BLAST table : Madu_00160

DB	UniProtKB

	accession	Evalue	Score	Ident.	link	product	gene	organism	ec
1	B0BLM5_9ACTO (B0BLM5)	0.0	700	100%	UniProt GenBank	C-methyltransferase	mdpB1	Actinomadura madurae
2	C0JWB3_9ACTO (C0JWB3)	1e-142	509	72%	UniProt GenBank	PokMT1	pokMT1	Streptomyces diastatochromogenes
3	F4FD33_VERMA (F4FD33)	1e-116	422	65%	UniProt GenBank	O-methyltransferase family protein	VAB18032_24825	Verrucosispora maris (strain AB-18-032)
4	D6R232_STRAQ (D6R232)	8e-55	218	40%	UniProt GenBank	Methyltransferase	acmL	Streptomyces anulatus Streptomyces chrysomallus
5	D6R245_STRAQ (D6R245)	6e-54	216	40%	UniProt GenBank	Methyltransferase	acmI	Streptomyces anulatus Streptomyces chrysomallus
6	D4TGJ7_9NOST (D4TGJ7)	5e-53	213	36%	UniProt GenBank	Putative uncharacterized protein	CRC_01452	Cylindrospermopsis raciborskii CS-505
7	Q10ZS1_TRIEI (Q10ZS1)	2e-52	211	36%	UniProt GenBank	O-methyltransferase, family 2	Tery_3121	Trichodesmium erythraeum (strain IMS101)
8	E0L2Y5_STRVO (E0L2Y5)	3e-52	210	40%	UniProt GenBank	O-methyltransferase family 2	StrviDRAFT_9263	Streptomyces violaceusniger Tu 4113
9	D6A5N3_9ACTO (D6A5N3)	3e-52	210	39%	UniProt GenBank	O-methyltransferase	SSFG_06981	Streptomyces ghanaensis ATCC 14672
10	D7BWH9_STRBB (D7BWH9)	1e-51	208	40%	UniProt GenBank	O-methyltransferase family protein	SBI_00214	Streptomyces bingchenggensis (strain BCW-1)
11	B0CN31_STRLA (B0CN31)	3e-51	207	38%	UniProt GenBank	SAM-dependent methyltransferase	sfmM2	Streptomyces lavendulae
12	Q5JCL5_PSEFL (Q5JCL5)	2e-50	204	36%	UniProt GenBank	Putative methyltransferase	sfcF	Pseudomonas fluorescens
13	A8W7F2_9ACTO (A8W7F2)	1e-48	198	38%	UniProt GenBank	Putative aromatic C-methyltransferase		Streptomyces refuineus subsp. thermotolerans
14	D0LMS0_HALO1 (D0LMS0)	2e-47	194	38%	UniProt GenBank	O-methyltransferase family 2	Hoch_6286	Haliangium ochraceum (strain DSM 14365 / JCM 11303 / SMP-2)
15	D9WZA0_STRVR (D9WZA0)	4e-47	193	38%	UniProt GenBank	SAM-dependent methyltransferase	SSQG_05921	Streptomyces viridochromogenes DSM 40736
16	E9L1M6_9ZZZZ (E9L1M6)	2e-46	191	37%	UniProt GenBank	Putative uncharacterized protein	CA878-27	uncultured organism CA878
17	F3NRW5_9ACTO (F3NRW5)	3e-45	187	39%	UniProt GenBank	O-methyltransferase	SGM_5879	Streptomyces griseoaurantiacus M045
18	E9L1Q3_9ZZZZ (E9L1Q3)	2e-44	184	36%	UniProt GenBank	Putative uncharacterized protein	CA915-11	uncultured organism CA915
19	C0LTM6_9ACTO (C0LTM6)	8e-44	182	36%	UniProt GenBank	SibL	sibL	Streptosporangium sibiricum
20	E9L1F9_9ZZZZ (E9L1F9)	3e-43	180	35%	UniProt GenBank	Putative uncharacterized protein	CA37-15	uncultured organism CA37
21	B5GTK6_STRCL (B5GTK6)	5e-43	179	35%	UniProt GenBank	O-methyltransferase SAM-dependent methyltransferase	SCLAV_p0587 SSCG_02754	Streptomyces clavuligerus ATCC 27064
22	C3AEA4_BACMY (C3AEA4)	1e-38	165	29%	UniProt GenBank	O-methyltransferase, family 2	bmyco0001_51000	Bacillus mycoides DSM 2048
23	A4X1D9_SALTO (A4X1D9)	4e-34	150	35%	UniProt GenBank	O-methyltransferase, family 2	Strop_0204	Salinispora tropica (strain ATCC BAA-916 / DSM 44818 / CNB-440)
24	A8LXV1_SALAI (A8LXV1)	4e-34	150	35%	UniProt GenBank	O-methyltransferase family 2	Sare_0232	Salinispora arenicola (strain CNS-205)
25	F5XMS3_9ACTO (F5XMS3)	9e-34	149	33%	UniProt GenBank	Putative O-methyltransferase	MLP_09820	Microlunatus phosphovorus NM-1	2.1.1.- niceE keggE
