BLAST table : Aran_00230

DB	UniProtKB

	accession	Evalue	Score	Ident.	link	product	gene	organism	ec
1	A1C190_9ACTO (A1C190)	1e-162	574	100%	UniProt GenBank	Oxidoreductase		Streptomyces echinatus
2	Q2PA05_9ACTO (Q2PA05)	3e-74	283	62%	UniProt GenBank	Ketoreductase	stfT	Streptomyces steffisburgensis
3	Q9RN66_STRNO (Q9RN66)	4e-74	282	60%	UniProt GenBank	C-7 ketoreductase	snoaF	Streptomyces nogalater
4	Q9L4U4_9ACTO (Q9L4U4)	1e-71	274	64%	UniProt GenBank	Putative aklaviketone reductase	aknU	Streptomyces galilaeus
5	D9UBL2_STRPR (D9UBL2)	3e-71	273	62%	UniProt GenBank	Putative ketoreductase	c104_02	Streptomyces pristinaespiralis
6	B5HJX5_STRPR (B5HJX5)	3e-71	273	62%	UniProt GenBank	C-7 ketoreductase	SSDG_05472	Streptomyces pristinaespiralis ATCC 25486
7	B5G8A0_9ACTO (B5G8A0)	5e-70	268	64%	UniProt GenBank	Ketoreductase	SSBG_00508	Streptomyces sp. SPB74
8	E8RWT2_MICSL (E8RWT2)	1e-69	268	60%	UniProt GenBank	Short-chain dehydrogenase/reductase SDR	ML5_4421	Micromonospora sp. (strain L5)
9	Q53882_STRS5 (Q53882)	9e-69	265	61%	UniProt GenBank	Aklaviketone reductase	dauE	Streptomyces sp. (strain C5)
10	D9T297_MICAI (D9T297)	4e-68	262	60%	UniProt GenBank	Short-chain dehydrogenase/reductase SDR	Micau_4000	Micromonospora aurantiaca (strain ATCC 27029 / DSM 43813 / JCM 10878 / NBRC 16125 / INA 9442)
11	Q54810_STRPE (Q54810)	3e-67	259	61%	UniProt GenBank	Daunorubicin-doxorubicin polyketide synthase	dnrH	Streptomyces peucetius
12	D1XUW2_9ACTO (D1XUW2)	8e-62	241	56%	UniProt GenBank	Short-chain dehydrogenase/reductase SDR	SACTEDRAFT_6472	Streptomyces sp. SA3_actE
13	Q82HG2_STRAW (Q82HG2)	4e-61	239	55%	UniProt GenBank	Putative ketoreductase	SAV3547 SAV_3547	Streptomyces avermitilis
14	Q4R0K9_STRCX (Q4R0K9)	1e-60	238	56%	UniProt GenBank	ChaL protein	chaL	Streptomyces chartreusis
15	B5HI32_STRPR (B5HI32)	1e-60	238	55%	UniProt GenBank	Ketoreductase	SSDG_04823	Streptomyces pristinaespiralis ATCC 25486
16	D9XU86_9ACTO (D9XU86)	9e-59	231	55%	UniProt GenBank	3-oxoacyl-[acyl-carrier-protein] reductase	SSRG_01089	Streptomyces griseoflavus Tu4000
17	D9WMS1_9ACTO (D9WMS1)	7e-58	228	48%	UniProt GenBank	3-oxoacyl-[acyl-carrier-protein] reductase	SSOG_07651	Streptomyces himastatinicus ATCC 53653
18	D9XFG9_STRVR (D9XFG9)	9e-58	228	54%	UniProt GenBank	3-oxoacyl-[acyl-carrier-protein] reductase	SSQG_03190	Streptomyces viridochromogenes DSM 40736
19	E8S731_MICSL (E8S731)	1e-55	221	55%	UniProt GenBank	Short-chain dehydrogenase/reductase SDR	ML5_3923	Micromonospora sp. (strain L5)
20	D9T583_MICAI (D9T583)	1e-55	221	55%	UniProt GenBank	Short-chain dehydrogenase/reductase SDR	Micau_4380	Micromonospora aurantiaca (strain ATCC 27029 / DSM 43813 / JCM 10878 / NBRC 16125 / INA 9442)
21	D9WGQ6_9ACTO (D9WGQ6)	5e-54	216	55%	UniProt GenBank	3-oxoacyl-[acyl-carrier-protein] reductase	SSOG_05158	Streptomyces himastatinicus ATCC 53653
22	D9VVR3_9ACTO (D9VVR3)	5e-54	216	57%	UniProt GenBank	3-oxoacyl-[acyl-carrier-protein] reductase	SSNG_04431	Streptomyces sp. C
23	D7C2R7_STRBB (D7C2R7)	2e-53	213	54%	UniProt GenBank	Ketoreductase	SBI_02829	Streptomyces bingchenggensis (strain BCW-1)
24	F2RGT6_STRVP (F2RGT6)	2e-52	211	53%	UniProt GenBank	3-oxoacyl-[acyl-carrier protein] reductase	SVEN_1610	Streptomyces venezuelae (strain ATCC 10712 / CBS 650.69 / DSM 40230 / JCM 4526 / NBRC 13096 / PD 04745)	1.1.1.100 niceE keggE
25	Q194Q5_STRAA (Q194Q5)	2e-52	210	53%	UniProt GenBank	Ketoreductase	mtmTIII	Streptomyces argillaceus
26	E0KYL5_STRVO (E0KYL5)	3e-52	209	52%	UniProt GenBank	Short-chain dehydrogenase/reductase SDR	StrviDRAFT_7743	Streptomyces violaceusniger Tu 4113
27	D9VG62_9ACTO (D9VG62)	2e-49	201	48%	UniProt GenBank	2-hydroxycyclohexanecarboxyl-CoA dehydrogenase	SSMG_06087	Streptomyces sp. AA4
28	E0KMJ0_STRVO (E0KMJ0)	5e-48	196	48%	UniProt GenBank	Short-chain dehydrogenase/reductase SDR	StrviDRAFT_3867	Streptomyces violaceusniger Tu 4113
29	A6VPT1_ACTSZ (A6VPT1)	4e-44	183	41%	UniProt GenBank	Short-chain dehydrogenase/reductase SDR	Asuc_1624	Actinobacillus succinogenes (strain ATCC 55618 / 130Z)
30	Q9FBU4_STRCO (Q9FBU4)	1e-42	178	41%	UniProt GenBank	Putative ketoreductase	SCO7147	Streptomyces coelicolor
31	D6EC83_STRLI (D6EC83)	1e-42	178	41%	UniProt GenBank	Ketoreductase	SSPG_00700	Streptomyces lividans TK24
32	D6UP60_9BACT (D6UP60)	2e-42	177	41%	UniProt GenBank	Short-chain dehydrogenase/reductase SDR	AciX8DRAFT_1040	Acidobacterium sp. MP5ACTX8
33	C3YX54_BRAFL (C3YX54)	2e-42	177	40%	UniProt GenBank	Putative uncharacterized protein	BRAFLDRAFT_59053	Branchiostoma floridae Florida lancelet Amphioxus
