BLAST table : A4092_00390

DB	UniProtKB

	accession	Evalue	Score	Ident.	link	product	gene	organism	ec
1	Q7WZ58_9ACTO (Q7WZ58)	0.0	862	100%	UniProt GenBank	Putative DpgC protein	dbv33	Nonomuraea sp. ATCC 39727
2	O52812_AMYOR (O52812)	0.0	706	82%	UniProt GenBank	PCZA361.8		Amycolatopsis orientalis Nocardia orientalis
3	Q939X1_9PSEU (Q939X1)	0.0	680	82%	UniProt GenBank	Hydroxyacyl-dehydrogenase	dpgC	Amycolatopsis balhimycina
4	E9L1P1_9ZZZZ (E9L1P1)	0.0	654	86%	UniProt GenBank	Putative uncharacterized protein	CA878-42	uncultured organism CA878
5	B7T1B1_9BACT (B7T1B1)	0.0	639	84%	UniProt GenBank	Veg39	veg39	uncultured soil bacterium
6	F8STZ8_AMYOR (F8STZ8)	1e-178	630	74%	UniProt GenBank	Hydroxyacyl-dehydrogenase	vcm25	Amycolatopsis orientalis Nocardia orientalis
7	Q8KLK7_STRTO (Q8KLK7)	1e-159	567	69%	UniProt GenBank	DpgC		Streptomyces toyocaensis
8	Q2JA69_FRASC (Q2JA69)	1e-152	544	68%	UniProt GenBank	Enoyl-CoA hydratase/isomerase	Francci3_2456	Frankia sp. (strain CcI3)
9	E2D2E7_9BACT (E2D2E7)	1e-152	543	68%	UniProt GenBank	Dihydroxyphenylglycine synthase subunit C		uncultured soil bacterium
10	E9L1J0_9ZZZZ (E9L1J0)	1e-149	533	66%	UniProt GenBank	Putative uncharacterized protein	CA37-46	uncultured organism CA37
11	Q6ZZH4_ACTTI (Q6ZZH4)	1e-143	512	67%	UniProt GenBank	DpgC protein	tcp32	Actinoplanes teichomyceticus
12	E9L1U1_9ZZZZ (E9L1U1)	1e-143	512	63%	UniProt GenBank	Putative uncharacterized protein	CA915-49	uncultured organism CA915
13	D9UHH7_9ACTO (D9UHH7)	1e-131	473	61%	UniProt GenBank	Hydroxyacyl-dehydrogenase	SSLG_05413	Streptomyces sp. SPB78
14	D7B4X5_NOCDD (D7B4X5)	1e-127	460	57%	UniProt GenBank	Enoyl-CoA hydratase/isomerase	Ndas_1737	Nocardiopsis dassonvillei (strain ATCC 23218 / DSM 43111 / IMRU 509 / JCM 7437 / NCTC 10488) Actinomadura dassonvillei
15	F2R790_STRVP (F2R790)	1e-127	460	57%	UniProt GenBank	Enoyl-CoA hydratase or isomerase	SVEN_0495	Streptomyces venezuelae (strain ATCC 10712 / CBS 650.69 / DSM 40230 / JCM 4526 / NBRC 13096 / PD 04745)
16	C0Z469_STRVN (C0Z469)	1e-121	439	58%	UniProt GenBank	Dioxygenase	ken4	Streptomyces violaceoruber
17	F3ZDK5_9ACTO (F3ZDK5)	1e-116	424	65%	UniProt GenBank	Putative enoyl-CoA hydratase/isomerase	STTU_1158	Streptomyces sp. Tu6071
18	D6A5M8_9ACTO (D6A5M8)	1e-106	389	51%	UniProt GenBank	DpgC protein	SSFG_06976	Streptomyces ghanaensis ATCC 14672
19	F3NRX6_9ACTO (F3NRX6)	1e-105	387	52%	UniProt GenBank	Putative enoyl-CoA hydratase/isomerase	SGM_5890	Streptomyces griseoaurantiacus M045
20	D2UD62_XANAP (D2UD62)	1e-103	382	51%	UniProt GenBank	Putative enoyl-coa hydratase isomerase protein	XALc_1061	Xanthomonas albilineans (strain GPE PC73 / CFBP 7063)
21	D0RB78_STRPR (D0RB78)	2e-95	353	48%	UniProt GenBank	Hydroxyacyl-dehydrogenase Putative hydroxyacyl-dehydrogenase	pglA	Streptomyces pristinaespiralis
22	B5HJU2_STRPR (B5HJU2)	2e-95	353	48%	UniProt GenBank	Enoyl-CoA hydratase/isomerase	SSDG_05431	Streptomyces pristinaespiralis ATCC 25486
23	D2PSN9_KRIFD (D2PSN9)	8e-95	352	54%	UniProt GenBank	Enoyl-CoA hydratase/isomerase	Kfla_4130	Kribbella flavida (strain DSM 17836 / JCM 10339 / NBRC 14399)
24	Q9RPT2_9BACT (Q9RPT2)	1e-57	229	48%	UniProt GenBank	Putative uncharacterized protein		uncultured bacterium AH6
25	E9LIP8_9ACTO (E9LIP8)	2e-38	164	35%	UniProt GenBank	Putative enoyl-CoA hydratase/isomerase	tiaN	Dactylosporangium aurantiacum subsp. hamdenensis
26	D4Z2S5_SPHJU (D4Z2S5)	3e-18	98.2	31%	UniProt GenBank	Enoyl-CoA hydratase	paaG SJA_C1-20730	Sphingobium japonicum (strain NBRC 101211 / UT26S)	4.2.1.17 niceE keggE
27	F6EUP7_SPHCR (F6EUP7)	5e-18	97.1	32%	UniProt GenBank	Enoyl-CoA hydratase/isomerase	Sphch_1075	Sphingobium chlorophenolicum L-1
