BLAST table : Nogl_00130

DB	UniProtKB

	accession	alignment	Evalue	Score	Ident.	link	product	gene	organism	ec
1	Q9RN66_STRNO (Q9RN66)		1e-152	541	100%	UniProt GenBank	C-7 ketoreductase	snoaF	Streptomyces nogalater
2	D9UBL2_STRPR (D9UBL2)		2e-77	293	63%	UniProt GenBank	Putative ketoreductase	c104_02	Streptomyces pristinaespiralis
3	B5HJX5_STRPR (B5HJX5)		3e-77	293	63%	UniProt GenBank	C-7 ketoreductase	SSDG_05472	Streptomyces pristinaespiralis ATCC 25486
4	A1C190_9ACTO (A1C190)		2e-68	263	60%	UniProt GenBank	Oxidoreductase		Streptomyces echinatus
5	E8RWT2_MICSL (E8RWT2)		5e-68	262	58%	UniProt GenBank	Short-chain dehydrogenase/reductase SDR	ML5_4421	Micromonospora sp. (strain L5)
6	D9T297_MICAI (D9T297)		2e-67	260	58%	UniProt GenBank	Short-chain dehydrogenase/reductase SDR	Micau_4000	Micromonospora aurantiaca (strain ATCC 27029 / DSM 43813 / JCM 10878 / NBRC 16125 / INA 9442)
7	Q9L4U4_9ACTO (Q9L4U4)		5e-67	259	60%	UniProt GenBank	Putative aklaviketone reductase	aknU	Streptomyces galilaeus
8	Q54810_STRPE (Q54810)		2e-66	256	60%	UniProt GenBank	Daunorubicin-doxorubicin polyketide synthase	dnrH	Streptomyces peucetius
9	Q2PA05_9ACTO (Q2PA05)		4e-66	256	57%	UniProt GenBank	Ketoreductase	stfT	Streptomyces steffisburgensis
10	Q53882_STRS5 (Q53882)		4e-66	255	60%	UniProt GenBank	Aklaviketone reductase	dauE	Streptomyces sp. (strain C5)
11	B5G8A0_9ACTO (B5G8A0)		2e-63	246	58%	UniProt GenBank	Ketoreductase	SSBG_00508	Streptomyces sp. SPB74
12	Q82HG2_STRAW (Q82HG2)		8e-61	238	53%	UniProt GenBank	Putative ketoreductase	SAV3547 SAV_3547	Streptomyces avermitilis
13	D9XFG9_STRVR (D9XFG9)		6e-60	235	54%	UniProt GenBank	3-oxoacyl-[acyl-carrier-protein] reductase	SSQG_03190	Streptomyces viridochromogenes DSM 40736
14	E8S731_MICSL (E8S731)		1e-58	231	55%	UniProt GenBank	Short-chain dehydrogenase/reductase SDR	ML5_3923	Micromonospora sp. (strain L5)
15	D9T583_MICAI (D9T583)		1e-58	231	55%	UniProt GenBank	Short-chain dehydrogenase/reductase SDR	Micau_4380	Micromonospora aurantiaca (strain ATCC 27029 / DSM 43813 / JCM 10878 / NBRC 16125 / INA 9442)
16	Q4R0K9_STRCX (Q4R0K9)		3e-58	229	52%	UniProt GenBank	ChaL protein	chaL	Streptomyces chartreusis
17	Q194Q5_STRAA (Q194Q5)		1e-56	224	54%	UniProt GenBank	Ketoreductase	mtmTIII	Streptomyces argillaceus
18	D1XUW2_9ACTO (D1XUW2)		4e-56	223	51%	UniProt GenBank	Short-chain dehydrogenase/reductase SDR	SACTEDRAFT_6472	Streptomyces sp. SA3_actE
19	F2RGT6_STRVP (F2RGT6)		1e-54	217	51%	UniProt GenBank	3-oxoacyl-[acyl-carrier protein] reductase	SVEN_1610	Streptomyces venezuelae (strain ATCC 10712 / CBS 650.69 / DSM 40230 / JCM 4526 / NBRC 13096 / PD 04745)	1.1.1.100 niceE keggE
20	D9XU86_9ACTO (D9XU86)		9e-54	214	51%	UniProt GenBank	3-oxoacyl-[acyl-carrier-protein] reductase	SSRG_01089	Streptomyces griseoflavus Tu4000
21	E0KYL5_STRVO (E0KYL5)		9e-54	214	54%	UniProt GenBank	Short-chain dehydrogenase/reductase SDR	StrviDRAFT_7743	Streptomyces violaceusniger Tu 4113
22	B5HI32_STRPR (B5HI32)		5e-53	212	49%	UniProt GenBank	Ketoreductase	SSDG_04823	Streptomyces pristinaespiralis ATCC 25486
23	D9WGQ6_9ACTO (D9WGQ6)		9e-50	201	51%	UniProt GenBank	3-oxoacyl-[acyl-carrier-protein] reductase	SSOG_05158	Streptomyces himastatinicus ATCC 53653
24	D7C2R7_STRBB (D7C2R7)		2e-49	200	51%	UniProt GenBank	Ketoreductase	SBI_02829	Streptomyces bingchenggensis (strain BCW-1)
25	D9VVR3_9ACTO (D9VVR3)		4e-49	199	56%	UniProt GenBank	3-oxoacyl-[acyl-carrier-protein] reductase	SSNG_04431	Streptomyces sp. C
26	D9VG62_9ACTO (D9VG62)		6e-48	195	50%	UniProt GenBank	2-hydroxycyclohexanecarboxyl-CoA dehydrogenase	SSMG_06087	Streptomyces sp. AA4
27	E0KMJ0_STRVO (E0KMJ0)		1e-47	194	48%	UniProt GenBank	Short-chain dehydrogenase/reductase SDR	StrviDRAFT_3867	Streptomyces violaceusniger Tu 4113
28	D9WMS1_9ACTO (D9WMS1)		8e-46	188	43%	UniProt GenBank	3-oxoacyl-[acyl-carrier-protein] reductase	SSOG_07651	Streptomyces himastatinicus ATCC 53653
29	Q9FBU4_STRCO (Q9FBU4)		7e-44	182	40%	UniProt GenBank	Putative ketoreductase	SCO7147	Streptomyces coelicolor
30	D6EC83_STRLI (D6EC83)		7e-44	182	40%	UniProt GenBank	Ketoreductase	SSPG_00700	Streptomyces lividans TK24
31	A8M462_SALAI (A8M462)		9e-43	178	45%	UniProt GenBank	Short-chain dehydrogenase/reductase SDR	Sare_4196	Salinispora arenicola (strain CNS-205)
32	A4XBD7_SALTO (A4XBD7)		2e-42	177	44%	UniProt GenBank	Short-chain dehydrogenase/reductase SDR	Strop_3805	Salinispora tropica (strain ATCC BAA-916 / DSM 44818 / CNB-440)
33	C6D110_PAESJ (C6D110)		3e-42	176	41%	UniProt GenBank	Short-chain dehydrogenase/reductase SDR	Pjdr2_3149	Paenibacillus sp. (strain JDR-2)
34	D6UP60_9BACT (D6UP60)		5e-41	172	41%	UniProt GenBank	Short-chain dehydrogenase/reductase SDR	AciX8DRAFT_1040	Acidobacterium sp. MP5ACTX8