34	A8M462_SALAI (A8M462)	2e-41	174	46%	UniProt GenBank	Short-chain dehydrogenase/reductase SDR	Sare_4196	Salinispora arenicola (strain CNS-205)
35	A4XBD7_SALTO (A4XBD7)	4e-41	172	45%	UniProt GenBank	Short-chain dehydrogenase/reductase SDR	Strop_3805	Salinispora tropica (strain ATCC BAA-916 / DSM 44818 / CNB-440)
36	B4L3S0_DROMO (B4L3S0)	1e-39	168	40%	UniProt GenBank	GI14997	GI14997 Dmoj\GI14997 Dmoj_GI14997	Drosophila mojavensis Fruit fly
37	B3MYD7_DROAN (B3MYD7)	1e-39	168	42%	UniProt GenBank	GF22046	GF22046 Dana\GF22046 Dana_GF22046	Drosophila ananassae Fruit fly
38	B3P9C5_DROER (B3P9C5)	1e-39	168	43%	UniProt GenBank	GG12728	GG12728 Dere\GG12728 Dere_GG12728	Drosophila erecta Fruit fly
39	B4MD32_DROVI (B4MD32)	1e-39	167	40%	UniProt GenBank	GJ15354	GJ15354 Dvir\GJ15354 Dvir_GJ15354	Drosophila virilis Fruit fly
40	D1K482_9BACE (D1K482)	2e-39	167	39%	UniProt GenBank	FabG protein	HMPREF0105_2424	Bacteroides sp. 3_1_33FAA
41	B6VV46_9BACE (B6VV46)	2e-39	167	39%	UniProt GenBank	Putative uncharacterized protein	BACDOR_01154	Bacteroides dorei DSM 17855
42	C3R9G6_9BACE (C3R9G6)	4e-39	166	39%	UniProt GenBank	FabG protein	BSEG_01816	Bacteroides dorei 5_1_36/D4
43	C3PYH0_9BACE (C3PYH0)	4e-39	166	39%	UniProt GenBank	FabG protein	BSBG_01338	Bacteroides sp. 9_1_42FAA
44	Q5BII6_DROME (Q5BII6)	6e-39	166	42%	UniProt GenBank	RH05486p	CG3699	Drosophila melanogaster Fruit fly
45	Q65SN2_MANSM (Q65SN2)	6e-39	165	38%	UniProt GenBank	FabG protein	fabG MS1421	Mannheimia succiniciproducens (strain MBEL55E)
46	Q9U1L2_DROME (Q9U1L2)	6e-39	165	42%	UniProt GenBank	CG3699 EG:BACR7A4.14 protein	EG:BACR7A4.14 CG3699 Dmel_CG3699	Drosophila melanogaster Fruit fly	1.1.-.- niceE keggE
47	B4R2K9_DROSI (B4R2K9)	6e-39	165	42%	UniProt GenBank	GD16445	GD16445 Dsim\GD16445 Dsim_GD16445	Drosophila simulans Fruit fly
48	B4I985_DROSE (B4I985)	6e-39	165	42%	UniProt GenBank	GM19006	GM19006 Dsec\GM19006 Dsec_GM19006	Drosophila sechellia Fruit fly
49	C6D110_PAESJ (C6D110)	3e-38	163	38%	UniProt GenBank	Short-chain dehydrogenase/reductase SDR	Pjdr2_3149	Paenibacillus sp. (strain JDR-2)
50	Q95PA3_AEDAE (Q95PA3)	4e-38	163	39%	UniProt GenBank	Putative short-chain dehydrogenase/reductase	SDR1	Aedes aegypti Yellowfever mosquito Culex aegypti
51	B4PXJ3_DROYA (B4PXJ3)	4e-38	162	42%	UniProt GenBank	GE16554	GE16554 Dyak\GE16554 Dyak_GE16554	Drosophila yakuba Fruit fly
52	Q333V8_9ACTO (Q333V8)	5e-38	162	45%	UniProt GenBank	NAD or NADP oxidoreductase	tioH	Micromonospora sp. ML1
53	B4KCR4_DROMO (B4KCR4)	7e-38	162	38%	UniProt GenBank	GI10241	GI10241 Dmoj\GI10241 Dmoj_GI10241	Drosophila mojavensis Fruit fly
54	B0X121_CULQU (B0X121)	2e-37	160	37%	UniProt GenBank	3-hydroxybutyrate dehydrogenase type 2	CpipJ_CPIJ013219	Culex quinquefasciatus Southern house mosquito Culex pungens
55	Q65QK8_MANSM (Q65QK8)	2e-37	160	37%	UniProt GenBank	FabG protein	fabG MS2145	Mannheimia succiniciproducens (strain MBEL55E)
56	Q66IW5_XENLA (Q66IW5)	2e-37	160	37%	UniProt GenBank	MGC84267 protein	MGC84267	Xenopus laevis African clawed frog
57	B3RXK7_TRIAD (B3RXK7)	3e-37	160	37%	UniProt GenBank	Putative uncharacterized protein	TRIADDRAFT_63298	Trichoplax adhaerens Trichoplax reptans
58	Q95PA6_AEDAE (Q95PA6)	3e-37	160	39%	UniProt GenBank	Putative short-chain dehydrogenase/reductase Mc1	SDR2	Aedes aegypti Yellowfever mosquito Culex aegypti
59	Q29IW6_DROPS (Q29IW6)	3e-37	160	40%	UniProt GenBank	GA17622	GA17622 Dpse\GA17622 Dpse_GA17622	Drosophila pseudoobscura pseudoobscura Fruit fly
60	B4GTT3_DROPE (B4GTT3)	3e-37	160	40%	UniProt GenBank	GL14417	GL14417 Dper\GL14417 Dper_GL14417	Drosophila persimilis Fruit fly
61	Q8T4Q4_AEDAE (Q8T4Q4)	3e-37	160	39%	UniProt GenBank	Short-chain dehydrogenease/reductase	SDR	Aedes aegypti Yellowfever mosquito Culex aegypti
62	C1C192_9MAXI (C1C192)	4e-37	159	37%	UniProt GenBank	3-oxoacyl-acyl-carrier-protein reductase	FABG	Caligus clemensi
63	Q8T4Q5_AEDAE (Q8T4Q5)	5e-37	159	39%	UniProt GenBank	Short-chain dehydrogenease/reductase	SDR	Aedes aegypti Yellowfever mosquito Culex aegypti
64	B4ND54_DROWI (B4ND54)	5e-37	159	39%	UniProt GenBank	GK10169	GK10169 Dwil\GK10169 Dwil_GK10169	Drosophila willistoni Fruit fly
65	Q2F652_BOMMO (Q2F652)	6e-37	159	37%	UniProt GenBank	Short-chain dehydrogenease/reductase		Bombyx mori Silk moth
66	D2SNW1_HELVI (D2SNW1)	9e-37	158	40%	UniProt GenBank	Hydroxybutyrate dehydrogenase	hvpg0117	Heliothis virescens Tobacco budworm moth
67	C3YX55_BRAFL (C3YX55)	1e-36	158	38%	UniProt GenBank	Putative uncharacterized protein	BRAFLDRAFT_225165	Branchiostoma floridae Florida lancelet Amphioxus
68	B5DWF7_DROPS (B5DWF7)	1e-36	157	40%	UniProt GenBank	GA27306	GA27306 Dpse\GA27306 Dpse_GA27306	Drosophila pseudoobscura pseudoobscura Fruit fly