28	Q1NB15_9SPHN (Q1NB15)	1e-17	95.9	30%	UniProt GenBank	Enoyl-CoA hydratase/isomerase	SKA58_07548	Sphingomonas sp. SKA58
29	B8FC62_DESAA (B8FC62)	2e-16	92	35%	UniProt GenBank	Enoyl-CoA hydratase/isomerase	Dalk_3794	Desulfatibacillum alkenivorans (strain AK-01)	4.2.1.18 niceE keggE
30	D8F324_9DELT (D8F324)	3e-16	91.7	31%	UniProt GenBank	Enoyl-CoA hydratase/isomerase family protein	NPH_7275	delta proteobacterium NaphS2
31	F6INA6_9SPHN (F6INA6)	3e-16	91.3	29%	UniProt GenBank	Enoyl-CoA hydratase	PP1Y_AT20327	Novosphingobium sp. PP1Y	4.2.1.17 niceE keggE
32	C8WPU8_EGGLE (C8WPU8)	4e-16	90.9	32%	UniProt GenBank	Enoyl-CoA hydratase/isomerase	Elen_3100	Eggerthella lenta (strain ATCC 25559 / DSM 2243 / JCM 9979 / NCTC 11813 / VPI 0255) Eubacterium lentum
33	A5PAX2_9SPHN (A5PAX2)	5e-16	90.5	29%	UniProt GenBank	Enoyl-CoA hydratase/isomerase family protein	ED21_21894	Erythrobacter sp. SD-21
34	Q2N892_ERYLH (Q2N892)	6e-16	90.1	29%	UniProt GenBank	Enoyl-CoA hydratase/isomerase family protein	ELI_10035	Erythrobacter litoralis (strain HTCC2594)
35	E8WNW0_GEOS8 (E8WNW0)	7e-16	90.1	30%	UniProt GenBank	Enoyl-CoA hydratase/isomerase	GM18_1287	Geobacter sp. (strain M18)
36	F0HQ19_9ACTN (F0HQ19)	1e-15	89.7	31%	UniProt GenBank	3-hydroxybutyryl-CoA dehydratase	crt HMPREF9404_4934	Eggerthella sp. HGA1	4.2.1.55 niceE keggE
37	E5X8P4_9ACTN (E5X8P4)	1e-15	89.7	31%	UniProt GenBank	Enoyl-CoA hydratase/isomerase	HMPREF1023_01434	Eggerthella sp. 1_3_56FAA
38	A3MVR3_PYRCJ (A3MVR3)	1e-15	89.4	29%	UniProt GenBank	Short chain enoyl-CoA hydratase	Pcal_1306	Pyrobaculum calidifontis (strain JCM 11548 / VA1)	4.2.1.17 niceE keggE
39	Q939X0_9PSEU (Q939X0)	1e-15	89	33%	UniProt GenBank	Putative enoyl-CoA-isomerase	dpgD	Amycolatopsis balhimycina
40	F8I8I9_9FIRM (F8I8I9)	3e-15	88.2	31%	UniProt GenBank	Enoyl-CoA hydratase/isomerase	paaG TPY_0690	Sulfobacillus acidophilus TPY
41	B1JBL8_PSEPW (B1JBL8)	4e-15	87.4	29%	UniProt GenBank	Enoyl-CoA hydratase/isomerase	PputW619_3454	Pseudomonas putida (strain W619)
42	Q4KC63_PSEF5 (Q4KC63)	8e-15	86.7	28%	UniProt GenBank	Enoyl-CoA hydratase/isomerase FadB1x	fad-3 PFL_3064	Pseudomonas fluorescens (strain Pf-5 / ATCC BAA-477)
43	F2KGA1_PSEBN (F2KGA1)	9e-15	86.3	30%	UniProt GenBank	Putative enoyl-CoA hydratase	PSEBR_a2935	Pseudomonas brassicacearum (strain NFM421)
44	F5IPU5_ACIBA (F5IPU5)	1e-14	85.9	27%	UniProt GenBank	Enoyl-CoA hydratase/isomerase family protein	HMPREF0022_03033	Acinetobacter baumannii 6014059
45	D0C2A3_9GAMM (D0C2A3)	1e-14	85.9	27%	UniProt GenBank	FadB1x	HMPREF0014_02514	Acinetobacter sp. RUH2624
46	F0QK44_ACIBD (F0QK44)	1e-14	85.9	27%	UniProt GenBank	FadB1x	ABTW07_0133	Acinetobacter baumannii (strain TCDC-AB0715)
47	F5JNN9_ACIBA (F5JNN9)	1e-14	85.9	27%	UniProt GenBank	FadB1x	AB210_1171	Acinetobacter baumannii AB210
48	B7I1R9_ACIB5 (B7I1R9)	1e-14	85.9	28%	UniProt GenBank	Short-chain enoyl-CoA hydratase	AB57_0148	Acinetobacter baumannii (strain AB0057)	4.2.1.17 niceE keggE
49	B7H2D9_ACIB3 (B7H2D9)	1e-14	85.9	28%	UniProt GenBank	Probable enoyl-CoA hydratase	ABBFA_003412	Acinetobacter baumannii (strain AB307-0294)	4.2.1.17 niceE keggE
50	B0V6P7_ACIBY (B0V6P7)	1e-14	85.9	28%	UniProt GenBank	Putative Enoyl-CoA hydratase	ABAYE3764	Acinetobacter baumannii (strain AYE)	4.2.1.17 niceE keggE
51	F5IBF0_ACIBA (F5IBF0)	1e-14	85.9	28%	UniProt GenBank	Enoyl-CoA hydratase/isomerase family protein	HMPREF0020_02345	Acinetobacter baumannii 6013113
52	F5I0C9_ACIBA (F5I0C9)	1e-14	85.9	28%	UniProt GenBank	Enoyl-CoA hydratase/isomerase family protein	HMPREF0021_02414	Acinetobacter baumannii 6013150
