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遺伝子 : Undecaprenyl phosphate-alpha-4-amino-4-deoxy-L-arabinose arabinosyl transferase (ARNT)

遺伝子情報

ID NRULE_0138
遺伝子ID ARNT
作成日 2013/02/12
タンパク質名
Protein name
Full
Undecaprenyl phosphate-alpha-4-amino-4-deoxy-L-arabinose arabinosyl transferase
EC
EC 2.4.2.43
Synonym
Full
4-amino-4-deoxy-L-arabinose lipid A transferase
Lipid IV(A) 4-amino-4-deoxy-L-arabinosyltransferase
Undecaprenyl phosphate-alpha-L-Ara4N transferase
遺伝子名 arnT
遺伝子条件 HAMAP; MF_01165; hit=1
参照
Gene Ontology
GO
GO:0000030, F:mannosyltransferase activity, IEA:InterPro
GO:0016763, F:transferase activity, transferring pentosyl groups, IMP:EcoCyc
GO:0009245, P:lipid A biosynthetic process, IEA:UniProtKB-KW
GO:0009103, P:lipopolysaccharide biosynthetic process, IMP:EcoCyc
GO:0006493, P:protein O-linked glycosylation, IEA:InterPro
GO:0010041, P:response to iron(III) ion, IGI:EcoCyc
Phylogenomic databases
KO
K07264, -
Family and domain databases
HAMAP
MF_01165, ArnT_transfer, 1, -
InterPro
IPR022839, ArnT_tfrase
IPR003342, Glyco_trans_39
Pfam
PF02366, PMT, 1
配列の特徴 該当データなし
注釈
Function
Catalyzes the transfer of the L-Ara4N moiety of the glycolipid undecaprenyl phosphate-alpha-L-Ara4N to lipid A. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides (By similarity)
Catalytic activity
4-amino-4-deoxy-alpha-L-arabinopyranosyl di- trans,octa-cis-undecaprenyl phosphate + lipid IV(A) = lipid II(A) + di-trans,octa-cis-undecaprenyl phosphate
Pathway
Lipopolysaccharide metabolism; 4-amino-4-deoxy-beta-L- arabinose-lipid A biosynthesis
Sequence similarities
Belongs to the glycosyltransferase 83 family
参考文献
P76473 Escherichia coli (strain K12).
11535604
An inner membrane enzyme in Salmonella and Escherichia coli that transfers 4-amino-4-deoxy-L-arabinose to lipid A: induction on polymyxin-resistant mutants and role of a novel lipid-linked donor. (J Biol Chem. 2001)



関与する機能

機能名
Polymyxin resistance

該当CDS

データダウンロード
学名 NBRC番号 CDS タンパク質名
Edwardsiella tarda105688ET1_02_00810undecaprenyl phosphate-alpha-4-amino-4-deoxy-L-arabinose arabinosyltransferase
Enterobacter aerogenes13534EAE_056804-amino-4-deoxy-L-arabinose transferase
Enterobacter cloacae subsp. cloacae13535ECL_048594-amino-4-deoxy-L-arabinose transferase
Escherichia coli3972EcolC_1392glycosyl transferase family 39
Escherichia coli13500WFL_119804-amino-4-deoxy-L-arabinose transferase
Escherichia coli12713Y75_22604-amino-4-deoxy-L-arabinose transferase
Escherichia fergusonii102419EFER_09124-amino-4-deoxy-L-arabinose transferase
Escherichia hermannii105704EH105704_01_08390undecaprenyl phosphate-alpha-4-amino-4-deoxy-L-arabinose arabinosyltransferase
Klebsiella pneumoniae14438KPR_5074
Klebsiella pneumoniae subsp. rhinoscleromatis105682HMPREF0484_0800dolichyl-phosphate-mannose-protein mannosyltransferase
Proteus mirabilis105697HMPREF0693_0620dolichyl-phosphate-mannose-protein mannosyltransferase
HMPREF0693_3176dolichyl-phosphate-mannose-protein mannosyltransferase
Providencia alcalifaciens105687PROVALCAL_02525dolichyl-phosphate-mannose-protein mannosyltransferase
Rahnella aquatilis105701Rahaq2_2849PMT family glycosyltransferase, 4-amino-4-deoxy-L-arabinose transferase
Serratia odorifera102598HMPREF0758_3967dolichyl-phosphate-mannose-protein mannosyltransferase
Shimwellia blattae105725EB105725_04_02100undecaprenyl phosphate-alpha-4-amino-4-deoxy-L-arabinose arabinosyltransferase
Yersinia bercovieri105717yberc0001_21970Undecaprenyl phosphate-alpha-4-amino-4-deoxy-L-arabinose arabinosyl transferase