BLAST table : Resis_00140

DB	UniProtKB

	accession	alignment	Evalue	Score	Ident.	link	product	gene	organism	ec
1	Q70DW4_9ACTO (Q70DW4)		0.0	822	100%	UniProt GenBank	RemE protein	remE	Streptomyces resistomycificus
2	B4VZM4_9CYAN (B4VZM4)		1e-68	265	36%	UniProt GenBank	Beta-ketoacyl synthase, N-terminal domain protein	MC7420_2490	Microcoleus chthonoplastes PCC 7420
3	Q3M5M8_ANAVT (Q3M5M8)		2e-67	261	36%	UniProt GenBank	Beta-ketoacyl synthase	Ava_4108	Anabaena variabilis (strain ATCC 29413 / PCC 7937)	2.3.1.94 niceE keggE 6.2.1.3 niceE keggE
4	Q6E7J7_9CYAN (Q6E7J7)		6e-67	259	36%	UniProt GenBank	JamM		Lyngbya majuscula
5	Q6E7K5_9CYAN (Q6E7K5)		3e-66	257	35%	UniProt GenBank	JamE		Lyngbya majuscula
6	Q094I7_STIAD (Q094I7)		2e-65	254	40%	UniProt GenBank	Aminotransferase, class III family Non-ribosomal peptide synthetase	STAUR_0820 STIAU_0525	Stigmatella aurantiaca (strain DW4/3-1)
7	Q8RJY4_STIAU (Q8RJY4)		5e-65	253	39%	UniProt GenBank	StiC protein	stiC	Stigmatella aurantiaca
8	F4XJI3_9CYAN (F4XJI3)		9e-65	252	36%	UniProt GenBank	BarE Polyketide synthase module	LYNGBM3L_06510	Lyngbya majuscula 3L
9	E1MJN8_9GAMM (E1MJN8)		1e-64	252	39%	UniProt GenBank	Beta-ketoacyl synthase	MettuDRAFT_0905	Methylobacter tundripaludum SV96
10	Q8GAQ5_9CYAN (Q8GAQ5)		1e-64	251	36%	UniProt GenBank	BarE	barE	Lyngbya majuscula
11	Q8RJY5_STIAU (Q8RJY5)		2e-64	251	37%	UniProt GenBank	StiB protein	stiB	Stigmatella aurantiaca
12	Q8RJX8_STIAU (Q8RJX8)		3e-64	250	38%	UniProt GenBank	StiJ protein	stiJ	Stigmatella aurantiaca
13	Q6E7J8_9CYAN (Q6E7J8)		4e-64	250	35%	UniProt GenBank	JamL		Lyngbya majuscula
14	B2IXK1_NOSP7 (B2IXK1)		7e-64	249	35%	UniProt GenBank	Amino acid adenylation domain protein	Npun_R3027	Nostoc punctiforme (strain ATCC 29133 / PCC 73102)	2.3.1.94 niceE keggE 5.1.1.13 niceE keggE
15	B7K7V0_CYAP7 (B7K7V0)		3e-63	247	38%	UniProt GenBank	Erythronolide synthase., Oleoyl-(Acyl-carrier-protein) hydrolase	PCC7424_2734	Cyanothece sp. (strain PCC 7424) Synechococcus sp. (strain ATCC 29155)	2.3.1.94 niceE keggE 3.1.2.14 niceE keggE
16	C4NCC1_9CYAN (C4NCC1)		3e-63	247	34%	UniProt GenBank	Polyketide synthase	anaF OSCI_4070012	Oscillatoria sp. PCC 6506
17	D8G899_9CYAN (D8G899)		5e-63	246	35%	UniProt GenBank	Putative Erythronolide synthase.,Oleoyl-(Acyl-carrier-protein) hydrolase	OSCI_3900013	Oscillatoria sp. PCC 6506	2.3.1.94 niceE keggE 3.1.2.14 niceE keggE
18	F4XMC8_9CYAN (F4XMC8)		5e-63	246	35%	UniProt GenBank	Amino acid adenylation domain protein	LYNGBM3L_21990	Lyngbya majuscula 3L
19	Q1EDB2_9CYAN (Q1EDB2)		8e-63	246	34%	UniProt GenBank	HctD		Lyngbya majuscula
20	E3FL96_STIAD (E3FL96)		1e-62	245	36%	UniProt GenBank	MtaF protein	mtaF STAUR_4018	Stigmatella aurantiaca (strain DW4/3-1)
21	Q9RFK6_STIAU (Q9RFK6)		1e-62	245	36%	UniProt GenBank	MtaF	mtaF	Stigmatella aurantiaca
22	Q3M5Z5_ANAVT (Q3M5Z5)		1e-62	245	36%	UniProt GenBank	Short-chain dehydrogenase/reductase SDR	Ava_3986	Anabaena variabilis (strain ATCC 29413 / PCC 7937)	2.3.1.165 niceE keggE
23	Q08QH1_STIAD (Q08QH1)		1e-62	245	36%	UniProt GenBank	Cyclopropane-fatty-acyl-phospholipid synthase family	STIAU_4028	Stigmatella aurantiaca (strain DW4/3-1)	2.1.1.79 niceE keggE
24	F4XRP3_9CYAN (F4XRP3)		1e-62	245	34%	UniProt GenBank	Polyketide synthase module	LYNGBM3L_03470	Lyngbya majuscula 3L
25	Q6DNF2_9CYAN (Q6DNF2)		1e-62	245	35%	UniProt GenBank	CurA	curA	Lyngbya majuscula
26	F4Y435_9CYAN (F4Y435)		1e-62	245	35%	UniProt GenBank	CurA Polyketide synthase module	LYNGBM3L_74570	Lyngbya majuscula 3L
27	E3FL94_STIAD (E3FL94)		2e-62	244	36%	UniProt GenBank	Amino acid adenylation domain protein	STAUR_4016	Stigmatella aurantiaca (strain DW4/3-1)
28	Q9RFK8_STIAU (Q9RFK8)		2e-62	244	36%	UniProt GenBank	MtaD	mtaD	Stigmatella aurantiaca
29	Q3M5Z6_ANAVT (Q3M5Z6)		5e-62	243	34%	UniProt GenBank	Short-chain dehydrogenase/reductase SDR	Ava_3985	Anabaena variabilis (strain ATCC 29413 / PCC 7937)	2.3.1.94 niceE keggE
30	B2J539_NOSP7 (B2J539)		7e-62	242	35%	UniProt GenBank	Beta-ketoacyl synthase	Npun_R2080	Nostoc punctiforme (strain ATCC 29133 / PCC 73102)	2.3.1.165 niceE keggE
31	Q8RJX9_STIAU (Q8RJX9)		7e-62	242	36%	UniProt GenBank	StiH protein	stiH	Stigmatella aurantiaca