35	B3RXK7_TRIAD (B3RXK7)		5e-39	166	40%	UniProt GenBank	Putative uncharacterized protein	TRIADDRAFT_63298	Trichoplax adhaerens Trichoplax reptans
36	C3YX54_BRAFL (C3YX54)		2e-38	164	40%	UniProt GenBank	Putative uncharacterized protein	BRAFLDRAFT_59053	Branchiostoma floridae Florida lancelet Amphioxus
37	A0NSD0_9RHOB (A0NSD0)		2e-38	163	41%	UniProt GenBank	Ketoreductase	SIAM614_04835	Labrenzia aggregata IAM 12614
38	C1C192_9MAXI (C1C192)		1e-37	161	38%	UniProt GenBank	3-oxoacyl-acyl-carrier-protein reductase	FABG	Caligus clemensi
39	Q67RW6_SYMTH (Q67RW6)		3e-37	160	45%	UniProt GenBank	Ketoreductase	STH592	Symbiobacterium thermophilum
40	D3TMV0_GLOMM (D3TMV0)		4e-37	159	37%	UniProt GenBank	3-oxoacyl		Glossina morsitans morsitans Savannah tsetse fly
41	B3RXK6_TRIAD (B3RXK6)		1e-36	158	38%	UniProt GenBank	Putative uncharacterized protein	TRIADDRAFT_56243	Trichoplax adhaerens Trichoplax reptans
42	Q95PA3_AEDAE (Q95PA3)		6e-36	155	37%	UniProt GenBank	Putative short-chain dehydrogenase/reductase	SDR1	Aedes aegypti Yellowfever mosquito Culex aegypti
43	E9G535_DAPPU (E9G535)		6e-36	155	39%	UniProt GenBank	Putative uncharacterized protein	DAPPUDRAFT_300459	Daphnia pulex Water flea
44	E9IXL5_SOLIN (E9IXL5)	(2 hsp)	2e-35	154	37%	UniProt GenBank	Putative uncharacterized protein	SINV_11101	Solenopsis invicta Red imported fire ant Solenopsis wagneri
45	C1BS68_9MAXI (C1BS68)		2e-35	153	38%	UniProt GenBank	3-oxoacyl-acyl-carrier-protein reductase	FABG	Lepeophtheirus salmonis (salmon louse)
46	C1BV43_9MAXI (C1BV43)		3e-35	153	36%	UniProt GenBank	3-oxoacyl-acyl-carrier-protein reductase	FABG	Lepeophtheirus salmonis (salmon louse)
47	D6WBF1_TRICA (D6WBF1)		4e-35	152	37%	UniProt GenBank	Putative uncharacterized protein	TcasGA2_TC000272	Tribolium castaneum Red flour beetle
48	A6VPT1_ACTSZ (A6VPT1)		6e-35	152	37%	UniProt GenBank	Short-chain dehydrogenase/reductase SDR	Asuc_1624	Actinobacillus succinogenes (strain ATCC 55618 / 130Z)
49	Q95PA6_AEDAE (Q95PA6)		6e-35	152	37%	UniProt GenBank	Putative short-chain dehydrogenase/reductase Mc1	SDR2	Aedes aegypti Yellowfever mosquito Culex aegypti
50	C1BQS5_9MAXI (C1BQS5)		8e-35	152	35%	UniProt GenBank	3-oxoacyl-acyl-carrier-protein reductase	FABG	Caligus rogercresseyi
51	Q8T4Q5_AEDAE (Q8T4Q5)		1e-34	151	37%	UniProt GenBank	Short-chain dehydrogenease/reductase	SDR	Aedes aegypti Yellowfever mosquito Culex aegypti
52	Q8T4Q4_AEDAE (Q8T4Q4)		1e-34	151	37%	UniProt GenBank	Short-chain dehydrogenease/reductase	SDR	Aedes aegypti Yellowfever mosquito Culex aegypti
53	C3Y896_BRAFL (C3Y896)		1e-34	151	37%	UniProt GenBank	Putative uncharacterized protein	BRAFLDRAFT_205155	Branchiostoma floridae Florida lancelet Amphioxus
54	Q9N5G4_CAEEL (Q9N5G4)		2e-34	150	38%	UniProt GenBank	Putative uncharacterized protein	R05D8.7	Caenorhabditis elegans
55	Q65SN2_MANSM (Q65SN2)		2e-34	150	37%	UniProt GenBank	FabG protein	fabG MS1421	Mannheimia succiniciproducens (strain MBEL55E)
56	C3XTH8_BRAFL (C3XTH8)		2e-34	150	37%	UniProt GenBank	Putative uncharacterized protein	BRAFLDRAFT_280406	Branchiostoma floridae Florida lancelet Amphioxus
57	B3RXK8_TRIAD (B3RXK8)		2e-34	150	40%	UniProt GenBank	Putative uncharacterized protein	TRIADDRAFT_50287	Trichoplax adhaerens Trichoplax reptans
58	Q170J0_AEDAE (Q170J0)		2e-34	150	37%	UniProt GenBank	AAEL007893-PA Short chain type dehydrogenase	AAEL007893 AaeL_AAEL007893 Aael_AAEL007893	Aedes aegypti Yellowfever mosquito Culex aegypti
59	B0X121_CULQU (B0X121)		4e-34	149	37%	UniProt GenBank	3-hydroxybutyrate dehydrogenase type 2	CpipJ_CPIJ013219	Culex quinquefasciatus Southern house mosquito Culex pungens
60	E0VS61_PEDHC (E0VS61)		5e-34	149	35%	UniProt GenBank	Alcohol dehydrogenase, putative	Phum_PHUM411900	Pediculus humanus subsp. corporis Body louse	1.1.1.100 niceE keggE
61	B8KMD5_9GAMM (B8KMD5)		9e-34	148	41%	UniProt GenBank	Oxidoreductase, short chain dehydrogenase/reductase family	NOR53_2564	gamma proteobacterium NOR5-3
62	B9B6I1_9BURK (B9B6I1)		1e-33	148	43%	UniProt GenBank	Oxidoreductase, short chain dehydrogenase/reductase family	BURMUCGD1_6440	Burkholderia multivorans CGD1
63	Q8IGG7_DROME (Q8IGG7)		1e-33	148	38%	UniProt GenBank	RH24570p	CG2907 CG31548	Drosophila melanogaster Fruit fly
64	B3LWF9_DROAN (B3LWF9)		1e-33	148	38%	UniProt GenBank	GF18656	GF18656 Dana\GF18656 Dana_GF18656	Drosophila ananassae Fruit fly
65	B4QWZ5_DROSI (B4QWZ5)		1e-33	148	38%	UniProt GenBank	GD19595	GD19595 Dsim\GD19595 Dsim_GD19595	Drosophila simulans Fruit fly
66	B4I447_DROSE (B4I447)		1e-33	148	38%	UniProt GenBank	GM10606	GM10606 Dsec\GM10606 Dsec_GM10606	Drosophila sechellia Fruit fly
67	E0VS60_PEDHC (E0VS60)		1e-33	148	36%	UniProt GenBank	Alcohol dehydrogenase, putative	Phum_PHUM411890	Pediculus humanus subsp. corporis Body louse	1.1.1.100 niceE keggE
