Pimar_00060
Pimar_00070 : CDS information
Location
| Organism | Streptomyces natalensis |
|---|---|
| Strain | ATCC 27448 (=NBRC 13367) |
| Entry name | Pimaricin |
| Contig | AJ278573 |
| Start / Stop / Direction | 50,477 / 21,954 / - [in whole cluster] 43,733 / 15,210 / - [in contig] |
| Location | complement(21954..50477) [in whole cluster] complement(15210..43733) [in contig] |
| Type | CDS |
| Length | 28,524 bp (9,507 aa) |
Annotation
| Category | 1.1 PKS |
|---|---|
| Product | polyketide synthase |
| Product (GenBank) | PimS2 protein |
| Gene | |
| Gene (GenBank) | pimS2 |
| EC number | |
| Keyword | |
| Note | |
| Note (GenBank) | |
| Reference |
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PKS/NRPS Module
| 5 |  | malonyl-CoA |
| 6 |  | malonyl-CoA |
| 7 | | methylmalonyl-CoA |
| 8 | | malonyl-CoA |
| 9 |  | malonyl-CoA |
| 10 | | malonyl-CoA |
Sequence
>polyketide synthase [PimS2 protein] MDQEQKLRDYLKRASADLRRSRQRVGELEAAAREPIAIVGMSCRFPGGVRSPEELWSLLA ADGDGITKSPADRGWELLAEDAGEFSGGFLHDAAEFDASFFGISPREALAMDPQQRLLLE SSWEAFERAGIDPAAVRGTRTGMFVGAMPQEYRVGPDDDVQGFALTGTTTSVISGRLAYF FGAVGPAVTVDTACSSSLVALHLAAHSLRQGECSLALAAGVTVMSSPTTFVEFNRQGGLS ADGRCRSFADSADGTGWSEGVGVLVLERLSEARRNGHEILAVIRGSAVNQDGASNGLTAP NGPSQRRVIEQALVSARLSADEVDVVEAHGTGTTLGDPVEAQALLATYGQGRDDDRPLLL GSVKSNLGHTQAAAGMAGVIKMVLAMRHGVLPRTLHVDAPSSHVDWTQGAVRLLTEHVPW PQGEQPRRAGVSSFGLSGTNAHTILEEAPAAPSPEAGQEDTAPVAEPLAAGAVPWLVSGR TREALRAQAARLLEHLTSRPGLAPLDVAYSLATARSGLEHRAAFTAAGPDGARAALTALA DGTPAPGLVQDTARTRSKLAFLFAGQGSQRPGMGRELAARFPVFATALDEVLGHFDEGLE RPLKDVLFAAEGTPEAALLDQTGYAQPALFAIEVALYRLAESFGITPDFLAGHSIGEIAA AHVAGVFTLADAAALVLARGRLMQALPEGGAMVSLEATEEEVLPLLEDRPDRLSIAAVNG PAAVVIAGEADDVTAVAEHFDALGRRTKRLRVSHAFHSPLMEPMLAEFRTAVSRLTPQAP VIPVVSGLTGTLATVEQLTSPDYWLDHARHAVRFADALRLARRARRRHLPRMGPDGVLSA MAQSCCRGHGHRRRRRLRHARRVRPGRPEAETLTAALAGLHTRGVAVQWEPYFQGTGARR ADLPTYAFQRRRYWPKSLPATGGDVRAAGLGAAHHPLLTAAVSVANSDGLLLTGRLSRRT HPWLADHAVRGTVLLPGTAFLELAVRAGDEAGCGRVEELTLAAPLVLPEEGGVQVQVWVG SPDASGRRAVSVHSRPDGPEELPWTQHAAGTLVAGEHHAGFDATVWPPADATPLDLDGFY ARMADTGFGYGPLFQGLRAAWRSGDDVYAEVALPDSDGAASTESSAAFGLHPALLDAALH AAAFVDLGEDARGGLPFSWQDVTLHASGASTVRVKLTPDGDDAVALAVADTTGAPVASIG SLVLRTLPDEQIDAAHSLVRDALFELRWSEARQTAHEAPASAAVLGPDLFGLERALAPTD LTVTAVPGPDAAPHAPDVVLAPVAGTTEDDVVTSVHARTAHVLERLRTWLTDERYAASRL VFVTRGALATDARQASDPVAAAVWGLVRAAQSEHPGRFGLLDLDPGTTEPATEPLLRALA