32	B2J015_NOSP7 (B2J015)		8e-62	242	35%	UniProt GenBank	Beta-ketoacyl synthase	Npun_F3359	Nostoc punctiforme (strain ATCC 29133 / PCC 73102)	2.3.1.94 niceE keggE
33	B1GYG2_CHOCO (B1GYG2)		2e-61	241	40%	UniProt GenBank	Polyketide synthase	ajuH	Chondromyces crocatus
34	C4NCC2_9CYAN (C4NCC2)		2e-61	241	34%	UniProt GenBank	Polyketide synthase	anaG OSCI_4070013	Oscillatoria sp. PCC 6506
35	D6TD67_9CHLR (D6TD67)		2e-61	241	37%	UniProt GenBank	Beta-ketoacyl synthase	Krac_11726	Ktedonobacter racemifer DSM 44963
36	Q8RJY1_STIAU (Q8RJY1)		2e-61	241	38%	UniProt GenBank	StiF protein	stiF	Stigmatella aurantiaca
37	B2J016_NOSP7 (B2J016)		3e-61	241	34%	UniProt GenBank	Beta-ketoacyl synthase	Npun_F3360	Nostoc punctiforme (strain ATCC 29133 / PCC 73102)	1.6.5.5 niceE keggE 2.3.1.94 niceE keggE
38	Q10Y11_TRIEI (Q10Y11)		4e-61	240	35%	UniProt GenBank	Beta-ketoacyl synthase	Tery_3819	Trichodesmium erythraeum (strain IMS101)
39	Q6DNE5_9CYAN (Q6DNE5)		6e-61	239	35%	UniProt GenBank	CurH	curH	Lyngbya majuscula
40	F4Y428_9CYAN (F4Y428)		6e-61	239	35%	UniProt GenBank	CurH Zn-dependent oxidoreductase/polyketide synthase module	LYNGBM3L_74480	Lyngbya majuscula 3L
41	B0LI38_9NOST (B0LI38)		9e-61	239	35%	UniProt GenBank	Polyketide synthase	cyrE	Cylindrospermopsis raciborskii AWT205
42	C4NCC0_9CYAN (C4NCC0)		9e-61	239	33%	UniProt GenBank	Polyketide synthase	anaE OSCI_4070011	Oscillatoria sp. PCC 6506
43	D6MS59_9NOST (D6MS59)		1e-60	238	35%	UniProt GenBank	Polyketide synthase	cyrE	Aphanizomenon sp. 10E6
44	B1GYF5_CHOCO (B1GYF5)		1e-60	238	39%	UniProt GenBank	Polyketide synthase	ajuA	Chondromyces crocatus
45	D4TFY4_9NOST (D4TFY4)		2e-60	238	35%	UniProt GenBank	Polyketide synthase (CyrE)	CRC_01710	Cylindrospermopsis raciborskii CS-505
46	Q10Y08_TRIEI (Q10Y08)		3e-60	237	34%	UniProt GenBank	Beta-ketoacyl synthase	Tery_3822	Trichodesmium erythraeum (strain IMS101)
47	D7F1A8_9CYAN (D7F1A8)		4e-60	236	34%	UniProt GenBank	Polyketide synthase	cyrF OSCI_3850020	Oscillatoria sp. PCC 6506
48	Q6E7K0_9CYAN (Q6E7K0)		5e-60	236	35%	UniProt GenBank	JamJ		Lyngbya majuscula
49	Q1D4F6_MYXXD (Q1D4F6)		5e-60	236	38%	UniProt GenBank	Polyketide synthase	MXAN_4292	Myxococcus xanthus (strain DK 1622)
50	B2J540_NOSP7 (B2J540)		6e-60	236	36%	UniProt GenBank	Beta-ketoacyl synthase	Npun_R2081	Nostoc punctiforme (strain ATCC 29133 / PCC 73102)	2.3.1.94 niceE keggE
51	Q6DNE3_9CYAN (Q6DNE3)		1e-59	235	35%	UniProt GenBank	CurJ	curJ	Lyngbya majuscula
52	F4Y426_9CYAN (F4Y426)		1e-59	235	35%	UniProt GenBank	CurJ Polyketide synthase module	LYNGBM3L_74460	Lyngbya majuscula 3L
53	E3FQI4_STIAD (E3FQI4)		2e-59	234	38%	UniProt GenBank	Tylactone synthase modules 4 & 5	STAUR_1685	Stigmatella aurantiaca (strain DW4/3-1)
54	Q1D448_MYXXD (Q1D448)		2e-59	234	38%	UniProt GenBank	Non-ribosomal peptide synthetase	MXAN_4402	Myxococcus xanthus (strain DK 1622)
55	F8CMZ7_MYXFU (F8CMZ7)		2e-59	234	38%	UniProt GenBank	Polyketide synthase	LILAB_29610	Myxococcus fulvus
56	F4Y2Q3_9CYAN (F4Y2Q3)		2e-59	234	34%	UniProt GenBank	Polyketide synthase module Putative polyketide synthase module-related protein PKS	LYNGBM3L_69620	Lyngbya majuscula 3L
57	B2JBV5_NOSP7 (B2JBV5)		5e-59	233	35%	UniProt GenBank	KR	Npun_CR073	Nostoc punctiforme (strain ATCC 29133 / PCC 73102)	1.1.1.100 niceE keggE 2.3.1.94 niceE keggE
58	A4D933_9NOSO (A4D933)		1e-58	231	33%	UniProt GenBank	CrpA	crpA	Nostoc sp. ATCC 53789
59	B1GYG6_CHOCO (B1GYG6)		2e-58	231	38%	UniProt GenBank	Hybrid polyketide synthase/nonribosomal polypetide synthetase	ajuL	Chondromyces crocatus
60	Q6DNE7_9CYAN (Q6DNE7)		2e-58	231	34%	UniProt GenBank	CurF	curF	Lyngbya majuscula
61	F4Y430_9CYAN (F4Y430)		2e-58	231	34%	UniProt GenBank	Amino acid adenylation domain protein CurF	LYNGBM3L_74510	Lyngbya majuscula 3L
62	B1GYF6_CHOCO (B1GYF6)	(2 hsp)	4e-58	230	40%	UniProt GenBank	Polyketide synthase	ajuB	Chondromyces crocatus
63	D7F1A6_9CYAN (D7F1A6)		8e-58	229	34%	UniProt GenBank	Polyketide synthase	cyrE OSCI_3850022	Oscillatoria sp. PCC 6506
64	B0UE67_METS4 (B0UE67)	(2 hsp)	8e-58	229	38%	UniProt GenBank	Beta-ketoacyl synthase	M446_0172	Methylobacterium sp. (strain 4-46)
65	Q3M3U4_ANAVT (Q3M3U4)		1e-57	228	35%	UniProt GenBank	Beta-ketoacyl synthase	Ava_4745	Anabaena variabilis (strain ATCC 29413 / PCC 7937)	2.3.1.94 niceE keggE 5.1.1.11 niceE keggE