69	A8X8G3_CAEBR (A8X8G3)	2e-36	157	37%	UniProt GenBank	Putative uncharacterized protein	CBG09704 CBG_09704	Caenorhabditis briggsae
70	F6T472_XENTR (F6T472)	2e-36	157	36%	UniProt GenBank	Uncharacterized protein	XB-GENE-5820599	Xenopus tropicalis Western clawed frog Silurana tropicalis
71	Q18946_CAEEL (Q18946)	2e-36	157	37%	UniProt GenBank	Protein D1054.8, confirmed by transcript evidence	D1054.8	Caenorhabditis elegans
72	B4G475_DROPE (B4G475)	2e-36	157	40%	UniProt GenBank	GL24510	GL24510 Dper\GL24510 Dper_GL24510	Drosophila persimilis Fruit fly
73	F6WNB8_XENTR (F6WNB8)	2e-36	157	37%	UniProt GenBank	Uncharacterized protein	XB-GENE-5820599	Xenopus tropicalis Western clawed frog Silurana tropicalis
74	Q6DFP0_XENTR (Q6DFP0)	3e-36	157	37%	UniProt GenBank	MGC79752 protein	MGC79752	Xenopus tropicalis Western clawed frog Silurana tropicalis
75	C3XTH8_BRAFL (C3XTH8)	3e-36	156	38%	UniProt GenBank	Putative uncharacterized protein	BRAFLDRAFT_280406	Branchiostoma floridae Florida lancelet Amphioxus
76	B3RXK6_TRIAD (B3RXK6)	4e-36	156	36%	UniProt GenBank	Putative uncharacterized protein	TRIADDRAFT_56243	Trichoplax adhaerens Trichoplax reptans
77	Q67RW6_SYMTH (Q67RW6)	4e-36	156	43%	UniProt GenBank	Ketoreductase	STH592	Symbiobacterium thermophilum
78	C1B4Y1_RHOOB (C1B4Y1)	6e-36	155	41%	UniProt GenBank	Oxidoreductase	ROP_70730	Rhodococcus opacus (strain B4)
79	B4PUV4_DROYA (B4PUV4)	7e-36	155	38%	UniProt GenBank	GE10146	GE10146 Dyak\GE10146 Dyak_GE10146	Drosophila yakuba Fruit fly
80	B4M524_DROVI (B4M524)	7e-36	155	38%	UniProt GenBank	GJ10124	GJ10124 Dvir\GJ10124 Dvir_GJ10124	Drosophila virilis Fruit fly
81	Q9N5G4_CAEEL (Q9N5G4)	8e-36	155	36%	UniProt GenBank	Putative uncharacterized protein	R05D8.7	Caenorhabditis elegans
82	Q8SX57_DROME (Q8SX57)	1e-35	154	38%	UniProt GenBank	CG31549 LD44221p	CG11005 CG31549 Dmel_CG31549	Drosophila melanogaster Fruit fly	1.-.-.- niceE keggE
83	B4I444_DROSE (B4I444)	2e-35	154	38%	UniProt GenBank	GM10825	GM10825 Dsec\GM10825 Dsec_GM10825	Drosophila sechellia Fruit fly
84	B0X924_CULQU (B0X924)	2e-35	154	37%	UniProt GenBank	3-oxoacyl-[acyl-carrier-protein] reductase	CpipJ_CPIJ015685	Culex quinquefasciatus Southern house mosquito Culex pungens
85	B4JSU0_DROGR (B4JSU0)	3e-35	153	37%	UniProt GenBank	GH22984	GH22984 Dgri\GH22984 Dgri_GH22984	Drosophila grimshawi Fruit fly Idiomyia grimshawi
86	E3N7A3_CAERE (E3N7A3)	3e-35	153	37%	UniProt GenBank	Putative uncharacterized protein	CRE_10586	Caenorhabditis remanei Caenorhabditis vulgaris
87	Q170J0_AEDAE (Q170J0)	3e-35	153	36%	UniProt GenBank	AAEL007893-PA Short chain type dehydrogenase	AAEL007893 AaeL_AAEL007893 Aael_AAEL007893	Aedes aegypti Yellowfever mosquito Culex aegypti
88	A8X8L5_CAEBR (A8X8L5)	4e-35	153	37%	UniProt GenBank	Putative uncharacterized protein	CBG09635 CBG_09635	Caenorhabditis briggsae
89	C2M6W6_CAPGI (C2M6W6)	4e-35	152	37%	UniProt GenBank	3-oxoacyl-[acyl-carrier-protein] reductase	CAPGI0001_0253	Capnocytophaga gingivalis ATCC 33624	1.1.1.100 niceE keggE
90	D6WBF1_TRICA (D6WBF1)	4e-35	152	36%	UniProt GenBank	Putative uncharacterized protein	TcasGA2_TC000272	Tribolium castaneum Red flour beetle
91	B3LWG2_DROAN (B3LWG2)	4e-35	152	37%	UniProt GenBank	GF16338	GF16338 Dana\GF16338 Dana_GF16338	Drosophila ananassae Fruit fly
92	Q16ZI8_AEDAE (Q16ZI8)	4e-35	152	37%	UniProt GenBank	Short-chain dehydrogenase	AAEL008152 AaeL_AAEL008152	Aedes aegypti Yellowfever mosquito Culex aegypti
93	B3P2H2_DROER (B3P2H2)	4e-35	152	38%	UniProt GenBank	GG12965	GG12965 Dere\GG12965 Dere_GG12965	Drosophila erecta Fruit fly
94	E3X654_ANODA (E3X654)	6e-35	152	36%	UniProt GenBank	Putative uncharacterized protein	AND_14486	Anopheles darlingi Mosquito
95	B4NKA4_DROWI (B4NKA4)	7e-35	152	38%	UniProt GenBank	GK13927	GK13927 Dwil\GK13927 Dwil_GK13927	Drosophila willistoni Fruit fly
96	Q7PR84_ANOGA (Q7PR84)	7e-35	152	37%	UniProt GenBank	AGAP002520-PA	AgaP_AGAP002520	Anopheles gambiae African malaria mosquito
97	E8KF78_9PAST (E8KF78)	8e-35	152	36%	UniProt GenBank	3-oxoacyl-[acyl-carrier-protein] reductase	fabG2 HMPREF0027_0495	Actinobacillus ureae ATCC 25976	1.1.1.100 niceE keggE
98	B4I445_DROSE (B4I445)	1e-34	151	37%	UniProt GenBank	GM10826	GM10826 Dsec\GM10826 Dsec_GM10826	Drosophila sechellia Fruit fly
99	A2BF91_DANRE (A2BF91)	1e-34	151	36%	UniProt GenBank	Novel protein (Zgc:101858) Uncharacterized protein	CH211-236K19.5 CH211-236K19.5-001 zgc:101858	Danio rerio Zebrafish Brachydanio rerio
100	B4JST9_DROGR (B4JST9)	1e-34	151	37%	UniProt GenBank	GH22973	GH22973 Dgri\GH22973 Dgri_GH22973	Drosophila grimshawi Fruit fly Idiomyia grimshawi