26	B4XY98_9ACTO (B4XY98)	1e-33	148	34%	UniProt GenBank	Azi5	azi5	Streptomyces sahachiroi
27	E2Q8B6_STRCL (E2Q8B6)	5e-28	129	34%	UniProt GenBank	O-methyltransferase family protein	SCLAV_0372	Streptomyces clavuligerus ATCC 27064
28	D6A8Q4_9ACTO (D6A8Q4)	3e-27	127	29%	UniProt GenBank	O-methyltransferase family 2	SSFG_07273	Streptomyces ghanaensis ATCC 14672
29	Q1Q4M5_9BACT (Q1Q4M5)	9e-26	122	26%	UniProt GenBank	Similar to tetracenomycin polyketide synthesis 8-O-methyltransferase	tcmO kuste4198	Candidatus Kuenenia stuttgartiensis	2.1.1.- niceE keggE
30	D3F6H0_CONWI (D3F6H0)	3e-25	120	31%	UniProt GenBank	O-methyltransferase family 2	Cwoe_2312	Conexibacter woesei (strain DSM 14684 / JCM 11494 / NBRC 100937 / ID131577)
31	Q0SIR2_RHOSR (Q0SIR2)	9e-25	119	31%	UniProt GenBank	Polyketide synthesis 8-O-methyltransferase	RHA1_ro00739	Rhodococcus sp. (strain RHA1)	2.1.1.- niceE keggE
32	D9VDF4_9ACTO (D9VDF4)	2e-24	117	31%	UniProt GenBank	Predicted protein	SSMG_05689	Streptomyces sp. AA4
33	D6TYB9_9CHLR (D6TYB9)	3e-24	117	29%	UniProt GenBank	O-methyltransferase family 2	Krac_4137	Ktedonobacter racemifer DSM 44963
34	C1B538_RHOOB (C1B538)	4e-24	117	31%	UniProt GenBank	Putative methyltransferase	ROP_27170	Rhodococcus opacus (strain B4)	2.1.1.- niceE keggE
35	Q2T088_BURTA (Q2T088)	4e-23	113	29%	UniProt GenBank	O-methyltransferase family protein	BTH_I0855	Burkholderia thailandensis (strain E264 / ATCC 700388 / DSM 13276 / CIP 106301)
36	D6MSX0_9ACTO (D6MSX0)	5e-23	113	31%	UniProt GenBank	SsfM1	ssfM1	Streptomyces sp. SF2575
37	C0QH96_DESAH (C0QH96)	2e-22	111	26%	UniProt GenBank	SAM-dependent methyltransferase	HRM2_47060	Desulfobacterium autotrophicum (strain ATCC 43914 / DSM 3382 / HRM2)
38	E8L6E2_9RHIZ (E8L6E2)	2e-22	110	28%	UniProt GenBank	O-methyltransferase family 2	Met49242DRAFT_3035	Methylocystis sp. ATCC 49242
39	A3JXP2_9RHOB (A3JXP2)	4e-22	110	28%	UniProt GenBank	Probable acetylserotonin O-methyltransferase	SSE37_19772	Sagittula stellata E-37
40	E0ULM5_CYAP2 (E0ULM5)	1e-21	108	25%	UniProt GenBank	O-methyltransferase family 2	Cyan7822_6008	Cyanothece sp. (strain PCC 7822)
41	B5IJZ5_9CHRO (B5IJZ5)	2e-21	108	30%	UniProt GenBank	Tetracenomycin polyketide synthesis 8-O-methyl transferase TcmO	CPCC7001_993	Cyanobium sp. PCC 7001
42	C4SGC7_YERMO (C4SGC7)	3e-21	107	24%	UniProt GenBank	SAM-dependent methyltransferase	ymoll0001_37470	Yersinia mollaretii ATCC 43969
43	Q3S8P6_STRRM (Q3S8P6)	3e-21	107	28%	UniProt GenBank	OxyT	oxyT	Streptomyces rimosus
44	F4XU33_9CYAN (F4XU33)	4e-21	107	33%	UniProt GenBank	Methylase involved in ubiquinone/menaquinone biosynthesis	LYNGBM3L_30420	Lyngbya majuscula 3L
45	D8PIA8_9BACT (D8PIA8)	1e-20	105	28%	UniProt GenBank	Putative O-methyltransferase, family 2	NIDE3307	Candidatus Nitrospira defluvii	2.1.1.- niceE keggE
46	F6CIK7_9FIRM (F6CIK7)	1e-20	105	29%	UniProt GenBank	Acetylserotonin O-methyltransferase	Desku_0280	Desulfotomaculum kuznetsovii DSM 6115	2.1.1.4 niceE keggE
47	B2H3D6_BURPS (B2H3D6)	1e-20	105	29%	UniProt GenBank	O-methyltransferase	BURPS1655_K0293	Burkholderia pseudomallei 1655
48	Q63W91_BURPS (Q63W91)	2e-20	105	30%	UniProt GenBank	Putative methyltransferase	BPSL0997	Burkholderia pseudomallei Pseudomonas pseudomallei
49	A3NSL5_BURP0 (A3NSL5)	2e-20	105	30%	UniProt GenBank	O-methyltransferase	BURPS1106A_1056	Burkholderia pseudomallei (strain 1106a)
50	A3N6Y0_BURP6 (A3N6Y0)	2e-20	105	30%	UniProt GenBank	O-methyltransferase	BURPS668_1051	Burkholderia pseudomallei (strain 668)