68	Q8IPP8_DROME (Q8IPP8)		1e-33	147	38%	UniProt GenBank	CG31548	CG31548 Dmel_CG31548	Drosophila melanogaster Fruit fly	1.-.-.- niceE keggE
69	C3YX55_BRAFL (C3YX55)		1e-33	147	38%	UniProt GenBank	Putative uncharacterized protein	BRAFLDRAFT_225165	Branchiostoma floridae Florida lancelet Amphioxus
70	B9CA03_9BURK (B9CA03)		1e-33	147	43%	UniProt GenBank	Oxidoreductase, short chain dehydrogenase/reductase family	BURMUCGD2M_6674	Burkholderia multivorans CGD2M
71	B9BPR1_9BURK (B9BPR1)		1e-33	147	43%	UniProt GenBank	Oxidoreductase, short chain dehydrogenase/reductase family	BURMUCGD2_6682	Burkholderia multivorans CGD2
72	A1ZKI7_9BACT (A1ZKI7)		2e-33	147	36%	UniProt GenBank	3-oxoacyl-acyl-carrier-protein reductase	M23134_02404	Microscilla marina ATCC 23134	1.1.1.100 niceE keggE
73	B5YAK3_DICT6 (B5YAK3)		2e-33	147	36%	UniProt GenBank	Versicolorin reductase	DICTH_1661	Dictyoglomus thermophilum (strain ATCC 35947 / DSM 3960 / H-6-12)	1.1.-.- niceE keggE
74	Q333V8_9ACTO (Q333V8)		2e-33	147	41%	UniProt GenBank	NAD or NADP oxidoreductase	tioH	Micromonospora sp. ML1
75	B4L3S0_DROMO (B4L3S0)		2e-33	147	39%	UniProt GenBank	GI14997	GI14997 Dmoj\GI14997 Dmoj_GI14997	Drosophila mojavensis Fruit fly
76	F4WG12_ACREC (F4WG12)		2e-33	147	36%	UniProt GenBank	3-oxoacyl-[acyl-carrier-protein] reductase	G5I_04583	Acromyrmex echinatior Panamanian leafcutter ant Acromyrmex octospinosus echinatior
77	F6WNB8_XENTR (F6WNB8)		3e-33	146	37%	UniProt GenBank	Uncharacterized protein	XB-GENE-5820599	Xenopus tropicalis Western clawed frog Silurana tropicalis
78	F7B9X1_CIOIN (F7B9X1)		3e-33	146	36%	UniProt GenBank	Uncharacterized protein	Cin.2919	Ciona intestinalis Transparent sea squirt Ascidia intestinalis
79	B4NKA5_DROWI (B4NKA5)		3e-33	146	40%	UniProt GenBank	GK13928	GK13928 Dwil\GK13928 Dwil_GK13928	Drosophila willistoni Fruit fly
80	F6T472_XENTR (F6T472)		3e-33	146	37%	UniProt GenBank	Uncharacterized protein	XB-GENE-5820599	Xenopus tropicalis Western clawed frog Silurana tropicalis
81	E9H3L7_DAPPU (E9H3L7)		3e-33	146	37%	UniProt GenBank	Putative uncharacterized protein	DAPPUDRAFT_307656	Daphnia pulex Water flea
82	D1K482_9BACE (D1K482)		3e-33	146	38%	UniProt GenBank	FabG protein	HMPREF0105_2424	Bacteroides sp. 3_1_33FAA
83	B6VV46_9BACE (B6VV46)		3e-33	146	38%	UniProt GenBank	Putative uncharacterized protein	BACDOR_01154	Bacteroides dorei DSM 17855
84	D3PIZ2_9MAXI (D3PIZ2)		4e-33	146	37%	UniProt GenBank	3-oxoacyl-acyl-carrier-protein reductase	FABG	Lepeophtheirus salmonis (salmon louse)
85	Q6DFP0_XENTR (Q6DFP0)		4e-33	146	37%	UniProt GenBank	MGC79752 protein	MGC79752	Xenopus tropicalis Western clawed frog Silurana tropicalis
86	B3P2H5_DROER (B3P2H5)		4e-33	146	37%	UniProt GenBank	GG10914	GG10914 Dere\GG10914 Dere_GG10914	Drosophila erecta Fruit fly
87	E2B879_HARSA (E2B879)		5e-33	146	35%	UniProt GenBank	3-oxoacyl-[acyl-carrier-protein] reductase	EAI_03591	Harpegnathos saltator Jerdon's jumping ant
88	A2W2B2_9BURK (A2W2B2)		5e-33	145	42%	UniProt GenBank	Dehydrogenase	BCPG_04482	Burkholderia cenocepacia PC184
89	B0X924_CULQU (B0X924)		5e-33	145	39%	UniProt GenBank	3-oxoacyl-[acyl-carrier-protein] reductase	CpipJ_CPIJ015685	Culex quinquefasciatus Southern house mosquito Culex pungens
90	Q18946_CAEEL (Q18946)		5e-33	145	37%	UniProt GenBank	Protein D1054.8, confirmed by transcript evidence	D1054.8	Caenorhabditis elegans
91	B4PUV7_DROYA (B4PUV7)		6e-33	145	37%	UniProt GenBank	GE24152	GE24152 Dyak\GE24152 Dyak_GE24152	Drosophila yakuba Fruit fly
92	O16971_CAEEL (O16971)		6e-33	145	38%	UniProt GenBank	Putative uncharacterized protein	T01G6.10	Caenorhabditis elegans
93	Q9VNF3_DROME (Q9VNF3)		6e-33	145	39%	UniProt GenBank	CG12171 RE01652p	CG12171 Dmel_CG12171	Drosophila melanogaster Fruit fly	1.1.-.- niceE keggE
94	B4MD32_DROVI (B4MD32)		7e-33	145	39%	UniProt GenBank	GJ15354	GJ15354 Dvir\GJ15354 Dvir_GJ15354	Drosophila virilis Fruit fly
95	B3P2H3_DROER (B3P2H3)		7e-33	145	39%	UniProt GenBank	GG12970	GG12970 Dere\GG12970 Dere_GG12970	Drosophila erecta Fruit fly
96	C3R9G6_9BACE (C3R9G6)		7e-33	145	38%	UniProt GenBank	FabG protein	BSEG_01816	Bacteroides dorei 5_1_36/D4
97	C3PYH0_9BACE (C3PYH0)		7e-33	145	38%	UniProt GenBank	FabG protein	BSBG_01338	Bacteroides sp. 9_1_42FAA
98	D2SNW1_HELVI (D2SNW1)		8e-33	145	37%	UniProt GenBank	Hydroxybutyrate dehydrogenase	hvpg0117	Heliothis virescens Tobacco budworm moth
99	Q7PR84_ANOGA (Q7PR84)		1e-32	145	38%	UniProt GenBank	AGAP002520-PA	AgaP_AGAP002520	Anopheles gambiae African malaria mosquito
100	A8XET8_CAEBR (A8XET8)		1e-32	144	37%	UniProt GenBank	CBR-DHS-14 protein	dhs-14 Cbr-dhs-14 cbr-dhs-14 CBG12129 CBG_12129	Caenorhabditis briggsae