LSSDEPQTAVRGTAVLTARLARAQAPQAATEWDPEGTVVLTGATGGLGRVLARHLVAERG VRHLLLVSRRGADADGAGELMAELAAHGAQVTLAACDLADRAAVRRLLSGVPAEHPVTAV VHSAGSLDDGVIASLTPERISAVLRPKADAVWHLHEATRDLDLAAFVVFSSLSGTVGAAG QGNYAAANAFLDALAQLRRAQGLPGLSLAWGPWAPTAGMTGGLTDDDLDRLARMGTPALT EEQGIALFDAATATDAAVLLPTRIDLSVLRVQSEIPPLWRGLIRTPARRSVVSASETAVT LVQQLSRLAETDRREVVLDLVAGQVAAVLGHAGTADIDPRRPLRELGFDSLTAVELRNRL SAATGLRTAATVIFDHPTVDALAAHLLDGLMGSEAAAAADAPRTAADDDPIVIVGMSCRY PGGVASPEDLWRLVSEGTDAISGLPTDRGWDLDALYDPDPDRTGTSYSRFGGFLHTAADF DPAFFGMSPREALATDSQQRLLLEASCEAVERAGIDPVSLRGSQTGVFAGVMYNDYATVL SGGQFEGHQGSGTAPSVASGRISYTLGLEGPAVTVDTACSSSLVAMHWAMQALRAGECSL ALAGGVTVMSTPGALIEFSRQRGLSPDGRCKAFSDGADGVGWSEGVGVLVLERLSDARRN GHRVLAVVRGSAVNQDGASNGLTAPNGPAQQRVIRQALSAAGLSATDIDAVEGHGTGTTL GDPIEAQALLAAYGQDREAGSPLLLGSVKSNIGHTQAAAGVAGVIKMVMAMRHGVLPRTL HADEPSSHVEWDSGAVRLLTEETPWPQADRPRRAAVSSFGFSGTNAHLIVEEPAAVAERR EEPALTPAVVPWTLSGKSRAALRDQAARLRSFLEERPALDPADVALSLATTRSAFDQRAV VTGDRDELLRALADLAADRPGPALTEGEVGGAGKLAVVFSGQGSQRPGAGRELAARFPVF AQALDEVTAALDPHLDRPLKDILFAPEGSPEAALLDRTEWTQPALFAIGVALHRLLGTWG IRPDVLLGHSIGEITAAHVAGVLSLPDAARLVIARGRLMQALPAGGAMISLEATEDETAP LLAGRDHEVSLAAVNGPRSVVVAGELAAAEEIAAHFADRGRKTKRLTVSHAFHSPLMEPA LDGLREAAAELTYHAPDVTVISGLTGRPATEAELRSADYWVAHARGAVRFADTLRAAHDC GAGTFLELGPDSVLSAAAQDALGDDAEAHIVPLLRHGRGEERCAATALARLHVRGTTADW PGYLAGTGARTIDLPTYAFQHERYWPEQAPARLAQGAADPADAELWGAVERGDATELAAL LGLRDEQHASLYALLPALSSWRQHRQEKALLDSTRYRVAWRPVQATAAPVLDGTWLLVTA DGIDSDEILDALRGHGAQFETLVLDDACRDRAHLAGRLAAVRDQDRPLTGVLSLLPLADR SGAEAGAEAGAETGAQPSTGLALSLVLIQALADTGLAAPLWTLTRGAVTTGADDPLTHPL QAAVWGLGRVAALEHPQLWSGLIDLPAALDAPATQHLVSALAAEGGEDQIAVRATGAFGR RLVRHPQAELPPADAFTARGTVLITGGTGALGAEAARWLARSGAEHLLLTSRRGPEAPGA AELAAEIEELGARVTLAACDTADRAALAALLDSLPDEHPLTGVVHAAGVGQAAALADTPL ADAAQAMAAKLLGAAHLDSLLDGHDLDFFVLVSSIAGVWGSAGQSAYSAANAYLDALAEH RAARGLPATSVAWGPWAEAGMATHEAVTDELHKRGLRFLAPATALAELRRAVVHRDVTVT VADIDWERYHPVFTSTRPSALFDELAEVQALIRPEDESAAPEFAARLRGLDQDGQERLLG DLVRAEAAIALGHDSADAIAERRAFRDAGFDSLTAVELRKRLAALTGLALPATLVFDYPT PVALARHLREQLLGTAQESAAPVAVPSGGFDEPIAIVGMSCRFPGGVRSPRQLWDLVSEG VDAISDFPVNRGWNTGLFHPDPDNPGTTYSTQGGFLHDAGEFDASFFGISPREALSMDPQ QRLLLETTWEAFEHAGIDPTTVHGTTTGTFIGSTYQEYGLGVEDGSAGHLVTGTSPSVLS GRLAYLFGLEGPAVTVDTACSSSLVALHLACQSLRNGESSLALAGGATVMTNPNPFVAFS RQRALAGDGRCKAFSEGADGMTLAEGVGVLVLERLSDAQRNGHEILAVVRGSAINQDGAS NGLSAPNGPSQQRVIRQALANSGLTPADIDAVEAHGTGTALGDPIEAQALLATYGPGRDP DSPLLLGSVKSNIGHTQSAAGVAGVIKMVLALRNGQLPRTLHADTPSSHIDWTPGTVSLL