53	A5V769_SPHWW (A5V769)	1e-14	85.9	31%	UniProt GenBank	Enoyl-CoA hydratase/isomerase	Swit_1773	Sphingomonas wittichii (strain RW1 / DSM 6014 / JCM 10273)
54	C4LH94_CORK4 (C4LH94)	2e-14	85.5	32%	UniProt GenBank	Enoyl-CoA hydratase	echA1 ckrop_0420	Corynebacterium kroppenstedtii (strain DSM 44385 / CCUG 35717)	4.2.1.17 niceE keggE
55	B2I0V7_ACIBC (B2I0V7)	2e-14	85.5	27%	UniProt GenBank	FadB1x	ACICU_00133	Acinetobacter baumannii (strain ACICU)
56	Q64BG5_9ARCH (Q64BG5)	2e-14	85.5	29%	UniProt GenBank	Enoyl-CoA hydratase/carnithine racemase	GZ27B6_24	uncultured archaeon GZfos27B6
57	D6JYB2_ACIG3 (D6JYB2)	2e-14	85.5	27%	UniProt GenBank	Putative uncharacterized protein	HMPREF0013_03357	Acinetobacter sp. SH024
58	F0QSR3_VULM7 (F0QSR3)	2e-14	85.5	26%	UniProt GenBank	3-hydroxyacyl-CoA dehydrogenase, NAD-binding protein	VMUT_1375	Vulcanisaeta moutnovskia (strain 768-28)
59	F0KJC4_ACICP (F0KJC4)	2e-14	85.1	27%	UniProt GenBank	Putative enoyl-CoA hydratase/isomerase	fadB1 BDGL_003033	Acinetobacter calcoaceticus (strain PHEA-2)
60	E1QT75_VULDI (E1QT75)	2e-14	85.1	26%	UniProt GenBank	3-hydroxyacyl-CoA dehydrogenase NAD-binding protein	Vdis_0258	Vulcanisaeta distributa (strain DSM 14429 / JCM 11212 / NBRC 100878 / IC-017)
61	A3K328_9RHOB (A3K328)	3e-14	84.7	30%	UniProt GenBank	Enoyl-CoA hydratase	SSE37_17283	Sagittula stellata E-37
62	E8PIG0_ACIB1 (E8PIG0)	3e-14	84.7	27%	UniProt GenBank	Enoyl-CoA hydratase	ABK1_0139	Acinetobacter baumannii (strain 1656-2)
63	E2XRW5_PSEFL (E2XRW5)	3e-14	84.7	30%	UniProt GenBank	Enoyl-CoA hydratase/isomerase FadB1x	fad-3 PFWH6_2756	Pseudomonas fluorescens WH6	4.2.1.17 niceE keggE
64	B5E7U4_GEOBB (B5E7U4)	3e-14	84.7	29%	UniProt GenBank	Enoyl-CoA hydratase/isomerase	Gbem_1462	Geobacter bemidjiensis (strain Bem / ATCC BAA-1014 / DSM 16622)
65	A5V400_SPHWW (A5V400)	3e-14	84.7	31%	UniProt GenBank	Short chain enoyl-CoA hydratase	Swit_0648	Sphingomonas wittichii (strain RW1 / DSM 6014 / JCM 10273)	4.2.1.17 niceE keggE
66	D3JTG2_ACISD (D3JTG2)	3e-14	84.7	27%	UniProt GenBank	Enoyl-CoA hydratase	AOLE_18800	Acinetobacter sp. (strain JCM 1667 / KCTC 23045 / DR1)
67	A5V798_SPHWW (A5V798)	3e-14	84.7	31%	UniProt GenBank	Short chain enoyl-CoA hydratase	Swit_1803	Sphingomonas wittichii (strain RW1 / DSM 6014 / JCM 10273)	4.2.1.17 niceE keggE
68	D0CEP9_ACIBA (D0CEP9)	4e-14	84.3	28%	UniProt GenBank	2-ketocyclohexanecarboxyl-CoA hydrolase	HMPREF0010_03229	Acinetobacter baumannii ATCC 19606
69	E7DDH9_ALCFA (E7DDH9)	4e-14	84.3	29%	UniProt GenBank	Enoyl-CoA hydratase family	acuK	Alcaligenes faecalis
70	C0Z573_BREBN (C0Z573)	4e-14	84.3	30%	UniProt GenBank	Probable enoyl-CoA hydratase	paaF BBR47_50020	Brevibacillus brevis (strain 47 / JCM 6285 / NBRC 100599)	4.2.1.17 niceE keggE
71	D0S7B3_ACICA (D0S7B3)	4e-14	84.3	27%	UniProt GenBank	FadB1x	HMPREF0012_03302	Acinetobacter calcoaceticus RUH2202
72	E6ZQ82_SPORE (E6ZQ82)	4e-14	84	30%	UniProt GenBank	Probable enoyl-CoA hydratase, mitochondrial	sr15854	Sporisorium reilianum (strain SRZ2) Maize head smut fungus
73	Q1GNL3_SPHAL (Q1GNL3)	5e-14	84	29%	UniProt GenBank	Short chain enoyl-CoA hydratase	Sala_3055	Sphingopyxis alaskensis (strain DSM 13593 / LMG 18877 / RB2256) Sphingomonas alaskensis	4.2.1.17 niceE keggE
74	C5VNX5_CLOBO (C5VNX5)	5e-14	84	28%	UniProt GenBank	3-hydroxybutyryl-CoA dehydratase	CLG_B0355	Clostridium botulinum D str. 1873	4.2.1.55 niceE keggE
75	F7MNE5_CLOBO (F7MNE5)	5e-14	84	28%	UniProt GenBank	3-hydroxybutyryl-CoA dehydratase	CBCST_10366	Clostridium botulinum C str. Stockholm	4.2.1.55 niceE keggE