66	D4TFZ3_9NOST (D4TFZ3)		2e-57	228	34%	UniProt GenBank	Polyketide synthase (CyrF)	CRC_01719	Cylindrospermopsis raciborskii CS-505
67	B0LI29_9NOST (B0LI29)		2e-57	228	34%	UniProt GenBank	Polyketide synthase	cyrF	Cylindrospermopsis raciborskii AWT205
68	Q6DNE2_9CYAN (Q6DNE2)		2e-57	228	34%	UniProt GenBank	CurK	curK	Lyngbya majuscula
69	F4Y425_9CYAN (F4Y425)		2e-57	228	34%	UniProt GenBank	CurK Polyketide synthase module	LYNGBM3L_74450	Lyngbya majuscula 3L
70	B1XKC6_SYNP2 (B1XKC6)		2e-57	228	33%	UniProt GenBank	Polyketide synthase	SYNPCC7002_A1173	Synechococcus sp. (strain ATCC 27264 / PCC 7002 / PR-6) Agmenellum quadruplicatum
71	B2IYP4_NOSP7 (B2IYP4)	(2 hsp)	2e-57	228	33%	UniProt GenBank	Beta-ketoacyl synthase	Npun_F3169	Nostoc punctiforme (strain ATCC 29133 / PCC 73102)	1.1.1.100 niceE keggE 2.3.1.165 niceE keggE
72	Q6DNE6_9CYAN (Q6DNE6)		2e-57	227	34%	UniProt GenBank	CurG	curG	Lyngbya majuscula
73	F4Y429_9CYAN (F4Y429)		2e-57	227	34%	UniProt GenBank	CurG Polyketide synthase module	LYNGBM3L_74500	Lyngbya majuscula 3L
74	F4XWJ8_9CYAN (F4XWJ8)		3e-57	227	32%	UniProt GenBank	Polyketide synthase module	LYNGBM3L_44030	Lyngbya majuscula 3L
75	B1X1S9_CYAA5 (B1X1S9)		3e-57	227	32%	UniProt GenBank	Polyketide synthase	cce_3761	Cyanothece sp. (strain ATCC 51142)
76	F4Y423_9CYAN (F4Y423)		4e-57	226	34%	UniProt GenBank	CurM Polyketide synthase module	LYNGBM3L_74580	Lyngbya majuscula 3L
77	D0E8E2_9CYAN (D0E8E2)		4e-57	226	34%	UniProt GenBank	Polyketide synthase	curM	Lyngbya majuscula 19L
78	D6MS54_9NOST (D6MS54)		5e-57	226	33%	UniProt GenBank	Polyketide synthase	cyrF	Aphanizomenon sp. 10E6
79	Q6DNE0_9CYAN (Q6DNE0)		1e-56	225	34%	UniProt GenBank	CurM	curM	Lyngbya majuscula
80	Q6DNE4_9CYAN (Q6DNE4)		1e-56	225	33%	UniProt GenBank	CurI	curI	Lyngbya majuscula
81	F4Y427_9CYAN (F4Y427)		1e-56	225	33%	UniProt GenBank	CurI Polyketide synthase module	LYNGBM3L_74470	Lyngbya majuscula 3L
82	C7QVE8_CYAP0 (C7QVE8)		1e-56	225	30%	UniProt GenBank	Acyl transferase	Cyan8802_3100	Cyanothece sp. (strain PCC 8802) Synechococcus sp. (strain RF-2)
83	E3FE04_STIAD (E3FE04)		2e-56	224	36%	UniProt GenBank	Polyketide synthase	cyrD STAUR_4829	Stigmatella aurantiaca (strain DW4/3-1)
84	F8CPD9_MYXFU (F8CPD9)		2e-56	224	38%	UniProt GenBank	Non-ribosomal peptide synthetase	LILAB_30100	Myxococcus fulvus
85	B7JWG0_CYAP8 (B7JWG0)		2e-56	224	30%	UniProt GenBank	Erythronolide synthase	PCC8801_3021	Cyanothece sp. (strain PCC 8801) Synechococcus sp. (strain PCC 8801 / RF-1)	2.3.1.94 niceE keggE
86	C8TEN5_PLARU (C8TEN5)		3e-56	224	33%	UniProt GenBank	MicA protein	micA	Planktothrix rubescens NIVA-CYA 98
87	F8TTM7_9BACT (F8TTM7)		3e-56	224	37%	UniProt GenBank	Polyketide synthase		uncultured Acidobacteria bacterium C5
88	F4XKC9_9CYAN (F4XKC9)		4e-56	223	31%	UniProt GenBank	Polyketide synthase module	LYNGBM3L_11280	Lyngbya majuscula 3L
89	D7F1A4_9CYAN (D7F1A4)		7e-56	223	34%	UniProt GenBank	Mixed NRPS/PKS Polyketide synthase	cyrB OSCI_3850024	Oscillatoria sp. PCC 6506	2.3.1.- niceE keggE
90	Q10Y09_TRIEI (Q10Y09)		1e-55	222	34%	UniProt GenBank	Beta-ketoacyl synthase	Tery_3821	Trichodesmium erythraeum (strain IMS101)
91	D4TFY5_9NOST (D4TFY5)		1e-55	222	34%	UniProt GenBank	Mixed NRPS/PKS (CyrB)	CRC_01711	Cylindrospermopsis raciborskii CS-505
92	B0LI37_9NOST (B0LI37)		1e-55	222	34%	UniProt GenBank	Mixed NRPS/PKS	cyrB	Cylindrospermopsis raciborskii AWT205
93	Q6DNE1_9CYAN (Q6DNE1)		1e-55	222	33%	UniProt GenBank	CurL	curL	Lyngbya majuscula
94	F4Y424_9CYAN (F4Y424)		1e-55	222	33%	UniProt GenBank	CurL Polyketide synthase module	LYNGBM3L_74440	Lyngbya majuscula 3L
95	D6MS58_9NOST (D6MS58)		1e-55	221	34%	UniProt GenBank	Mixed NRPS/PKS	cyrB	Aphanizomenon sp. 10E6
96	F8CI86_MYXFU (F8CI86)		2e-55	221	40%	UniProt GenBank	Beta-ketoacyl synthase	LILAB_09170	Myxococcus fulvus
97	Q8L334_9NOST (Q8L334)		3e-55	221	33%	UniProt GenBank	Peptide synthetase	aoaB	Aphanizomenon ovalisporum
98	A3R4R5_9ACTO (A3R4R5)		4e-55	220	38%	UniProt GenBank	Polyketide synthase	pyr24	Streptomyces vitaminophilus
99	Q8YWG5_NOSS1 (Q8YWG5)		5e-55	219	33%	UniProt GenBank	All1648 protein	all1648	Nostoc sp. (strain PCC 7120 / UTEX 2576)
100	Q311J0_DESDG (Q311J0)		5e-55	219	35%	UniProt GenBank	Amino acid adenylation	Dde_1609	Desulfovibrio desulfuricans (strain G20)