accession

alignment

Evalue

Score

Ident.

link

information

pubmed

Q9RN66_STRNO
(Q9RN66)

1e-152

541

100%

Product: C-7 ketoreductase
Gene: snoaF
Organism: Streptomyces nogalater

[pubmed all]
1uniprot[Pubmed] 9349712 [Medline] 98007868 Characterization of Streptomyces nogalater genes encoding enzymes involved in glycosylation steps in nogalamycin biosynthesis.(Mol. Gen. Genet.) [1997]
2uniprot[Pubmed] 10639368 [Medline] 20106987 Identification of a cyclase gene dictating the C-9 stereochemistry of anthracyclines from Streptomyces nogalater.(Antimicrob. Agents Chemother.) [2000]

D9UBL2_STRPR
(D9UBL2)

2e-77

293

63%

Product: Putative ketoreductase
Gene: c104_02
Organism: Streptomyces pristinaespiralis

1uniprot[Pubmed] 21342465
Characterization of the 'pristinamycin supercluster' of Streptomyces pristinaespiralis.(Microb Biotechnol) [2011]

Q9L4U4_9ACTO
(Q9L4U4)

5e-67

259

60%

Product: Putative aklaviketone reductase
Gene: aknU
Organism: Streptomyces galilaeus

1uniprot[Pubmed] 11016846 [Medline] 20469061
A gene cluster from Streptomyces galilaeus involved in glycosylation of aclarubicin.(Mol. Gen. Genet.) [2000]

Q54810_STRPE
(Q54810)

2e-66

256

60%

Product: Daunorubicin-doxorubicin polyketide synthase
Gene: dnrH
Organism: Streptomyces peucetius

1uniprot[Pubmed] 7828855 [Medline] 95129838
Characterization of the Streptomyces peucetius ATCC 29050 genes encoding doxorubicin polyketide synthase.(Gene) [1994]

Q2PA05_9ACTO
(Q2PA05)

4e-66

256

57%

Product: Ketoreductase
Gene: stfT
Organism: Streptomyces steffisburgensis

1uniprot[Pubmed] 16751529
Isolation, characterization, and heterologous expression of the biosynthesis gene cluster for the antitumor anthracycline steffimycin.(Appl. Environ. Microbiol.) [2006]