51	C6TVM4_BURPS (C6TVM4)	2e-20	105	30%	UniProt GenBank	O-methyltransferase	BURPS1710A_1347	Burkholderia pseudomallei 1710a
52	C5ZB28_BURPS (C5ZB28)	2e-20	105	30%	UniProt GenBank	O-methyltransferase	BURPS1106B_A0307	Burkholderia pseudomallei 1106b
53	C0XZX5_BURPS (C0XZX5)	2e-20	105	30%	UniProt GenBank	O-methyltransferase	BUH_0968	Burkholderia pseudomallei Pakistan 9
54	B1HER8_BURPS (B1HER8)	2e-20	105	30%	UniProt GenBank	O-methyltransferase	BURPSS13_I0088	Burkholderia pseudomallei S13
55	A8KTI4_BURPS (A8KTI4)	2e-20	105	30%	UniProt GenBank	O-methyltransferase	BURPSPAST_A1165	Burkholderia pseudomallei Pasteur 52237
56	A8EFI1_BURPS (A8EFI1)	2e-20	105	30%	UniProt GenBank	O-methyltransferase	BURPS406E_R0114	Burkholderia pseudomallei 406e
57	B5IIH6_9CHRO (B5IIH6)	2e-20	104	29%	UniProt GenBank	Tetracenomycin polyketide synthesis 8-O-methyl transferase TcmO	CPCC7001_2675	Cyanobium sp. PCC 7001
58	Q62LE1_BURMA (Q62LE1)	2e-20	104	30%	UniProt GenBank	O-methyltransferase family protein	BMA0708	Burkholderia mallei Pseudomonas mallei
59	A3MLM6_BURM7 (A3MLM6)	2e-20	104	30%	UniProt GenBank	O-methyltransferase	BMA10247_1618	Burkholderia mallei (strain NCTC 10247)
60	A2SAF6_BURM9 (A2SAF6)	2e-20	104	30%	UniProt GenBank	O-methyltransferase family protein	BMA10229_A2981	Burkholderia mallei (strain NCTC 10229)
61	A1V5W1_BURMS (A1V5W1)	2e-20	104	30%	UniProt GenBank	O-methyltransferase family protein	BMASAVP1_A2305	Burkholderia mallei (strain SAVP1)
62	C5NIR9_BURMA (C5NIR9)	2e-20	104	30%	UniProt GenBank	O-methyltransferase	BMAPRL20_A0721	Burkholderia mallei PRL-20
63	C4B248_BURMA (C4B248)	2e-20	104	30%	UniProt GenBank	O-methyltransferase	BMAGB8_0744	Burkholderia mallei GB8 horse 4
64	B7CI53_BURPS (B7CI53)	2e-20	104	30%	UniProt GenBank	O-methyltransferase	BUC_1260	Burkholderia pseudomallei 576
65	A9KAA2_BURMA (A9KAA2)	2e-20	104	30%	UniProt GenBank	O-methyltransferase	BMA10399_E0206	Burkholderia mallei ATCC 10399
66	A5XNA8_BURMA (A5XNA8)	2e-20	104	30%	UniProt GenBank	O-methyltransferase	BMAJHU_C0217	Burkholderia mallei JHU
67	A5XHN7_BURMA (A5XHN7)	2e-20	104	30%	UniProt GenBank	O-methyltransferase	BMAFMH_C0207	Burkholderia mallei FMH
68	A5TJD7_BURMA (A5TJD7)	2e-20	104	30%	UniProt GenBank	O-methyltransferase	BMA721280_A1268	Burkholderia mallei 2002721280
69	Q3JUY2_BURP1 (Q3JUY2)	2e-20	104	29%	UniProt GenBank	O-methyltransferase family protein	BURPS1710b_1210	Burkholderia pseudomallei (strain 1710b)	2.1.1.4 niceE keggE
70	D2QXW1_PIRSD (D2QXW1)	2e-20	104	29%	UniProt GenBank	O-methyltransferase family 2	Psta_3374	Pirellula staleyi (strain ATCC 27377 / DSM 6068 / ICPB 4128) Pirella staleyi
71	F2NJA2_DESAR (F2NJA2)	2e-20	104	27%	UniProt GenBank	O-methyltransferase family 2	Desac_1418	Desulfobacca acetoxidans (strain ATCC 700848 / DSM 11109 / ASRB2)
72	D5W6P9_BURSC (D5W6P9)	3e-20	103	28%	UniProt GenBank	O-methyltransferase family 2	BC1002_1107	Burkholderia sp. (strain CCGE1002)
73	C4KSN9_BURPS (C4KSN9)	4e-20	103	29%	UniProt GenBank	O-methyltransferase family protein	GBP346_A1050	Burkholderia pseudomallei MSHR346
74	A3ZPN0_9PLAN (A3ZPN0)	5e-20	103	28%	UniProt GenBank	Putative methyltransferase	DSM3645_29042	Blastopirellula marina DSM 3645
75	D5C2Y3_NITHN (D5C2Y3)	5e-20	103	24%	UniProt GenBank	O-methyltransferase family 2	Nhal_1752	Nitrosococcus halophilus (strain Nc4)