76	F4A6J9_CLOBO (F4A6J9)	6e-14	84	28%	UniProt GenBank	Enoyl-CoA hydratase/isomerase	CbC4_2221	Clostridium botulinum BKT015925	4.2.1.55 niceE keggE
77	A3M0Z9_ACIBT (A3M0Z9)	7e-14	83.6	27%	UniProt GenBank	Putative enoyl-CoA hydratase/isomerase	A1S_0106	Acinetobacter baumannii (strain ATCC 17978 / NCDC KC 755)
78	Q2GA18_NOVAD (Q2GA18)	7e-14	83.6	29%	UniProt GenBank	Short chain enoyl-CoA hydratase	Saro_0860	Novosphingobium aromaticivorans (strain DSM 12444)	4.2.1.17 niceE keggE
79	D7VWY8_9FLAO (D7VWY8)	8e-14	83.2	27%	UniProt GenBank	3-hydroxybutyryl-CoA dehydratase	crt HMPREF0204_11036	Chryseobacterium gleum ATCC 35910	4.2.1.55 niceE keggE
80	D8J8B4_HALJB (D8J8B4)	8e-14	83.2	29%	UniProt GenBank	Enoyl-CoA hydratase	HacjB3_13895	Halalkalicoccus jeotgali (strain DSM 18796 / CECT 7217 / JCM 14584 / KCTC 4019 / B3)
81	D3D8V1_9ACTO (D3D8V1)	8e-14	83.2	32%	UniProt GenBank	Enoyl-CoA hydratase/isomerase	FrEUN1fDRAFT_6223	Frankia sp. EUN1f
82	F1Z4G9_9SPHN (F1Z4G9)	9e-14	83.2	29%	UniProt GenBank	Short chain enoyl-CoA hydratase	Y88_2869	Novosphingobium nitrogenifigens DSM 19370
83	Q4P4J0_USTMA (Q4P4J0)	9e-14	83.2	30%	UniProt GenBank	Putative uncharacterized protein	UM04973.1	Ustilago maydis (strain 521 / FGSC 9021) Smut fungus
84	B5IZY8_9RHOB (B5IZY8)	1e-13	82.8	29%	UniProt GenBank	Enoyl-CoA hydratase/isomerase family protein	OA307_3504	Octadecabacter antarcticus 307
85	A6WWT3_OCHA4 (A6WWT3)	1e-13	82.4	29%	UniProt GenBank	Enoyl-CoA hydratase/isomerase	Oant_0715	Ochrobactrum anthropi (strain ATCC 49188 / DSM 6882 / NCTC 12168)
86	C2FS94_9SPHI (C2FS94)	1e-13	82.4	27%	UniProt GenBank	3-hydroxybutyryl-CoA dehydratase	crt HMPREF0765_0200	Sphingobacterium spiritivorum ATCC 33300	4.2.1.55 niceE keggE
87	A5G5Z5_GEOUR (A5G5Z5)	2e-13	82.4	27%	UniProt GenBank	Short chain enoyl-CoA hydratase	Gura_3041	Geobacter uraniireducens (strain Rf4) Geobacter uraniumreducens	4.2.1.17 niceE keggE
88	E7RGX3_9BACL (E7RGX3)	2e-13	82	28%	UniProt GenBank	Enoyx-CoA hydratase/isomerase family protein	GPDM_08605	Planococcus donghaensis MPA1U2
89	B5JZC2_9RHOB (B5JZC2)	2e-13	82	28%	UniProt GenBank	Enoyl-CoA hydratase	OA238_1996	Octadecabacter antarcticus 238	4.2.1.17 niceE keggE
90	C0G3D5_9RHIZ (C0G3D5)	2e-13	81.6	30%	UniProt GenBank	Enoyl-CoA hydratase	BCETI_1000165	Brucella ceti str. Cudo
91	E8JTC1_STRCR (E8JTC1)	2e-13	81.6	25%	UniProt GenBank	3-hydroxybutyryl-CoA dehydratase	crt HMPREF9422_0551	Streptococcus cristatus ATCC 51100	4.2.1.55 niceE keggE
92	C4IU10_BRUAO (C4IU10)	2e-13	81.6	30%	UniProt GenBank	Enoyl-CoA hydratase	BAAA_6000321	Brucella abortus str. 2308 A
93	F7YA06_9RHIZ (F7YA06)	2e-13	81.6	28%	UniProt GenBank	Enoyl-CoA hydratase/isomerase	Mesop_6684	Mesorhizobium opportunistum WSM2075	4.2.1.17 niceE keggE
94	D7H0T0_BRUAO (D7H0T0)	3e-13	81.6	30%	UniProt GenBank	Enoyl-CoA hydratase	BAYG_00309	Brucella abortus bv. 5 str. B3196
95	D6LMB6_9RHIZ (D6LMB6)	3e-13	81.6	30%	UniProt GenBank	Enoyl-CoA hydratase	BAZG_00310	Brucella sp. NVSL 07-0026
96	E9L1P2_9ZZZZ (E9L1P2)	3e-13	81.6	31%	UniProt GenBank	Putative uncharacterized protein	CA878-43	uncultured organism CA878
97	F2LY45_HIPMA (F2LY45)	3e-13	81.6	28%	UniProt GenBank	Enoyl-CoA hydratase	Hipma_1412	Hippea maritima (strain ATCC 700847 / DSM 10411 / MH2)	4.2.1.17 niceE keggE 4.2.1.55 niceE keggE
98	E0DJT0_9RHIZ (E0DJT0)	3e-13	81.6	30%	UniProt GenBank	Enoyl-CoA hydratase	BIBO1_0254	Brucella sp. BO1	4.2.1.17 niceE keggE
99	Q8FXR5_BRUSU (Q8FXR5)	3e-13	81.3	30%	UniProt GenBank	Enoyl-CoA hydratase/isomerase family protein	BR2184	Brucella suis biovar 1 (strain 1330)
100	Q57A82_BRUAO (Q57A82)	3e-13	81.3	30%	UniProt GenBank	Enoyl-CoA hydratase/isomerase family protein	BruAb1_2157	Brucella abortus