Q53882_STRS5
(Q53882)

4e-66

255

60%

Product: Aklaviketone reductase
Gene: dauE
Organism: Streptomyces sp. (strain C5)

1uniprot[Pubmed] 8655529 [Medline] 96236066
Cloning, sequencing, and analysis of aklaviketone reductase from Streptomyces sp. strain C5.(J. Bacteriol.) [1996]

Q82HG2_STRAW
(Q82HG2)

8e-61

238

53%

Product: Putative ketoreductase
Gene: SAV3547
SAV_3547
Organism: Streptomyces avermitilis

1uniprot[Pubmed] 11572948 [Medline] 21477403
Genome sequence of an industrial microorganism Streptomyces avermitilis: deducing the ability of producing secondary metabolites.(Proc. Natl. Acad. Sci. U.S.A.) [2001]

Q4R0K9_STRCX
(Q4R0K9)

3e-58

229

52%

Product: ChaL protein
Gene: chaL
Organism: Streptomyces chartreusis

1uniprot[Pubmed] 15911378
Biosynthesis of the antitumor agent chartreusin involves the oxidative rearrangement of an anthracyclic polyketide.(Chem. Biol.) [2005]

Q194Q5_STRAA
(Q194Q5)

1e-56

224

54%

Product: Ketoreductase
Gene: mtmTIII
Organism: Streptomyces argillaceus

[pubmed all]
1uniprot[Pubmed] 8654997 [Medline] 96257259 Characterization of Streptomyces argillaceus genes encoding a polyketide synthase involved in the biosynthesis of the antitumor mithramycin.(Gene) [1996]
2uniprot[Pubmed] 8757400 [Medline] 96335144 An ABC transporter is essential for resistance to the antitumor agent mithramycin in the producer Streptomyces argillaceus.(Mol. Gen. Genet.) [1996]
3uniprot[Pubmed] 9150235 [Medline] 97294479 Cloning and insertional inactivation of Streptomyces argillaceus genes involved in the earliest steps of biosynthesis of the sugar moieties of the antitumor polyketide mithramycin.(J. Bacteriol.) [1997]
4uniprot[Pubmed] 9733697 [Medline] 98406047 Identification of two genes from Streptomyces argillaceus encoding glycosyltransferases involved in transfer of a disaccharide during biosynthesis of the antitumor drug mithramycin.(J. Bacteriol.) [1998]
5uniprot[Pubmed] 10102355 [Medline] 99200478 Analysis of two chromosomal regions adjacent to genes for a type II polyketide synthase involved in the biosynthesis of the antitumor polyketide mithramycin in Streptomyces argillaceus.(Mol. Gen. Genet.) [1999]
6uniprot[Pubmed] 9889148 [Medline] 99111236 Oxidative cleavage of premithramycin B is one of the last steps in the biosynthesis of the antitumor drug mithramycin.(Chem. Biol.) [1999]
7uniprot[Pubmed] 10660060 [Medline] 20123456 Characterization of two glycosyltransferases involved in early glycosylation steps during biosynthesis of the antitumor polyketide mithramycin by Streptomyces argillaceus.(Mol. Gen. Genet.) [2000]
8uniprot[Pubmed] 11254130 [Medline] 21148776 The mtmVUC genes of the mithramycin gene cluster in Streptomyces argillaceus are involved in the biosynthesis of the sugar moieties.(Mol. Gen. Genet.) [2001]
9uniprot[Pubmed] 12733914 [Medline] 22619809 Mithramycin SK, a novel antitumor drug with improved therapeutic index, mithramycin SA, and demycarosyl-mithramycin SK: three new products generated in the mithramycin producer Streptomyces argillaceus through combinatorial biosynthesis.(J. Am. Chem. Soc.) [2003]
10uniprot[Pubmed] 9917296 [Medline] 99115752 The structure of mithramycin reinvestigated.(J. Nat. Prod.) [1999]
11uniprot[Pubmed] 11853433 [Medline] 21843297 Ketopremithramycins and ketomithramycins, four new aureolic acid-type compounds obtained upon inactivation of two genes involved in the biosynthesis of the deoxysugar moieties of the antitumor drug mithramycin by Streptomyces argillaceus, reveal novel insights into post-PKS tailoring steps of the mithramycin biosynthetic pathway.(J. Am. Chem. Soc.) [2002]
12uniprot[Pubmed] 10652287 [Medline] 20119254 Characterization of two polyketide methyltransferases involved in the biosynthesis of the antitumor drug mithramycin by Streptomyces argillaceus.(J. Biol. Chem.) [2000]
13uniprot[Pubmed] 10779713 [Medline] 20243461 Insertional inactivation of mtrX and mtrY genes from the mithramycin gene cluster affects production and growth of the producer organism Streptomyces argillaceus.(FEMS Microbiol. Lett.) [2000]
14uniprot[Pubmed] 12022840 [Medline] 22017994 Rationally designed glycosylated premithramycins: hybrid aromatic polyketides using genes from three different biosynthetic pathways.(J. Am. Chem. Soc.) [2002]
15uniprot[Pubmed] 12813091 [Medline] 22697398 Purification and characterization of a monooxygenase involved in the biosynthetic pathway of the antitumor drug mithramycin.(J. Bacteriol.) [2003]
16uniprot[Pubmed] 8807845 [Medline] 97113238 Deciphering the biosynthetic origin of the aglycone of the aureolic acid group of anti-tumor agents.(Chem. Biol.) [1996]
17uniprot[Pubmed] 14660589 MtmMII-mediated C-methylation during biosynthesis of the antitumor drug mithramycin is essential for biological activity and DNA-drug interaction.(J. Biol. Chem.) [2004]
18uniprot[Pubmed] 9375253 [Medline] 98042823 Folding of the polyketide chain is not dictated by minimal polyketide synthase in the biosynthesis of mithramycin and anthracycline.(Chem. Biol.) [1997]
19uniprot[Pubmed] 15712316 Elucidation of the glycosylation sequence of mithramycin biosynthesis: isolation of 3A-deolivosylpremithramycin B and its conversion to premithramycin B by glycosyltransferase MtmGII.(Chembiochem) [2005]
20uniprot[Pubmed] 10760873 The Novel Hybrid Antitumor Compound Premithramycinone H Provides Indirect Evidence for a Tricyclic Intermediate of the Biosynthesis of the Aureolic Acid Antibiotic Mithramycin.(Angew. Chem. Int. Ed.) [2000]