accession

alignment

Evalue

Score

Ident.

link

information

pubmed

Q70DW4_9ACTO
(Q70DW4)

0.0

822

100%

Product: RemE protein
Gene: remE
Organism: Streptomyces resistomycificus

1uniprot[Pubmed] 14982421
A gene cluster encoding resistomycin biosynthesis in Streptomyces resistomycificus; exploring polyketide cyclization beyond linear and angucyclic patterns.(J. Am. Chem. Soc.) [2004]

Q6E7J7_9CYAN
(Q6E7J7)

6e-67

259

36%

Product: JamM
Gene
Organism: Lyngbya majuscula

1uniprot[Pubmed] 15217615
Structure and biosynthesis of the jamaicamides, new mixed polyketide-peptide neurotoxins from the marine cyanobacterium Lyngbya majuscula.(Chem. Biol.) [2004]

Q6E7K5_9CYAN
(Q6E7K5)

3e-66

257

35%

Product: JamE
Gene
Organism: Lyngbya majuscula

1uniprot[Pubmed] 15217615
Structure and biosynthesis of the jamaicamides, new mixed polyketide-peptide neurotoxins from the marine cyanobacterium Lyngbya majuscula.(Chem. Biol.) [2004]

Q8RJY4_STIAU
(Q8RJY4)

5e-65

253

39%

Product: StiC protein
Gene: stiC
Organism: Stigmatella aurantiaca

1uniprot[Pubmed] 11809757 [Medline] 21935336
The biosynthesis of the aromatic myxobacterial electron transport inhibitor stigmatellin is directed by a novel type of modular polyketide synthase.(J. Biol. Chem.) [2002]

F4XJI3_9CYAN
(F4XJI3)

9e-65

252

36%

Product: BarE
Polyketide synthase module
Gene: LYNGBM3L_06510
Organism: Lyngbya majuscula 3L

1uniprot
Genomic insights into the physiology and ecology of the marine filamentous cyanobacterium Lyngbya majuscula.(Proc. Natl. Acad. Sci. U.S.A.) [2011]

2uniprot[Pubmed] 21555588
Genomic insights into the physiology and ecology of the marine filamentous cyanobacterium Lyngbya majuscula.(Proc. Natl. Acad. Sci. U.S.A.) [2011]

Q8GAQ5_9CYAN
(Q8GAQ5)

1e-64

251

36%

Product: BarE
Gene: barE
Organism: Lyngbya majuscula

1uniprot[Pubmed] 12383521 [Medline] 22271559
The barbamide biosynthetic gene cluster: a novel marine cyanobacterial system of mixed polyketide synthase (PKS)-non-ribosomal peptide synthetase (NRPS) origin involving an unusual trichloroleucyl starter unit.(Gene) [2002]

Q8RJY5_STIAU
(Q8RJY5)

2e-64

251

37%

Product: StiB protein
Gene: stiB
Organism: Stigmatella aurantiaca

Q8RJX8_STIAU
(Q8RJX8)

3e-64

250

38%

Product: StiJ protein
Gene: stiJ
Organism: Stigmatella aurantiaca

Q6E7J8_9CYAN
(Q6E7J8)

4e-64

250

35%

Product: JamL
Gene
Organism: Lyngbya majuscula

1uniprot[Pubmed] 15217615
Structure and biosynthesis of the jamaicamides, new mixed polyketide-peptide neurotoxins from the marine cyanobacterium Lyngbya majuscula.(Chem. Biol.) [2004]

C4NCC1_9CYAN
(C4NCC1)

3e-63

247

34%

Product: Polyketide synthase
Gene: anaF
OSCI_4070012
Organism: Oscillatoria sp. PCC 6506

1uniprot[Pubmed] 19489636
Evidence that biosynthesis of the neurotoxic alkaloids anatoxin-a and homoanatoxin-a in the cyanobacterium Oscillatoria PCC 6506 occurs on a modular polyketide synthase initiated by L-proline.(J. Am. Chem. Soc.) [2009]

2uniprot
The Genome Sequence of the Cyanobacterium Oscillatoria sp. PCC 6506 Reveals Several Gene Clusters Responsible for the Biosynthesis of Toxins and Secondary Metabolites.(J. Bacteriol.) [2010]

D8G899_9CYAN
(D8G899)

5e-63

246

35%

Product: Putative Erythronolide synthase.,Oleoyl-(Acyl-carrier-protein) hydrolase
Gene: OSCI_3900013
Organism: Oscillatoria sp. PCC 6506

1uniprot
The Genome Sequence of the Cyanobacterium Oscillatoria sp. PCC 6506 Reveals Several Gene Clusters Responsible for the Biosynthesis of Toxins and Secondary Metabolites.(J. Bacteriol.) [2010]