accession

alignment

Evalue

Score

Ident.

link

information

pubmed

Q7WZ58_9ACTO
(Q7WZ58)

0.0

862

100%

Product: Putative DpgC protein
Gene: dbv33
Organism: Nonomuraea sp. ATCC 39727

1uniprot[Pubmed] 12837387 [Medline] 22721464
The gene cluster for the biosynthesis of the glycopeptide antibiotic A40926 by nonomuraea species.(Chem. Biol.) [2003]

O52812_AMYOR
(O52812)

0.0

706

82%

Product: PCZA361.8
Gene
Organism: Amycolatopsis orientalis
Nocardia orientalis

1uniprot[Pubmed] 9545426 [Medline] 98212597
Sequencing and analysis of genes involved in the biosynthesis of a vancomycin group antibiotic.(Chem. Biol.) [1998]

Q939X1_9PSEU
(Q939X1)

0.0

680

82%

Product: Hydroxyacyl-dehydrogenase
Gene: dpgC
Organism: Amycolatopsis balhimycina

[pubmed all]
1uniprot[Pubmed] 10390204 [Medline] 99318579 Identification and analysis of the balhimycin biosynthetic gene cluster and its use for manipulating glycopeptide biosynthesis in Amycolatopsis mediterranei DSM5908.(Antimicrob. Agents Chemother.) [1999]
2uniprot[Pubmed] 11932455 [Medline] 21930292 Nonribosomal biosynthesis of vancomycin-type antibiotics: a heptapeptide backbone and eight peptide synthetase modules.(Microbiology) [2002]
3uniprot[Pubmed] 11495926 [Medline] 21486455 A polyketide synthase in glycopeptide biosynthesis: the biosynthesis of the non-proteinogenic amino acid (S)-3,5-dihydroxyphenylglycine.(J. Biol. Chem.) [2001]
4uniprot[Pubmed] 12404385 The biosynthesis of vancomycin-type glycopeptide antibiotics - the order of cyclization steps.(Angew. Chem. Int. Ed. Engl.) [2001]
5uniprot[Pubmed] 11880037 [Medline] 21869276 Glycopeptide biosynthesis in Amycolatopsis mediterranei DSM5908: function of a halogenase and a haloperoxidase/perhydrolase.(Chem. Biol.) [2002]
6uniprot Precursor-directed biosynthesis for the generation of novel glycopetides.(Ernst Schering Res. Found. Workshop) [2005]

E9L1P1_9ZZZZ
(E9L1P1)

0.0

654

86%

Product: Putative uncharacterized protein
Gene: CA878-42
Organism: uncultured organism CA878

1uniprot[Pubmed] 20945895
Tailoring enzyme-rich environmental DNA clones: a source of enzymes for generating libraries of unnatural natural products.(J. Am. Chem. Soc.) [2010]

B7T1B1_9BACT
(B7T1B1)

0.0

639

84%

Product: Veg39
Gene: veg39
Organism: uncultured soil bacterium

1uniprot[Pubmed] 18987322
Cloning and characterization of new glycopeptide gene clusters found in an environmental DNA megalibrary.(Proc. Natl. Acad. Sci. U.S.A.) [2008]

Q8KLK7_STRTO
(Q8KLK7)

1e-159

567

69%

Product: DpgC
Gene
Organism: Streptomyces toyocaensis

[pubmed all]
1uniprot[Pubmed] 9177243 [Medline] 97322398 D-Ala-D-Ala ligases from glycopeptide antibiotic-producing organisms are highly homologous to the enterococcal vancomycin-resistance ligases VanA and VanB.(Proc. Natl. Acad. Sci. U.S.A.) [1997]
2uniprot[Pubmed] 12060705 [Medline] 22080153 Assembling the glycopeptide antibiotic scaffold: the biosynthesis of A47934 from Streptomyces toyocaensis NRRL15009.(Proc. Natl. Acad. Sci. U.S.A.) [2002]
3uniprot[Pubmed] 17507985 Structural basis for cofactor-independent dioxygenation in vancomycin biosynthesis.(Nature) [2007]
4uniprot[Pubmed] 18004875 Substrate recognition and catalysis by the cofactor-independent dioxygenase DpgC.(Biochemistry) [2007]

Q2JA69_FRASC
(Q2JA69)

1e-152

544

68%

Product: Enoyl-CoA hydratase/isomerase
Gene: Francci3_2456
Organism: Frankia sp. (strain CcI3)

1uniprot[Pubmed] 17151343
Genome characteristics of facultatively symbiotic Frankia sp. strains reflect host range and host plant biogeography.(Genome Res.) [2007]

E2D2E7_9BACT
(E2D2E7)

1e-152

543

68%

Product: Dihydroxyphenylglycine synthase subunit C
Gene
Organism: uncultured soil bacterium

1uniprot[Pubmed] 20577994
Cloning large natural product gene clusters from the environment: piecing environmental DNA gene clusters back together with TAR.(Biopolymers) [2010]

E9L1J0_9ZZZZ
(E9L1J0)

1e-149

533

66%

Product: Putative uncharacterized protein
Gene: CA37-46
Organism: uncultured organism CA37

1uniprot[Pubmed] 20945895
Tailoring enzyme-rich environmental DNA clones: a source of enzymes for generating libraries of unnatural natural products.(J. Am. Chem. Soc.) [2010]

Q6ZZH4_ACTTI
(Q6ZZH4)