F2RGT6_STRVP
(F2RGT6)

1e-54

217

51%

Product: 3-oxoacyl-[acyl-carrier protein] reductase
Gene: SVEN_1610
Organism: Streptomyces venezuelae (strain ATCC 10712 / CBS 650.69 / DSM 40230 / JCM 4526 / NBRC 13096 / PD 04745)

1uniprot[Pubmed] 21463507
Genome-wide analysis of the role of GlnR in Streptomyces venezuelae provides new insights into global nitrogen regulation in actinomycetes.(BMC Genomics) [2011]

D7C2R7_STRBB
(D7C2R7)

2e-49

200

51%

Product: Ketoreductase
Gene: SBI_02829
Organism: Streptomyces bingchenggensis (strain BCW-1)

1uniprot[Pubmed] 20581206
Genome sequence of the milbemycin-producing bacterium Streptomyces bingchenggensis.(J. Bacteriol.) [2010]

Q9FBU4_STRCO
(Q9FBU4)

7e-44

182

40%

Product: Putative ketoreductase
Gene: SCO7147
Organism: Streptomyces coelicolor

1uniprot[Pubmed] 12000953 [Medline] 21996410
Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).(Nature) [2002]

B3RXK7_TRIAD
(B3RXK7)

5e-39

166

40%

Product: Putative uncharacterized protein
Gene: TRIADDRAFT_63298
Organism: Trichoplax adhaerens
Trichoplax reptans

1uniprot[Pubmed] 18719581
The Trichoplax genome and the nature of placozoans.(Nature) [2008]

C3YX54_BRAFL
(C3YX54)

2e-38

164

40%

Product: Putative uncharacterized protein
Gene: BRAFLDRAFT_59053
Organism: Branchiostoma floridae
Florida lancelet
Amphioxus

1uniprot[Pubmed] 18563158
The amphioxus genome and the evolution of the chordate karyotype.(Nature) [2008]

Q67RW6_SYMTH
(Q67RW6)

3e-37

160

45%

Product: Ketoreductase
Gene: STH592
Organism: Symbiobacterium thermophilum

1uniprot[Pubmed] 15383646
Genome sequence of Symbiobacterium thermophilum, an uncultivable bacterium that depends on microbial commensalism.(Nucleic Acids Res.) [2004]

D3TMV0_GLOMM
(D3TMV0)

4e-37

159

37%

Product: 3-oxoacyl
Gene
Organism: Glossina morsitans morsitans
Savannah tsetse fly

1uniprot[Pubmed] 20353571
An insight into the sialome of Glossina morsitans morsitans.(BMC Genomics) [2010]

B3RXK6_TRIAD
(B3RXK6)

1e-36

158

38%

Product: Putative uncharacterized protein
Gene: TRIADDRAFT_56243
Organism: Trichoplax adhaerens
Trichoplax reptans

1uniprot[Pubmed] 18719581
The Trichoplax genome and the nature of placozoans.(Nature) [2008]

Q95PA3_AEDAE
(Q95PA3)

6e-36

155

37%

Product: Putative short-chain dehydrogenase/reductase
Gene: SDR1
Organism: Aedes aegypti
Yellowfever mosquito
Culex aegypti

1uniprot[Pubmed] 14513362 [Medline] 22875075
A targeted approach to the identification of candidate genes determining susceptibility to Plasmodium gallinaceum in Aedes aegypti.(Mol. Genet. Genomics) [2003]

E9G535_DAPPU
(E9G535)

6e-36

155

39%

Product: Putative uncharacterized protein
Gene: DAPPUDRAFT_300459
Organism: Daphnia pulex
Water flea

1uniprot[Pubmed] 21292972
The ecoresponsive genome of Daphnia pulex.(Science) [2011]

E9IXL5_SOLIN
(E9IXL5)

(2 hsp)

2e-35

154

37%

Product: Putative uncharacterized protein
Gene: SINV_11101
Organism: Solenopsis invicta
Red imported fire ant
Solenopsis wagneri

1uniprot[Pubmed] 21282665
The genome of the fire ant Solenopsis invicta.(Proc. Natl. Acad. Sci. U.S.A.) [2011]

D6WBF1_TRICA
(D6WBF1)

4e-35

152

37%

Product: Putative uncharacterized protein
Gene: TcasGA2_TC000272
Organism: Tribolium castaneum
Red flour beetle

[pubmed all]
1uniprot[Pubmed] 18362917 The genome of the model beetle and pest Tribolium castaneum.(Nature) [2008]
2uniprot[Pubmed] 19820115 38(Nucleic Acids Res.) [2010]

Q95PA6_AEDAE
(Q95PA6)

6e-35

152

37%

Product: Putative short-chain dehydrogenase/reductase Mc1
Gene: SDR2
Organism: Aedes aegypti
Yellowfever mosquito
Culex aegypti

C3Y896_BRAFL
(C3Y896)

1e-34

151

37%

Product: Putative uncharacterized protein
Gene: BRAFLDRAFT_205155
Organism: Branchiostoma floridae
Florida lancelet
Amphioxus

1uniprot[Pubmed] 18563158
The amphioxus genome and the evolution of the chordate karyotype.(Nature) [2008]

Q9N5G4_CAEEL
(Q9N5G4)

2e-34

150

38%

Product: Putative uncharacterized protein
Gene: R05D8.7
Organism: Caenorhabditis elegans

1uniprot[Pubmed] 9851916 [Medline] 99069613
Genome sequence of the nematode C. elegans: a platform for investigating biology.(Science) [1998]