TEPTDWPEGERPRRCAVSSFGISGTNAHTLLEEAPRPHEATPAGPVPPAGDAIPWVLSAR TPGALRAQAAQLAAHLDGEAPDALDVGHTLVAARTLFDHRAVVVGTDDASRRAALDALAT GGSAPGIVQGTADTDGRTVFVFPGQGSQWAGMGARLLEESPVFAARLTECATALSEFVDW SLLDVLRQADGAPTLDRVDVVQPASFAVMVSLAALWTSHGITPDAVVGHSQGEIAAAAVA GALSLEDAARVVALRSQAIARGLAGTGGMLSVPLPAADVEQRLAAYEDLSIAAVNGPRST VVSGATAPLDALQAELVGEDIRARRIAVDYASHSAQVERVRDELRTVLEPVRPRPAQVPF FSTVTGDWLDTTVMDAEYWFTNLRRTVHFQPAIGELLAQGHHFFIEVSSHPVLSMGIQAT AEEAGAAAAVLGTLRRDTGATDRFLASLAEAFVRGADADWSAVFAGTGARRVPLPTYAFQ REHLWAIPERSPDRPEADPADAEFWTAVEEEDVEALASRLRLDRTSLAPVLPALSHWRKR RRELSTVDSWRYRATWKPLTGLPAAALTGTWLVVAPEGADTDTLTGVLAAHGAGTRTLVL DDSCADRATLTARLTGLDGAADLTGVVSLPAPADEASATHPTLSRAVTLTVALVQALGDA GIDAPLWCLTQGAVSTGRADRLTRPDQAQILGLGWTAALEHPQRCGAGLVDLPEELDRRA GERLAAVLTGRSGEDQLAVRSSGVFARRVVRAAPADPAPARPWTPRGTTLVTGGTGTLAP HLARWLAQQGAEHIVLTSRRGPAAPGAAELVQELAELGCQAEAVACDLTDRDAVAQMLAA LRAEGRTVRTVVHTAVTIELAPLDETTLDDFAKVMDAKVIGARHLDELLGDDLDAFVLYS STAGMWGSGAHAAYVAGNAYLNALAEHRRARGARATAVSWGIWADDLKLGRVDPGQIRRS GLVFMDPQLALTGLRQALDDEETHLAVADVDWGRYYPVFTAARPTRLFEDLPEVRQLAQE SAEVTDSGSEFATRLDGLAAVEQDRLLLDLVRTEAATALGHASPDVLSEQRAFRDVGFDS LTAVDLRNRIASVTGLALPSTMVFDYPNPLALVAFLRESLAGSATGTAATTTHTAAADEP IAIIGMSCRYPGGVGSPEDLWRLVTEGGDATGEFPADRGWDAEGLYDPDPDRAGHTYSTR GGFLHDAADFDASFFGISPREALAMDPQQRLLLETSWEAMERAGIDPATLRGSSTGTFIG ASYQDYRAFGAGPDGAEGHLITGTISSVLSGRLSYTYGFEGPAVSLDTACSSSLVALHLA CQSLRNGESSLALAGGVSIMSTPGAFVGFSRQRAMAADGRCKAYSDQADGMSLAEGVGLV LVERLSDARRNGHQVLAVIRGSAVNQDGASNGLTAPNGPSQQRVIRQALANAEVDPDGID VIDGHGTGTALGDPIEAQALLATYGQGRDPEHPLLLGSVKSNIGHTQMASGVASVIKMVM AMRHAAVPRSLHIDRPSSHVDWSSGAIQLLTEPLPWPATGHPRRAGVSSFGLSGTNVHTI LEQAPEDRTEEDTDTAPARPADPTPVPVTLSGRTEAGLRAQAGRLLTHLADHPELPLTDL AFSLATSRAALEHRAAVVTDDPDTLTRALTALRDATPDGGLLTGRPDRGRLAFLFTGQGS QRPGMGRELYDRHPVYAEALDAVLARFDLELDRPLREILFADPGTPEAELLDDTGYTQPA LFALEVALFRLAESWGLRPDYVAGHSIGELAAAHAAGVLSLEDACTLVAARGRLMAALPS GGAMASVEATEDEAAAVLAPYEGRAAVAAVNTPTSLVVSGDEDAVHAVAAHFHELGRRTK QLRVSHAFHSPHMDAMLDDFTRAAEGITFHAPELPLVSTLTGELILADDLCSAPYWTRQV RGTVRFADAVRHLTEHGVTTFFELGPDAVLSGAVRESTGEQTPATAVPALRRDRPEAPAL TTALARLHLHGVRVDWDAVFAGGGARRIDLPTYPFQRERYWPEAAAGAAAPAHPADAADA EFWSAVERADLPSLGSSLDLDDDTLTAVVPALSSWRRKSRERSTVDGWRYRTTWKPLTGT ATAGHPAGTWLVLAPADGDRAWTDAVAGALGADAVRVEVSTAQRQELAERLSELAAEHGE FAGVLSLLATAGEGAEDADDATTEGLLLTATALQALGDAGIDAPLWCVTRTAVAVDRAEH PARPAQAAVWGLGRVAALEHPQRWGGLVDLPDELDGATLRRLAAVLADSGDEDQLAVRTT ATFVRRLAHHRAAPAPEAATFRPTGTVLVTGGTGALGGHVARWLAEAGAEHLLLVSRRGT