BLAST table : Polk_00290

DB	UniProtKB

	accession	Evalue	Score	Ident.	link	product	gene	organism	ec
1	C0JWC4_9ACTO (C0JWC4)	1e-139	498	100%	UniProt GenBank	PokT1	pokT1	Streptomyces diastatochromogenes
2	D7BZS0_STRBB (D7BZS0)	4e-55	219	54%	UniProt GenBank	Short-chain dehydrogenase/reductase SDR	SBI_06855	Streptomyces bingchenggensis (strain BCW-1)
3	E8W962_STRFA (E8W962)	2e-51	206	48%	UniProt GenBank	Short-chain dehydrogenase/reductase SDR	Sfla_5328	Streptomyces flavogriseus (strain ATCC 33331 / DSM 40990 / IAF-45CD)
4	Q70J96_STRGR (Q70J96)	1e-44	184	46%	UniProt GenBank	Ketoreductase	cmmTI	Streptomyces griseus subsp. griseus
5	Q3S8Q3_STRRM (Q3S8Q3)	2e-41	173	44%	UniProt GenBank	OxyM	oxyM	Streptomyces rimosus
6	Q194Q8_STRAA (Q194Q8)	1e-39	167	45%	UniProt GenBank	Ketoreductase	mtmTI	Streptomyces argillaceus
7	A8V058_9AQUI (A8V058)	1e-33	147	35%	UniProt GenBank	Short-chain dehydrogenase/reductase SDR	HG1285_05530	Hydrogenivirga sp. 128-5-R1-1
8	B3QVF0_CHLT3 (B3QVF0)	5e-31	139	38%	UniProt GenBank	Short-chain dehydrogenase/reductase SDR	Ctha_2098	Chloroherpeton thalassium (strain ATCC 35110 / GB-78)
9	E6U207_BACCJ (E6U207)	5e-31	139	34%	UniProt GenBank	Short-chain dehydrogenase/reductase SDR	Bcell_0978	Bacillus cellulosilyticus (strain ATCC 21833 / DSM 2522 / FERM P-1141 / JCM 9156 / N-4)
10	C0QR70_PERMH (C0QR70)	5e-31	139	33%	UniProt GenBank	3-oxoacyl-[acyl-carrier-protein] reductase (3-ketoacyl-acyl carrier protein reductase)	PERMA_1399	Persephonella marina (strain DSM 14350 / EX-H1)	1.1.1.100 niceE keggE
11	C1DXR7_SULAA (C1DXR7)	7e-31	138	35%	UniProt GenBank	3-oxoacyl-[acyl-carrier-protein] reductase (3-ketoacyl-acyl carrier protein reductase)	SULAZ_0183	Sulfurihydrogenibium azorense (strain Az-Fu1 / DSM 15241 / OCM 825)	1.1.1.100 niceE keggE
12	D1CG27_THET1 (D1CG27)	2e-30	137	37%	UniProt GenBank	Short-chain dehydrogenase/reductase SDR	Tter_0966	Thermobaculum terrenum (strain ATCC BAA-798 / YNP1)
13	F7TUI3_9BACL (F7TUI3)	3e-30	136	35%	UniProt GenBank	Enoyl-[acyl-carrier-protein] reductase	fabL BRLA_c18170	Brevibacillus laterosporus LMG 15441	1.3.1.10 niceE keggE
14	B2V750_SULSY (B2V750)	2e-29	134	34%	UniProt GenBank	Short-chain dehydrogenase/reductase SDR	SYO3AOP1_0187	Sulfurihydrogenibium sp. (strain YO3AOP1)
15	C4FJM7_9AQUI (C4FJM7)	2e-29	134	34%	UniProt GenBank	3-oxoacyl-[acyl-carrier-protein] reductase	SULYE_0776	Sulfurihydrogenibium yellowstonense SS-5	1.1.1.100 niceE keggE
16	D5WTM5_BACT2 (D5WTM5)	3e-29	133	37%	UniProt GenBank	Enoyl-[acyl-carrier-protein] reductase [NADH]	Btus_2604	Bacillus tusciae (strain DSM 2912 / NBRC 15312 / T2)	1.3.1.9 niceE keggE
17	D3FUQ6_BACPE (D3FUQ6)	5e-29	132	35%	UniProt GenBank	Enoyl-(Acyl carrier protein) reductase	BpOF4_10865	Bacillus pseudofirmus (strain OF4)	1.3.1.10 niceE keggE
18	A0LU59_ACIC1 (A0LU59)	6e-29	132	32%	UniProt GenBank	Short-chain dehydrogenase/reductase SDR	Acel_1197	Acidothermus cellulolyticus (strain ATCC 43068 / 11B)
19	C5N8L8_BURMA (C5N8L8)	7e-29	132	36%	UniProt GenBank	Multi-domain beta keto-acyl synthase	BMAPRL20_0001	Burkholderia mallei PRL-20
20	Q8YQD6_NOSS1 (Q8YQD6)	7e-29	132	33%	UniProt GenBank	Alr3897 protein	alr3897	Nostoc sp. (strain PCC 7120 / UTEX 2576)
21	C4B2K7_BURMA (C4B2K7)	8e-29	132	36%	UniProt GenBank	Multi-domain beta keto-acyl synthase	BMAGB8_A2394	Burkholderia mallei GB8 horse 4
22	D5T7Y2_LEGP2 (D5T7Y2)	1e-28	131	34%	UniProt GenBank	Glucose-1-dehydrogenase	lpa_00572	Legionella pneumophila serogroup 1 (strain 2300/99 Alcoy)
23	A5IHN7_LEGPC (A5IHN7)	1e-28	131	34%	UniProt GenBank	Glucose-1-dehydrogenase	LPC_2986	Legionella pneumophila (strain Corby)
24	Q5X830_LEGPA (Q5X830)	1e-28	131	34%	UniProt GenBank	Putative uncharacterized protein	lpp0423	Legionella pneumophila (strain Paris)
25	A3MH15_BURM7 (A3MH15)	1e-28	130	36%	UniProt GenBank	Putative polyketide synthase	BMA10247_A2380	Burkholderia mallei (strain NCTC 10247)