Q65SN2_MANSM
(Q65SN2)

2e-34

150

37%

Product: FabG protein
Gene: fabG
MS1421
Organism: Mannheimia succiniciproducens (strain MBEL55E)

1uniprot[Pubmed] 15378067
The genome sequence of the capnophilic rumen bacterium Mannheimia succiniciproducens.(Nat. Biotechnol.) [2004]

C3XTH8_BRAFL
(C3XTH8)

2e-34

150

37%

Product: Putative uncharacterized protein
Gene: BRAFLDRAFT_280406
Organism: Branchiostoma floridae
Florida lancelet
Amphioxus

1uniprot[Pubmed] 18563158
The amphioxus genome and the evolution of the chordate karyotype.(Nature) [2008]

B3RXK8_TRIAD
(B3RXK8)

2e-34

150

40%

Product: Putative uncharacterized protein
Gene: TRIADDRAFT_50287
Organism: Trichoplax adhaerens
Trichoplax reptans

1uniprot[Pubmed] 18719581
The Trichoplax genome and the nature of placozoans.(Nature) [2008]

Q170J0_AEDAE
(Q170J0)

2e-34

150

37%

Product: AAEL007893-PA
Short chain type dehydrogenase
Gene: AAEL007893
AaeL_AAEL007893
Aael_AAEL007893
Organism: Aedes aegypti
Yellowfever mosquito
Culex aegypti

[pubmed all]
1uniprot[Pubmed] 17510324 Genome sequence of Aedes aegypti, a major arbovirus vector.(Science) [2007]
2uniprot[Pubmed] 17519023 Analysis of 14 BAC sequences from the Aedes aegypti genome: a benchmark for genome annotation and assembly.(Genome Biol.) [2007]

E0VS61_PEDHC
(E0VS61)

5e-34

149

35%

Product: Alcohol dehydrogenase, putative
Gene: Phum_PHUM411900
Organism: Pediculus humanus subsp. corporis
Body louse

1uniprot[Pubmed] 20566863
Genome sequences of the human body louse and its primary endosymbiont provide insights into the permanent parasitic lifestyle.(Proc. Natl. Acad. Sci. U.S.A.) [2010]

B3LWF9_DROAN
(B3LWF9)

1e-33

148

38%

Product: GF18656
Gene: GF18656
Dana\GF18656
Dana_GF18656
Organism: Drosophila ananassae
Fruit fly

1uniprot[Pubmed] 17994087
Evolution of genes and genomes on the Drosophila phylogeny.(Nature) [2007]

B4QWZ5_DROSI
(B4QWZ5)

1e-33

148

38%

Product: GD19595
Gene: GD19595
Dsim\GD19595
Dsim_GD19595
Organism: Drosophila simulans
Fruit fly

1uniprot[Pubmed] 17994087
Evolution of genes and genomes on the Drosophila phylogeny.(Nature) [2007]

B4I447_DROSE
(B4I447)

1e-33

148

38%

Product: GM10606
Gene: GM10606
Dsec\GM10606
Dsec_GM10606
Organism: Drosophila sechellia
Fruit fly

1uniprot[Pubmed] 17994087
Evolution of genes and genomes on the Drosophila phylogeny.(Nature) [2007]

E0VS60_PEDHC
(E0VS60)

1e-33

148

36%

Product: Alcohol dehydrogenase, putative
Gene: Phum_PHUM411890
Organism: Pediculus humanus subsp. corporis
Body louse

1uniprot[Pubmed] 20566863
Genome sequences of the human body louse and its primary endosymbiont provide insights into the permanent parasitic lifestyle.(Proc. Natl. Acad. Sci. U.S.A.) [2010]

Q8IPP8_DROME
(Q8IPP8)

1e-33

147

38%

Product: CG31548
Gene: CG31548
Dmel_CG31548
Organism: Drosophila melanogaster
Fruit fly

[pubmed all]
1uniprot[Pubmed] 12537572 [Medline] 22426069 Annotation of the Drosophila melanogaster euchromatic genome: a systematic review.(Genome Biol.) [2002]
2uniprot[Pubmed] 10731132 [Medline] 20196006 The genome sequence of Drosophila melanogaster.(Science) [2000]

C3YX55_BRAFL
(C3YX55)

1e-33

147

38%

Product: Putative uncharacterized protein
Gene: BRAFLDRAFT_225165
Organism: Branchiostoma floridae
Florida lancelet
Amphioxus

1uniprot[Pubmed] 18563158
The amphioxus genome and the evolution of the chordate karyotype.(Nature) [2008]

Q333V8_9ACTO
(Q333V8)

2e-33

147

41%

Product: NAD or NADP oxidoreductase
Gene: tioH
Organism: Micromonospora sp. ML1

1uniprot
Deciphering the biosynthesis pathway of the antitumor thiocoraline from a marine actinomycete and its expression in Streptomyces hosts.(Chembiochem) [2006]

B4L3S0_DROMO
(B4L3S0)

2e-33

147

39%

Product: GI14997
Gene: GI14997
Dmoj\GI14997
Dmoj_GI14997
Organism: Drosophila mojavensis
Fruit fly

1uniprot[Pubmed] 17994087
Evolution of genes and genomes on the Drosophila phylogeny.(Nature) [2007]

F4WG12_ACREC
(F4WG12)

2e-33

147

36%

Product: 3-oxoacyl-[acyl-carrier-protein] reductase
Gene: G5I_04583
Organism: Acromyrmex echinatior
Panamanian leafcutter ant
Acromyrmex octospinosus echinatior

1uniprot[Pubmed] 21719571
The genome of the leaf-cutting ant Acromyrmex echinatior suggests key adaptations to advanced social life and fungus farming.(Genome Res.) [2011]

F6WNB8_XENTR
(F6WNB8)

3e-33

146

37%

Product: Uncharacterized protein
Gene: XB-GENE-5820599
Organism: Xenopus tropicalis
Western clawed frog
Silurana tropicalis

