遺伝子 : 2''-aminoglycoside nucleotidyltransferase (ANT2)

遺伝子情報

ID	NRULE_0153
遺伝子ID	ANT2
作成日	2013/03/06
タンパク質名	Protein name Full 2''-aminoglycoside nucleotidyltransferase EC EC 2.7.7.46 Synonym Full AAD(2'') Gentamicin 2''-nucleotidyltransferase Gentamicin resistance protein
遺伝子名	aadB
遺伝子条件	PFAM; PF10706; hit=1
参照	Gene Ontology GO GO:0008871, F:aminoglycoside 2''-nucleotidyltransferase activity, IEA:EC GO:0046677, P:response to antibiotic, IEA:UniProtKB-KW Family and domain databases InterPro IPR019646, Aminoglyc_AdlTrfase Pfam PF10706, Aminoglyc_resit, 1
配列の特徴	該当データなし
注釈	Function This enzyme confers resistance to kanamycin, gentamicin and tobramycin by adenylating the 2''-hydroxyl group of these antibiotics Catalytic activity Nucleoside triphosphate + gentamicin = diphosphate + 2''-nucleotidylgentamicin
参考文献	P0AE04 Escherichia coli. 3024112 Nucleotide sequence of the AAD(2'') aminoglycoside adenylyltransferase determinant aadB. Evolutionary relationship of this region with those surrounding aadA in R538-1 and dhfrII in R388. (Nucleic Acids Res. 1986)

関与する機能

機能名
Aminoglycoside resistance (by aminoglycoside O-nucleotidyltransferase)
Gentamicin resistance
Kanamycin resistance

該当CDS

学名	NBRC番号	CDS	タンパク質名
Actinoplanes missouriensis	102363	AMIS_30840	hypothetical protein
		AMIS_47970	hypothetical protein
Catenulispora acidiphila	102108	Caci_4744	conserved hypothetical protein
Cellulomonas flavigena	3775	Cfla_0433	Aminoglycoside-2''-adenylyltransferase
		Cfla_3641	conserved hypothetical protein
Gordonia effusa	100432	GOEFS_124_00190	hypothetical protein
Halobacillus halophilus	102448	HBHAL_1352	hypothetical protein
Kitasatospora setae	14216	KSE_71230	hypothetical protein
Ktedonobacter racemifer		Krac_0902	conserved hypothetical protein
		Krac_3174	hypothetical protein
		Krac_9633	Aminoglycoside-2''-adenylyltransferase
Microlunatus phosphovorus	101784	MLP_03960	hypothetical protein
Micromonospora aurantiaca	16155	Micau_5230	hypothetical protein
Nostoc sp.		alr7069	aminoglycoside adenylyltransferase
Streptosporangium roseum	3776	Sros_0450	conserved hypothetical protein