76	C7PAY6_CHIPD (C7PAY6)	6e-20	103	24%	UniProt GenBank	Methyltransferase type 12	Cpin_1862	Chitinophaga pinensis (strain ATCC 43595 / DSM 2588 / NCIB 11800 / UQM 2034)
77	D1J9X6_9ARCH (D1J9X6)	7e-20	102	25%	UniProt GenBank	Putative uncharacterized protein	BSM_23830	uncultured archaeon
78	Q70DX4_9ACTO (Q70DX4)	9e-20	102	31%	UniProt GenBank	RemG protein	remG	Streptomyces resistomycificus
79	F8GLV2_9PROT (F8GLV2)	1e-19	102	24%	UniProt GenBank	O-methyltransferase family 2	Nit79A3_3300	Nitrosomonas sp. Is79A3
80	HIOM_BOVIN (P10950)	1e-19	101	28%	UniProt GenBank	Hydroxyindole O-methyltransferase Acetylserotonin O-methyltransferase Acetylserotonin O-methyltransferase	ASMT	Bos taurus Bovine	2.1.1.4 niceE keggE
81	E8YT36_9BURK (E8YT36)	2e-19	101	28%	UniProt GenBank	O-methyltransferase family 2	BC1001_5255	Burkholderia sp. CCGE1001
82	A7DWL9_STRTE (A7DWL9)	2e-19	101	28%	UniProt GenBank	Putative O-methyltransferase	llpMVI	Streptomyces tendae	2.1.1.- niceE keggE
83	B2IZS2_NOSP7 (B2IZS2)	2e-19	101	24%	UniProt GenBank	O-methyltransferase, family 2	Npun_R1510	Nostoc punctiforme (strain ATCC 29133 / PCC 73102)	2.1.1.4 niceE keggE
84	Q46PN2_CUPPJ (Q46PN2)	2e-19	101	27%	UniProt GenBank	O-methyltransferase, family 2	Reut_B5557	Cupriavidus pinatubonensis (strain JMP134 / LMG 1197) Alcaligenes eutrophus Ralstonia eutropha
85	TCMO_STRGA (P39896)	2e-19	101	29%	UniProt GenBank	Tetracenomycin polyketide synthesis 8-O-methyl transferase tcmO	tcmO	Streptomyces glaucescens	2.1.1.- niceE keggE
86	Q01QE9_SOLUE (Q01QE9)	3e-19	100	26%	UniProt GenBank	O-methyltransferase, family 2	Acid_7210	Solibacter usitatus (strain Ellin6076)
87	E3T6I1_9BACT (E3T6I1)	3e-19	100	32%	UniProt GenBank	O-methyltransferase family 2		uncultured bacterium 70
88	F5J3Q3_9PORP (F5J3Q3)	4e-19	100	26%	UniProt GenBank	Putative uncharacterized protein	HMPREF9455_03970	Dysgonomonas gadei ATCC BAA-286
89	A0SZW0_9ACTO (A0SZW0)	4e-19	100	28%	UniProt GenBank	PdmT	pdmT	Actinomadura hibisca
90	A8KPS1_BURPS (A8KPS1)	5e-19	100	28%	UniProt GenBank	O-methyltransferase	BURPSPAST_E0095	Burkholderia pseudomallei Pasteur 52237
91	Q3JHI1_BURP1 (Q3JHI1)	5e-19	100	28%	UniProt GenBank	O-methyltransferase family protein	hioM BURPS1710b_A1815	Burkholderia pseudomallei (strain 1710b)
92	A3P271_BURP0 (A3P271)	5e-19	100	28%	UniProt GenBank	O-methyltransferase	BURPS1106A_A0388	Burkholderia pseudomallei (strain 1106a)
93	C6U7G6_BURPS (C6U7G6)	5e-19	100	28%	UniProt GenBank	O-methyltransferase family protein	BURPS1710A_A2884	Burkholderia pseudomallei 1710a
94	C5ZML4_BURPS (C5ZML4)	5e-19	100	28%	UniProt GenBank	O-methyltransferase	BURPS1106B_1605	Burkholderia pseudomallei 1106b
95	C4I6Y1_BURPS (C4I6Y1)	5e-19	100	28%	UniProt GenBank	O-methyltransferase	GBP346_B3061	Burkholderia pseudomallei MSHR346
96	A4LL77_BURPS (A4LL77)	5e-19	100	28%	UniProt GenBank	O-methyltransferase, putative	BURPS305_3382	Burkholderia pseudomallei 305
97	B4R7V6_PHEZH (B4R7V6)	6e-19	99.8	30%	UniProt GenBank	Methyltransferase/methylase	PHZ_c1075	Phenylobacterium zucineum (strain HLK1)
98	E1TE69_BURSG (E1TE69)	7e-19	99.8	28%	UniProt GenBank	O-methyltransferase family 2	BC1003_4162	Burkholderia sp. (strain CCGE1003)
99	B2JR16_BURP8 (B2JR16)	7e-19	99.8	27%	UniProt GenBank	O-methyltransferase family 2	Bphy_4597	Burkholderia phymatum (strain DSM 17167 / STM815)
100	D2SYZ3_MICEC (D2SYZ3)	7e-19	99.8	28%	UniProt GenBank	O-methyltransferase		Micromonospora echinospora subsp. challisensis

