Rule : Muconate cycloisomerase (CATB1)

Rule Description

NRULE_0386

Rule name

CATB1

Created

2015-03-31

Protein name

Synonym

Gene name

catB

Rule Trigger

BLASTP; P08310; hit=1; score=829; pid=49

BLASTP; P95608; hit=1; score=930; pid=48

Cross Reference

Gene Ontology

GO: GO:0018850, F:chloromuconate cycloisomerase activity, IEA:InterPro; GO:0030145, F:manganese ion binding, IEA:InterPro; GO:0018849, F:muconate cycloisomerase activity, IEA:EC; GO:0042952, P:beta-ketoadipate pathway, IEA:UniProtKB-UniPathway

Phylogenomic databases

Enzyme and pathway databases

Family and domain databases

InterPro: IPR013370, Chloromuconate_cycloisomerase; IPR029065, Enolase_C-like; IPR029017, Enolase_N_like; IPR018110, Mandel_Rmase/mucon_lact_enz_CS; IPR013342, Mandelate_racemase_C; IPR013341, Mandelate_racemase_N_dom; IPR001354, MR/MLE/MAL
Pfam: PF02746, MR_MLE_N, 1
SMART: SM00922, MR_MLE, 1
TIGRFAMs: TIGR02534, mucon_cyclo, 1
PROSITE: PS00908, MR_MLE_1, 1; PS00909, MR_MLE_2, 1

Feature

P08310 Pseudomonas putida (Arthrobacter siderocapsulatus).

General annotation

Function: Catalyzes a syn cycloisomerization
Catalytic activity: 2,5-dihydro-5-oxofuran-2-acetate = cis,cis-hexadienedioate
Cofactor: Mn(2+)
Pathway: Aromatic compound metabolism; beta-ketoadipate pathway; 5-oxo-4,5-dihydro-2-furylacetate from catechol: step 2/3
Subunit structure: Homooctamer
Sequence similarities: Belongs to the mandelate racemase/muconate lactonizing enzyme family

Reference

P08310 Pseudomonas putida (Arthrobacter siderocapsulatus).

7500361: The refined X-ray structure of muconate lactonizing enzyme from Pseudomonas putida PRS2000 at 1.85 A resolution. (J Mol Biol. 1995)

P95608 Rhodococcus opacus (Nocardia opaca).

8990288: Characterization of catechol catabolic genes from Rhodococcus erythropolis 1CP. (J Bacteriol. 1997)

Function name
Catechol degradation (beta-ketoadipate pathway)


Scientific name	NBRC No.	CDS	Product name
Acinetobacter radioresistens	102413	ACRAD_32_00690	muconate cycloisomerase
Acinetobacter sp.	100985	ACT4_038_00490	muconate cycloisomerase
Brevundimonas diminuta	12697	BDIM_06720	muconate cycloisomerase 1-2
Corynebacterium ammoniagenes	12612	HMPREF0281_01042	muconate and chloromuconate cycloisomerase
Corynebacterium callunae	15359	H924_10110	chloromuconate cycloisomerase
Corynebacterium efficiens	100395	CE2303	putative muconate cycloisomerase
Corynebacterium glutamicum	12168	Cgl2401	O-succinylbenzoate synthase and related enzymes
Corynebacterium glutamicum	12153	KIQ_00495	hypothetical protein
Cupriavidus metallidurans	102507	Rmet_4878	muconate cycloisomerase
Enterobacter aerogenes	13534	EAE_19910	muconate and chloromuconate cycloisomerase
Escherichia fergusonii	102419	EFER_1479	Muconate cycloisomerase I (Cis,cis-muconate lactonizing enzyme I) (MLE)
Marinomonas mediterranea	103028	Marme_3630	muconate and chloromuconate cycloisomerase
Pseudomonas putida	100650	PP_3715	muconate cycloisomerase
Pseudomonas stutzeri	14165	PSTAB_1582	muconate cycloisomerase
Rhodococcus erythropolis	100887	RER_54220	muconate cycloisomerase
Rhodococcus opacus	108011	ROP_20860	muconate cycloisomerase
Shimwellia blattae	105725	EB105725_23_00480	muconate cycloisomerase
Sphingobium japonicum	101211	SJA_C1-25200	muconate cycloisomerase I
Sphingomonas wittichii	105917	Swit_0975	muconate cycloisomerase