BLAST table : Balhi_00290

DB	UniProtKB

	accession	Evalue	Score	Ident.	link	product	gene	organism	ec
1	Q939X6_9PSEU (Q939X6)	6e-48	193	100%	UniProt GenBank	Putative 4-ketoreductase	dvaE	Amycolatopsis balhimycina
2	F8STZ3_AMYOR (F8STZ3)	3e-26	122	72%	UniProt GenBank	4-ketoreductase	vcm20	Amycolatopsis orientalis Nocardia orientalis
3	E9L1N5_9ZZZZ (E9L1N5)	3e-25	118	73%	UniProt GenBank	Putative uncharacterized protein	CA878-36	uncultured organism CA878
4	O52794_AMYOR (O52794)	4e-24	114	69%	UniProt GenBank	PCZA361.4		Amycolatopsis orientalis Nocardia orientalis
5	B7T1A5_9BACT (B7T1A5)	3e-23	111	69%	UniProt GenBank	Veg33	veg33	uncultured soil bacterium
6	Q83WG0_9ACTO (Q83WG0)	8e-15	84	63%	UniProt GenBank	4-ketoreductase	staK	Streptomyces sp. TP-A0274
7	A4F7N7_SACEN (A4F7N7)	1e-09	66.6	49%	UniProt GenBank	DTDP-4-keto-6-deoxy-L-hexose 4-reductase	eryBIV SACE_0720	Saccharopolyspora erythraea (strain NRRL 23338)
8	O33938_SACER (O33938)	1e-09	66.6	49%	UniProt GenBank	EryBIV Putative deoxyhexose reductase	eryBIV EryBIV	Saccharopolyspora erythraea Streptomyces erythraeus
9	E9L1H1_9ZZZZ (E9L1H1)	3e-08	62.4	51%	UniProt GenBank	Putative uncharacterized protein	CA37-27	uncultured organism CA37
10	E9L1R8_9ZZZZ (E9L1R8)	5e-08	61.2	50%	UniProt GenBank	Putative uncharacterized protein	CA915-26	uncultured organism CA915
11	Q83X63_STRRO (Q83X63)	2e-07	59.3	53%	UniProt GenBank	Putative NDP-3-methyl-4-keto-2,6-dideoxyhexose 4-ketoreductase	lkmBIV	Streptomyces rochei Streptomyces parvullus
12	A4X717_SALTO (A4X717)	3e-07	58.9	49%	UniProt GenBank	NAD-dependent epimerase/dehydratase	Strop_2216	Salinispora tropica (strain ATCC BAA-916 / DSM 44818 / CNB-440)
13	Q939Q3_9ACTO (Q939Q3)	2e-06	56.2	50%	UniProt GenBank	NDP-4-keto-6-deoxyhexose 4-ketoreductase	jadV	Streptomyces venezuelae
14	F2RC35_STRVP (F2RC35)	2e-06	56.2	50%	UniProt GenBank	UDP-glucose 4-epimerase	SVEN_6000	Streptomyces venezuelae (strain ATCC 10712 / CBS 650.69 / DSM 40230 / JCM 4526 / NBRC 13096 / PD 04745)	5.1.3.2 niceE keggE
15	Q5Y9G3_9ACTO (Q5Y9G3)	4e-06	55.1	49%	UniProt GenBank	Deoxyhexose dehydratase	eryBIV	Aeromicrobium erythreum
16	D5SL05_STRCL (D5SL05)	4e-06	55.1	59%	UniProt GenBank	Staurosporine biosynthesis 4-ketoreductase StaK	staK SCLAV_p1112	Streptomyces clavuligerus ATCC 27064
17	B3TMP6_9ACTO (B3TMP6)	6e-06	54.3	48%	UniProt GenBank	Sugar 4-ketoreductase	KijC2	Actinomadura kijaniata
18	Q9F831_9ACTO (Q9F831)	1e-05	53.5	48%	UniProt GenBank	TDP-4-keto-6-deoxyhexose 4-ketoreductase	megBIV	Micromonospora megalomicea subsp. nigra
19	A8M281_SALAI (A8M281)	6e-05	50.8	49%	UniProt GenBank	NAD-dependent epimerase/dehydratase	Sare_2339	Salinispora arenicola (strain CNS-205)
20	Q9S0P3_STRAW (Q9S0P3)	0.0001	49.7	42%	UniProt GenBank	dTDP-4-keto-6-deoxy-L-hexose 4-reductase	aveBIV SAV948 SAV_948	Streptomyces avermitilis