accession

alignment

Evalue

Score

Ident.

link

information

pubmed

B0BLM5_9ACTO
(B0BLM5)

0.0

700

100%

Product: C-methyltransferase
Gene: mdpB1
Organism: Actinomadura madurae

[pubmed all]
1uniprot[Pubmed] 14528002 [Medline] 22922109 Rapid PCR amplification of minimal enediyne polyketide synthase cassettes leads to a predictive familial classification model.(Proc. Natl. Acad. Sci. U.S.A.) [2003]
2uniprot[Pubmed] 17918933 Characterization of the maduropeptin biosynthetic gene cluster from Actinomadura madurae ATCC 39144 supporting a unifying paradigm for enediyne biosynthesis.(J. Am. Chem. Soc.) [2007]

C0JWB3_9ACTO
(C0JWB3)

1e-142

509

72%

Product: PokMT1
Gene: pokMT1
Organism: Streptomyces diastatochromogenes

1uniprot[Pubmed] 19266534
Organisation of the Biosynthetic Gene Cluster and Tailoring Enzymes in the Biosynthesis of the Tetracyclic Quinone Glycoside Antibiotic Polyketomycin.(Chembiochem) [2009]

F4FD33_VERMA
(F4FD33)

1e-116

422

65%

Product: O-methyltransferase family protein
Gene: VAB18032_24825
Organism: Verrucosispora maris (strain AB-18-032)

1uniprot[Pubmed] 21551311
Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.(J. Bacteriol.) [2011]

D6R232_STRAQ
(D6R232)

8e-55

218

40%

Product: Methyltransferase
Gene: acmL
Organism: Streptomyces anulatus
Streptomyces chrysomallus

[pubmed all]
1uniprot[Pubmed] 10212227 [Medline] 99230270 Molecular characterization of the genes of actinomycin synthetase I and of a 4-methyl-3-hydroxyanthranilic acid carrier protein involved in the assembly of the acylpeptide chain of actinomycin in Streptomyces.(J. Biol. Chem.) [1999]
2uniprot[Pubmed] 10780924 [Medline] 20243879 Construction and in vitro analysis of a new bi-modular polypeptide synthetase for synthesis of N-methylated acyl peptides.(Chem. Biol.) [2000]
3uniprot[Pubmed] 20304989 The actinomycin biosynthetic gene cluster of Streptomyces chrysomallus: a genetic hall of mirrors for synthesis of a molecule with mirror symmetry.(J. Bacteriol.) [2010]

D6R245_STRAQ
(D6R245)

6e-54

216

40%

Product: Methyltransferase
Gene: acmI
Organism: Streptomyces anulatus
Streptomyces chrysomallus