F4XMC8_9CYAN
(F4XMC8)

5e-63

246

35%

Product: Amino acid adenylation domain protein
Gene: LYNGBM3L_21990
Organism: Lyngbya majuscula 3L

1uniprot
Genomic insights into the physiology and ecology of the marine filamentous cyanobacterium Lyngbya majuscula.(Proc. Natl. Acad. Sci. U.S.A.) [2011]

Q1EDB2_9CYAN
(Q1EDB2)

8e-63

246

34%

Product: HctD
Gene
Organism: Lyngbya majuscula

1uniprot[Pubmed] 18001088
Cloning and biochemical characterization of the hectochlorin biosynthetic gene cluster from the marine cyanobacterium Lyngbya majuscula.(J. Nat. Prod.) [2007]

Q9RFK6_STIAU
(Q9RFK6)

1e-62

245

36%

Product: MtaF
Gene: mtaF
Organism: Stigmatella aurantiaca

1uniprot[Pubmed] 10601310 [Medline] 20069734
New lessons for combinatorial biosynthesis from myxobacteria. The myxothiazol biosynthetic gene cluster of Stigmatella aurantiaca DW4/3-1.(J. Biol. Chem.) [1999]

F4XRP3_9CYAN
(F4XRP3)

1e-62

245

34%

Product: Polyketide synthase module
Gene: LYNGBM3L_03470
Organism: Lyngbya majuscula 3L

1uniprot
Genomic insights into the physiology and ecology of the marine filamentous cyanobacterium Lyngbya majuscula.(Proc. Natl. Acad. Sci. U.S.A.) [2011]

Q6DNF2_9CYAN
(Q6DNF2)

1e-62

245

35%

Product: CurA
Gene: curA
Organism: Lyngbya majuscula

[pubmed all]
1uniprot[Pubmed] 15332855 Biosynthetic pathway and gene cluster analysis of curacin A, an antitubulin natural product from the tropical marine cyanobacterium Lyngbya majuscula.(J. Nat. Prod.) [2004]
2uniprot[Pubmed] 20660778 Conformational switch triggered by alpha-ketoglutarate in a halogenase of curacin A biosynthesis.(Proc. Natl. Acad. Sci. U.S.A.) [2010]
3uniprot[Pubmed] 17991863 GNAT-like strategy for polyketide chain initiation.(Science) [2007]

F4Y435_9CYAN
(F4Y435)

1e-62

245

35%

Product: CurA
Polyketide synthase module
Gene: LYNGBM3L_74570
Organism: Lyngbya majuscula 3L

1uniprot
Genomic insights into the physiology and ecology of the marine filamentous cyanobacterium Lyngbya majuscula.(Proc. Natl. Acad. Sci. U.S.A.) [2011]

2uniprot[Pubmed] 21555588
Genomic insights into the physiology and ecology of the marine filamentous cyanobacterium Lyngbya majuscula.(Proc. Natl. Acad. Sci. U.S.A.) [2011]

Q9RFK8_STIAU
(Q9RFK8)

2e-62

244

36%

Product: MtaD
Gene: mtaD
Organism: Stigmatella aurantiaca

Q8RJX9_STIAU
(Q8RJX9)

7e-62

242

36%

Product: StiH protein
Gene: stiH
Organism: Stigmatella aurantiaca

C4NCC2_9CYAN
(C4NCC2)

2e-61

241

34%

Product: Polyketide synthase
Gene: anaG
OSCI_4070013
Organism: Oscillatoria sp. PCC 6506

2uniprot
The Genome Sequence of the Cyanobacterium Oscillatoria sp. PCC 6506 Reveals Several Gene Clusters Responsible for the Biosynthesis of Toxins and Secondary Metabolites.(J. Bacteriol.) [2010]

Q8RJY1_STIAU
(Q8RJY1)

2e-61

241

38%

Product: StiF protein
Gene: stiF
Organism: Stigmatella aurantiaca

Q6DNE5_9CYAN
(Q6DNE5)

6e-61

239

35%

Product: CurH
Gene: curH
Organism: Lyngbya majuscula

[pubmed all]
1uniprot[Pubmed] 15332855 Biosynthetic pathway and gene cluster analysis of curacin A, an antitubulin natural product from the tropical marine cyanobacterium Lyngbya majuscula.(J. Nat. Prod.) [2004]
2uniprot[Pubmed] 20152156 Crystal structures of dehydratase domains from the curacin polyketide biosynthetic pathway.(Structure) [2010]

F4Y428_9CYAN
(F4Y428)

6e-61

239

35%

Product: CurH
Zn-dependent oxidoreductase/polyketide synthase module
Gene: LYNGBM3L_74480
Organism: Lyngbya majuscula 3L

1uniprot
Genomic insights into the physiology and ecology of the marine filamentous cyanobacterium Lyngbya majuscula.(Proc. Natl. Acad. Sci. U.S.A.) [2011]

2uniprot[Pubmed] 21555588
Genomic insights into the physiology and ecology of the marine filamentous cyanobacterium Lyngbya majuscula.(Proc. Natl. Acad. Sci. U.S.A.) [2011]

B0LI38_9NOST
(B0LI38)

9e-61

239

35%

Product: Polyketide synthase
Gene: cyrE
Organism: Cylindrospermopsis raciborskii AWT205

1uniprot[Pubmed] 18065631
Characterization of the gene cluster responsible for cylindrospermopsin biosynthesis.(Appl. Environ. Microbiol.) [2008]

C4NCC0_9CYAN
(C4NCC0)

9e-61

239

33%

Product: Polyketide synthase
Gene: anaE
OSCI_4070011
Organism: Oscillatoria sp. PCC 6506

2uniprot
The Genome Sequence of the Cyanobacterium Oscillatoria sp. PCC 6506 Reveals Several Gene Clusters Responsible for the Biosynthesis of Toxins and Secondary Metabolites.(J. Bacteriol.) [2010]

D6MS59_9NOST
(D6MS59)

1e-60

238

35%

Product: Polyketide synthase
Gene: cyrE
Organism: Aphanizomenon sp. 10E6

1uniprot
The cylindrospermopsin gene cluster of Aphanizomenon sp. 10E6: organization and recombination.(Microbiology (Mosc.)) [2010]

D4TFY4_9NOST
(D4TFY4)