1uniprot[Pubmed] 20431018
The genome of the Western clawed frog Xenopus tropicalis.(Science) [2010]

F7B9X1_CIOIN
(F7B9X1)

3e-33

146

36%

Product: Uncharacterized protein
Gene: Cin.2919
Organism: Ciona intestinalis
Transparent sea squirt
Ascidia intestinalis

1uniprot[Pubmed] 12481130 [Medline] 22369169
The draft genome of Ciona intestinalis: insights into chordate and vertebrate origins.(Science) [2002]

B4NKA5_DROWI
(B4NKA5)

3e-33

146

40%

Product: GK13928
Gene: GK13928
Dwil\GK13928
Dwil_GK13928
Organism: Drosophila willistoni
Fruit fly

1uniprot[Pubmed] 17994087
Evolution of genes and genomes on the Drosophila phylogeny.(Nature) [2007]

F6T472_XENTR
(F6T472)

3e-33

146

37%

Product: Uncharacterized protein
Gene: XB-GENE-5820599
Organism: Xenopus tropicalis
Western clawed frog
Silurana tropicalis

1uniprot[Pubmed] 20431018
The genome of the Western clawed frog Xenopus tropicalis.(Science) [2010]

E9H3L7_DAPPU
(E9H3L7)

3e-33

146

37%

Product: Putative uncharacterized protein
Gene: DAPPUDRAFT_307656
Organism: Daphnia pulex
Water flea

1uniprot[Pubmed] 21292972
The ecoresponsive genome of Daphnia pulex.(Science) [2011]

B3P2H5_DROER
(B3P2H5)

4e-33

146

37%

Product: GG10914
Gene: GG10914
Dere\GG10914
Dere_GG10914
Organism: Drosophila erecta
Fruit fly

1uniprot[Pubmed] 17994087
Evolution of genes and genomes on the Drosophila phylogeny.(Nature) [2007]

E2B879_HARSA
(E2B879)

5e-33

146

35%

Product: 3-oxoacyl-[acyl-carrier-protein] reductase
Gene: EAI_03591
Organism: Harpegnathos saltator
Jerdon's jumping ant

1uniprot[Pubmed] 20798317
Genomic comparison of the ants Camponotus floridanus and Harpegnathos saltator.(Science) [2010]

Q18946_CAEEL
(Q18946)

5e-33

145

37%

Product: Protein D1054.8, confirmed by transcript evidence
Gene: D1054.8
Organism: Caenorhabditis elegans

1uniprot[Pubmed] 9851916 [Medline] 99069613
Genome sequence of the nematode C. elegans: a platform for investigating biology.(Science) [1998]

B4PUV7_DROYA
(B4PUV7)

6e-33

145

37%

Product: GE24152
Gene: GE24152
Dyak\GE24152
Dyak_GE24152
Organism: Drosophila yakuba
Fruit fly

[pubmed all]
1uniprot[Pubmed] 17994087 Evolution of genes and genomes on the Drosophila phylogeny.(Nature) [2007]
2uniprot[Pubmed] 17550304 Principles of genome evolution in the Drosophila melanogaster species group.(PLoS Biol.) [2007]

O16971_CAEEL
(O16971)

6e-33

145

38%

Product: Putative uncharacterized protein
Gene: T01G6.10
Organism: Caenorhabditis elegans

1uniprot[Pubmed] 9851916 [Medline] 99069613
Genome sequence of the nematode C. elegans: a platform for investigating biology.(Science) [1998]

Q9VNF3_DROME
(Q9VNF3)

6e-33

145

39%

Product: CG12171
RE01652p
Gene: CG12171
Dmel_CG12171
Organism: Drosophila melanogaster
Fruit fly

[pubmed all]
1uniprot[Pubmed] 10731132 [Medline] 20196006 The genome sequence of Drosophila melanogaster.(Science) [2000]
2uniprot[Pubmed] 12537572 [Medline] 22426069 Annotation of the Drosophila melanogaster euchromatic genome: a systematic review.(Genome Biol.) [2002]

B4MD32_DROVI
(B4MD32)

7e-33

145

39%

Product: GJ15354
Gene: GJ15354
Dvir\GJ15354
Dvir_GJ15354
Organism: Drosophila virilis
Fruit fly

[pubmed all]
1uniprot[Pubmed] 17994087 Evolution of genes and genomes on the Drosophila phylogeny.(Nature) [2007]
2uniprot[Pubmed] 18057021 Assembly reconciliation.(Bioinformatics) [2008]

B3P2H3_DROER
(B3P2H3)

7e-33

145

39%

Product: GG12970
Gene: GG12970
Dere\GG12970
Dere_GG12970
Organism: Drosophila erecta
Fruit fly

1uniprot[Pubmed] 17994087
Evolution of genes and genomes on the Drosophila phylogeny.(Nature) [2007]

D2SNW1_HELVI
(D2SNW1)

8e-33

145

37%

Product: Hydroxybutyrate dehydrogenase
Gene: hvpg0117
Organism: Heliothis virescens
Tobacco budworm moth

1uniprot[Pubmed] 20074338
Transcriptome analysis of the sex pheromone gland of the noctuid moth Heliothis virescens.(BMC Genomics) [2010]

Q7PR84_ANOGA
(Q7PR84)

1e-32

145

38%

Product: AGAP002520-PA
Gene: AgaP_AGAP002520
Organism: Anopheles gambiae
African malaria mosquito

1uniprot[Pubmed] 12364791 [Medline] 22251359
The genome sequence of the malaria mosquito Anopheles gambiae.(Science) [2002]

100

A8XET8_CAEBR
(A8XET8)

1e-32

144

37%

Product: CBR-DHS-14 protein
Gene: dhs-14
Cbr-dhs-14
cbr-dhs-14
CBG12129
CBG_12129
Organism: Caenorhabditis briggsae

1uniprot[Pubmed] 14624247
The genome sequence of Caenorhabditis briggsae: a platform for comparative genomics.(PLoS Biol.) [2003]