26	Q629N6_BURMA (Q629N6)	2e-28	130	36%	UniProt GenBank	Putative polyketide synthase	BMAA2089	Burkholderia mallei Pseudomonas mallei
27	A3PA16_BURP0 (A3PA16)	2e-28	130	36%	UniProt GenBank	Putative polyketide synthase	BURPS1106A_A3147	Burkholderia pseudomallei (strain 1106a)
28	A1UXL2_BURMS (A1UXL2)	3e-28	130	36%	UniProt GenBank	Putative polyketide synthase	BMASAVP1_1116	Burkholderia mallei (strain SAVP1)
29	E1Y0P7_LEGPN (E1Y0P7)	7e-28	128	34%	UniProt GenBank	Putative uncharacterized protein	LPW_04371	Legionella pneumophila
30	B9BGR1_9BURK (B9BGR1)	8e-28	128	37%	UniProt GenBank	Multi-domain beta keto-acyl synthase	BURMUCGD1_2018	Burkholderia multivorans CGD1
31	A9ACE6_BURM1 (A9ACE6)	1e-27	128	37%	UniProt GenBank	Beta-ketoacyl synthase Putative multi-domain beta keto-acyl synthase	BMULJ_01288 Bmul_1953	Burkholderia multivorans (strain ATCC 17616 / 249)
32	E8RFG2_9DELT (E8RFG2)	1e-27	127	35%	UniProt GenBank	Enoyl-[acyl-carrier-protein] reductase [NADH]	Despr_0937	Desulfobulbus propionicus DSM 2032	1.3.1.9 niceE keggE
33	A2RZS7_BURM9 (A2RZS7)	1e-27	127	36%	UniProt GenBank	Putative polyketide synthase	BMA10229_1394	Burkholderia mallei (strain NCTC 10229)
34	A9K6R8_BURMA (A9K6R8)	1e-27	127	36%	UniProt GenBank	Putative polyketide synthase	BMA10399_K0022	Burkholderia mallei ATCC 10399
35	A5XMP5_BURMA (A5XMP5)	1e-27	127	36%	UniProt GenBank	Putative polyketide synthase	BMAJHU_I1343	Burkholderia mallei JHU
36	Q5WIF4_BACSK (Q5WIF4)	1e-27	127	34%	UniProt GenBank	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabL ABC1313	Bacillus clausii (strain KSM-K16)	1.3.1.9 niceE keggE
37	Q5ZYL4_LEGPH (Q5ZYL4)	2e-27	127	33%	UniProt GenBank	Glucose-1-dehydrogenase	lpg0358	Legionella pneumophila subsp. pneumophila (strain Philadelphia 1 / ATCC 33152 / DSM 7513)
38	Q5WZI3_LEGPL (Q5WZI3)	2e-27	127	33%	UniProt GenBank	Putative uncharacterized protein	lpl0399	Legionella pneumophila (strain Lens)
39	Q6ZZV1_STRAT (Q6ZZV1)	2e-27	127	38%	UniProt GenBank	Putative 3-keto-acyl carrier protein reductase		Streptomyces antibioticus
40	C5ZNT1_BURPS (C5ZNT1)	2e-27	127	37%	UniProt GenBank	Putative polyketide synthase	BURPS1106B_2024	Burkholderia pseudomallei 1106b
41	D7P5V2_9ACTO (D7P5V2)	2e-27	127	33%	UniProt GenBank	AsuB3	asuB3	Streptomyces nodosus subsp. asukaensis
42	Q63HU2_BURPS (Q63HU2)	2e-27	127	36%	UniProt GenBank	Putative multi-domain beta keto-acyl synthase	BPSS2328	Burkholderia pseudomallei Pseudomonas pseudomallei
43	Q2T2R4_BURTA (Q2T2R4)	2e-27	127	36%	UniProt GenBank	Polyketide synthase, putative	BTH_II2348	Burkholderia thailandensis (strain E264 / ATCC 700388 / DSM 13276 / CIP 106301)
44	C0YDQ6_BURPS (C0YDQ6)	4e-27	126	36%	UniProt GenBank	Putative polyketide synthase	BUH_7550	Burkholderia pseudomallei Pakistan 9
45	Q3MC64_ANAVT (Q3MC64)	4e-27	126	33%	UniProt GenBank	Short-chain dehydrogenase/reductase SDR	Ava_1800	Anabaena variabilis (strain ATCC 29413 / PCC 7937)	1.1.1.100 niceE keggE
46	Q3JIG9_BURP1 (Q3JIG9)	6e-27	125	36%	UniProt GenBank	Putative multi-domain beta keto-acyl synthase	BURPS1710b_A1477	Burkholderia pseudomallei (strain 1710b)
47	C6U4Q0_BURPS (C6U4Q0)	6e-27	125	36%	UniProt GenBank	Putative polyketide synthase	BURPS1710A_A2450	Burkholderia pseudomallei 1710a
48	A5TEN1_BURMA (A5TEN1)	1e-26	124	36%	UniProt GenBank	Putative polyketide synthase	BMA721280_M0023	Burkholderia mallei 2002721280
49	B7CWP2_BURPS (B7CWP2)	2e-26	124	36%	UniProt GenBank	Putative polyketide synthase	BUC_7481	Burkholderia pseudomallei 576
50	C4I4J7_BURPS (C4I4J7)	2e-26	124	36%	UniProt GenBank	Multi-domain beta keto-acyl synthase	GBP346_B2636	Burkholderia pseudomallei MSHR346
51	B1H4F3_BURPS (B1H4F3)	2e-26	124	36%	UniProt GenBank	Putative polyketide synthase	BURPSS13_0259	Burkholderia pseudomallei S13
