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Rule : Zinc-responsive transcriptional regulator ZntR (ZNTR)

Rule Description

ID NRULE_0330
Rule name ZNTR
Created 2014-10-09
Protein name
Protein name
Full
Zinc-responsive transcriptional regulator ZntR
Synonym
Full
MerR family transcriptional regulator ZntR
Gene name zntR
Rule Trigger TIGRFAMs; TIGR02043; hit=1
Cross Reference
Gene Ontology
GO
GO:0003677, F:DNA binding, IEA:UniProtKB-KW
GO:0003700, F:sequence-specific DNA binding transcription factor activity, IDA:EcoCyc
GO:0008270, F:zinc ion binding, IEA:InterPro
GO:0045893, P:positive regulation of transcription, DNA-templated, IDA:EcoCyc
GO:0006351, P:transcription, DNA-templated, IEA:UniProtKB-KW
Phylogenomic databases
eggNOG
COG0789, -
HOGENOM
HOG000266084, -
KO
K13638, -
Family and domain databases
InterPro
IPR009061, DNA-bd_dom_put
IPR000551, MerR-type_HTH_dom
IPR015358, Tscrpt_reg_MerR_DNA-bd
IPR011788, ZntR
Pfam
PF00376, MerR, 1
PF09278, MerR-DNA-bind, 1
PRINTS
PR00040, HTHMERR
SMART
SM00422, HTH_MERR, 1
TIGRFAMs
TIGR02043, ZntR, 1
PROSITE
PS00552, HTH_MERR_1, 1
PS50937, HTH_MERR_2, 1
Feature
P0ACS5 Escherichia coli (strain K12).
METAL114Zinc.
METAL115Zinc.
METAL119Zinc.
METAL124Zinc.
General annotation
Function
Zinc-responsive transcriptional regulator of zntA (Zn(II)/Cd(II)/Pb(II) translocating P-type ATPase). Involved in zinc homeostasis
Subunit structure
Homodimer
Domain
Contains 1 HTH merR-type DNA-binding domain
Reference
P0ACS5 Escherichia coli (strain K12).
10048032
ZntR is a Zn(II)-responsive MerR-like transcriptional regulator of zntA in Escherichia coli. (Mol Microbiol. 1999)
12958362
Molecular basis of metal-ion selectivity and zeptomolar sensitivity by CueR. (Science. 2003)



Related Function

Function name
Metal-binding protein

CDS

Data Download
Scientific name NBRC No. CDS Product name
Edwardsiella tarda105688ET1_28_00140MerR family transcriptional regulator ZntR
Enterobacter aerogenes13534EAE_04815zinc-responsive transcriptional regulator
Enterobacter cloacae subsp. cloacae13535ECL_04669zinc-responsive transcriptional regulator
Enterobacter hormaechei105718HMPREF9086_4145MerR family transcriptional regulator
Escherichia coli3972EcolC_0421transcriptional regulator, MerR family
Escherichia coli13500WFL_17385zinc-responsive transcriptional regulator
Escherichia coli12713Y75_3928DNA-binding transcriptional activator
Escherichia fergusonii102419EFER_3276DNA-binding transcriptional activator in response to Zn(II)
Escherichia hermannii105704EH105704_27_00130MerR family transcriptional regulator ZntR
Marinomonas mediterranea103028Marme_0138transcriptional regulator, MerR family
Proteus mirabilis105697HMPREF0693_0214Zn(II)-responsive transcriptional regulator
Providencia alcalifaciens105687PROVALCAL_00038Zn(II)-responsive transcriptional regulator
Rahnella aquatilis105701Rahaq2_0389Zn(II)-responsive transcriptional regulator
Serratia odorifera102598HMPREF0758_0934Zn(II)-responsive transcriptional regulator
Shimwellia blattae105725EB105725_45_00150MerR family transcriptional regulator ZntR
Vibrio alginolyticus15630N646_1982zinc-responsive transcriptional regulator
Vibrio ichthyoenteri15847VII00023_15603zinc-responsive transcriptional regulator
Vibrio metschnikovii103153VIB_002872zinc-responsive transcriptional regulator
Vibrio orientalis15638VIOR3934_12762zinc-responsive transcriptional regulator
Vibrio tubiashii15644VITU9109_13247zinc-responsive transcriptional regulator
Vibrio vulnificus15645B736_05465zinc-responsive transcriptional regulator
Yersinia bercovieri105717yberc0001_2770HTH-type transcriptional regulator zntR
Yersinia rohdei105715yrohd0001_13980HTH-type transcriptional regulator zntR