DAPGAGELAAEIAELGARVTVAACDTADRDALAAVLAAIPDEHPLTAVFHTAGTVDDGTL DTLTPEQFASVLRTKVTATRNLHETTREQDLSAFVLFSSVAGTLGAPGQGNYAAGNAFLD AFAAHRRAHGLPATSLAWGPWAETGMAADGTGIQDRVRRGGFTPMPPRLALTALRRAIEH DATALTLADIDWQRYAEVFTATRPSLFVADLPELQQVTPPAGTPEAALREPALRQRLAGL SPAARPRFVLDLVRTQVAAVLGHSGTSAIGAERAFSDLGFDSLTTVELRNTLTATTGLKL PATLVYDYPTPTALADFLLAELLGALPESGAPAFVGRAADDDPIVIVGMNCRFPGGIRSP EDLWQLLSSGEDAISGFPADRGWDLDALARGASATLEGGFLDGVGLFDAPFFGISPREAL AMDPQQRLLLETSWEAFERAGIDATTLRGSRTGVFVGTNGQDYATLLRQGTGTTDIRGHV ATGNTASVMSGRLSYAFGLEGPAVTVDTACSSALVALHMAAGALRSGECTLALAGGVSVM SSPDSFTEFTVQGGLAPDGRCKPFADAADGTSWSEGVGVLLLERLSDARRNGHDVWGIVR GTAVNQDGASNGLTAPSGRAQQRAIRQALADADLAPADVDVVEAHGTGTTLGDPIEAHAL IAAYGQDRPTDRPLLLGAVKSNLGHTQAAAGVAGTIKVLLAMRHGVLPKTLHTDSPSAHV DWTAGTVSLLTEQQEWPETGHARRAGVSAFGVSGTNAHVIIEQAPDAEESVAPEPTTVPG LVPWPVSGKSEAALEAGIERVSALTGRSPVDVGHSLTTGRAAFTHRAVLAADGAGVRELA RGVAHEADGKLAVLFSGQGAQRVGMGRELYVRFPVFAEALDGVLAHFDAGLRDVMFGDAE GLDETGFTQPALFAIEVALFRLAESLGVRPDFVGGHSIGEIAAAHVAGVFSLADACALVA ARARLMQALPAGGAMVAVQATAEEAAARLVDGVSIAAVNGPEAVVIAGEQREVLRIAKEF TGLGRKTRRLPVSHAFHSPLMEPMLEDFRRVAEGLSYEAPRIALVSNLTGELATEDLVRS AEYWVRHVRETVRFADGVSALAAEGASVFLELGPDGVLTAMAQHTLDGTATAVPALRKDW SEETALLTALAQLHVVGVGVDWSGIFAGTGARRVDLPTYPFQHQWYWPDGAPAAEATTGA QDPVDAEFWDAVERADLSSLSDSLELDDAALSALVPALSAWRRKRVERSTVDGWRYHVTF KPLTGTAPGTLAGTWLALVPTGAADDEWTTAVLAALGDAVVIAEVDPADRGAFAGRLGEL AERGTEFTGVVSSSQSRTPSPSPSDRPGPTRRWRALAEAGIDAPLWCVTRDAVPVDRSES EVSPAQAAVWGLGRVAALDHPDRWGGLVDVPQEHDRRTAERLRAVLSGAGDEDQVALRPS GAFGRRLVRATDDTPATPWQPAGTVLVVGPASGTGGHCARWLAGQGAQHLVLADRTAPDT AQLIGELDALGVPLTVLDCAPADGEALLSALAALPEPLTAVIYADGPSDADAYGTATTAD PGASLAALYADVESLAAVAEAATGARPLGAFVLFSSIAGTWGAGGRGTEAAAGAQLDALA GMLRARGLPATAVSWGGWADATSGSLAAHLRANGLPPMDPARALTALARSLGTDTPSVTV ADVRWDEFAPAFTRRRHSALFAELPEAREALAESDGSAPGTADAASGLRAELAARPDAER TEHLLALVRDRVAAVLGFADADAVPSGQAFTDLGFDSLTAVDLRNQLAVATGLALPATLV FDYPTADALAGYLRAELLGEGGKDAEELPAVVRTKDADTAEDPVVIVGMSCRYPGGIRSP EDLWQLVMGEADAIGGFPTDRGWDLDRLLHGDRDGRGRTVTGQGGFLYDVADFDPGFFGI APREAMVMDPQQRILLEATWEALERTGIDPARLRGGDTGVFIGGGSGDYRPEAGQLGHAQ TAQSASLLSGRVAYHFGLEGPSVSVDTACSSSLVALHLAAQALRNGECSIALTGGVTVMS SPVNFVEFGEMGALAPDGRCRPFASAAGGTGWSEGVGVLVLERLSDARRNGHEVLAVLRG SAVNQDGASNGITAPNGPSQRRVIQRALANAGLAPADVDAVEAHGTGTTLGDPIEAQALL ATYGQGRDPELPLLLGSVKSNIGHTQAAAGIAGVIKMVLAMRHGMLPRSLHIDEPSAHVD WSAGAVELLAQAADWPRTGRPRRAGISAFGASGTNSHVIIEQPAPTVAEEPERPQEAGGP