52	A3NPI1_BURP6 (A3NPI1)	2e-26	124	36%	UniProt GenBank	Multi-domain beta keto-acyl synthase	BURPS668_A3261	Burkholderia pseudomallei (strain 668)
53	D2PXF6_KRIFD (D2PXF6)	3e-26	123	38%	UniProt GenBank	Short-chain dehydrogenase/reductase SDR	Kfla_0683	Kribbella flavida (strain DSM 17836 / JCM 10339 / NBRC 14399)
54	A6CLS0_9BACI (A6CLS0)	6e-26	122	33%	UniProt GenBank	Enoyl-(Acyl carrier protein) reductase	BSG1_05649	Bacillus sp. SG-1	1.3.1.10 niceE keggE
55	C6MY14_9GAMM (C6MY14)	6e-26	122	32%	UniProt GenBank	Enoyl-(Acyl carrier protein) reductase	LDG_0396	Legionella drancourtii LLAP12
56	E0URM7_SULAO (E0URM7)	6e-26	122	31%	UniProt GenBank	Short-chain dehydrogenase/reductase SDR	Saut_0922	Sulfurimonas autotrophica (strain ATCC BAA-671 / DSM 16294 / JCM 11897 / OK10)
57	B0LJ23_9ACTO (B0LJ23)	7e-26	122	37%	UniProt GenBank	Lct40	lct40	Streptomyces rishiriensis
58	C8XGV0_NAKMY (C8XGV0)	8e-26	122	37%	UniProt GenBank	Beta-ketoacyl synthase	Namu_3886	Nakamurella multipartita (strain ATCC 700099 / DSM 44233 / JCM 9543 / Y-104) Microsphaera multipartita
59	E8N5P0_ANATU (E8N5P0)	9e-26	121	33%	UniProt GenBank	Putative oxidoreductase	ANT_17280	Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)
60	F8IIQ6_ALIAC (F8IIQ6)	1e-25	121	33%	UniProt GenBank	Short-chain dehydrogenase/reductase SDR	fabG TC41_2687	Alicyclobacillus acidocaldarius Bacillus acidocaldarius
61	B2H4M6_BURPS (B2H4M6)	1e-25	121	35%	UniProt GenBank	Putative polyketide synthase	BURPS1655_J0021	Burkholderia pseudomallei 1655
62	Q0REK7_FRAAA (Q0REK7)	1e-25	121	36%	UniProt GenBank	Putative short-chain type dehydrogenase/reductase	FRAAL5468	Frankia alni (strain ACN14a)	1.1.1.- niceE keggE
63	E1UPB6_BACAS (E1UPB6)	1e-25	120	34%	UniProt GenBank	Enoyl-acyl carrier protein reductase III	fabL BAMF_0873	Bacillus amyloliquefaciens (strain ATCC 23350 / DSM 7 / NBRC 15535 / NRRL B-14393)	1.3.1.9 niceE keggE
64	F4EMJ1_BACAM (F4EMJ1)	1e-25	120	34%	UniProt GenBank	Enoyl-acyl carrier protein reductase III	fabL LL3_00935	Bacillus amyloliquefaciens Bacillus velezensis
65	F4E3E1_BACAM (F4E3E1)	1e-25	120	34%	UniProt GenBank	Enoyl-(Acyl carrier protein) reductase	fabL BAMTA208_03980	Bacillus amyloliquefaciens TA208	1.3.1.10 niceE keggE
66	D3Q2H9_STANL (D3Q2H9)	1e-25	120	35%	UniProt GenBank	Short-chain dehydrogenase/reductase SDR	Snas_4263	Stackebrandtia nassauensis (strain DSM 44728 / NRRL B-16338 / NBRC 102104 / LLR-40K-21)
67	B0T962_CAUSK (B0T962)	1e-25	120	33%	UniProt GenBank	Short-chain dehydrogenase/reductase SDR	Caul_5117	Caulobacter sp. (strain K31)
68	D3HPN7_LEGLN (D3HPN7)	2e-25	120	34%	UniProt GenBank	Putative 3-oxoacyl-[acyl-carrier protein] reductase	LLO_0519	Legionella longbeachae serogroup 1 (strain NSW150)
69	D1RI98_LEGLO (D1RI98)	2e-25	120	34%	UniProt GenBank	Glucose-1-dehydrogenase	LLB_1340	Legionella longbeachae D-4968
70	E0KI91_STRVO (E0KI91)	2e-25	120	38%	UniProt GenBank	Short-chain dehydrogenase/reductase SDR	StrviDRAFT_2259	Streptomyces violaceusniger Tu 4113
71	C8WSD4_ALIAD (C8WSD4)	3e-25	120	31%	UniProt GenBank	Short-chain dehydrogenase/reductase SDR	Aaci_2412	Alicyclobacillus acidocaldarius subsp. acidocaldarius (strain ATCC 27009 / DSM 446 / 104-1A) Bacillus acidocaldarius
72	A7Z2N2_BACA2 (A7Z2N2)	3e-25	119	33%	UniProt GenBank	FabL	fabL RBAM_008740	Bacillus amyloliquefaciens (strain FZB42)	1.3.1.9 niceE keggE
73	F8I8U5_9FIRM (F8I8U5)	3e-25	119	33%	UniProt GenBank	Short-chain dehydrogenase/reductase SDR	fabL TPY_3240	Sulfobacillus acidophilus TPY
74	F8IIR9_ALIAC (F8IIR9)	3e-25	119	31%	UniProt GenBank	Short-chain dehydrogenase/reductase SDR	fabL TC41_2700	Alicyclobacillus acidocaldarius Bacillus acidocaldarius
75	A8KGU0_BURPS (A8KGU0)	4e-25	119	35%	UniProt GenBank	Putative polyketide synthase	BURPSPAST_H0164	Burkholderia pseudomallei Pasteur 52237