accession

alignment

Evalue

Score

Ident.

link

information

pubmed

Q939X6_9PSEU
(Q939X6)

6e-48

193

100%

Product: Putative 4-ketoreductase
Gene: dvaE
Organism: Amycolatopsis balhimycina

[pubmed all]
1uniprot[Pubmed] 10390204 [Medline] 99318579 Identification and analysis of the balhimycin biosynthetic gene cluster and its use for manipulating glycopeptide biosynthesis in Amycolatopsis mediterranei DSM5908.(Antimicrob. Agents Chemother.) [1999]
2uniprot[Pubmed] 11932455 [Medline] 21930292 Nonribosomal biosynthesis of vancomycin-type antibiotics: a heptapeptide backbone and eight peptide synthetase modules.(Microbiology) [2002]
3uniprot[Pubmed] 11495926 [Medline] 21486455 A polyketide synthase in glycopeptide biosynthesis: the biosynthesis of the non-proteinogenic amino acid (S)-3,5-dihydroxyphenylglycine.(J. Biol. Chem.) [2001]
4uniprot[Pubmed] 12404385 The biosynthesis of vancomycin-type glycopeptide antibiotics - the order of cyclization steps.(Angew. Chem. Int. Ed. Engl.) [2001]
5uniprot[Pubmed] 11880037 [Medline] 21869276 Glycopeptide biosynthesis in Amycolatopsis mediterranei DSM5908: function of a halogenase and a haloperoxidase/perhydrolase.(Chem. Biol.) [2002]
6uniprot Precursor-directed biosynthesis for the generation of novel glycopetides.(Ernst Schering Res. Found. Workshop) [2005]

E9L1N5_9ZZZZ
(E9L1N5)

3e-25

118

73%

Product: Putative uncharacterized protein
Gene: CA878-36
Organism: uncultured organism CA878

1uniprot[Pubmed] 20945895
Tailoring enzyme-rich environmental DNA clones: a source of enzymes for generating libraries of unnatural natural products.(J. Am. Chem. Soc.) [2010]

O52794_AMYOR
(O52794)

4e-24

114

69%

Product: PCZA361.4
Gene
Organism: Amycolatopsis orientalis
Nocardia orientalis

1uniprot[Pubmed] 9545426 [Medline] 98212597
Sequencing and analysis of genes involved in the biosynthesis of a vancomycin group antibiotic.(Chem. Biol.) [1998]

B7T1A5_9BACT
(B7T1A5)

3e-23

111

69%

Product: Veg33
Gene: veg33
Organism: uncultured soil bacterium

1uniprot[Pubmed] 18987322
Cloning and characterization of new glycopeptide gene clusters found in an environmental DNA megalibrary.(Proc. Natl. Acad. Sci. U.S.A.) [2008]

Q83WG0_9ACTO
(Q83WG0)