LPVPVSGAVPDALRAQARQLHAYVAGRPGLTVAEFALSTATTRSAFTHRAAVLAEDREEL LAGLAALAGGLDTPQVLRGRVAERRGRLAVLFSGQGSQRVGMGRELHARFPVFAEALDEV TARLEAELELPLREVMFGDSERLNETGYTQPALFAIEVALFRLVASWGIRPDFVAGHSIG EIAAAHVAGVFSLDDACRLVAARARLMNALPAGGAMVAVQATEEETRACLTDGVSIAAVN GPRSVVLSGDEAAVLDLAEKFTADGRKTRRLRVSHAFHSLHMDAVLDDFRRVAQSVGYDA PTIPLVSNVTGEAATERQVCSPDYWVRHVREAVRFGDGVRTLADRGVTAFLELGPDGALC AMAQETLDTLPSPAVTVPALRRDRGEQECVVTALARLHVDGVSPHWPAVLTGPRTAPRRT DLPTYPFQHQRFWPAAQPATDPTPATAADDGFWSAVREADFADLATTLDVERDALSTVLP ALADWRRRREESGTVDGWRQQITFEPLTRTPSHTPAGTRLAVIPAGHEQDPLVADVVAAL GPDTVRLTAPGSDRAALADLLRQQAADGTEFTAVVSLLALATEPAHSEPAHSEPAHPAHA PEALALTTTLIQALGDADLAAPLWCVTRGAVAAAPGEPVSGPAQAAVWGLGRVAALEYPQ RWGGLIDLPAALDDRTAARLADVLAAPGGEDQIAIRPSAVLGRRLVPVPAGRTTREWNPT GTVLITGGTGALGARVARELARAGAEHLLLLSRRGPDAPGADALRAELTALGADVTLTAC DAADRDALAKVLADIPETSPLTGVVHTAGVIDDGVLDSLTPDRFEDVFRAKAASALALHD LTEDLDLAVFALFSSSSGAVGNAGQANYAAANAFLDALAERRRAQGLAATSLAWGVWGGG GMAADQRAADVARRTGIRPLDPDLAVVALRRAVMDGRPTEVVADIERDLFVRSFTAVRPS PLLGAPTVDAEHRAAGDTGEDTTGDALRAKLTGLPPAKRSEAVRDLVRTRAAAVLGHPTA DAVGADRAFRDLGFDSLSAVELRNQLGAATGLNLTATLVFDHPNPAALADHLLSLLVPDE DPGEGTADDGDPDSSAIRALLASVSVAQLREIGVLEPLLKLAAEQTAASGAEAAAATAAD AYDESIDAMDIADLVQAAFDGNSPQER
>polyketide synthase [PimS2 protein] ATGGACCAGGAACAGAAGCTCCGCGACTACCTAAAGCGGGCAAGTGCCGATCTGCGGCGC TCCCGGCAGCGGGTGGGCGAGCTGGAGGCGGCGGCCCGCGAGCCGATCGCGATCGTGGGC ATGAGCTGCCGCTTCCCGGGCGGCGTGCGCAGTCCCGAGGAGCTCTGGTCCCTGCTCGCC GCCGACGGGGACGGCATCACCAAGTCCCCCGCCGACCGCGGCTGGGAGCTCCTGGCCGAG GACGCGGGGGAATTCTCCGGCGGATTCCTGCACGACGCGGCCGAGTTCGACGCCTCCTTC TTCGGGATCTCGCCCCGTGAGGCGCTCGCCATGGACCCGCAGCAGCGACTGCTGCTGGAG TCCTCCTGGGAAGCCTTCGAGCGGGCCGGCATCGACCCGGCGGCGGTCCGGGGCACCAGG ACGGGCATGTTCGTCGGGGCGATGCCCCAGGAATACCGGGTGGGCCCGGACGACGACGTC CAGGGCTTCGCCCTGACGGGCACCACCACCAGCGTCATCTCGGGCCGACTCGCCTACTTC TTCGGCGCCGTGGGCCCGGCGGTCACCGTCGACACCGCCTGCTCGTCCTCGCTCGTGGCC CTGCACCTGGCCGCCCACTCCCTGCGCCAGGGCGAGTGCTCCCTGGCGCTTGCCGCCGGC GTCACCGTGATGTCCAGCCCCACCACCTTCGTGGAGTTCAACCGCCAGGGCGGGCTCTCC GCCGACGGGCGCTGCCGCTCCTTCGCCGACTCCGCCGACGGCACCGGCTGGTCCGAGGGC GTCGGCGTCCTGGTCCTGGAACGCCTCTCGGAGGCCCGTCGCAACGGGCACGAGATCCTG GCCGTGATCCGCGGCTCCGCCGTCAACCAGGACGGCGCCTCCAACGGGCTGACCGCACCC AACGGCCCCTCGCAGCGACGGGTGATCGAGCAGGCGCTGGTCAGCGCGCGGCTCTCGGCC GATGAGGTCGACGTCGTCGAGGCACACGGCACCGGCACCACCCTGGGCGACCCGGTCGAG GCCCAGGCGCTGCTGGCGACCTACGGCCAGGGCCGCGACGACGACCGCCCGCTGCTGCTG GGGTCCGTCAAATCGAACCTCGGCCACACCCAGGCGGCGGCCGGTATGGCCGGCGTCATC