76	D5DA14_BACMD (D5DA14)	5e-25	119	32%	UniProt GenBank	Short chain dehydrogenase	BMD_0405	Bacillus megaterium (strain DSM 319)	1.1.1.1 niceE keggE
77	Q9X7T4_STRCO (Q9X7T4)	5e-25	119	35%	UniProt GenBank	Putative 3-oxoacyl-[acyl-carrier protein] reductase	SCO7266	Streptomyces coelicolor
78	D6EXC1_STRLI (D6EXC1)	5e-25	119	35%	UniProt GenBank	3-oxoacyl-[acyl-carrier protein] reductase	SSPG_00582	Streptomyces lividans TK24
79	E0SFW2_DICD3 (E0SFW2)	5e-25	119	34%	UniProt GenBank	Probable short-chain dehydrogenase	Dda3937_03279	Dickeya dadantii (strain 3937) Erwinia chrysanthemi (strain 3937)	1.1.1.100 niceE keggE
80	E8VEV7_BACST (E8VEV7)	5e-25	119	34%	UniProt GenBank	Enoyl-(Acyl carrier protein) reductase	BSn5_16190	Bacillus subtilis (strain BSn5)	1.3.1.10 niceE keggE
81	E0TWC2_BACPZ (E0TWC2)	5e-25	119	34%	UniProt GenBank	Enoyl-(Acyl carrier protein) reductase	fabL BSUW23_04355	Bacillus subtilis subsp. spizizenii (strain ATCC 23059 / NRRL B-14472 / W23)	1.3.1.10 niceE keggE
82	D5N223_BACPN (D5N223)	5e-25	119	34%	UniProt GenBank	Enoyl-(Acyl carrier protein) reductase	BSU6633_12612	Bacillus subtilis subsp. spizizenii ATCC 6633	1.3.1.10 niceE keggE
83	D4G6M8_BACNA (D4G6M8)	5e-25	119	34%	UniProt GenBank	Enoyl-(Acyl carrier protein) reductase	fabL BSNT_01436	Bacillus subtilis subsp. natto BEST195
84	FABL_BACSU (P71079)	5e-25	119	34%	UniProt GenBank	Enoyl-[acyl-carrier-protein] reductase [NADPH] FabL Enoyl-acyl carrier protein reductase III NADPH-dependent enoyl-ACP reductase	fabL yfhR ygaA BSU08650	Bacillus subtilis	1.3.1.10 niceE keggE
85	Q98ML3_RHILO (Q98ML3)	6e-25	119	35%	UniProt GenBank	Probable short-chain dehydrogenase	mll0534	Rhizobium loti Mesorhizobium loti
86	Q5V8A5_9CYAN (Q5V8A5)	6e-25	119	35%	UniProt GenBank	LtxD		Lyngbya majuscula
87	E3DSD5_BACA1 (E3DSD5)	7e-25	118	33%	UniProt GenBank	Enoyl-(Acyl carrier protein) reductase	BATR1942_01895	Bacillus atrophaeus (strain 1942)	1.3.1.10 niceE keggE
88	Q6V1M4_9ACTO (Q6V1M4)	9e-25	118	33%	UniProt GenBank	ChcA	chcA	Streptomyces sp. HK803
89	D7C3F6_STRBB (D7C3F6)	9e-25	118	38%	UniProt GenBank	3-oxoacyl-(Acyl-carrier protein) reductase	SBI_07061	Streptomyces bingchenggensis (strain BCW-1)
90	C5D5T3_GEOSW (C5D5T3)	1e-24	118	33%	UniProt GenBank	Short-chain dehydrogenase/reductase SDR	GWCH70_0470	Geobacillus sp. (strain WCH70)
91	B9L9Q6_NAUPA (B9L9Q6)	1e-24	118	29%	UniProt GenBank	7-alpha-hydroxysteroid dehydrogenase	NAMH_0962	Nautilia profundicola (strain ATCC BAA-1463 / DSM 18972 / AmH)
92	D5DXS1_BACMQ (D5DXS1)	1e-24	117	32%	UniProt GenBank	Short chain dehydrogenase	BMQ_0404	Bacillus megaterium (strain ATCC 12872 / QMB1551)	1.1.1.1 niceE keggE
93	B7DNK4_9BACL (B7DNK4)	1e-24	117	31%	UniProt GenBank	Short-chain dehydrogenase/reductase SDR	AaLAA1DRAFT_0579	Alicyclobacillus acidocaldarius LAA1
94	A8FB79_BACP2 (A8FB79)	1e-24	117	32%	UniProt GenBank	Enoyl-[acyl-carrier-protein] reductase (NADH)	fabL BPUM_0812	Bacillus pumilus (strain SAFR-032)	1.3.1.9 niceE keggE
95	B4ANX5_BACPU (B4ANX5)	1e-24	117	32%	UniProt GenBank	Enoyl-[acyl-carrier-protein] reductase	BAT_3272	Bacillus pumilus ATCC 7061
96	E5WR47_9BACI (E5WR47)	1e-24	117	32%	UniProt GenBank	Enoyl-(Acyl carrier protein) reductase	HMPREF1013_04937	Bacillus sp. 2_A_57_CT2
97	B1KU70_CLOBM (B1KU70)	2e-24	117	33%	UniProt GenBank	3-oxoacyl-[acyl-carrier-protein] reductase	fabG CLK_3073	Clostridium botulinum (strain Loch Maree / Type A3)	1.1.1.100 niceE keggE
98	D2BVJ6_DICD5 (D2BVJ6)	2e-24	117	34%	UniProt GenBank	Short-chain dehydrogenase/reductase SDR	Dd586_1266	Dickeya dadantii (strain Ech586)
99	F3Z6E4_9ACTO (F3Z6E4)	2e-24	117	32%	UniProt GenBank	Putative short-chain dehydrogenase/reductase SDR	STTU_5672	Streptomyces sp. Tu6071
100	E4M729_9FIRM (E4M729)	2e-24	117	35%	UniProt GenBank	Short-chain dehydrogenase/reductase SDR	ThesuDRAFT_0166	Thermaerobacter subterraneus DSM 13965