2e-60

238

35%

Product: Polyketide synthase (CyrE)
Gene: CRC_01710
Organism: Cylindrospermopsis raciborskii CS-505

1uniprot[Pubmed] 20169071
The smallest known genomes of multicellular and toxic cyanobacteria: comparison, minimal gene sets for linked traits and the evolutionary implications.(PLoS ONE) [2010]

D7F1A8_9CYAN
(D7F1A8)

4e-60

236

34%

Product: Polyketide synthase
Gene: cyrF
OSCI_3850020
Organism: Oscillatoria sp. PCC 6506

1uniprot[Pubmed] 19447947
Identification of a Polyketide Synthase Coding Sequence Specific for Anatoxin-a Producing Oscillatoria Cyanobacteria.(Appl. Environ. Microbiol.) [2009]

2uniprot
Biosynthesis of Cylindrospermopsin and 7-Epicylindrospermopsin in Oscillatoria PCC 6506; Identification of the Gene Cluster and Toxin Analysis.(Appl. Environ. Microbiol.) [2010]

3uniprot
The Genome Sequence of the Cyanobacterium Oscillatoria sp. PCC 6506 Reveals Several Gene Clusters Responsible for the Biosynthesis of Toxins and Secondary Metabolites.(J. Bacteriol.) [2010]

Q6E7K0_9CYAN
(Q6E7K0)

5e-60

236

35%

Product: JamJ
Gene
Organism: Lyngbya majuscula

1uniprot[Pubmed] 15217615
Structure and biosynthesis of the jamaicamides, new mixed polyketide-peptide neurotoxins from the marine cyanobacterium Lyngbya majuscula.(Chem. Biol.) [2004]

Q1D4F6_MYXXD
(Q1D4F6)

5e-60

236

38%

Product: Polyketide synthase
Gene: MXAN_4292
Organism: Myxococcus xanthus (strain DK 1622)

1uniprot[Pubmed] 17015832
Evolution of sensory complexity recorded in a myxobacterial genome.(Proc. Natl. Acad. Sci. U.S.A.) [2006]

Q6DNE3_9CYAN
(Q6DNE3)

1e-59

235

35%

Product: CurJ
Gene: curJ
Organism: Lyngbya majuscula

[pubmed all]
1uniprot[Pubmed] 15332855 Biosynthetic pathway and gene cluster analysis of curacin A, an antitubulin natural product from the tropical marine cyanobacterium Lyngbya majuscula.(J. Nat. Prod.) [2004]
2uniprot[Pubmed] 20152156 Crystal structures of dehydratase domains from the curacin polyketide biosynthetic pathway.(Structure) [2010]

F4Y426_9CYAN
(F4Y426)

1e-59

235

35%

Product: CurJ
Polyketide synthase module
Gene: LYNGBM3L_74460
Organism: Lyngbya majuscula 3L

1uniprot
Genomic insights into the physiology and ecology of the marine filamentous cyanobacterium Lyngbya majuscula.(Proc. Natl. Acad. Sci. U.S.A.) [2011]

2uniprot[Pubmed] 21555588
Genomic insights into the physiology and ecology of the marine filamentous cyanobacterium Lyngbya majuscula.(Proc. Natl. Acad. Sci. U.S.A.) [2011]

Q1D448_MYXXD
(Q1D448)

2e-59

234

38%

Product: Non-ribosomal peptide synthetase
Gene: MXAN_4402
Organism: Myxococcus xanthus (strain DK 1622)

1uniprot[Pubmed] 17015832
Evolution of sensory complexity recorded in a myxobacterial genome.(Proc. Natl. Acad. Sci. U.S.A.) [2006]

F4Y2Q3_9CYAN
(F4Y2Q3)

2e-59

234

34%

Product: Polyketide synthase module
Putative polyketide synthase module-related protein PKS
Gene: LYNGBM3L_69620
Organism: Lyngbya majuscula 3L

1uniprot
Genomic insights into the physiology and ecology of the marine filamentous cyanobacterium Lyngbya majuscula.(Proc. Natl. Acad. Sci. U.S.A.) [2011]

2uniprot[Pubmed] 21555588
Genomic insights into the physiology and ecology of the marine filamentous cyanobacterium Lyngbya majuscula.(Proc. Natl. Acad. Sci. U.S.A.) [2011]

A4D933_9NOSO
(A4D933)

1e-58

231

33%

Product: CrpA
Gene: crpA
Organism: Nostoc sp. ATCC 53789

1uniprot[Pubmed] 17240975
Biosynthetic characterization and chemoenzymatic assembly of the cryptophycins. Potent anticancer agents from cyanobionts.(ACS Chem. Biol.) [2006]

Q6DNE7_9CYAN
(Q6DNE7)

2e-58

231

34%

Product: CurF
Gene: curF
Organism: Lyngbya majuscula

[pubmed all]
1uniprot[Pubmed] 15332855 Biosynthetic pathway and gene cluster analysis of curacin A, an antitubulin natural product from the tropical marine cyanobacterium Lyngbya majuscula.(J. Nat. Prod.) [2004]
2uniprot[Pubmed] 20152156 Crystal structures of dehydratase domains from the curacin polyketide biosynthetic pathway.(Structure) [2010]
3uniprot[Pubmed] 17928301 Crystal structure of the ECH2 catalytic domain of CurF from Lyngbya majuscula. Insights into a decarboxylase involved in polyketide chain beta-branching.(J. Biol. Chem.) [2007]

F4Y430_9CYAN
(F4Y430)

2e-58

231

34%

Product: Amino acid adenylation domain protein
CurF
Gene: LYNGBM3L_74510
Organism: Lyngbya majuscula 3L

1uniprot
Genomic insights into the physiology and ecology of the marine filamentous cyanobacterium Lyngbya majuscula.(Proc. Natl. Acad. Sci. U.S.A.) [2011]

2uniprot[Pubmed] 21555588
Genomic insights into the physiology and ecology of the marine filamentous cyanobacterium Lyngbya majuscula.(Proc. Natl. Acad. Sci. U.S.A.) [2011]

D7F1A6_9CYAN
(D7F1A6)

8e-58

229

34%

Product: Polyketide synthase
Gene: cyrE
OSCI_3850022
Organism: Oscillatoria sp. PCC 6506

1uniprot[Pubmed] 19447947
Identification of a Polyketide Synthase Coding Sequence Specific for Anatoxin-a Producing Oscillatoria Cyanobacteria.(Appl. Environ. Microbiol.) [2009]