accession

alignment

Evalue

Score

Ident.

link

information

pubmed

Q2PA05_9ACTO
(Q2PA05)

3e-74

283

62%

Product: Ketoreductase
Gene: stfT
Organism: Streptomyces steffisburgensis

1uniprot[Pubmed] 16751529
Isolation, characterization, and heterologous expression of the biosynthesis gene cluster for the antitumor anthracycline steffimycin.(Appl. Environ. Microbiol.) [2006]

Q9RN66_STRNO
(Q9RN66)

4e-74

282

60%

Product: C-7 ketoreductase
Gene: snoaF
Organism: Streptomyces nogalater

[pubmed all]
1uniprot[Pubmed] 9349712 [Medline] 98007868 Characterization of Streptomyces nogalater genes encoding enzymes involved in glycosylation steps in nogalamycin biosynthesis.(Mol. Gen. Genet.) [1997]
2uniprot[Pubmed] 10639368 [Medline] 20106987 Identification of a cyclase gene dictating the C-9 stereochemistry of anthracyclines from Streptomyces nogalater.(Antimicrob. Agents Chemother.) [2000]

Q9L4U4_9ACTO
(Q9L4U4)

1e-71

274

64%

Product: Putative aklaviketone reductase
Gene: aknU
Organism: Streptomyces galilaeus

1uniprot[Pubmed] 11016846 [Medline] 20469061
A gene cluster from Streptomyces galilaeus involved in glycosylation of aclarubicin.(Mol. Gen. Genet.) [2000]

D9UBL2_STRPR
(D9UBL2)

3e-71

273

62%

Product: Putative ketoreductase
Gene: c104_02
Organism: Streptomyces pristinaespiralis

1uniprot[Pubmed] 21342465
Characterization of the 'pristinamycin supercluster' of Streptomyces pristinaespiralis.(Microb Biotechnol) [2011]

Q53882_STRS5
(Q53882)

9e-69

265

61%

Product: Aklaviketone reductase
Gene: dauE
Organism: Streptomyces sp. (strain C5)

1uniprot[Pubmed] 8655529 [Medline] 96236066
Cloning, sequencing, and analysis of aklaviketone reductase from Streptomyces sp. strain C5.(J. Bacteriol.) [1996]

Q54810_STRPE
(Q54810)

3e-67

259

61%

Product: Daunorubicin-doxorubicin polyketide synthase
Gene: dnrH
Organism: Streptomyces peucetius

1uniprot[Pubmed] 7828855 [Medline] 95129838
Characterization of the Streptomyces peucetius ATCC 29050 genes encoding doxorubicin polyketide synthase.(Gene) [1994]

Q82HG2_STRAW
(Q82HG2)

4e-61

239

55%

Product: Putative ketoreductase
Gene: SAV3547
SAV_3547
Organism: Streptomyces avermitilis

1uniprot[Pubmed] 11572948 [Medline] 21477403
Genome sequence of an industrial microorganism Streptomyces avermitilis: deducing the ability of producing secondary metabolites.(Proc. Natl. Acad. Sci. U.S.A.) [2001]

Q4R0K9_STRCX
(Q4R0K9)