1e-143

512

67%

Product: DpgC protein
Gene: tcp32
Organism: Actinoplanes teichomyceticus

[pubmed all]
1uniprot[Pubmed] 15113000 Biosynthetic gene cluster of the glycopeptide antibiotic teicoplanin: characterization of two glycosyltransferases and the key acyltransferase.(Chem. Biol.) [2004]
2uniprot[Pubmed] 14702401 Organization of the teicoplanin gene cluster in Actinoplanes teichomyceticus.(Microbiology) [2004]

E9L1U1_9ZZZZ
(E9L1U1)

1e-143

512

63%

Product: Putative uncharacterized protein
Gene: CA915-49
Organism: uncultured organism CA915

1uniprot[Pubmed] 20945895
Tailoring enzyme-rich environmental DNA clones: a source of enzymes for generating libraries of unnatural natural products.(J. Am. Chem. Soc.) [2010]

D7B4X5_NOCDD
(D7B4X5)

1e-127

460

57%

Product: Enoyl-CoA hydratase/isomerase
Gene: Ndas_1737
Organism: Nocardiopsis dassonvillei (strain ATCC 23218 / DSM 43111 / IMRU 509 / JCM 7437 / NCTC 10488)
Actinomadura dassonvillei

1uniprot
Complete genome sequence of Nocardiopsis dassonvillei type strain (IMRU 509T).(Stand. Genomic Sci.) [2010]

F2R790_STRVP
(F2R790)

1e-127

460

57%

Product: Enoyl-CoA hydratase or isomerase
Gene: SVEN_0495
Organism: Streptomyces venezuelae (strain ATCC 10712 / CBS 650.69 / DSM 40230 / JCM 4526 / NBRC 13096 / PD 04745)

1uniprot[Pubmed] 21463507
Genome-wide analysis of the role of GlnR in Streptomyces venezuelae provides new insights into global nitrogen regulation in actinomycetes.(BMC Genomics) [2011]

F3NRX6_9ACTO
(F3NRX6)

1e-105

387

52%

Product: Putative enoyl-CoA hydratase/isomerase
Gene: SGM_5890
Organism: Streptomyces griseoaurantiacus M045

1uniprot[Pubmed] 21551298
Draft Genome Sequence of the Marine Bacterium Streptomyces griseoaurantiacus M045, Which Produces Novel Manumycin-Type Antibiotics with a pABA Core Component.(J. Bacteriol.) [2011]

D2UD62_XANAP
(D2UD62)

1e-103

382

51%

Product: Putative enoyl-coa hydratase isomerase protein
Gene: XALc_1061
Organism: Xanthomonas albilineans (strain GPE PC73 / CFBP 7063)

1uniprot
The complete genome sequence of Xanthomonas albilineans provides new insights into the reductive genome evolution of the xylem-limited Xanthomonadaceae.(BMC Genomics) [2009]

D0RB78_STRPR
(D0RB78)

2e-95

353

48%

Product: Hydroxyacyl-dehydrogenase
Putative hydroxyacyl-dehydrogenase
Gene: pglA
Organism: Streptomyces pristinaespiralis

1uniprot[Pubmed] 21342465
Characterization of the 'pristinamycin supercluster' of Streptomyces pristinaespiralis.(Microb Biotechnol) [2011]

Q9RPT2_9BACT
(Q9RPT2)

1e-57

229

48%

Product: Putative uncharacterized protein
Gene
Organism: uncultured bacterium AH6

1uniprot[Pubmed] 10473393 [Medline] 99402727
Construction of environmental DNA libraries in Escherichia coli and screening for the presence of genes conferring utilization of 4-hydroxybutyrate.(Appl. Environ. Microbiol.) [1999]

E9LIP8_9ACTO
(E9LIP8)

2e-38

164

35%

Product: Putative enoyl-CoA hydratase/isomerase
Gene: tiaN
Organism: Dactylosporangium aurantiacum subsp. hamdenensis

1uniprot[Pubmed] 21186805
Characterization of tiacumicin B biosynthetic gene cluster affording diversified tiacumicin analogues and revealing a tailoring dihalogenase.(J. Am. Chem. Soc.) [2011]

D8F324_9DELT
(D8F324)

3e-16

91.7

31%

Product: Enoyl-CoA hydratase/isomerase family protein
Gene: NPH_7275
Organism: delta proteobacterium NaphS2

1uniprot[Pubmed] 21124915
Genome Sequence of the Deltaproteobacterial Strain NaphS2 and Analysis of Differential Gene Expression during Anaerobic Growth on Naphthalene.(PLoS ONE) [2010]

C8WPU8_EGGLE
(C8WPU8)

4e-16

90.9

32%

Product: Enoyl-CoA hydratase/isomerase
Gene: Elen_3100
Organism: Eggerthella lenta (strain ATCC 25559 / DSM 2243 / JCM 9979 / NCTC 11813 / VPI 0255)
Eubacterium lentum

1uniprot[Pubmed] 21304654
Complete genome sequence of Eggerthella lenta type strain (IPP VPI 0255).(Stand. Genomic Sci.) [2009]

Q2N892_ERYLH
(Q2N892)

6e-16

90.1

29%

Product: Enoyl-CoA hydratase/isomerase family protein
Gene: ELI_10035
Organism: Erythrobacter litoralis (strain HTCC2594)

1uniprot[Pubmed] 19168610
Complete genome sequence of Erythrobacter litoralis HTCC2594.(J. Bacteriol.) [2009]

Q939X0_9PSEU
(Q939X0)

1e-15

33%

Product: Putative enoyl-CoA-isomerase
Gene: dpgD
Organism: Amycolatopsis balhimycina