AAGATGGTGCTGGCGATGCGGCACGGCGTGCTCCCGCGCACGCTCCATGTGGACGCGCCG TCCTCGCACGTCGACTGGACGCAGGGGGCCGTACGCCTGCTCACCGAGCACGTTCCGTGG CCGCAGGGCGAACAGCCGCGCCGGGCCGGTGTTTCGTCGTTCGGGCTCAGCGGCACCAAT GCGCACACCATTCTGGAGGAGGCCCCGGCCGCCCCGTCGCCCGAGGCGGGCCAGGAAGAC ACCGCGCCGGTCGCGGAACCTCTGGCGGCGGGCGCCGTCCCGTGGCTCGTCTCCGGCCGC ACCCGCGAGGCGCTTCGTGCCCAGGCGGCGCGACTGCTCGAACACCTCACCTCCCGCCCC GGCCTCGCGCCCCTGGACGTGGCCTACTCCCTGGCCACGGCCCGCTCCGGCCTGGAGCAC CGCGCCGCGTTCACCGCGGCCGGCCCGGACGGCGCCCGCGCCGCCCTCACCGCGCTCGCC GACGGCACACCGGCCCCGGGTCTGGTGCAGGACACCGCCCGTACCCGGTCCAAGCTCGCC TTCCTCTTCGCGGGCCAGGGCTCCCAGCGGCCGGGCATGGGGCGTGAACTGGCCGCCCGC TTCCCCGTCTTCGCCACCGCCCTCGACGAGGTCCTCGGCCACTTCGACGAGGGTCTTGAA CGGCCCCTGAAGGACGTCCTGTTCGCCGCCGAGGGCACGCCCGAGGCCGCCCTGCTGGAC CAGACCGGCTATGCCCAGCCCGCGCTGTTCGCGATCGAGGTCGCGCTGTACCGGCTCGCC GAGTCCTTCGGCATCACGCCGGACTTCCTCGCCGGGCACTCCATCGGCGAAATCGCCGCG GCGCACGTCGCCGGCGTCTTCACCCTGGCCGACGCCGCGGCCTTGGTGCTCGCCCGCGGC CGCCTCATGCAGGCGCTGCCCGAAGGCGGCGCCATGGTCTCCCTCGAAGCCACCGAGGAA GAGGTCCTGCCCCTCCTGGAGGACCGGCCCGACCGCCTCTCGATCGCCGCGGTCAACGGG CCCGCCGCCGTCGTAATCGCCGGTGAGGCCGACGACGTCACCGCCGTCGCCGAGCACTTC GACGCGCTGGGCCGCAGGACCAAGCGGCTGCGTGTCTCGCACGCGTTCCACTCCCCGCTC ATGGAACCCATGCTGGCGGAGTTCCGCACGGCCGTCTCCCGGCTCACCCCGCAGGCACCC GTGATCCCGGTCGTCTCCGGCCTGACGGGCACCCTCGCCACGGTGGAGCAGCTGACCTCC CCCGACTACTGGTTGGACCACGCCCGCCACGCCGTACGGTTCGCCGACGCCCTCCGCCTG GCTCGACGGGCACGGCGCCGCCACCTTCCTCGAATGGGCCCCGACGGCGTCCTGTCCGCC ATGGCCCAGTCCTGCTGCCGCGGACACGGACACCGCCGCCGACGGCGTCTCCGCCACGCT CGCCGTGTGCGCCCCGGCCGCCCCGAGGCCGAGACGCTCACCGCCGCGCTGGCGGGTCTG CACACCCGCGGCGTGGCCGTCCAGTGGGAGCCCTACTTCCAGGGCACCGGCGCCCGCCGC GCCGACCTGCCCACGTACGCCTTCCAGCGCCGCCGCTACTGGCCCAAGAGCCTGCCCGCG ACGGGCGGTGACGTGCGTGCCGCCGGTCTGGGCGCGGCACACCACCCGTTGCTGACGGCG GCCGTGTCGGTCGCCAACTCCGACGGGCTCCTGCTGACCGGACGGCTGTCGCGGCGTACC CACCCCTGGCTCGCCGACCACGCCGTGCGCGGCACGGTGCTGCTGCCGGGCACCGCCTTC CTGGAGCTGGCCGTACGCGCCGGGGACGAGGCCGGCTGCGGCCGCGTGGAGGAACTCACC CTCGCCGCCCCGCTGGTGCTGCCCGAGGAGGGCGGCGTCCAGGTGCAGGTGTGGGTGGGC AGCCCCGACGCGTCGGGCCGCCGCGCCGTCAGCGTTCACTCCCGCCCCGACGGGCCCGAG GAGCTGCCCTGGACCCAGCACGCCGCGGGCACCCTCGTCGCCGGTGAGCACCACGCCGGA TTCGACGCCACCGTCTGGCCGCCCGCCGACGCGACCCCGCTGGACCTCGACGGCTTCTAC GCCCGCATGGCCGACACCGGCTTCGGATACGGCCCCCTCTTCCAGGGCCTGCGCGCCGCC TGGCGCAGCGGCGACGACGTCTACGCCGAGGTGGCGCTGCCCGACTCCGACGGCGCCGCG TCCACCGAGTCGTCCGCGGCATTCGGGCTCCACCCGGCCCTGCTGGACGCCGCGCTGCAC