遺伝子 : Aminoglycoside N(6')-acetyltransferase (AAC6)

遺伝子情報

ID	NRULE_0150
遺伝子ID	AAC6
作成日	2013/03/05
タンパク質名	Protein name Full Aminoglycoside N(6')-acetyltransferase EC EC 2.3.1.82 Synonym Full AAC(6') Aminoglycoside resistance protein
遺伝子名	aacA
遺伝子条件	PIRSF; PIRSF000452; hit=1
参照	Gene Ontology GO GO:0047663, F:aminoglycoside 6'-N-acetyltransferase activity, IEA:EC GO:0046677, P:response to antibiotic, IDA:UniProtKB Family and domain databases InterPro IPR024170, Aminoglycoside_N6-AcTrfrase IPR000182, GNAT_dom Pfam PF00583, Acetyltransf_1, 1 PIRSF PIRSF000452, 6-N-acetyltransf, 1 PROSITE PS51186, GNAT, 1
配列の特徴	Q9R381 Salmonella enteritidis. BINDING 22 Substrate. BINDING 25 Substrate. BINDING 66 Substrate. BINDING 79 Substrate. BINDING 115 Substrate. BINDING 120 Acetyl-CoA. BINDING 136 Substrate.
注釈	Function Catalyzes the transfer of an acetyl group from acetyl- CoA to the 6'-amino group of aminoglycoside molecules conferring resistance to antibiotics containing the purpurosamine ring including amikacin, tobramycin, dibekacin and ribostamycin Catalytic activity Acetyl-CoA + kanamycin-B = CoA + N(6')- acetylkanamycin-B Subunit structure Homodimer Sequence similarities Contains 1 N-acetyltransferase domain
参考文献	Q9R381 Salmonella enteritidis. 18095712 Kinetic and structural analysis of bisubstrate inhibition of the Salmonella enterica aminoglycoside 6'-N-acetyltransferase. (Biochemistry. 2008) P50858 Enterobacter aerogenes (Aerobacter aerogenes). 7793874 New mobile gene cassettes containing an aminoglycoside resistance gene, aacA7, and a chloramphenicol resistance gene, catB3, in an integron in pBWH301. (Antimicrob Agents Chemother. 1995)

関与する機能

機能名
Aminoglycoside resistance (by aminoglycoside N-acetyltransferase)
Kanamycin resistance

該当CDS

学名	NBRC番号	CDS	タンパク質名
Caulobacter segnis	15250	Cseg_4049	GCN5-related N-acetyltransferase
Chromobacterium violaceum	12614	CV_0230	probable aminoglycoside N6'-acetyltransferase
Chthoniobacter flavus		CfE428DRAFT_6550	GCN5-related N-acetyltransferase
Fischerella sp.		PCC9339_RS0133135	GCN5 family acetyltransferase
Meiothermus ruber	106122	Mrub_0158	GCN5-related N-acetyltransferase
Meiothermus silvanus	106475	Mesil_2409	GCN5-related N-acetyltransferase
Providencia alcalifaciens	105687	PROVALCAL_00921	acetyltransferase, GNAT family