[pubmed all]
1uniprot[Pubmed] 10212227 [Medline] 99230270 Molecular characterization of the genes of actinomycin synthetase I and of a 4-methyl-3-hydroxyanthranilic acid carrier protein involved in the assembly of the acylpeptide chain of actinomycin in Streptomyces.(J. Biol. Chem.) [1999]
2uniprot[Pubmed] 10780924 [Medline] 20243879 Construction and in vitro analysis of a new bi-modular polypeptide synthetase for synthesis of N-methylated acyl peptides.(Chem. Biol.) [2000]
3uniprot[Pubmed] 20304989 The actinomycin biosynthetic gene cluster of Streptomyces chrysomallus: a genetic hall of mirrors for synthesis of a molecule with mirror symmetry.(J. Bacteriol.) [2010]

D4TGJ7_9NOST
(D4TGJ7)

5e-53

213

36%

Product: Putative uncharacterized protein
Gene: CRC_01452
Organism: Cylindrospermopsis raciborskii CS-505

1uniprot[Pubmed] 20169071
The smallest known genomes of multicellular and toxic cyanobacteria: comparison, minimal gene sets for linked traits and the evolutionary implications.(PLoS ONE) [2010]

D7BWH9_STRBB
(D7BWH9)

1e-51

208

40%

Product: O-methyltransferase family protein
Gene: SBI_00214
Organism: Streptomyces bingchenggensis (strain BCW-1)

1uniprot[Pubmed] 20581206
Genome sequence of the milbemycin-producing bacterium Streptomyces bingchenggensis.(J. Bacteriol.) [2010]

B0CN31_STRLA
(B0CN31)

3e-51

207

38%

Product: SAM-dependent methyltransferase
Gene: sfmM2
Organism: Streptomyces lavendulae

1uniprot[Pubmed] 17981978
Characterization of the saframycin A gene cluster from Streptomyces lavendulae NRRL 11002 revealing a nonribosomal peptide synthetase system for assembling the unusual tetrapeptidyl skeleton in an iterative manner.(J. Bacteriol.) [2008]

Q5JCL5_PSEFL
(Q5JCL5)

2e-50

204

36%

Product: Putative methyltransferase
Gene: sfcF
Organism: Pseudomonas fluorescens

1uniprot[Pubmed] 15773985
Molecular characterization of the safracin biosynthetic pathway from Pseudomonas fluorescens A2-2: designing new cytotoxic compounds.(Mol. Microbiol.) [2005]

A8W7F2_9ACTO
(A8W7F2)

1e-48

198

38%

Product: Putative aromatic C-methyltransferase
Gene
Organism: Streptomyces refuineus subsp. thermotolerans

1uniprot[Pubmed] 17584616
Benzodiazepine biosynthesis in Streptomyces refuineus.(Chem. Biol.) [2007]

E9L1M6_9ZZZZ
(E9L1M6)

2e-46

191

37%

Product: Putative uncharacterized protein
Gene: CA878-27
Organism: uncultured organism CA878

1uniprot[Pubmed] 20945895
Tailoring enzyme-rich environmental DNA clones: a source of enzymes for generating libraries of unnatural natural products.(J. Am. Chem. Soc.) [2010]

F3NRW5_9ACTO
(F3NRW5)

3e-45

187

39%

Product: O-methyltransferase
Gene: SGM_5879
Organism: Streptomyces griseoaurantiacus M045

1uniprot[Pubmed] 21551298
Draft Genome Sequence of the Marine Bacterium Streptomyces griseoaurantiacus M045, Which Produces Novel Manumycin-Type Antibiotics with a pABA Core Component.(J. Bacteriol.) [2011]

E9L1Q3_9ZZZZ
(E9L1Q3)

2e-44

184

36%

Product: Putative uncharacterized protein
Gene: CA915-11
Organism: uncultured organism CA915

1uniprot[Pubmed] 20945895
Tailoring enzyme-rich environmental DNA clones: a source of enzymes for generating libraries of unnatural natural products.(J. Am. Chem. Soc.) [2010]

C0LTM6_9ACTO
(C0LTM6)

8e-44

182

36%

Product: SibL
Gene: sibL
Organism: Streptosporangium sibiricum

1uniprot[Pubmed] 19270142
Biosynthesis of sibiromycin, a potent antitumor antibiotic.(Appl. Environ. Microbiol.) [2009]

E9L1F9_9ZZZZ
(E9L1F9)

3e-43

180

35%

Product: Putative uncharacterized protein
Gene: CA37-15
Organism: uncultured organism CA37

1uniprot[Pubmed] 20945895
Tailoring enzyme-rich environmental DNA clones: a source of enzymes for generating libraries of unnatural natural products.(J. Am. Chem. Soc.) [2010]

B5GTK6_STRCL
(B5GTK6)

5e-43

179

35%

Product: O-methyltransferase
SAM-dependent methyltransferase
Gene: SCLAV_p0587
SSCG_02754
Organism: Streptomyces clavuligerus ATCC 27064

1uniprot
The sequence of a 1.8 Mb bacterial linear plasmid reveals a rich evolutionary reservoir of secondary metabolic pathways.(Genome Biol. Evol.) [2010]