1e-60

238

56%

Product: ChaL protein
Gene: chaL
Organism: Streptomyces chartreusis

1uniprot[Pubmed] 15911378
Biosynthesis of the antitumor agent chartreusin involves the oxidative rearrangement of an anthracyclic polyketide.(Chem. Biol.) [2005]

D7C2R7_STRBB
(D7C2R7)

2e-53

213

54%

Product: Ketoreductase
Gene: SBI_02829
Organism: Streptomyces bingchenggensis (strain BCW-1)

1uniprot[Pubmed] 20581206
Genome sequence of the milbemycin-producing bacterium Streptomyces bingchenggensis.(J. Bacteriol.) [2010]

F2RGT6_STRVP
(F2RGT6)

2e-52

211

53%

Product: 3-oxoacyl-[acyl-carrier protein] reductase
Gene: SVEN_1610
Organism: Streptomyces venezuelae (strain ATCC 10712 / CBS 650.69 / DSM 40230 / JCM 4526 / NBRC 13096 / PD 04745)

1uniprot[Pubmed] 21463507
Genome-wide analysis of the role of GlnR in Streptomyces venezuelae provides new insights into global nitrogen regulation in actinomycetes.(BMC Genomics) [2011]

Q194Q5_STRAA
(Q194Q5)

2e-52

210

53%

Product: Ketoreductase
Gene: mtmTIII
Organism: Streptomyces argillaceus

[pubmed all]
1uniprot[Pubmed] 8654997 [Medline] 96257259 Characterization of Streptomyces argillaceus genes encoding a polyketide synthase involved in the biosynthesis of the antitumor mithramycin.(Gene) [1996]
2uniprot[Pubmed] 8757400 [Medline] 96335144 An ABC transporter is essential for resistance to the antitumor agent mithramycin in the producer Streptomyces argillaceus.(Mol. Gen. Genet.) [1996]
3uniprot[Pubmed] 9150235 [Medline] 97294479 Cloning and insertional inactivation of Streptomyces argillaceus genes involved in the earliest steps of biosynthesis of the sugar moieties of the antitumor polyketide mithramycin.(J. Bacteriol.) [1997]
4uniprot[Pubmed] 9733697 [Medline] 98406047 Identification of two genes from Streptomyces argillaceus encoding glycosyltransferases involved in transfer of a disaccharide during biosynthesis of the antitumor drug mithramycin.(J. Bacteriol.) [1998]
5uniprot[Pubmed] 10102355 [Medline] 99200478 Analysis of two chromosomal regions adjacent to genes for a type II polyketide synthase involved in the biosynthesis of the antitumor polyketide mithramycin in Streptomyces argillaceus.(Mol. Gen. Genet.) [1999]
6uniprot[Pubmed] 9889148 [Medline] 99111236 Oxidative cleavage of premithramycin B is one of the last steps in the biosynthesis of the antitumor drug mithramycin.(Chem. Biol.) [1999]
7uniprot[Pubmed] 10660060 [Medline] 20123456 Characterization of two glycosyltransferases involved in early glycosylation steps during biosynthesis of the antitumor polyketide mithramycin by Streptomyces argillaceus.(Mol. Gen. Genet.) [2000]
8uniprot[Pubmed] 11254130 [Medline] 21148776 The mtmVUC genes of the mithramycin gene cluster in Streptomyces argillaceus are involved in the biosynthesis of the sugar moieties.(Mol. Gen. Genet.) [2001]
9uniprot[Pubmed] 12733914 [Medline] 22619809 Mithramycin SK, a novel antitumor drug with improved therapeutic index, mithramycin SA, and demycarosyl-mithramycin SK: three new products generated in the mithramycin producer Streptomyces argillaceus through combinatorial biosynthesis.(J. Am. Chem. Soc.) [2003]
10uniprot[Pubmed] 9917296 [Medline] 99115752 The structure of mithramycin reinvestigated.(J. Nat. Prod.) [1999]
11uniprot[Pubmed] 11853433 [Medline] 21843297 Ketopremithramycins and ketomithramycins, four new aureolic acid-type compounds obtained upon inactivation of two genes involved in the biosynthesis of the deoxysugar moieties of the antitumor drug mithramycin by Streptomyces argillaceus, reveal novel insights into post-PKS tailoring steps of the mithramycin biosynthetic pathway.(J. Am. Chem. Soc.) [2002]
12uniprot[Pubmed] 10652287 [Medline] 20119254 Characterization of two polyketide methyltransferases involved in the biosynthesis of the antitumor drug mithramycin by Streptomyces argillaceus.(J. Biol. Chem.) [2000]
13uniprot[Pubmed] 10779713 [Medline] 20243461 Insertional inactivation of mtrX and mtrY genes from the mithramycin gene cluster affects production and growth of the producer organism Streptomyces argillaceus.(FEMS Microbiol. Lett.) [2000]
14uniprot[Pubmed] 12022840 [Medline] 22017994 Rationally designed glycosylated premithramycins: hybrid aromatic polyketides using genes from three different biosynthetic pathways.(J. Am. Chem. Soc.) [2002]
15uniprot[Pubmed] 12813091 [Medline] 22697398 Purification and characterization of a monooxygenase involved in the biosynthetic pathway of the antitumor drug mithramycin.(J. Bacteriol.) [2003]
16uniprot[Pubmed] 8807845 [Medline] 97113238 Deciphering the biosynthetic origin of the aglycone of the aureolic acid group of anti-tumor agents.(Chem. Biol.) [1996]
17uniprot[Pubmed] 14660589 MtmMII-mediated C-methylation during biosynthesis of the antitumor drug mithramycin is essential for biological activity and DNA-drug interaction.(J. Biol. Chem.) [2004]
18uniprot[Pubmed] 9375253 [Medline] 98042823 Folding of the polyketide chain is not dictated by minimal polyketide synthase in the biosynthesis of mithramycin and anthracycline.(Chem. Biol.) [1997]
19uniprot[Pubmed] 15712316 Elucidation of the glycosylation sequence of mithramycin biosynthesis: isolation of 3A-deolivosylpremithramycin B and its conversion to premithramycin B by glycosyltransferase MtmGII.(Chembiochem) [2005]
20uniprot[Pubmed] 10760873 The Novel Hybrid Antitumor Compound Premithramycinone H Provides Indirect Evidence for a Tricyclic Intermediate of the Biosynthesis of the Aureolic Acid Antibiotic Mithramycin.(Angew. Chem. Int. Ed.) [2000]

