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Rule : Alcohol dehydrogenase (GBSB)

Rule Description

ID NRULE_0176
Rule name GBSB
Created 2013-03-27
Protein name
Protein name
Full
Alcohol dehydrogenase
EC
EC 1.1.1.1
Gene name gbsB
Rule Trigger BLASTP; P71017; hit=1; score=1100; pid=60
Cross Reference
Gene Ontology
GO
GO:0004022, F:alcohol dehydrogenase (NAD) activity, IEA:EC
GO:0046872, F:metal ion binding, IEA:InterPro
GO:0019285, P:glycine betaine biosynthetic process from choline, IEA:UniProtKB-UniPathway
Phylogenomic databases
eggNOG
COG1454, -
HOGENOM
HOG000243333, -
KO
K11440, -
Enzyme and pathway databases
UniPathway
UPA00529, UER00587
Family and domain databases
InterPro
IPR001670, ADH_Fe
IPR018211, ADH_Fe_CS
Pfam
PF00465, Fe-ADH, 1
PROSITE
PS00913, ADH_IRON_1, 1
PS00060, ADH_IRON_2, 1
Feature Not assigned
General annotation
Function
Essential for the utilization of choline as a precursor
Catalytic activity
An alcohol + NAD(+) = an aldehyde or ketone + NADH
Pathway
Amine and polyamine biosynthesis; betaine biosynthesis via choline pathway; betaine aldehyde from choline (dehydrogenase route): step 1/1
Sequence similarities
Belongs to the iron-containing alcohol dehydrogenase family
Reference
P71017 Bacillus subtilis (strain 168).
8752328
Synthesis of the osmoprotectant glycine betaine in Bacillus subtilis: characterization of the gbsAB genes. (J Bacteriol. 1996)



Related Function

Function name
Betaine biosynthesis (from choline)

CDS

Data Download
Scientific name NBRC No. CDS Product name
Bacillus amyloliquefaciens15535BAMF_2871choline dehydrogenase (FAD-dependent)
Bacillus atrophaeus13721BATRMS_20_00080alcohol dehydrogenase, class IV
Bacillus licheniformis12200BL02563alcohol dehydrogenase
Bacillus licheniformis12195BLi03269alcohol dehydrogenase GbsB
Bacillus mojavensis15718GYU_03_00070GbsB
Bacillus pumilus12092BAT_0010alcohol dehydrogenase
Bacillus subtilis3134BSU6633_11405choline dehydrogenase
Bacillus subtilis subsp. subtilis13719BSU31050choline dehydrogenase
Bacillus vallismortis101236BvalD_010100011480alcohol dehydrogenase
Tetragenococcus halophilus12172TEH_04600alcohol dehydrogenase