8e-15

63%

Product: 4-ketoreductase
Gene: staK
Organism: Streptomyces sp. TP-A0274

[pubmed all]
1uniprot Direct formation of chromopyrrolic acid from indole-3-pyruvic acid by StaD, a novel hemoprotein in indolocarbazole biosynthesis.(Tetrahedron Lett.) [2006]
2uniprot Biosynthesis of heterocyclic antibiotics in actinomycetes and an approach to synthesize the natural compounds.(Nihon Hosenkin Gakkaishi) [2006]
3uniprot[Pubmed] 12617516 [Medline] 22504382 Cloning of the staurosporine biosynthetic gene cluster from Streptomyces sp. TP-A0274 and its heterologous expression in Streptomyces lividans.(J. Antibiot.) [2002]
4uniprot Characterization of the biosynthetic gene cluster of rebecamycin from Lechevalieria aerocolonigenes ATCC 39243.(Biosci. Biotechnol. Biochem.) [2003]
5uniprot[Pubmed] 16195595 Cytochrome P450 homolog is responsible for C-N bond formation between aglycone and deoxysugar in the staurosporine biosynthesis of Streptomyces sp. TP-A0274.(Biosci. Biotechnol. Biochem.) [2005]

A4F7N7_SACEN
(A4F7N7)

1e-09

66.6

49%

Product: DTDP-4-keto-6-deoxy-L-hexose 4-reductase
Gene: eryBIV
SACE_0720
Organism: Saccharopolyspora erythraea (strain NRRL 23338)

1uniprot[Pubmed] 17369815
Complete genome sequence of the erythromycin-producing bacterium Saccharopolyspora erythraea NRRL23338.(Nat. Biotechnol.) [2007]

O33938_SACER
(O33938)

1e-09

66.6

49%

Product: EryBIV
Putative deoxyhexose reductase
Gene: eryBIV
EryBIV
Organism: Saccharopolyspora erythraea
Streptomyces erythraeus

[pubmed all]
1uniprot[Pubmed] 9353926 [Medline] 98015410 Sequencing and mutagenesis of genes from the erythromycin biosynthetic gene cluster of Saccharopolyspora erythraea that are involved in L-mycarose and D-desosamine production.(Microbiology)
2uniprot[Pubmed] 9393448 [Medline] 98055166 Analysis of seven genes from the eryAI-eryK region of the erythromycin biosynthetic gene cluster in Saccharopolyspora erythraea.(Mol. Gen. Genet.) [1997]

E9L1H1_9ZZZZ
(E9L1H1)

3e-08

62.4

51%

Product: Putative uncharacterized protein
Gene: CA37-27
Organism: uncultured organism CA37

1uniprot[Pubmed] 20945895
Tailoring enzyme-rich environmental DNA clones: a source of enzymes for generating libraries of unnatural natural products.(J. Am. Chem. Soc.) [2010]

E9L1R8_9ZZZZ
(E9L1R8)

5e-08

61.2

50%

Product: Putative uncharacterized protein
Gene: CA915-26
Organism: uncultured organism CA915

1uniprot[Pubmed] 20945895
Tailoring enzyme-rich environmental DNA clones: a source of enzymes for generating libraries of unnatural natural products.(J. Am. Chem. Soc.) [2010]

Q83X63_STRRO
(Q83X63)

2e-07

59.3

53%

Product: Putative NDP-3-methyl-4-keto-2,6-dideoxyhexose 4-ketoreductase
Gene: lkmBIV
Organism: Streptomyces rochei
Streptomyces parvullus

[pubmed all]
1uniprot[Pubmed] 12791134 [Medline] 22676866 The large linear plasmid pSLA2-L of Streptomyces rochei has an unusually condensed gene organization for secondary metabolism.(Mol. Microbiol.) [2003]
2uniprot[Pubmed] 10954087 [Medline] 20408175 Cloning and analysis of the replication origin and the telomeres of the large linear plasmid pSLA2-L in Streptomyces rochei.(Mol. Gen. Genet.) [2000]
3uniprot[Pubmed] 10767533 [Medline] 20231737 Identification of two polyketide synthase gene clusters on the linear plasmid pSLA2-L in Streptomyces rochei.(Gene) [2000]
4uniprot[Pubmed] 9836424 [Medline] 99053144 Physical mapping of the linear plasmid pSLA2-L and localization of the eryAI and actI homologs.(Biosci. Biotechnol. Biochem.) [1998]