accession

alignment

Evalue

Score

Ident.

link

information

pubmed

C0JWC4_9ACTO
(C0JWC4)

1e-139

498

100%

Product: PokT1
Gene: pokT1
Organism: Streptomyces diastatochromogenes

1uniprot[Pubmed] 19266534
Organisation of the Biosynthetic Gene Cluster and Tailoring Enzymes in the Biosynthesis of the Tetracyclic Quinone Glycoside Antibiotic Polyketomycin.(Chembiochem) [2009]

D7BZS0_STRBB
(D7BZS0)

4e-55

219

54%

Product: Short-chain dehydrogenase/reductase SDR
Gene: SBI_06855
Organism: Streptomyces bingchenggensis (strain BCW-1)

1uniprot[Pubmed] 20581206
Genome sequence of the milbemycin-producing bacterium Streptomyces bingchenggensis.(J. Bacteriol.) [2010]

Q3S8Q3_STRRM
(Q3S8Q3)

2e-41

173

44%

Product: OxyM
Gene: oxyM
Organism: Streptomyces rimosus

1uniprot[Pubmed] 16597959
Engineered biosynthesis of a novel amidated polyketide, using the malonamyl-specific initiation module from the oxytetracycline polyketide synthase.(Appl. Environ. Microbiol.) [2006]

Q194Q8_STRAA
(Q194Q8)

1e-39

167

45%

Product: Ketoreductase
Gene: mtmTI
Organism: Streptomyces argillaceus

[pubmed all]
1uniprot[Pubmed] 8654997 [Medline] 96257259 Characterization of Streptomyces argillaceus genes encoding a polyketide synthase involved in the biosynthesis of the antitumor mithramycin.(Gene) [1996]
2uniprot[Pubmed] 8757400 [Medline] 96335144 An ABC transporter is essential for resistance to the antitumor agent mithramycin in the producer Streptomyces argillaceus.(Mol. Gen. Genet.) [1996]
3uniprot[Pubmed] 9150235 [Medline] 97294479 Cloning and insertional inactivation of Streptomyces argillaceus genes involved in the earliest steps of biosynthesis of the sugar moieties of the antitumor polyketide mithramycin.(J. Bacteriol.) [1997]
4uniprot[Pubmed] 9733697 [Medline] 98406047 Identification of two genes from Streptomyces argillaceus encoding glycosyltransferases involved in transfer of a disaccharide during biosynthesis of the antitumor drug mithramycin.(J. Bacteriol.) [1998]
5uniprot[Pubmed] 10102355 [Medline] 99200478 Analysis of two chromosomal regions adjacent to genes for a type II polyketide synthase involved in the biosynthesis of the antitumor polyketide mithramycin in Streptomyces argillaceus.(Mol. Gen. Genet.) [1999]
6uniprot[Pubmed] 9889148 [Medline] 99111236 Oxidative cleavage of premithramycin B is one of the last steps in the biosynthesis of the antitumor drug mithramycin.(Chem. Biol.) [1999]
7uniprot[Pubmed] 10660060 [Medline] 20123456 Characterization of two glycosyltransferases involved in early glycosylation steps during biosynthesis of the antitumor polyketide mithramycin by Streptomyces argillaceus.(Mol. Gen. Genet.) [2000]
8uniprot[Pubmed] 11254130 [Medline] 21148776 The mtmVUC genes of the mithramycin gene cluster in Streptomyces argillaceus are involved in the biosynthesis of the sugar moieties.(Mol. Gen. Genet.) [2001]
9uniprot[Pubmed] 12733914 [Medline] 22619809 Mithramycin SK, a novel antitumor drug with improved therapeutic index, mithramycin SA, and demycarosyl-mithramycin SK: three new products generated in the mithramycin producer Streptomyces argillaceus through combinatorial biosynthesis.(J. Am. Chem. Soc.) [2003]
10uniprot[Pubmed] 9917296 [Medline] 99115752 The structure of mithramycin reinvestigated.(J. Nat. Prod.) [1999]
11uniprot[Pubmed] 11853433 [Medline] 21843297 Ketopremithramycins and ketomithramycins, four new aureolic acid-type compounds obtained upon inactivation of two genes involved in the biosynthesis of the deoxysugar moieties of the antitumor drug mithramycin by Streptomyces argillaceus, reveal novel insights into post-PKS tailoring steps of the mithramycin biosynthetic pathway.(J. Am. Chem. Soc.) [2002]
12uniprot[Pubmed] 10652287 [Medline] 20119254 Characterization of two polyketide methyltransferases involved in the biosynthesis of the antitumor drug mithramycin by Streptomyces argillaceus.(J. Biol. Chem.) [2000]
13uniprot[Pubmed] 10779713 [Medline] 20243461 Insertional inactivation of mtrX and mtrY genes from the mithramycin gene cluster affects production and growth of the producer organism Streptomyces argillaceus.(FEMS Microbiol. Lett.) [2000]
14uniprot[Pubmed] 12022840 [Medline] 22017994 Rationally designed glycosylated premithramycins: hybrid aromatic polyketides using genes from three different biosynthetic pathways.(J. Am. Chem. Soc.) [2002]
15uniprot[Pubmed] 12813091 [Medline] 22697398 Purification and characterization of a monooxygenase involved in the biosynthetic pathway of the antitumor drug mithramycin.(J. Bacteriol.) [2003]
16uniprot[Pubmed] 8807845 [Medline] 97113238 Deciphering the biosynthetic origin of the aglycone of the aureolic acid group of anti-tumor agents.(Chem. Biol.) [1996]
17uniprot[Pubmed] 14660589 MtmMII-mediated C-methylation during biosynthesis of the antitumor drug mithramycin is essential for biological activity and DNA-drug interaction.(J. Biol. Chem.) [2004]
18uniprot[Pubmed] 9375253 [Medline] 98042823 Folding of the polyketide chain is not dictated by minimal polyketide synthase in the biosynthesis of mithramycin and anthracycline.(Chem. Biol.) [1997]
19uniprot[Pubmed] 15712316 Elucidation of the glycosylation sequence of mithramycin biosynthesis: isolation of 3A-deolivosylpremithramycin B and its conversion to premithramycin B by glycosyltransferase MtmGII.(Chembiochem) [2005]
20uniprot[Pubmed] 10760873 The Novel Hybrid Antitumor Compound Premithramycinone H Provides Indirect Evidence for a Tricyclic Intermediate of the Biosynthesis of the Aureolic Acid Antibiotic Mithramycin.(Angew. Chem. Int. Ed.) [2000]