Q9FBU4_STRCO
(Q9FBU4)

1e-42

178

41%

Product: Putative ketoreductase
Gene: SCO7147
Organism: Streptomyces coelicolor

1uniprot[Pubmed] 12000953 [Medline] 21996410
Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).(Nature) [2002]

C3YX54_BRAFL
(C3YX54)

2e-42

177

40%

Product: Putative uncharacterized protein
Gene: BRAFLDRAFT_59053
Organism: Branchiostoma floridae
Florida lancelet
Amphioxus

1uniprot[Pubmed] 18563158
The amphioxus genome and the evolution of the chordate karyotype.(Nature) [2008]

B4L3S0_DROMO
(B4L3S0)

1e-39

168

40%

Product: GI14997
Gene: GI14997
Dmoj\GI14997
Dmoj_GI14997
Organism: Drosophila mojavensis
Fruit fly

1uniprot[Pubmed] 17994087
Evolution of genes and genomes on the Drosophila phylogeny.(Nature) [2007]

B3MYD7_DROAN
(B3MYD7)

1e-39

168

42%

Product: GF22046
Gene: GF22046
Dana\GF22046
Dana_GF22046
Organism: Drosophila ananassae
Fruit fly

1uniprot[Pubmed] 17994087
Evolution of genes and genomes on the Drosophila phylogeny.(Nature) [2007]

B3P9C5_DROER
(B3P9C5)

1e-39

168

43%

Product: GG12728
Gene: GG12728
Dere\GG12728
Dere_GG12728
Organism: Drosophila erecta
Fruit fly

1uniprot[Pubmed] 17994087
Evolution of genes and genomes on the Drosophila phylogeny.(Nature) [2007]

B4MD32_DROVI
(B4MD32)

1e-39

167

40%

Product: GJ15354
Gene: GJ15354
Dvir\GJ15354
Dvir_GJ15354
Organism: Drosophila virilis
Fruit fly

[pubmed all]
1uniprot[Pubmed] 17994087 Evolution of genes and genomes on the Drosophila phylogeny.(Nature) [2007]
2uniprot[Pubmed] 18057021 Assembly reconciliation.(Bioinformatics) [2008]

Q65SN2_MANSM
(Q65SN2)

6e-39

165

38%

Product: FabG protein
Gene: fabG
MS1421
Organism: Mannheimia succiniciproducens (strain MBEL55E)

1uniprot[Pubmed] 15378067
The genome sequence of the capnophilic rumen bacterium Mannheimia succiniciproducens.(Nat. Biotechnol.) [2004]

Q9U1L2_DROME
(Q9U1L2)

6e-39

165

42%

Product: CG3699
EG:BACR7A4.14 protein
Gene: EG:BACR7A4.14
CG3699
Dmel_CG3699
Organism: Drosophila melanogaster
Fruit fly

[pubmed all]
1uniprot[Pubmed] 10731132 [Medline] 20196006 The genome sequence of Drosophila melanogaster.(Science) [2000]
2uniprot[Pubmed] 12537572 [Medline] 22426069 Annotation of the Drosophila melanogaster euchromatic genome: a systematic review.(Genome Biol.) [2002]

B4R2K9_DROSI
(B4R2K9)

6e-39

165

42%

Product: GD16445
Gene: GD16445
Dsim\GD16445
Dsim_GD16445
Organism: Drosophila simulans
Fruit fly

1uniprot[Pubmed] 17994087
Evolution of genes and genomes on the Drosophila phylogeny.(Nature) [2007]

B4I985_DROSE
(B4I985)

6e-39

165

42%

Product: GM19006
Gene: GM19006
Dsec\GM19006
Dsec_GM19006
Organism: Drosophila sechellia
Fruit fly

1uniprot[Pubmed] 17994087
Evolution of genes and genomes on the Drosophila phylogeny.(Nature) [2007]

Q95PA3_AEDAE
(Q95PA3)

4e-38

163

39%

Product: Putative short-chain dehydrogenase/reductase
Gene: SDR1
Organism: Aedes aegypti
Yellowfever mosquito
Culex aegypti

1uniprot[Pubmed] 14513362 [Medline] 22875075
A targeted approach to the identification of candidate genes determining susceptibility to Plasmodium gallinaceum in Aedes aegypti.(Mol. Genet. Genomics) [2003]

B4PXJ3_DROYA
(B4PXJ3)

4e-38

162

42%

Product: GE16554
Gene: GE16554
Dyak\GE16554
Dyak_GE16554
Organism: Drosophila yakuba
Fruit fly

[pubmed all]
1uniprot[Pubmed] 17994087 Evolution of genes and genomes on the Drosophila phylogeny.(Nature) [2007]
2uniprot[Pubmed] 17550304 Principles of genome evolution in the Drosophila melanogaster species group.(PLoS Biol.) [2007]

Q333V8_9ACTO
(Q333V8)

5e-38

162

45%

Product: NAD or NADP oxidoreductase
Gene: tioH
Organism: Micromonospora sp. ML1

1uniprot
Deciphering the biosynthesis pathway of the antitumor thiocoraline from a marine actinomycete and its expression in Streptomyces hosts.(Chembiochem) [2006]

B4KCR4_DROMO
(B4KCR4)

7e-38

162

38%

Product: GI10241
Gene: GI10241
Dmoj\GI10241
Dmoj_GI10241
Organism: Drosophila mojavensis
Fruit fly

1uniprot[Pubmed] 17994087
Evolution of genes and genomes on the Drosophila phylogeny.(Nature) [2007]

Q65QK8_MANSM
(Q65QK8)

2e-37

160

37%

Product: FabG protein
Gene: fabG
MS2145
Organism: Mannheimia succiniciproducens (strain MBEL55E)

1uniprot[Pubmed] 15378067
The genome sequence of the capnophilic rumen bacterium Mannheimia succiniciproducens.(Nat. Biotechnol.) [2004]

B3RXK7_TRIAD
(B3RXK7)

3e-37

160

37%

Product: Putative uncharacterized protein
Gene: TRIADDRAFT_63298
Organism: Trichoplax adhaerens
Trichoplax reptans