2uniprot
Biosynthesis of Cylindrospermopsin and 7-Epicylindrospermopsin in Oscillatoria PCC 6506; Identification of the Gene Cluster and Toxin Analysis.(Appl. Environ. Microbiol.) [2010]

3uniprot
The Genome Sequence of the Cyanobacterium Oscillatoria sp. PCC 6506 Reveals Several Gene Clusters Responsible for the Biosynthesis of Toxins and Secondary Metabolites.(J. Bacteriol.) [2010]

D4TFZ3_9NOST
(D4TFZ3)

2e-57

228

34%

Product: Polyketide synthase (CyrF)
Gene: CRC_01719
Organism: Cylindrospermopsis raciborskii CS-505

1uniprot[Pubmed] 20169071
The smallest known genomes of multicellular and toxic cyanobacteria: comparison, minimal gene sets for linked traits and the evolutionary implications.(PLoS ONE) [2010]

B0LI29_9NOST
(B0LI29)

2e-57

228

34%

Product: Polyketide synthase
Gene: cyrF
Organism: Cylindrospermopsis raciborskii AWT205

1uniprot[Pubmed] 18065631
Characterization of the gene cluster responsible for cylindrospermopsin biosynthesis.(Appl. Environ. Microbiol.) [2008]

Q6DNE2_9CYAN
(Q6DNE2)

2e-57

228

34%

Product: CurK
Gene: curK
Organism: Lyngbya majuscula

[pubmed all]
1uniprot[Pubmed] 15332855 Biosynthetic pathway and gene cluster analysis of curacin A, an antitubulin natural product from the tropical marine cyanobacterium Lyngbya majuscula.(J. Nat. Prod.) [2004]
2uniprot[Pubmed] 20152156 Crystal structures of dehydratase domains from the curacin polyketide biosynthetic pathway.(Structure) [2010]

F4Y425_9CYAN
(F4Y425)

2e-57

228

34%

Product: CurK
Polyketide synthase module
Gene: LYNGBM3L_74450
Organism: Lyngbya majuscula 3L

1uniprot
Genomic insights into the physiology and ecology of the marine filamentous cyanobacterium Lyngbya majuscula.(Proc. Natl. Acad. Sci. U.S.A.) [2011]

2uniprot[Pubmed] 21555588
Genomic insights into the physiology and ecology of the marine filamentous cyanobacterium Lyngbya majuscula.(Proc. Natl. Acad. Sci. U.S.A.) [2011]

Q6DNE6_9CYAN
(Q6DNE6)

2e-57

227

34%

Product: CurG
Gene: curG
Organism: Lyngbya majuscula

1uniprot[Pubmed] 15332855
Biosynthetic pathway and gene cluster analysis of curacin A, an antitubulin natural product from the tropical marine cyanobacterium Lyngbya majuscula.(J. Nat. Prod.) [2004]

F4Y429_9CYAN
(F4Y429)

2e-57

227

34%

Product: CurG
Polyketide synthase module
Gene: LYNGBM3L_74500
Organism: Lyngbya majuscula 3L

1uniprot
Genomic insights into the physiology and ecology of the marine filamentous cyanobacterium Lyngbya majuscula.(Proc. Natl. Acad. Sci. U.S.A.) [2011]

2uniprot[Pubmed] 21555588
Genomic insights into the physiology and ecology of the marine filamentous cyanobacterium Lyngbya majuscula.(Proc. Natl. Acad. Sci. U.S.A.) [2011]

F4XWJ8_9CYAN
(F4XWJ8)

3e-57

227

32%

Product: Polyketide synthase module
Gene: LYNGBM3L_44030
Organism: Lyngbya majuscula 3L

1uniprot
Genomic insights into the physiology and ecology of the marine filamentous cyanobacterium Lyngbya majuscula.(Proc. Natl. Acad. Sci. U.S.A.) [2011]

B1X1S9_CYAA5
(B1X1S9)

3e-57

227

32%

Product: Polyketide synthase
Gene: cce_3761
Organism: Cyanothece sp. (strain ATCC 51142)

1uniprot[Pubmed] 18812508
The genome of Cyanothece 51142, a unicellular diazotrophic cyanobacterium important in the marine nitrogen cycle.(Proc. Natl. Acad. Sci. U.S.A.) [2008]

F4Y423_9CYAN
(F4Y423)

4e-57

226

34%

Product: CurM
Polyketide synthase module
Gene: LYNGBM3L_74580
Organism: Lyngbya majuscula 3L

1uniprot
Genomic insights into the physiology and ecology of the marine filamentous cyanobacterium Lyngbya majuscula.(Proc. Natl. Acad. Sci. U.S.A.) [2011]

2uniprot[Pubmed] 21555588
Genomic insights into the physiology and ecology of the marine filamentous cyanobacterium Lyngbya majuscula.(Proc. Natl. Acad. Sci. U.S.A.) [2011]

D0E8E2_9CYAN
(D0E8E2)

4e-57

226

34%

Product: Polyketide synthase
Gene: curM
Organism: Lyngbya majuscula 19L

[pubmed all]
1uniprot[Pubmed] 19835378 Polyketide decarboxylative chain termination preceded by o-sulfonation in curacin a biosynthesis.(J. Am. Chem. Soc.) [2009]
2uniprot[Pubmed] 21357626 Terminal alkene formation by the thioesterase of curacin a biosynthesis: Structure of a decarboxylating thioesterase.(J. Biol. Chem.) [2011]

D6MS54_9NOST
(D6MS54)

5e-57

226

33%

Product: Polyketide synthase
Gene: cyrF
Organism: Aphanizomenon sp. 10E6

1uniprot
The cylindrospermopsin gene cluster of Aphanizomenon sp. 10E6: organization and recombination.(Microbiology (Mosc.)) [2010]

Q6DNE0_9CYAN
(Q6DNE0)

1e-56

225

34%

Product: CurM
Gene: curM
Organism: Lyngbya majuscula

1uniprot[Pubmed] 15332855
Biosynthetic pathway and gene cluster analysis of curacin A, an antitubulin natural product from the tropical marine cyanobacterium Lyngbya majuscula.(J. Nat. Prod.) [2004]

Q6DNE4_9CYAN
(Q6DNE4)