B4XY98_9ACTO
(B4XY98)

1e-33

148

34%

Product: Azi5
Gene: azi5
Organism: Streptomyces sahachiroi

1uniprot[Pubmed] 18635006
Characterization of the azinomycin B biosynthetic gene cluster revealing a different iterative type I polyketide synthase for naphthoate biosynthesis.(Chem. Biol.) [2008]

E2Q8B6_STRCL
(E2Q8B6)

5e-28

129

34%

Product: O-methyltransferase family protein
Gene: SCLAV_0372
Organism: Streptomyces clavuligerus ATCC 27064

1uniprot[Pubmed] 20624727
The sequence of a 1.8-mb bacterial linear plasmid reveals a rich evolutionary reservoir of secondary metabolic pathways.(Genome Biol. Evol.) [2010]

Q1Q4M5_9BACT
(Q1Q4M5)

9e-26

122

26%

Product: Similar to tetracenomycin polyketide synthesis 8-O-methyltransferase
Gene: tcmO
kuste4198
Organism: Candidatus Kuenenia stuttgartiensis

1uniprot[Pubmed] 16598256
Deciphering the evolution and metabolism of an anammox bacterium from a community genome.(Nature) [2006]

Q0SIR2_RHOSR
(Q0SIR2)

9e-25

119

31%

Product: Polyketide synthesis 8-O-methyltransferase
Gene: RHA1_ro00739
Organism: Rhodococcus sp. (strain RHA1)

1uniprot[Pubmed] 17030794
The complete genome of Rhodococcus sp. RHA1 provides insights into a catabolic powerhouse.(Proc. Natl. Acad. Sci. U.S.A.) [2006]

Q2T088_BURTA
(Q2T088)

4e-23

113

29%

Product: O-methyltransferase family protein
Gene: BTH_I0855
Organism: Burkholderia thailandensis (strain E264 / ATCC 700388 / DSM 13276 / CIP 106301)

1uniprot[Pubmed] 16336651
Bacterial genome adaptation to niches: divergence of the potential virulence genes in three Burkholderia species of different survival strategies.(BMC Genomics) [2005]

D6MSX0_9ACTO
(D6MSX0)

5e-23

113

31%

Product: SsfM1
Gene: ssfM1
Organism: Streptomyces sp. SF2575

1uniprot[Pubmed] 19908837
Biochemical analysis of the biosynthetic pathway of an anticancer tetracycline SF2575.(J. Am. Chem. Soc.) [2009]

C0QH96_DESAH
(C0QH96)

2e-22

111

26%

Product: SAM-dependent methyltransferase
Gene: HRM2_47060
Organism: Desulfobacterium autotrophicum (strain ATCC 43914 / DSM 3382 / HRM2)

1uniprot[Pubmed] 19187283
Genome sequence of Desulfobacterium autotrophicum HRM2, a marine sulfate reducer oxidizing organic carbon completely to carbon dioxide.(Environ. Microbiol.) [2009]

E8L6E2_9RHIZ
(E8L6E2)

2e-22

110

28%

Product: O-methyltransferase family 2
Gene: Met49242DRAFT_3035
Organism: Methylocystis sp. ATCC 49242

1uniprot[Pubmed] 21441518
Genome Sequence of the Methanotrophic Alphaproteobacterium Methylocystis sp. Strain Rockwell (ATCC 49242).(J. Bacteriol.) [2011]

Q3S8P6_STRRM
(Q3S8P6)

3e-21

107

28%

Product: OxyT
Gene: oxyT
Organism: Streptomyces rimosus

1uniprot[Pubmed] 16597959
Engineered biosynthesis of a novel amidated polyketide, using the malonamyl-specific initiation module from the oxytetracycline polyketide synthase.(Appl. Environ. Microbiol.) [2006]

F4XU33_9CYAN
(F4XU33)

4e-21

107

33%

Product: Methylase involved in ubiquinone/menaquinone biosynthesis
Gene: LYNGBM3L_30420
Organism: Lyngbya majuscula 3L

1uniprot
Genomic insights into the physiology and ecology of the marine filamentous cyanobacterium Lyngbya majuscula.(Proc. Natl. Acad. Sci. U.S.A.) [2011]

D8PIA8_9BACT
(D8PIA8)

1e-20

105

28%

Product: Putative O-methyltransferase, family 2
Gene: NIDE3307
Organism: Candidatus Nitrospira defluvii

1uniprot
A Nitrospira metagenome illuminates the physiology and evolution of globally important nitrite-oxidizing bacteria.(Proc. Natl. Acad. Sci. U.S.A.) [2010]

Q63W91_BURPS
(Q63W91)

2e-20

105

30%

Product: Putative methyltransferase
Gene: BPSL0997
Organism: Burkholderia pseudomallei
Pseudomonas pseudomallei