1uniprot[Pubmed] 18719581
The Trichoplax genome and the nature of placozoans.(Nature) [2008]

Q95PA6_AEDAE
(Q95PA6)

3e-37

160

39%

Product: Putative short-chain dehydrogenase/reductase Mc1
Gene: SDR2
Organism: Aedes aegypti
Yellowfever mosquito
Culex aegypti

Q29IW6_DROPS
(Q29IW6)

3e-37

160

40%

Product: GA17622
Gene: GA17622
Dpse\GA17622
Dpse_GA17622
Organism: Drosophila pseudoobscura pseudoobscura
Fruit fly

1uniprot[Pubmed] 15632085
Comparative genome sequencing of Drosophila pseudoobscura: chromosomal, gene, and cis-element evolution.(Genome Res.) [2005]

B4GTT3_DROPE
(B4GTT3)

3e-37

160

40%

Product: GL14417
Gene: GL14417
Dper\GL14417
Dper_GL14417
Organism: Drosophila persimilis
Fruit fly

1uniprot[Pubmed] 17994087
Evolution of genes and genomes on the Drosophila phylogeny.(Nature) [2007]

B4ND54_DROWI
(B4ND54)

5e-37

159

39%

Product: GK10169
Gene: GK10169
Dwil\GK10169
Dwil_GK10169
Organism: Drosophila willistoni
Fruit fly

1uniprot[Pubmed] 17994087
Evolution of genes and genomes on the Drosophila phylogeny.(Nature) [2007]

D2SNW1_HELVI
(D2SNW1)

9e-37

158

40%

Product: Hydroxybutyrate dehydrogenase
Gene: hvpg0117
Organism: Heliothis virescens
Tobacco budworm moth

1uniprot[Pubmed] 20074338
Transcriptome analysis of the sex pheromone gland of the noctuid moth Heliothis virescens.(BMC Genomics) [2010]

C3YX55_BRAFL
(C3YX55)

1e-36

158

38%

Product: Putative uncharacterized protein
Gene: BRAFLDRAFT_225165
Organism: Branchiostoma floridae
Florida lancelet
Amphioxus

1uniprot[Pubmed] 18563158
The amphioxus genome and the evolution of the chordate karyotype.(Nature) [2008]

B5DWF7_DROPS
(B5DWF7)

1e-36

157

40%

Product: GA27306
Gene: GA27306
Dpse\GA27306
Dpse_GA27306
Organism: Drosophila pseudoobscura pseudoobscura
Fruit fly

1uniprot[Pubmed] 15632085
Comparative genome sequencing of Drosophila pseudoobscura: chromosomal, gene, and cis-element evolution.(Genome Res.) [2005]

A8X8G3_CAEBR
(A8X8G3)

2e-36

157

37%

Product: Putative uncharacterized protein
Gene: CBG09704
CBG_09704
Organism: Caenorhabditis briggsae

1uniprot[Pubmed] 14624247
The genome sequence of Caenorhabditis briggsae: a platform for comparative genomics.(PLoS Biol.) [2003]

F6T472_XENTR
(F6T472)

2e-36

157

36%

Product: Uncharacterized protein
Gene: XB-GENE-5820599
Organism: Xenopus tropicalis
Western clawed frog
Silurana tropicalis

1uniprot[Pubmed] 20431018
The genome of the Western clawed frog Xenopus tropicalis.(Science) [2010]

Q18946_CAEEL
(Q18946)

2e-36

157

37%

Product: Protein D1054.8, confirmed by transcript evidence
Gene: D1054.8
Organism: Caenorhabditis elegans

1uniprot[Pubmed] 9851916 [Medline] 99069613
Genome sequence of the nematode C. elegans: a platform for investigating biology.(Science) [1998]

B4G475_DROPE
(B4G475)

2e-36

157

40%

Product: GL24510
Gene: GL24510
Dper\GL24510
Dper_GL24510
Organism: Drosophila persimilis
Fruit fly

1uniprot[Pubmed] 17994087
Evolution of genes and genomes on the Drosophila phylogeny.(Nature) [2007]

F6WNB8_XENTR
(F6WNB8)

2e-36

157

37%

Product: Uncharacterized protein
Gene: XB-GENE-5820599
Organism: Xenopus tropicalis
Western clawed frog
Silurana tropicalis

1uniprot[Pubmed] 20431018
The genome of the Western clawed frog Xenopus tropicalis.(Science) [2010]

C3XTH8_BRAFL
(C3XTH8)

3e-36

156

38%

Product: Putative uncharacterized protein
Gene: BRAFLDRAFT_280406
Organism: Branchiostoma floridae
Florida lancelet
Amphioxus

1uniprot[Pubmed] 18563158
The amphioxus genome and the evolution of the chordate karyotype.(Nature) [2008]

B3RXK6_TRIAD
(B3RXK6)

4e-36

156

36%

Product: Putative uncharacterized protein
Gene: TRIADDRAFT_56243
Organism: Trichoplax adhaerens
Trichoplax reptans

1uniprot[Pubmed] 18719581
The Trichoplax genome and the nature of placozoans.(Nature) [2008]

Q67RW6_SYMTH
(Q67RW6)

4e-36

156

43%

Product: Ketoreductase
Gene: STH592
Organism: Symbiobacterium thermophilum

1uniprot[Pubmed] 15383646
Genome sequence of Symbiobacterium thermophilum, an uncultivable bacterium that depends on microbial commensalism.(Nucleic Acids Res.) [2004]

B4PUV4_DROYA
(B4PUV4)

7e-36

155

38%

Product: GE10146
Gene: GE10146
Dyak\GE10146
Dyak_GE10146
Organism: Drosophila yakuba
Fruit fly

[pubmed all]
1uniprot[Pubmed] 17994087 Evolution of genes and genomes on the Drosophila phylogeny.(Nature) [2007]
2uniprot[Pubmed] 17550304 Principles of genome evolution in the Drosophila melanogaster species group.(PLoS Biol.) [2007]

B4M524_DROVI
(B4M524)

7e-36

155

38%

Product: GJ10124
Gene: GJ10124
Dvir\GJ10124
Dvir_GJ10124
Organism: Drosophila virilis
Fruit fly