1e-56

225

33%

Product: CurI
Gene: curI
Organism: Lyngbya majuscula

1uniprot[Pubmed] 15332855
Biosynthetic pathway and gene cluster analysis of curacin A, an antitubulin natural product from the tropical marine cyanobacterium Lyngbya majuscula.(J. Nat. Prod.) [2004]

F4Y427_9CYAN
(F4Y427)

1e-56

225

33%

Product: CurI
Polyketide synthase module
Gene: LYNGBM3L_74470
Organism: Lyngbya majuscula 3L

1uniprot
Genomic insights into the physiology and ecology of the marine filamentous cyanobacterium Lyngbya majuscula.(Proc. Natl. Acad. Sci. U.S.A.) [2011]

2uniprot[Pubmed] 21555588
Genomic insights into the physiology and ecology of the marine filamentous cyanobacterium Lyngbya majuscula.(Proc. Natl. Acad. Sci. U.S.A.) [2011]

C8TEN5_PLARU
(C8TEN5)

3e-56

224

33%

Product: MicA protein
Gene: micA
Organism: Planktothrix rubescens NIVA-CYA 98

1uniprot[Pubmed] 19706155
A genome-wide analysis of nonribosomal peptide synthetase gene clusters and their peptides in a Planktothrix rubescens strain.(BMC Genomics) [2009]

F8TTM7_9BACT
(F8TTM7)

3e-56

224

37%

Product: Polyketide synthase
Gene
Organism: uncultured Acidobacteria bacterium C5

1uniprot[Pubmed] 21539584
Polyketide synthase pathways identified from a metagenomic library are derived from soil Acidobacteria.(FEMS Microbiol. Ecol.) [2011]

F4XKC9_9CYAN
(F4XKC9)

4e-56

223

31%

Product: Polyketide synthase module
Gene: LYNGBM3L_11280
Organism: Lyngbya majuscula 3L

1uniprot
Genomic insights into the physiology and ecology of the marine filamentous cyanobacterium Lyngbya majuscula.(Proc. Natl. Acad. Sci. U.S.A.) [2011]

D7F1A4_9CYAN
(D7F1A4)

7e-56

223

34%

Product: Mixed NRPS/PKS
Polyketide synthase
Gene: cyrB
OSCI_3850024
Organism: Oscillatoria sp. PCC 6506

1uniprot[Pubmed] 19447947
Identification of a Polyketide Synthase Coding Sequence Specific for Anatoxin-a Producing Oscillatoria Cyanobacteria.(Appl. Environ. Microbiol.) [2009]

2uniprot
Biosynthesis of Cylindrospermopsin and 7-Epicylindrospermopsin in Oscillatoria PCC 6506; Identification of the Gene Cluster and Toxin Analysis.(Appl. Environ. Microbiol.) [2010]

3uniprot
The Genome Sequence of the Cyanobacterium Oscillatoria sp. PCC 6506 Reveals Several Gene Clusters Responsible for the Biosynthesis of Toxins and Secondary Metabolites.(J. Bacteriol.) [2010]

D4TFY5_9NOST
(D4TFY5)

1e-55

222

34%

Product: Mixed NRPS/PKS (CyrB)
Gene: CRC_01711
Organism: Cylindrospermopsis raciborskii CS-505

1uniprot[Pubmed] 20169071
The smallest known genomes of multicellular and toxic cyanobacteria: comparison, minimal gene sets for linked traits and the evolutionary implications.(PLoS ONE) [2010]

B0LI37_9NOST
(B0LI37)

1e-55

222

34%

Product: Mixed NRPS/PKS
Gene: cyrB
Organism: Cylindrospermopsis raciborskii AWT205

1uniprot[Pubmed] 18065631
Characterization of the gene cluster responsible for cylindrospermopsin biosynthesis.(Appl. Environ. Microbiol.) [2008]

Q6DNE1_9CYAN
(Q6DNE1)

1e-55

222

33%

Product: CurL
Gene: curL
Organism: Lyngbya majuscula

1uniprot[Pubmed] 15332855
Biosynthetic pathway and gene cluster analysis of curacin A, an antitubulin natural product from the tropical marine cyanobacterium Lyngbya majuscula.(J. Nat. Prod.) [2004]

F4Y424_9CYAN
(F4Y424)

1e-55

222

33%

Product: CurL
Polyketide synthase module
Gene: LYNGBM3L_74440
Organism: Lyngbya majuscula 3L

1uniprot
Genomic insights into the physiology and ecology of the marine filamentous cyanobacterium Lyngbya majuscula.(Proc. Natl. Acad. Sci. U.S.A.) [2011]

2uniprot[Pubmed] 21555588
Genomic insights into the physiology and ecology of the marine filamentous cyanobacterium Lyngbya majuscula.(Proc. Natl. Acad. Sci. U.S.A.) [2011]

D6MS58_9NOST
(D6MS58)

1e-55

221

34%

Product: Mixed NRPS/PKS
Gene: cyrB
Organism: Aphanizomenon sp. 10E6

1uniprot
The cylindrospermopsin gene cluster of Aphanizomenon sp. 10E6: organization and recombination.(Microbiology (Mosc.)) [2010]

Q8L334_9NOST
(Q8L334)

3e-55

221

33%

Product: Peptide synthetase
Gene: aoaB
Organism: Aphanizomenon ovalisporum

1uniprot[Pubmed] 12007659 [Medline] 22003735
A novel gene encoding amidinotransferase in the cylindrospermopsin producing cyanobacterium Aphanizomenon ovalisporum.(FEMS Microbiol. Lett.) [2002]

A3R4R5_9ACTO
(A3R4R5)

4e-55

220

38%

Product: Polyketide synthase
Gene: pyr24
Organism: Streptomyces vitaminophilus

1uniprot[Pubmed] 17158935
Cloning and characterization of the pyrrolomycin biosynthetic gene clusters from Actinosporangium vitaminophilum ATCC 31673 and Streptomyces sp. strain UC 11065.(Antimicrob. Agents Chemother.) [2007]

Q8YWG5_NOSS1
(Q8YWG5)

5e-55

219

33%

Product: All1648 protein
Gene: all1648
Organism: Nostoc sp. (strain PCC 7120 / UTEX 2576)

1uniprot[Pubmed] 11759840 [Medline] 21595285
Complete genomic sequence of the filamentous nitrogen-fixing cyanobacterium Anabaena sp. strain PCC 7120.(DNA Res.) [2001]