[pubmed all]
1uniprot[Pubmed] 10390204 [Medline] 99318579 Identification and analysis of the balhimycin biosynthetic gene cluster and its use for manipulating glycopeptide biosynthesis in Amycolatopsis mediterranei DSM5908.(Antimicrob. Agents Chemother.) [1999]
2uniprot[Pubmed] 11932455 [Medline] 21930292 Nonribosomal biosynthesis of vancomycin-type antibiotics: a heptapeptide backbone and eight peptide synthetase modules.(Microbiology) [2002]
3uniprot[Pubmed] 11495926 [Medline] 21486455 A polyketide synthase in glycopeptide biosynthesis: the biosynthesis of the non-proteinogenic amino acid (S)-3,5-dihydroxyphenylglycine.(J. Biol. Chem.) [2001]
4uniprot[Pubmed] 12404385 The biosynthesis of vancomycin-type glycopeptide antibiotics - the order of cyclization steps.(Angew. Chem. Int. Ed. Engl.) [2001]
5uniprot[Pubmed] 11880037 [Medline] 21869276 Glycopeptide biosynthesis in Amycolatopsis mediterranei DSM5908: function of a halogenase and a haloperoxidase/perhydrolase.(Chem. Biol.) [2002]
6uniprot Precursor-directed biosynthesis for the generation of novel glycopetides.(Ernst Schering Res. Found. Workshop) [2005]

Q4KC63_PSEF5
(Q4KC63)

8e-15

86.7

28%

Product: Enoyl-CoA hydratase/isomerase FadB1x
Gene: fad-3
PFL_3064
Organism: Pseudomonas fluorescens (strain Pf-5 / ATCC BAA-477)

1uniprot[Pubmed] 15980861
Complete genome sequence of the plant commensal Pseudomonas fluorescens Pf-5.(Nat. Biotechnol.) [2005]

F2KGA1_PSEBN
(F2KGA1)

9e-15

86.3

30%

Product: Putative enoyl-CoA hydratase
Gene: PSEBR_a2935
Organism: Pseudomonas brassicacearum (strain NFM421)

1uniprot[Pubmed] 21515771
Complete genome sequence of a beneficial plant root-associated bacterium, Pseudomonas brassicacearum.(J. Bacteriol.) [2011]

F0QK44_ACIBD
(F0QK44)

1e-14

85.9

27%

Product: FadB1x
Gene: ABTW07_0133
Organism: Acinetobacter baumannii (strain TCDC-AB0715)

1uniprot[Pubmed] 21398540
Genome sequence of a dominant multidrug-resistant Acinetobacter baumannii strain TCDC-AB0715.(J. Bacteriol.) [2011]

F5JNN9_ACIBA
(F5JNN9)

1e-14

85.9

27%

Product: FadB1x
Gene: AB210_1171
Organism: Acinetobacter baumannii AB210

1uniprot[Pubmed] 21565804
Whole-genome comparison of two Acinetobacter baumannii isolates from a single patient, where resistance developed during tigecycline therapy.(J. Antimicrob. Chemother.) [2011]

B7I1R9_ACIB5
(B7I1R9)

1e-14

85.9

28%

Product: Short-chain enoyl-CoA hydratase
Gene: AB57_0148
Organism: Acinetobacter baumannii (strain AB0057)

1uniprot[Pubmed] 18931120
Comparative genome sequence analysis of multidrug-resistant Acinetobacter baumannii.(J. Bacteriol.) [2008]

B7H2D9_ACIB3
(B7H2D9)

1e-14

85.9

28%

Product: Probable enoyl-CoA hydratase
Gene: ABBFA_003412
Organism: Acinetobacter baumannii (strain AB307-0294)

1uniprot[Pubmed] 18931120
Comparative genome sequence analysis of multidrug-resistant Acinetobacter baumannii.(J. Bacteriol.) [2008]

B0V6P7_ACIBY
(B0V6P7)

1e-14

85.9

28%

Product: Putative Enoyl-CoA hydratase
Gene: ABAYE3764
Organism: Acinetobacter baumannii (strain AYE)

1uniprot[Pubmed] 18350144
Comparative analysis of Acinetobacters: three genomes for three lifestyles.(PLoS ONE) [2008]

C4LH94_CORK4
(C4LH94)

2e-14

85.5

32%

Product: Enoyl-CoA hydratase
Gene: echA1
ckrop_0420
Organism: Corynebacterium kroppenstedtii (strain DSM 44385 / CCUG 35717)

1uniprot[Pubmed] 18430482
Ultrafast pyrosequencing of Corynebacterium kroppenstedtii DSM44385 revealed insights into the physiology of a lipophilic corynebacterium that lacks mycolic acids.(J. Biotechnol.) [2008]

B2I0V7_ACIBC
(B2I0V7)

2e-14

85.5

27%

Product: FadB1x
Gene: ACICU_00133
Organism: Acinetobacter baumannii (strain ACICU)

1uniprot[Pubmed] 18411315
Whole-genome pyrosequencing of an epidemic multidrug-resistant Acinetobacter baumannii strain belonging to the European clone II group.(Antimicrob. Agents Chemother.) [2008]

Q64BG5_9ARCH
(Q64BG5)

2e-14

85.5

29%

Product: Enoyl-CoA hydratase/carnithine racemase
Gene: GZ27B6_24
Organism: uncultured archaeon GZfos27B6

1uniprot[Pubmed] 15353801
Reverse methanogenesis: testing the hypothesis with environmental genomics.(Science) [2004]

F0QSR3_VULM7
(F0QSR3)

2e-14

85.5

26%

Product: 3-hydroxyacyl-CoA dehydrogenase, NAD-binding protein
Gene: VMUT_1375
Organism: Vulcanisaeta moutnovskia (strain 768-28)

1uniprot[Pubmed] 21398550
Complete genome sequence of "Vulcanisaeta moutnovskia" strain 768-28, a novel member of the hyperthermophilic crenarchaeal genus vulcanisaeta.(J. Bacteriol.) [2011]

F0KJC4_ACICP
(F0KJC4)

2e-14

85.1

27%

Product: Putative enoyl-CoA hydratase/isomerase
Gene: fadB1
BDGL_003033
Organism: Acinetobacter calcoaceticus (strain PHEA-2)