Q939Q3_9ACTO
(Q939Q3)

2e-06

56.2

50%

Product: NDP-4-keto-6-deoxyhexose 4-ketoreductase
Gene: jadV
Organism: Streptomyces venezuelae

1uniprot[Pubmed] 11932454 [Medline] 21930291
Biosynthesis of the dideoxysugar component of jadomycin B: genes in the jad cluster of Streptomyces venezuelae ISP5230 for L-digitoxose assembly and transfer to the angucycline aglycone.(Microbiology) [2002]

F2RC35_STRVP
(F2RC35)

2e-06

56.2

50%

Product: UDP-glucose 4-epimerase
Gene: SVEN_6000
Organism: Streptomyces venezuelae (strain ATCC 10712 / CBS 650.69 / DSM 40230 / JCM 4526 / NBRC 13096 / PD 04745)

1uniprot[Pubmed] 21463507
Genome-wide analysis of the role of GlnR in Streptomyces venezuelae provides new insights into global nitrogen regulation in actinomycetes.(BMC Genomics) [2011]

Q5Y9G3_9ACTO
(Q5Y9G3)

4e-06

55.1

49%

Product: Deoxyhexose dehydratase
Gene: eryBIV
Organism: Aeromicrobium erythreum

1uniprot[Pubmed] 15257441
The erythromycin biosynthetic gene cluster of Aeromicrobium erythreum.(J. Ind. Microbiol. Biotechnol.) [2004]

D5SL05_STRCL
(D5SL05)

4e-06

55.1

59%

Product: Staurosporine biosynthesis 4-ketoreductase StaK
Gene: staK
SCLAV_p1112
Organism: Streptomyces clavuligerus ATCC 27064

1uniprot
The sequence of a 1.8 Mb bacterial linear plasmid reveals a rich evolutionary reservoir of secondary metabolic pathways.(Genome Biol. Evol.) [2010]

B3TMP6_9ACTO
(B3TMP6)

6e-06

54.3

48%

Product: Sugar 4-ketoreductase
Gene: KijC2
Organism: Actinomadura kijaniata

1uniprot[Pubmed] 17985890
Elucidation of the kijanimicin gene cluster: insights into the biosynthesis of spirotetronate antibiotics and nitrosugars.(J. Am. Chem. Soc.) [2007]

Q9F831_9ACTO
(Q9F831)

1e-05

53.5

48%

Product: TDP-4-keto-6-deoxyhexose 4-ketoreductase
Gene: megBIV
Organism: Micromonospora megalomicea subsp. nigra

1uniprot[Pubmed] 10972798 [Medline] 20430101
Biosynthesis of the anti-parasitic agent megalomicin: transformation of erythromycin to megalomicin in Saccharopolyspora erythraea.(Mol. Microbiol.) [2000]

Q9S0P3_STRAW
(Q9S0P3)

0.0001

49.7

42%

Product: dTDP-4-keto-6-deoxy-L-hexose 4-reductase
Gene: aveBIV
SAV948
SAV_948
Organism: Streptomyces avermitilis

[pubmed all]
1uniprot[Pubmed] 10449723 [Medline] 99380548 Organization of the biosynthetic gene cluster for the polyketide anthelmintic macrolide avermectin in Streptomyces avermitilis.(Proc. Natl. Acad. Sci. U.S.A.) [1999]
2uniprot[Pubmed] 11572948 [Medline] 21477403 Genome sequence of an industrial microorganism Streptomyces avermitilis: deducing the ability of producing secondary metabolites.(Proc. Natl. Acad. Sci. U.S.A.) [2001]
3uniprot[Pubmed] 12692562 [Medline] 22608306 Complete genome sequence and comparative analysis of the industrial microorganism Streptomyces avermitilis.(Nat. Biotechnol.) [2003]