C0QR70_PERMH
(C0QR70)

5e-31

139

33%

Product: 3-oxoacyl-[acyl-carrier-protein] reductase (3-ketoacyl-acyl carrier protein reductase)
Gene: PERMA_1399
Organism: Persephonella marina (strain DSM 14350 / EX-H1)

1uniprot[Pubmed] 19136599
Complete and draft genome sequences of six members of the Aquificales.(J. Bacteriol.) [2009]

C1DXR7_SULAA
(C1DXR7)

7e-31

138

35%

Product: 3-oxoacyl-[acyl-carrier-protein] reductase (3-ketoacyl-acyl carrier protein reductase)
Gene: SULAZ_0183
Organism: Sulfurihydrogenibium azorense (strain Az-Fu1 / DSM 15241 / OCM 825)

1uniprot[Pubmed] 19136599
Complete and draft genome sequences of six members of the Aquificales.(J. Bacteriol.) [2009]

D1CG27_THET1
(D1CG27)

2e-30

137

37%

Product: Short-chain dehydrogenase/reductase SDR
Gene: Tter_0966
Organism: Thermobaculum terrenum (strain ATCC BAA-798 / YNP1)

1uniprot
Complete genome sequence of Thermobaculum terrenum type strain (YNP1T).(Stand. Genomic Sci.) [2010]

B2V750_SULSY
(B2V750)

2e-29

134

34%

Product: Short-chain dehydrogenase/reductase SDR
Gene: SYO3AOP1_0187
Organism: Sulfurihydrogenibium sp. (strain YO3AOP1)

1uniprot[Pubmed] 19136599
Complete and draft genome sequences of six members of the Aquificales.(J. Bacteriol.) [2009]

Q8YQD6_NOSS1
(Q8YQD6)

7e-29

132

33%

Product: Alr3897 protein
Gene: alr3897
Organism: Nostoc sp. (strain PCC 7120 / UTEX 2576)

1uniprot[Pubmed] 11759840 [Medline] 21595285
Complete genomic sequence of the filamentous nitrogen-fixing cyanobacterium Anabaena sp. strain PCC 7120.(DNA Res.) [2001]

D5T7Y2_LEGP2
(D5T7Y2)

1e-28

131

34%

Product: Glucose-1-dehydrogenase
Gene: lpa_00572
Organism: Legionella pneumophila serogroup 1 (strain 2300/99 Alcoy)

1uniprot[Pubmed] 20236513
Legionella pneumophila pangenome reveals strain-specific virulence factors.(BMC Genomics) [2010]

Q5X830_LEGPA
(Q5X830)

1e-28

131

34%

Product: Putative uncharacterized protein
Gene: lpp0423
Organism: Legionella pneumophila (strain Paris)

1uniprot[Pubmed] 15467720
Evidence in the Legionella pneumophila genome for exploitation of host cell functions and high genome plasticity.(Nat. Genet.) [2004]

Q629N6_BURMA
(Q629N6)

2e-28

130

36%

Product: Putative polyketide synthase
Gene: BMAA2089
Organism: Burkholderia mallei
Pseudomonas mallei

1uniprot[Pubmed] 15377793
Structural flexibility in the Burkholderia mallei genome.(Proc. Natl. Acad. Sci. U.S.A.) [2004]

E1Y0P7_LEGPN
(E1Y0P7)

7e-28

128

34%

Product: Putative uncharacterized protein
Gene: LPW_04371
Organism: Legionella pneumophila

1uniprot
The genome of Legionella pneumophila strain 130b contains a unique combination of type IV secretion systems and encodes novel Dot/Icm secretion system effector proteins.(J. Bacteriol.) [2010]

E8RFG2_9DELT
(E8RFG2)

1e-27

127

35%

Product: Enoyl-[acyl-carrier-protein] reductase [NADH]
Gene: Despr_0937
Organism: Desulfobulbus propionicus DSM 2032

1uniprot[Pubmed] 21475592
Complete genome sequence of Desulfobulbus propionicus type strain (1pr3).(Stand. Genomic Sci.) [2011]

Q5ZYL4_LEGPH
(Q5ZYL4)

2e-27

127

33%

Product: Glucose-1-dehydrogenase
Gene: lpg0358
Organism: Legionella pneumophila subsp. pneumophila (strain Philadelphia 1 / ATCC 33152 / DSM 7513)

1uniprot[Pubmed] 15448271
The genomic sequence of the accidental pathogen Legionella pneumophila.(Science) [2004]

Q5WZI3_LEGPL
(Q5WZI3)

2e-27

127

33%

Product: Putative uncharacterized protein
Gene: lpl0399
Organism: Legionella pneumophila (strain Lens)

