遺伝子 : Hygromycin-B 7''-O-kinase (APH7)

遺伝子情報

ID	NRULE_0157
遺伝子ID	APH7
作成日	2013/03/06
タンパク質名	Protein name Full Hygromycin-B 7''-O-kinase EC EC 2.7.1.119 Synonym Full APH(7'') Hygromycin B phosphotransferase Hygromycin-B kinase
遺伝子名	hyg
遺伝子条件	PIRSF; PIRSF000707; hit=1
参照	Gene Ontology GO GO:0005524, F:ATP binding, IEA:UniProtKB-KW GO:0008904, F:hygromycin-B 7''-O-phosphotransferase activity, IEA:EC GO:0046677, P:response to antibiotic, IEA:UniProtKB-KW Family and domain databases InterPro IPR002575, Aminoglycoside_PTrfase IPR016259, Hygromycin-B_Kinase Pfam PF01636, APH, 1 PIRSF PIRSF000707, Hygromycin-B_kinase, 1
配列の特徴	P09979 Streptomyces hygroscopicus. ACT_SITE 223 Proton acceptor (By similarity).
注釈	Function The aminoglycoside phosphotransferases achieve inactivation of their antibiotic substrates by phosphorylation Catalytic activity ATP + hygromycin B = ADP + 7''-O- phosphohygromycin B Sequence similarities Belongs to the aminoglycoside phosphotransferase family
参考文献	P09979 Streptomyces hygroscopicus. 3005976 Nucleotide sequence of the hygromycin B phosphotransferase gene from Streptomyces hygroscopicus. (Nucleic Acids Res. 1986)

関与する機能

機能名
Aminoglycoside resistance (by aminoglycoside O-phosphotransferase)
Hygromycin resistance

該当CDS

学名	NBRC番号	CDS	タンパク質名
Actinopolyspora iraqiensis	103187	ACTIR_140_00030
Actinosynnema mirum	14064	Amir_2164	aminoglycoside phosphotransferase
Amycolatopsis azurea	14573	C791_5651	putative phosphotransferase
Beutenbergia cavernae	16432	Bcav_1948	aminoglycoside phosphotransferase
Bradyrhizobium diazoefficiens	14792	blr1035	putative phosphotransferase
Kineococcus radiotolerans	101839	Krad_2754	aminoglycoside phosphotransferase
Ktedonobacter racemifer		Krac_3354	aminoglycoside phosphotransferase
Saccharomonospora azurea	14651	SacazDRAFT_03696	putative homoserine kinase type II (protein kinase fold)
Saccharomonospora cyanea	14841	SaccyDRAFT_1007	putative homoserine kinase type II (protein kinase fold)
Saccharothrix espanaensis	15066	BN6_18860	Aminoglycoside phosphotransferase
Stackebrandtia nassauensis	102104	Snas_2803	hypothetical protein
Streptomyces avermitilis	14893	SAV4746	hypothetical protein
Streptomyces venezuelae	13096	SVEN_5979	hypothetical protein
Thermobispora bispora	14880	Tbis_2343	aminoglycoside phosphotransferase