1uniprot[Pubmed] 21441526
Genome sequence of Acinetobacter calcoaceticus PHEA-2, isolated from industry wastewater.(J. Bacteriol.) [2011]

E1QT75_VULDI
(E1QT75)

2e-14

85.1

26%

Product: 3-hydroxyacyl-CoA dehydrogenase NAD-binding protein
Gene: Vdis_0258
Organism: Vulcanisaeta distributa (strain DSM 14429 / JCM 11212 / NBRC 100878 / IC-017)

1uniprot
Complete genome sequence of Vulcanisaeta distributa type strain (IC-017T).(Stand. Genomic Sci.) [2010]

E2XRW5_PSEFL
(E2XRW5)

3e-14

84.7

30%

Product: Enoyl-CoA hydratase/isomerase FadB1x
Gene: fad-3
PFWH6_2756
Organism: Pseudomonas fluorescens WH6

1uniprot[Pubmed] 20920191
An improved, high-quality draft genome sequence of the Germination-Arrest Factor-producing Pseudomonas fluorescens WH6.(BMC Genomics) [2010]

D3JTG2_ACISD
(D3JTG2)

3e-14

84.7

27%

Product: Enoyl-CoA hydratase
Gene: AOLE_18800
Organism: Acinetobacter sp. (strain JCM 1667 / KCTC 23045 / DR1)

[pubmed all]
1uniprot[Pubmed] 20629796 Contribution of quorum-sensing system to hexadecane degradation and biofilm formation in Acinetobacter sp. strain DR1.(J. Appl. Microbiol.) [2010]
2uniprot[Pubmed] 20639327 Complete genome sequence of the diesel-degrading Acinetobacter sp. strain DR1.(J. Bacteriol.) [2010]

E7DDH9_ALCFA
(E7DDH9)

4e-14

84.3

29%

Product: Enoyl-CoA hydratase family
Gene: acuK
Organism: Alcaligenes faecalis

1uniprot[Pubmed] 21248856
DddY, a periplasmic dimethylsulfoniopropionate lyase found in taxonomically diverse species of Proteobacteria.(ISME J.) [2011]

E6ZQ82_SPORE
(E6ZQ82)

4e-14

30%

Product: Probable enoyl-CoA hydratase, mitochondrial
Gene: sr15854
Organism: Sporisorium reilianum (strain SRZ2)
Maize head smut fungus

1uniprot[Pubmed] 21148393
Pathogenicity determinants in smut fungi revealed by genome comparison.(Science) [2010]

F7MNE5_CLOBO
(F7MNE5)

5e-14

28%

Product: 3-hydroxybutyryl-CoA dehydratase
Gene: CBCST_10366
Organism: Clostridium botulinum C str. Stockholm

1uniprot[Pubmed] 21486474
Clostridium botulinum group III: a group with dual identity shaped by plasmids, phages and mobile elements.(BMC Genomics) [2011]

F4A6J9_CLOBO
(F4A6J9)

6e-14

28%

Product: Enoyl-CoA hydratase/isomerase
Gene: CbC4_2221
Organism: Clostridium botulinum BKT015925

1uniprot[Pubmed] 21486474
Clostridium botulinum group III: a group with dual identity shaped by plasmids, phages and mobile elements.(BMC Genomics) [2011]

A3M0Z9_ACIBT
(A3M0Z9)

7e-14

83.6

27%

Product: Putative enoyl-CoA hydratase/isomerase
Gene: A1S_0106
Organism: Acinetobacter baumannii (strain ATCC 17978 / NCDC KC 755)

1uniprot[Pubmed] 17344419
New insights into Acinetobacter baumannii pathogenesis revealed by high-density pyrosequencing and transposon mutagenesis.(Genes Dev.) [2007]

D8J8B4_HALJB
(D8J8B4)

8e-14

83.2

29%

Product: Enoyl-CoA hydratase
Gene: HacjB3_13895
Organism: Halalkalicoccus jeotgali (strain DSM 18796 / CECT 7217 / JCM 14584 / KCTC 4019 / B3)

1uniprot[Pubmed] 20601480
Complete genome sequence of Halalkalicoccus jeotgali B3(T), an extremely halophilic archaeon.(J. Bacteriol.) [2010]

Q4P4J0_USTMA
(Q4P4J0)

9e-14

83.2

30%

Product: Putative uncharacterized protein
Gene: UM04973.1
Organism: Ustilago maydis (strain 521 / FGSC 9021)
Smut fungus

1uniprot[Pubmed] 17080091
Insights from the genome of the biotrophic fungal plant pathogen Ustilago maydis.(Nature) [2006]

E9L1P2_9ZZZZ
(E9L1P2)

3e-13

81.6

31%

Product: Putative uncharacterized protein
Gene: CA878-43
Organism: uncultured organism CA878

1uniprot[Pubmed] 20945895
Tailoring enzyme-rich environmental DNA clones: a source of enzymes for generating libraries of unnatural natural products.(J. Am. Chem. Soc.) [2010]

Q8FXR5_BRUSU
(Q8FXR5)

3e-13

81.3

30%

Product: Enoyl-CoA hydratase/isomerase family protein
Gene: BR2184
Organism: Brucella suis biovar 1 (strain 1330)

1uniprot[Pubmed] 12271122 [Medline] 22247741
The Brucella suis genome reveals fundamental similarities between animal and plant pathogens and symbionts.(Proc. Natl. Acad. Sci. U.S.A.) [2002]

100

Q57A82_BRUAO
(Q57A82)

3e-13

81.3

30%

Product: Enoyl-CoA hydratase/isomerase family protein
Gene: BruAb1_2157
Organism: Brucella abortus

1uniprot[Pubmed] 15805518
Completion of the genome sequence of Brucella abortus and comparison to the highly similar genomes of Brucella melitensis and Brucella suis.(J. Bacteriol.) [2005]