1uniprot[Pubmed] 15467720
Evidence in the Legionella pneumophila genome for exploitation of host cell functions and high genome plasticity.(Nat. Genet.) [2004]

D7P5V2_9ACTO
(D7P5V2)

2e-27

127

33%

Product: AsuB3
Gene: asuB3
Organism: Streptomyces nodosus subsp. asukaensis

1uniprot[Pubmed] 20522559
Biochemical and genetic insights into asukamycin biosynthesis.(J. Biol. Chem.) [2010]

Q63HU2_BURPS
(Q63HU2)

2e-27

127

36%

Product: Putative multi-domain beta keto-acyl synthase
Gene: BPSS2328
Organism: Burkholderia pseudomallei
Pseudomonas pseudomallei

1uniprot[Pubmed] 15377794
Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.(Proc. Natl. Acad. Sci. U.S.A.) [2004]

Q2T2R4_BURTA
(Q2T2R4)

2e-27

127

36%

Product: Polyketide synthase, putative
Gene: BTH_II2348
Organism: Burkholderia thailandensis (strain E264 / ATCC 700388 / DSM 13276 / CIP 106301)

1uniprot[Pubmed] 16336651
Bacterial genome adaptation to niches: divergence of the potential virulence genes in three Burkholderia species of different survival strategies.(BMC Genomics) [2005]

E0URM7_SULAO
(E0URM7)

6e-26

122

31%

Product: Short-chain dehydrogenase/reductase SDR
Gene: Saut_0922
Organism: Sulfurimonas autotrophica (strain ATCC BAA-671 / DSM 16294 / JCM 11897 / OK10)

1uniprot
Complete genome sequence of Sulfurimonas autotrophica type strain (OK10T).(Stand. Genomic Sci.) [2010]

B0LJ23_9ACTO
(B0LJ23)

7e-26

122

37%

Product: Lct40
Gene: lct40
Organism: Streptomyces rishiriensis

1uniprot[Pubmed] 18070976
Biosynthetic investigations of lactonamycin and lactonamycin z: cloning of the biosynthetic gene clusters and discovery of an unusual starter unit.(Antimicrob. Agents Chemother.) [2008]

Q0REK7_FRAAA
(Q0REK7)

1e-25

121

36%

Product: Putative short-chain type dehydrogenase/reductase
Gene: FRAAL5468
Organism: Frankia alni (strain ACN14a)

1uniprot[Pubmed] 17151343
Genome characteristics of facultatively symbiotic Frankia sp. strains reflect host range and host plant biogeography.(Genome Res.) [2007]

E1UPB6_BACAS
(E1UPB6)

1e-25

120

34%

Product: Enoyl-acyl carrier protein reductase III
Gene: fabL
BAMF_0873
Organism: Bacillus amyloliquefaciens (strain ATCC 23350 / DSM 7 / NBRC 15535 / NRRL B-14393)

1uniprot[Pubmed] 21262282
Genome sequence of B. amyloliquefaciens type strain DSM7(T) reveals differences to plant-associated B. amyloliquefaciens FZB42.(J. Biotechnol.) [2011]

F4EMJ1_BACAM
(F4EMJ1)

1e-25

120

34%

Product: Enoyl-acyl carrier protein reductase III
Gene: fabL
LL3_00935
Organism: Bacillus amyloliquefaciens
Bacillus velezensis

1uniprot[Pubmed] 21551302
Complete Genome Sequence of Bacillus amyloliquefaciens LL3, Which Exhibits Glutamic Acid-Independent Production of Poly-{gamma}-Glutamic Acid.(J. Bacteriol.) [2011]

F4E3E1_BACAM
(F4E3E1)

1e-25

120

34%

Product: Enoyl-(Acyl carrier protein) reductase
Gene: fabL
BAMTA208_03980
Organism: Bacillus amyloliquefaciens TA208

1uniprot[Pubmed] 21515778
Complete Genome Sequence of Bacillus amyloliquefaciens TA208, a Strain for Industrial Production of Guanosine and Ribavirin.(J. Bacteriol.) [2011]

D3Q2H9_STANL
(D3Q2H9)

1e-25

120

35%

Product: Short-chain dehydrogenase/reductase SDR
Gene: Snas_4263
Organism: Stackebrandtia nassauensis (strain DSM 44728 / NRRL B-16338 / NBRC 102104 / LLR-40K-21)

1uniprot
Complete genome sequence of Stackebrandtia nassauensis type strain (LLR-40K-21T).(Stand. Genomic Sci.) [2009]

D3HPN7_LEGLN
(D3HPN7)

2e-25

120

34%

Product: Putative 3-oxoacyl-[acyl-carrier protein] reductase
Gene: LLO_0519
Organism: Legionella longbeachae serogroup 1 (strain NSW150)

1uniprot[Pubmed] 20174605
Analysis of the Legionella longbeachae genome and transcriptome uncovers unique strategies to cause Legionnaires' disease.(PLoS Genet.) [2010]

D1RI98_LEGLO
(D1RI98)

2e-25

120

34%

Product: Glucose-1-dehydrogenase
Gene: LLB_1340
Organism: Legionella longbeachae D-4968

1uniprot
The Genomic Sequence of the Soil-Dwelling Opportunistic Pathogen Legionella longbeachae.(J. Bacteriol.) [2010]

A7Z2N2_BACA2
(A7Z2N2)

3e-25

119

33%

Product: FabL
Gene: fabL
RBAM_008740
Organism: Bacillus amyloliquefaciens (strain FZB42)

1uniprot[Pubmed] 17704766
Comparative analysis of the complete genome sequence of the plant growth-promoting bacterium Bacillus amyloliquefaciens FZB42.(Nat. Biotechnol.) [2007]

Q9X7T4_STRCO
(Q9X7T4)

