遺伝子 : Undecaprenyl phosphate-alpha-4-amino-4-deoxy-L-arabinose arabinosyl transferase (ARNT)

遺伝子情報

ID	NRULE_0138
遺伝子ID	ARNT
作成日	2013/02/12
タンパク質名	Protein name Full Undecaprenyl phosphate-alpha-4-amino-4-deoxy-L-arabinose arabinosyl transferase EC EC 2.4.2.43 Synonym Full 4-amino-4-deoxy-L-arabinose lipid A transferase Lipid IV(A) 4-amino-4-deoxy-L-arabinosyltransferase Undecaprenyl phosphate-alpha-L-Ara4N transferase
遺伝子名	arnT
遺伝子条件	HAMAP; MF_01165; hit=1
参照	Gene Ontology GO GO:0000030, F:mannosyltransferase activity, IEA:InterPro GO:0016763, F:transferase activity, transferring pentosyl groups, IMP:EcoCyc GO:0009245, P:lipid A biosynthetic process, IEA:UniProtKB-KW GO:0009103, P:lipopolysaccharide biosynthetic process, IMP:EcoCyc GO:0006493, P:protein O-linked glycosylation, IEA:InterPro GO:0010041, P:response to iron(III) ion, IGI:EcoCyc Phylogenomic databases KO K07264, - Family and domain databases HAMAP MF_01165, ArnT_transfer, 1, - InterPro IPR022839, ArnT_tfrase IPR003342, Glyco_trans_39 Pfam PF02366, PMT, 1
配列の特徴	該当データなし
注釈	Function Catalyzes the transfer of the L-Ara4N moiety of the glycolipid undecaprenyl phosphate-alpha-L-Ara4N to lipid A. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides (By similarity) Catalytic activity 4-amino-4-deoxy-alpha-L-arabinopyranosyl di- trans,octa-cis-undecaprenyl phosphate + lipid IV(A) = lipid II(A) + di-trans,octa-cis-undecaprenyl phosphate Pathway Lipopolysaccharide metabolism; 4-amino-4-deoxy-beta-L- arabinose-lipid A biosynthesis Sequence similarities Belongs to the glycosyltransferase 83 family
参考文献	P76473 Escherichia coli (strain K12). 11535604 An inner membrane enzyme in Salmonella and Escherichia coli that transfers 4-amino-4-deoxy-L-arabinose to lipid A: induction on polymyxin-resistant mutants and role of a novel lipid-linked donor. (J Biol Chem. 2001)

関与する機能

機能名
Polymyxin resistance

該当CDS

学名	NBRC番号	CDS	タンパク質名
Edwardsiella tarda	105688	ET1_02_00810	undecaprenyl phosphate-alpha-4-amino-4-deoxy-L-arabinose arabinosyltransferase
Enterobacter aerogenes	13534	EAE_05680	4-amino-4-deoxy-L-arabinose transferase
Enterobacter cloacae subsp. cloacae	13535	ECL_04859	4-amino-4-deoxy-L-arabinose transferase
Escherichia coli	3972	EcolC_1392	glycosyl transferase family 39
Escherichia coli	13500	WFL_11980	4-amino-4-deoxy-L-arabinose transferase
Escherichia coli	12713	Y75_2260	4-amino-4-deoxy-L-arabinose transferase
Escherichia fergusonii	102419	EFER_0912	4-amino-4-deoxy-L-arabinose transferase
Escherichia hermannii	105704	EH105704_01_08390	undecaprenyl phosphate-alpha-4-amino-4-deoxy-L-arabinose arabinosyltransferase
Klebsiella pneumoniae	14438	KPR_5074
Klebsiella pneumoniae subsp. rhinoscleromatis	105682	HMPREF0484_0800	dolichyl-phosphate-mannose-protein mannosyltransferase
Proteus mirabilis	105697	HMPREF0693_0620	dolichyl-phosphate-mannose-protein mannosyltransferase
		HMPREF0693_3176	dolichyl-phosphate-mannose-protein mannosyltransferase
Providencia alcalifaciens	105687	PROVALCAL_02525	dolichyl-phosphate-mannose-protein mannosyltransferase
Rahnella aquatilis	105701	Rahaq2_2849	PMT family glycosyltransferase, 4-amino-4-deoxy-L-arabinose transferase
Serratia odorifera	102598	HMPREF0758_3967	dolichyl-phosphate-mannose-protein mannosyltransferase
Shimwellia blattae	105725	EB105725_04_02100	undecaprenyl phosphate-alpha-4-amino-4-deoxy-L-arabinose arabinosyltransferase
Yersinia bercovieri	105717	yberc0001_21970	Undecaprenyl phosphate-alpha-4-amino-4-deoxy-L-arabinose arabinosyl transferase