GCCGCGGCCTTCGTTGACCTGGGCGAGGACGCCCGCGGCGGCCTGCCCTTCTCGTGGCAG GACGTCACCCTGCACGCGAGCGGCGCGAGCACGGTCCGGGTGAAGCTGACCCCGGACGGG GACGATGCGGTGGCCCTCGCCGTCGCCGACACCACCGGCGCCCCCGTCGCCTCCATCGGC TCGCTGGTCCTGCGCACCCTGCCCGACGAGCAGATCGACGCGGCCCACTCCCTCGTCCGC GACGCCCTGTTCGAGCTGCGGTGGAGCGAGGCGCGCCAGACCGCCCACGAGGCGCCCGCC TCGGCCGCCGTCCTCGGCCCCGACCTCTTCGGCCTGGAGCGGGCCCTTGCACCGACGGAC CTCACGGTCACGGCGGTGCCCGGCCCGGACGCCGCCCCCCACGCCCCGGACGTGGTCCTC GCCCCCGTCGCGGGCACGACCGAGGACGACGTCGTCACCTCCGTGCACGCCCGCACCGCC CACGTACTGGAGCGCCTGCGGACCTGGCTGACGGACGAGCGGTACGCCGCCTCCCGGCTG GTCTTCGTCACCCGTGGCGCCCTCGCCACCGACGCCCGGCAGGCATCCGACCCGGTGGCC GCCGCCGTCTGGGGCCTCGTACGGGCCGCGCAGAGCGAACACCCCGGCCGCTTCGGGCTG TTGGACCTCGACCCCGGCACCACCGAGCCCGCCACGGAGCCGCTGCTGCGGGCCCTGGCC CTGTCCTCGGACGAGCCGCAGACCGCCGTCCGCGGCACCGCCGTGCTCACCGCGCGACTC GCCCGCGCCCAGGCGCCGCAGGCCGCCACGGAGTGGGACCCGGAGGGCACCGTGGTGCTC ACCGGAGCCACCGGCGGCCTGGGCCGCGTACTGGCCCGGCACCTGGTCGCCGAGCGCGGC GTACGCCATCTGCTGCTCGTCAGCCGCCGCGGCGCCGACGCCGACGGCGCCGGGGAACTC ATGGCCGAACTGGCCGCGCACGGCGCGCAGGTGACCCTCGCGGCATGCGACCTGGCCGAC CGCGCCGCCGTGCGGCGGCTGCTGTCCGGTGTGCCCGCCGAGCACCCCGTCACCGCCGTC GTGCACAGCGCCGGCAGCCTCGACGACGGCGTGATCGCCTCGCTCACCCCCGAGCGGATC AGTGCCGTCCTGCGGCCCAAGGCCGACGCCGTCTGGCACCTCCACGAGGCCACCCGGGAC CTGGACCTGGCCGCCTTCGTCGTCTTCTCGTCCCTCTCCGGCACCGTGGGCGCGGCGGGC CAGGGCAACTACGCCGCCGCCAACGCCTTCCTCGATGCGCTCGCCCAACTGCGCCGTGCC CAGGGGCTGCCGGGCCTCTCCCTGGCCTGGGGCCCGTGGGCGCCCACCGCCGGAATGACC GGCGGCCTGACGGACGACGACCTCGATCGCCTGGCCCGGATGGGCACGCCCGCGCTCACC GAGGAACAGGGCATCGCCCTCTTCGACGCGGCCACCGCCACGGACGCCGCCGTCCTGCTG CCGACCCGCATCGACCTTTCCGTCCTGCGCGTCCAGAGCGAGATTCCGCCGCTGTGGCGC GGCCTGATCCGTACCCCGGCCCGCCGCTCGGTGGTCTCCGCCTCGGAGACCGCCGTCACC CTCGTCCAGCAGCTGTCCCGGCTGGCGGAGACCGACCGCCGCGAGGTCGTGCTCGACCTC GTGGCCGGACAGGTGGCCGCCGTGCTCGGCCACGCCGGCACCGCCGACATCGACCCGCGG CGCCCGCTGCGGGAGCTGGGCTTCGACTCGCTGACCGCCGTGGAACTGCGCAACCGGCTC AGCGCGGCCACCGGCCTGCGCACCGCCGCGACGGTCATCTTCGACCACCCGACCGTCGAT GCCCTCGCCGCGCACCTCCTCGACGGACTCATGGGCTCCGAAGCCGCCGCCGCGGCCGAC GCGCCCCGCACCGCCGCGGACGACGACCCCATCGTCATCGTCGGCATGAGCTGCCGCTAC CCGGGCGGCGTCGCCTCGCCCGAGGACCTGTGGCGGCTGGTCAGCGAGGGCACCGACGCC ATCTCGGGCCTGCCCACCGACCGGGGCTGGGACCTGGACGCGCTCTACGACCCGGACCCG GACCGCACCGGCACCTCCTACTCCCGTTTCGGCGGATTCCTGCACACCGCCGCCGACTTC GACCCCGCCTTCTTCGGCATGAGCCCCCGCGAGGCCCTGGCCACCGACTCCCAGCAGCGC CTCCTCCTCGAAGCGTCCTGCGAGGCCGTCGAGCGGGCGGGCATCGACCCGGTGTCCCTG CGCGGCAGCCAGACCGGCGTGTTCGCGGGCGTGATGTACAACGACTACGCCACGGTGCTC