5e-25

119

35%

Product: Putative 3-oxoacyl-[acyl-carrier protein] reductase
Gene: SCO7266
Organism: Streptomyces coelicolor

1uniprot[Pubmed] 12000953 [Medline] 21996410
Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).(Nature) [2002]

E8VEV7_BACST
(E8VEV7)

5e-25

119

34%

Product: Enoyl-(Acyl carrier protein) reductase
Gene: BSn5_16190
Organism: Bacillus subtilis (strain BSn5)

1uniprot[Pubmed] 21317323
Complete genome sequence of Bacillus subtilis BSn5, an endophytic bacterium of Amorphophallus konjac with antimicrobial activity to plant pathogen Erwinia carotovora subsp. carotovora.(J. Bacteriol.) [2011]

D4G6M8_BACNA
(D4G6M8)

5e-25

119

34%

Product: Enoyl-(Acyl carrier protein) reductase
Gene: fabL
BSNT_01436
Organism: Bacillus subtilis subsp. natto BEST195

1uniprot[Pubmed] 20398357
Whole genome assembly of a natto production strain Bacillus subtilis natto from very short read data.(BMC Genomics) [2010]

FABL_BACSU
(P71079)

5e-25

119

34%

Product: Enoyl-[acyl-carrier-protein] reductase [NADPH] FabL
Enoyl-acyl carrier protein reductase III
NADPH-dependent enoyl-ACP reductase
Gene: fabL
yfhR
ygaA
BSU08650
Organism: Bacillus subtilis

[pubmed all]
1uniprot[Pubmed] 8946165 [Medline] 97101647 Cloning and sequencing of a 27.8-kb nucleotide sequence of the 79 degrees-81 degrees region of the Bacillus subtilis genome containing the sspE locus.(DNA Res.) [1996]
2uniprot[Pubmed] 9202460 [Medline] 97346037 The Bacillus subtilis 168 chromosome from sspE to katA.(Microbiology) [1997]
3uniprot[Pubmed] 9384377 [Medline] 98044033 The complete genome sequence of the Gram-positive bacterium Bacillus subtilis.(Nature) [1997]
4uniprot[Pubmed] 10463184 Transcription of genes near the sspE locus of the Bacillus subtilis genome.(Microbiology) [1999]
5uniprot[Pubmed] 11007778 The enoyl-[acyl-carrier-protein] reductases FabI and FabL from Bacillus subtilis.(J. Biol. Chem.) [2000]
6uniprot[Pubmed] 17329825 Crystallization and preliminary X-ray crystallographic analysis of enoyl-ACP reductase III (FabL) from Bacillus subtilis.(Acta Crystallogr. F) [2007]
7uniprot[Pubmed] 21185310 Crystal structures of Enoyl-ACP reductases I (FabI) and III (FabL) from B. subtilis.(J. Mol. Biol.) [2011]

Q98ML3_RHILO
(Q98ML3)

6e-25

119

35%

Product: Probable short-chain dehydrogenase
Gene: mll0534
Organism: Rhizobium loti
Mesorhizobium loti

1uniprot[Pubmed] 11214968 [Medline] 21082930
Complete genome structure of the nitrogen-fixing symbiotic bacterium Mesorhizobium loti.(DNA Res.) [2000]

Q5V8A5_9CYAN
(Q5V8A5)

6e-25

119

35%

Product: LtxD
Gene
Organism: Lyngbya majuscula

1uniprot[Pubmed] 15366877
Lyngbyatoxin biosynthesis: sequence of biosynthetic gene cluster and identification of a novel aromatic prenyltransferase.(J. Am. Chem. Soc.) [2004]

Q6V1M4_9ACTO
(Q6V1M4)

9e-25

118

33%

Product: ChcA
Gene: chcA
Organism: Streptomyces sp. HK803

1uniprot[Pubmed] 12819191 [Medline] 22841069
Enhancement and selective production of phoslactomycin B, a protein phosphatase IIa inhibitor, through identification and engineering of the corresponding biosynthetic gene cluster.(J. Biol. Chem.) [2003]

D7C3F6_STRBB
(D7C3F6)

9e-25

118

38%

Product: 3-oxoacyl-(Acyl-carrier protein) reductase
Gene: SBI_07061
Organism: Streptomyces bingchenggensis (strain BCW-1)

1uniprot[Pubmed] 20581206
Genome sequence of the milbemycin-producing bacterium Streptomyces bingchenggensis.(J. Bacteriol.) [2010]

B9L9Q6_NAUPA
(B9L9Q6)

1e-24

118

29%

Product: 7-alpha-hydroxysteroid dehydrogenase
Gene: NAMH_0962
Organism: Nautilia profundicola (strain ATCC BAA-1463 / DSM 18972 / AmH)

1uniprot[Pubmed] 19197347
Adaptations to submarine hydrothermal environments exemplified by the genome of Nautilia profundicola.(PLoS Genet.) [2009]

A8FB79_BACP2
(A8FB79)

1e-24

117

32%

Product: Enoyl-[acyl-carrier-protein] reductase (NADH)
Gene: fabL
BPUM_0812
Organism: Bacillus pumilus (strain SAFR-032)

1uniprot[Pubmed] 17895969
Paradoxical DNA repair and peroxide resistance gene conservation in Bacillus pumilus SAFR-032.(PLoS ONE) [2007]

B1KU70_CLOBM
(B1KU70)

2e-24

117

33%

Product: 3-oxoacyl-[acyl-carrier-protein] reductase
Gene: fabG
CLK_3073
Organism: Clostridium botulinum (strain Loch Maree / Type A3)

1uniprot[Pubmed] 18060065
Analysis of the neurotoxin complex genes in Clostridium botulinum A1-A4 and B1 strains: BoNT/A3, /Ba4 and /B1 clusters are located within plasmids.(PLoS ONE) [2007]