1uniprot[Pubmed] 15377794
Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.(Proc. Natl. Acad. Sci. U.S.A.) [2004]

Q62LE1_BURMA
(Q62LE1)

2e-20

104

30%

Product: O-methyltransferase family protein
Gene: BMA0708
Organism: Burkholderia mallei
Pseudomonas mallei

1uniprot[Pubmed] 15377793
Structural flexibility in the Burkholderia mallei genome.(Proc. Natl. Acad. Sci. U.S.A.) [2004]

D2QXW1_PIRSD
(D2QXW1)

2e-20

104

29%

Product: O-methyltransferase family 2
Gene: Psta_3374
Organism: Pirellula staleyi (strain ATCC 27377 / DSM 6068 / ICPB 4128)
Pirella staleyi

1uniprot
Complete genome sequence of Pirellula staleyi type strain (ATCC 27377T).(Stand. Genomic Sci.) [2009]

D1J9X6_9ARCH
(D1J9X6)

7e-20

102

25%

Product: Putative uncharacterized protein
Gene: BSM_23830
Organism: uncultured archaeon

1uniprot
Metagenome and mRNA expression analyses of anaerobic methanotrophic archaea of the ANME-1 group.(Environ. Microbiol.) [2010]

Q70DX4_9ACTO
(Q70DX4)

9e-20

102

31%

Product: RemG protein
Gene: remG
Organism: Streptomyces resistomycificus

1uniprot[Pubmed] 14982421
A gene cluster encoding resistomycin biosynthesis in Streptomyces resistomycificus; exploring polyketide cyclization beyond linear and angucyclic patterns.(J. Am. Chem. Soc.) [2004]

HIOM_BOVIN
(P10950)

1e-19

101

28%

Product: Hydroxyindole O-methyltransferase
Acetylserotonin O-methyltransferase
Acetylserotonin O-methyltransferase
Gene: ASMT
Organism: Bos taurus
Bovine

[pubmed all]
1uniprot[Pubmed] 3818627 [Medline] 87137548 Molecular cloning and nucleotide sequence of cDNA encoding hydroxyindole O-methyltransferase of bovine pineal glands.(J. Biol. Chem.) [1987]
2uniprot[Pubmed] 1544900 [Medline] 92184762 Bovine hydroxyindole-O-methyltransferase. Significant sequence revision.(J. Biol. Chem.) [1992]

A7DWL9_STRTE
(A7DWL9)

2e-19

101

28%

Product: Putative O-methyltransferase
Gene: llpMVI
Organism: Streptomyces tendae

1uniprot
Isolation of the lysolipin gene cluster of Streptomyces tendae Tu 4042.(Gene) [2010]

TCMO_STRGA
(P39896)

2e-19

101

29%

Product: Tetracenomycin polyketide synthesis 8-O-methyl transferase tcmO
Gene: tcmO
Organism: Streptomyces glaucescens

1uniprot[Pubmed] 1548230 [Medline] 92193265
Nucleotide sequence of the tcmII-tcmIV region of the tetracenomycin C biosynthetic gene cluster of Streptomyces glaucescens and evidence that the tcmN gene encodes a multifunctional cyclase-dehydratase-O-methyl transferase.(J. Bacteriol.) [1992]

Q01QE9_SOLUE
(Q01QE9)

3e-19

100

26%

Product: O-methyltransferase, family 2
Gene: Acid_7210
Organism: Solibacter usitatus (strain Ellin6076)

1uniprot[Pubmed] 19201974
Three genomes from the phylum Acidobacteria provide insight into the lifestyles of these microorganisms in soils.(Appl. Environ. Microbiol.) [2009]

E3T6I1_9BACT
(E3T6I1)

3e-19

100

32%

Product: O-methyltransferase family 2
Gene
Organism: uncultured bacterium 70

1uniprot[Pubmed] 20729323
Comparative analysis of acidobacterial genomic fragments from terrestrial and aquatic metagenomic libraries, with emphasis on acidobacteria subdivision 6.(Appl. Environ. Microbiol.) [2010]

B4R7V6_PHEZH
(B4R7V6)

6e-19

99.8

30%

Product: Methyltransferase/methylase
Gene: PHZ_c1075
Organism: Phenylobacterium zucineum (strain HLK1)

1uniprot[Pubmed] 18700039
Complete genome of Phenylobacterium zucineum - a novel facultative intracellular bacterium isolated from human erythroleukemia cell line K562.(BMC Genomics) [2008]

100

D2SYZ3_MICEC
(D2SYZ3)

7e-19

99.8

28%

Product: O-methyltransferase
Gene
Organism: Micromonospora echinospora subsp. challisensis

1uniprot[Pubmed] 19680283
TLN-05220, TLN-05223, new Echinosporamicin-type antibiotics, and proposed revision of the structure of bravomicins(*).(J. Antibiot.) [2009]