[pubmed all]
1uniprot[Pubmed] 17994087 Evolution of genes and genomes on the Drosophila phylogeny.(Nature) [2007]
2uniprot[Pubmed] 18057021 Assembly reconciliation.(Bioinformatics) [2008]

Q9N5G4_CAEEL
(Q9N5G4)

8e-36

155

36%

Product: Putative uncharacterized protein
Gene: R05D8.7
Organism: Caenorhabditis elegans

1uniprot[Pubmed] 9851916 [Medline] 99069613
Genome sequence of the nematode C. elegans: a platform for investigating biology.(Science) [1998]

Q8SX57_DROME
(Q8SX57)

1e-35

154

38%

Product: CG31549
LD44221p
Gene: CG11005
CG31549
Dmel_CG31549
Organism: Drosophila melanogaster
Fruit fly

[pubmed all]
1uniprot[Pubmed] 10731132 [Medline] 20196006 The genome sequence of Drosophila melanogaster.(Science) [2000]
2uniprot[Pubmed] 12537572 [Medline] 22426069 Annotation of the Drosophila melanogaster euchromatic genome: a systematic review.(Genome Biol.) [2002]

B4I444_DROSE
(B4I444)

2e-35

154

38%

Product: GM10825
Gene: GM10825
Dsec\GM10825
Dsec_GM10825
Organism: Drosophila sechellia
Fruit fly

1uniprot[Pubmed] 17994087
Evolution of genes and genomes on the Drosophila phylogeny.(Nature) [2007]

B4JSU0_DROGR
(B4JSU0)

3e-35

153

37%

Product: GH22984
Gene: GH22984
Dgri\GH22984
Dgri_GH22984
Organism: Drosophila grimshawi
Fruit fly
Idiomyia grimshawi

1uniprot[Pubmed] 17994087
Evolution of genes and genomes on the Drosophila phylogeny.(Nature) [2007]

Q170J0_AEDAE
(Q170J0)

3e-35

153

36%

Product: AAEL007893-PA
Short chain type dehydrogenase
Gene: AAEL007893
AaeL_AAEL007893
Aael_AAEL007893
Organism: Aedes aegypti
Yellowfever mosquito
Culex aegypti

[pubmed all]
1uniprot[Pubmed] 17510324 Genome sequence of Aedes aegypti, a major arbovirus vector.(Science) [2007]
2uniprot[Pubmed] 17519023 Analysis of 14 BAC sequences from the Aedes aegypti genome: a benchmark for genome annotation and assembly.(Genome Biol.) [2007]

A8X8L5_CAEBR
(A8X8L5)

4e-35

153

37%

Product: Putative uncharacterized protein
Gene: CBG09635
CBG_09635
Organism: Caenorhabditis briggsae

1uniprot[Pubmed] 14624247
The genome sequence of Caenorhabditis briggsae: a platform for comparative genomics.(PLoS Biol.) [2003]

D6WBF1_TRICA
(D6WBF1)

4e-35

152

36%

Product: Putative uncharacterized protein
Gene: TcasGA2_TC000272
Organism: Tribolium castaneum
Red flour beetle

[pubmed all]
1uniprot[Pubmed] 18362917 The genome of the model beetle and pest Tribolium castaneum.(Nature) [2008]
2uniprot[Pubmed] 19820115 38(Nucleic Acids Res.) [2010]

B3LWG2_DROAN
(B3LWG2)

4e-35

152

37%

Product: GF16338
Gene: GF16338
Dana\GF16338
Dana_GF16338
Organism: Drosophila ananassae
Fruit fly

1uniprot[Pubmed] 17994087
Evolution of genes and genomes on the Drosophila phylogeny.(Nature) [2007]

Q16ZI8_AEDAE
(Q16ZI8)

4e-35

152

37%

Product: Short-chain dehydrogenase
Gene: AAEL008152
AaeL_AAEL008152
Organism: Aedes aegypti
Yellowfever mosquito
Culex aegypti

1uniprot[Pubmed] 17510324
Genome sequence of Aedes aegypti, a major arbovirus vector.(Science) [2007]

B3P2H2_DROER
(B3P2H2)

4e-35

152

38%

Product: GG12965
Gene: GG12965
Dere\GG12965
Dere_GG12965
Organism: Drosophila erecta
Fruit fly

1uniprot[Pubmed] 17994087
Evolution of genes and genomes on the Drosophila phylogeny.(Nature) [2007]

E3X654_ANODA
(E3X654)

6e-35

152

36%

Product: Putative uncharacterized protein
Gene: AND_14486
Organism: Anopheles darlingi
Mosquito

1uniprot[Pubmed] 20920257
Combination of measures distinguishes pre-miRNAs from other stem-loops in the genome of the newly sequenced Anopheles darlingi.(BMC Genomics) [2010]

B4NKA4_DROWI
(B4NKA4)

7e-35

152

38%

Product: GK13927
Gene: GK13927
Dwil\GK13927
Dwil_GK13927
Organism: Drosophila willistoni
Fruit fly

1uniprot[Pubmed] 17994087
Evolution of genes and genomes on the Drosophila phylogeny.(Nature) [2007]

Q7PR84_ANOGA
(Q7PR84)

7e-35

152

37%

Product: AGAP002520-PA
Gene: AgaP_AGAP002520
Organism: Anopheles gambiae
African malaria mosquito

1uniprot[Pubmed] 12364791 [Medline] 22251359
The genome sequence of the malaria mosquito Anopheles gambiae.(Science) [2002]

B4I445_DROSE
(B4I445)

1e-34

151

37%

Product: GM10826
Gene: GM10826
Dsec\GM10826
Dsec_GM10826
Organism: Drosophila sechellia
Fruit fly

1uniprot[Pubmed] 17994087
Evolution of genes and genomes on the Drosophila phylogeny.(Nature) [2007]

100

B4JST9_DROGR
(B4JST9)

1e-34

151

37%

Product: GH22973
Gene: GH22973
Dgri\GH22973
Dgri_GH22973
Organism: Drosophila grimshawi
Fruit fly
Idiomyia grimshawi

1uniprot[Pubmed] 17994087
Evolution of genes and genomes on the Drosophila phylogeny.(Nature) [2007]