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Rule : 2''-aminoglycoside nucleotidyltransferase (ANT2)

Rule Description

ID NRULE_0153
Rule name ANT2
Created 2013-03-06
Protein name
Protein name
Full
2''-aminoglycoside nucleotidyltransferase
EC
EC 2.7.7.46
Synonym
Full
AAD(2'')
Gentamicin 2''-nucleotidyltransferase
Gentamicin resistance protein
Gene name aadB
Rule Trigger PFAM; PF10706; hit=1
Cross Reference
Gene Ontology
GO
GO:0008871, F:aminoglycoside 2''-nucleotidyltransferase activity, IEA:EC
GO:0046677, P:response to antibiotic, IEA:UniProtKB-KW
Family and domain databases
InterPro
IPR019646, Aminoglyc_AdlTrfase
Pfam
PF10706, Aminoglyc_resit, 1
Feature Not assigned
General annotation
Function
This enzyme confers resistance to kanamycin, gentamicin and tobramycin by adenylating the 2''-hydroxyl group of these antibiotics
Catalytic activity
Nucleoside triphosphate + gentamicin = diphosphate + 2''-nucleotidylgentamicin
Reference
P0AE04 Escherichia coli.
3024112
Nucleotide sequence of the AAD(2'') aminoglycoside adenylyltransferase determinant aadB. Evolutionary relationship of this region with those surrounding aadA in R538-1 and dhfrII in R388. (Nucleic Acids Res. 1986)



Related Function

Function name
Aminoglycoside resistance (by aminoglycoside O-nucleotidyltransferase)
Gentamicin resistance
Kanamycin resistance

CDS

Data Download
Scientific name NBRC No. CDS Product name
Actinoplanes missouriensis102363AMIS_30840hypothetical protein
AMIS_47970hypothetical protein
Catenulispora acidiphila102108Caci_4744conserved hypothetical protein
Cellulomonas flavigena3775Cfla_0433Aminoglycoside-2''-adenylyltransferase
Cfla_3641conserved hypothetical protein
Gordonia effusa100432GOEFS_124_00190hypothetical protein
Halobacillus halophilus102448HBHAL_1352hypothetical protein
Kitasatospora setae14216KSE_71230hypothetical protein
Ktedonobacter racemiferKrac_0902conserved hypothetical protein
Krac_3174hypothetical protein
Krac_9633Aminoglycoside-2''-adenylyltransferase
Microlunatus phosphovorus101784MLP_03960hypothetical protein
Micromonospora aurantiaca16155Micau_5230hypothetical protein
Nostoc sp.alr7069aminoglycoside adenylyltransferase
Streptosporangium roseum3776Sros_0450conserved hypothetical protein