antibiotic, IEA:UniProtKB-KW GO:0010041, P:response to iron(III) ion, IGI:EcoCyc Phylogenomic databases KO K13014, - Family and domain databases HAMAP MF_01870, ArnD, 1, - InterPro IPR023557, ArnD IPR002509, Polysac_deacetylase Pfam PF01522, Polysacc_deac_1, 1
配列の特徴	該当データなし
注釈	Function Catalyzes the deformylation of 4-deoxy-4-formamido-L- arabinose-phosphoundecaprenol to 4-amino-4-deoxy-L-arabinose- phosphoundecaprenol. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides (By similarity) Catalytic activity 4-deoxy-4-formamido-beta-L-arabinose di- trans,poly-cis-undecaprenyl phosphate + H(2)O = 4-amino-4-deoxy- alpha-L-arabinose di-trans,poly-cis-undecaprenyl phosphate + formate Pathway Glycolipid biosynthesis; 4-amino-4-deoxy-alpha-L- arabinose undecaprenyl phosphate biosynthesis; 4-amino-4-deoxy- alpha-L-arabinose undecaprenyl phosphate from UDP-4-deoxy-4- formamido-beta-L-arabinose and undecaprenyl phosphate: step 2/2 Bacterial outer membrane biogenesis; lipopolysaccharide biosynthesis Sequence similarities Belongs to the polysaccharide deacetylase family. ArnD deformylase subfamily
参考文献	P76472 Escherichia coli (strain K12). 15695810 A formyltransferase required for polymyxin resistance in Escherichia coli and the modification of lipid A with 4-Amino-4-deoxy-L-arabinose. Identification and function oF UDP-4-deoxy-4-formamido-L-arabinose. (J Biol Chem. 2005) 17928292 An undecaprenyl phosphate-aminoarabinose flippase required for polymyxin resistance in Escherichia coli. (J Biol Chem. 2007)

関与する機能

機能名
Polymyxin resistance

該当CDS

学名	NBRC番号	CDS	タンパク質名
Edwardsiella tarda	105688	ET1_02_00800	putative 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD
Enterobacter aerogenes	13534	EAE_05685	4-deoxy-4-formamido-L-arabinose- phosphoundecaprenol deformylase ArnD
Enterobacter cloacae subsp. cloacae	13535	ECL_04860	polysaccharide deacetylase domain protein
Escherichia coli	3972	EcolC_1393	polysaccharide deacetylase
Escherichia coli	13500	WFL_11975	4-deoxy-4-formamido-L-arabinose- phosphoundecaprenol deformylase ArnD
Escherichia coli	12713	Y75_2259	conserved hypothetical protein
Escherichia fergusonii	102419	EFER_0913	conserved hypothetical protein
Escherichia hermannii	105704	EH105704_01_08400	putative 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD
Klebsiella pneumoniae	14438	KPR_5073
Klebsiella pneumoniae subsp. rhinoscleromatis	105682	HMPREF0484_0801	polysaccharide deacetylase
Proteus mirabilis	105697	HMPREF0693_0619	polysaccharide deacetylase
Providencia alcalifaciens	105687	PROVALCAL_02524	polysaccharide deacetylase
Rahnella aquatilis	105701	Rahaq2_2850	putative xylanase/chitin deacetylase
Serratia odorifera	102598	HMPREF0758_3968	polysaccharide deacetylase
Shimwellia blattae	105725	EB105725_04_02090	putative 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD
Yersinia bercovieri	105717	yberc0001_21960	hypothetical protein
Yersinia rohdei	105715	yrohd0001_27810	hypothetical protein