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Rule : D-erythrose-4-phosphate dehydrogenase (EPD)

Rule Description

ID NRULE_0208
Rule name EPD
Created 2013-05-09
Protein name
Protein name
Full
D-erythrose-4-phosphate dehydrogenase
Short
E4PDH
EC
EC 1.2.1.72
Gene name epd
Rule Trigger HAMAP; MF_01640; hit=1
Cross Reference
Gene Ontology
GO
GO:0005737, C:cytoplasm, IEA:UniProtKB-SubCell
GO:0048001, F:erythrose-4-phosphate dehydrogenase activity, IDA:EcoCyc
GO:0004365, F:glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity, IDA:EcoCyc
GO:0051287, F:NAD binding, IDA:EcoCyc
GO:0006006, P:glucose metabolic process, IDA:EcoCyc
GO:0042823, P:pyridoxal phosphate biosynthetic process, IDA:EcoCyc
GO:0008615, P:pyridoxine biosynthetic process, IMP:EcoCyc
Phylogenomic databases
eggNOG
COG0057, -
HOGENOM
HOG000071679, -
KO
K03472, -
ProtClustDB
PRK13535, -
Enzyme and pathway databases
BioCyc
MetaCyc:ERYTH4PDEHYDROG-MONOMER, -
UniPathway
UPA00244, UER00309
Family and domain databases
HAMAP
MF_01640, E4P_dehydrog, 1, -
InterPro
IPR006422, E4P_DH_bac
IPR020831, GlycerAld/Erythrose_P_DH
IPR020830, GlycerAld_3-P_DH_AS
IPR020829, GlycerAld_3-P_DH_cat
IPR020828, GlycerAld_3-P_DH_NAD(P)-bd
IPR016040, NAD(P)-bd_dom
Pfam
PF02800, Gp_dh_C, 1
PF00044, Gp_dh_N, 1
PIRSF
PIRSF000149, GAP_DH, 1
PRINTS
PR00078, G3PDHDRGNASE
SMART
SM00846, Gp_dh_N, 1
TIGRFAMs
TIGR01532, E4PD_g-proteo, 1
PROSITE
PS00071, GAPDH, 1
Feature
P0A9B6 Escherichia coli (strain K12).
NP_BIND12 - 13NAD (By similarity).
ACT_SITE155Nucleophile (By similarity).
BINDING81NAD; via carbonyl oxygen (By similarity).
BINDING200Substrate (Potential).
BINDING236Substrate (Potential).
BINDING318NAD (By similarity).
General annotation
Function
Catalyzes the NAD-dependent conversion of D-erythrose 4- phosphate to 4-phosphoerythronate (By similarity)
Catalytic activity
D-erythrose 4-phosphate + NAD(+) + H(2)O = 4- phosphoerythronate + NADH
Pathway
Cofactor biosynthesis; pyridoxine 5'-phosphate biosynthesis; pyridoxine 5'-phosphate from D-erythrose 4- phosphate: step 1/5
Subunit structure
Homotetramer (By similarity)
Subcellular location
Cytoplasm (By similarity)
Sequence similarities
Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. Epd subfamily
Reference
P0A9B6 Escherichia coli (strain K12).
2546007
Identification, molecular cloning and sequence analysis of a gene cluster encoding the class II fructose 1,6-bisphosphate aldolase, 3-phosphoglycerate kinase and a putative second glyceraldehyde 3-phosphate dehydrogenase of Escherichia coli. (Mol Microbiol. 1989)
16738553
Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110. (Mol Syst Biol. 2006)
9182530
Comparative enzymatic properties of GapB-encoded erythrose-4-phosphate dehydrogenase of Escherichia coli and phosphorylating glyceraldehyde-3-phosphate dehydrogenase. (J Biol Chem. 1997)
9696782
Involvement of the gapA- and epd (gapB)-encoded dehydrogenases in pyridoxal 5'-phosphate coenzyme biosynthesis in Escherichia coli K-12. (J Bacteriol. 1998)



Related Function

Function name
Vitamin B6 biosynthesis (PdxA/PdxJ pathway)

CDS

Data Download
Scientific name NBRC No. CDS Product name
Alteromonas macleodii102226MASE_03575D-erythrose 4-phosphate dehydrogenase
Edwardsiella tarda105688ET1_16_00160D-erythrose-4-phosphate dehydrogenase
Enterobacter aerogenes13534EAE_02970erythrose 4-phosphate dehydrogenase
Enterobacter cloacae subsp. cloacae13535ECL_04247erythrose 4-phosphate dehydrogenase
Enterobacter hormaechei105718HMPREF9086_3785D-erythrose-4-phosphate dehydrogenase
Escherichia coli3972EcolC_0783D-erythrose-4-phosphate dehydrogenase
Escherichia coli13500WFL_15535erythrose 4-phosphate dehydrogenase
Escherichia coli12713Y75_2898D-erythrose 4-phosphate dehydrogenase
Escherichia fergusonii102419EFER_2859D-erythrose 4-phosphate dehydrogenase
Escherichia hermannii105704EH105704_02_03810D-erythrose-4-phosphate dehydrogenase
Klebsiella pneumoniae14438KPR_4620
Klebsiella pneumoniae subsp. rhinoscleromatis105682HMPREF0484_2741D-erythrose-4-phosphate dehydrogenase
Photobacterium damselae subsp. damselae corrig.15633VDA_001240D-erythrose-4-phosphate dehydrogenase
Proteus mirabilis105697HMPREF0693_3212D-erythrose-4-phosphate dehydrogenase
Providencia alcalifaciens105687PROVALCAL_00260D-erythrose-4-phosphate dehydrogenase
Rahnella aquatilis105701Rahaq2_3600erythrose-4-phosphate dehydrogenase
Serratia odorifera102598HMPREF0758_2198D-erythrose-4-phosphate dehydrogenase
Shimwellia blattae105725EB105725_20_00670D-erythrose-4-phosphate dehydrogenase
Vibrio alginolyticus15630N646_1691D-erythrose 4-phosphate dehydrogenase
Vibrio ichthyoenteri15847VII00023_13127erythrose 4-phosphate dehydrogenase
Vibrio metschnikovii103153VIB_002064D-erythrose-4-phosphate dehydrogenase
Vibrio orientalis15638VIOR3934_09645erythrose 4-phosphate dehydrogenase
Vibrio tubiashii15644VITU9109_25515erythrose 4-phosphate dehydrogenase
Vibrio vulnificus15645B736_05995glyceraldehyde-3-phosphate dehydrogenase
Yersinia bercovieri105717yberc0001_32580D-erythrose-4-phosphate dehydrogenase
Yersinia rohdei105715yrohd0001_18940D-erythrose-4-phosphate dehydrogenase