TCCGGCGGGCAGTTCGAGGGCCACCAGGGCAGCGGCACCGCCCCGAGCGTCGCCTCCGGG CGCATCTCCTACACCCTCGGCCTCGAAGGCCCCGCCGTCACCGTCGACACCGCCTGCTCG TCCTCGCTGGTCGCCATGCACTGGGCGATGCAGGCCCTGCGCGCGGGGGAGTGCTCGCTC GCGCTGGCCGGCGGAGTCACGGTCATGTCGACGCCGGGTGCCCTCATCGAGTTCTCCCGG CAGCGCGGCCTGTCCCCGGACGGGCGCTGCAAGGCGTTCTCCGACGGCGCCGACGGCGTC GGCTGGTCCGAGGGCGTGGGCGTCCTCGTCCTGGAACGCCTCTCCGACGCCCGCCGCAAC GGGCACCGGGTCCTGGCCGTCGTACGGGGCTCCGCCGTCAACCAGGACGGCGCCTCCAAC GGCCTGACCGCCCCCAACGGCCCCGCCCAGCAGCGGGTGATCCGGCAGGCCCTGTCCGCC GCCGGCCTGTCCGCCACGGACATCGACGCGGTGGAGGGCCACGGCACCGGCACCACCCTC GGCGACCCCATCGAGGCGCAGGCCCTGCTCGCCGCCTACGGCCAGGACCGCGAGGCGGGG AGTCCGCTGCTGCTGGGCTCGGTGAAGTCCAACATCGGCCACACCCAGGCCGCGGCCGGC GTCGCCGGCGTCATCAAGATGGTCATGGCCATGCGCCACGGCGTGCTGCCCCGCACCCTG CACGCCGACGAGCCGTCCTCACACGTGGAGTGGGACTCCGGGGCGGTGCGCCTGCTCACC GAGGAGACACCCTGGCCGCAGGCCGACCGGCCGCGCCGCGCCGCCGTCTCCTCCTTCGGA TTCAGCGGTACCAACGCGCACCTCATCGTCGAGGAGCCGGCGGCCGTCGCCGAGCGGCGC GAGGAGCCGGCGCTCACCCCGGCCGTCGTGCCCTGGACGCTGTCGGGCAAGAGCCGGGCC GCGCTGCGCGACCAGGCCGCCCGCCTGCGGTCCTTCCTGGAGGAGCGCCCCGCCCTGGAC CCGGCCGATGTCGCGCTCTCCCTGGCCACCACCCGCTCGGCCTTCGACCAGCGCGCCGTC GTCACCGGCGACCGCGACGAACTGCTGCGCGCCCTCGCCGACCTGGCCGCCGACCGGCCC GGCCCCGCGCTGACCGAGGGCGAGGTCGGCGGCGCGGGCAAACTGGCCGTGGTGTTCTCC GGGCAGGGCAGCCAGCGCCCCGGCGCCGGCCGGGAACTCGCCGCCCGCTTCCCCGTGTTC GCCCAGGCCCTCGACGAGGTGACCGCCGCCCTCGACCCGCACCTGGACCGCCCCCTCAAG GACATCCTGTTCGCCCCGGAGGGCAGCCCCGAGGCGGCGCTGCTGGACCGCACCGAGTGG ACCCAGCCCGCGCTGTTCGCCATCGGGGTCGCGCTCCACCGGCTGCTCGGCACCTGGGGC ATCCGCCCCGACGTGCTGCTGGGCCACTCCATCGGCGAGATCACCGCCGCGCATGTCGCG GGCGTCCTCTCGCTGCCCGACGCGGCCCGCCTGGTGATCGCGCGCGGACGGCTGATGCAG GCGCTGCCCGCCGGCGGCGCGATGATCTCCCTTGAGGCCACCGAGGACGAGACCGCGCCG CTGCTCGCCGGGCGCGACCACGAGGTCTCCCTGGCCGCCGTCAACGGCCCCCGCAGCGTC GTGGTCGCCGGAGAACTGGCCGCCGCCGAGGAGATCGCCGCCCACTTCGCCGACCGGGGC CGCAAGACCAAGCGCCTGACGGTCAGCCACGCCTTCCACTCGCCGCTCATGGAACCCGCG CTCGACGGGCTGCGCGAGGCCGCCGCCGAACTCACCTACCACGCGCCGGACGTGACCGTC ATCTCCGGCCTGACCGGACGGCCCGCCACCGAAGCGGAACTGCGCTCGGCCGACTACTGG GTCGCGCACGCCCGCGGCGCCGTCCGCTTCGCCGACACCCTGCGCGCCGCGCACGACTGC GGCGCCGGCACCTTCCTCGAACTCGGCCCCGACAGCGTGCTGTCGGCCGCCGCCCAGGAC GCCCTCGGCGACGACGCGGAGGCGCATATCGTCCCGCTGCTGCGCCACGGGCGCGGCGAG GAGCGCTGCGCGGCCACCGCGCTGGCCCGCCTGCACGTCCGCGGCACGACCGCTGACTGG CCCGGATACCTCGCCGGCACCGGCGCCCGCACCATCGACCTGCCCACCTACGCCTTCCAG CACGAGCGCTACTGGCCCGAACAGGCCCCGGCCCGCCTCGCGCAGGGTGCCGCCGACCCC GCGGACGCCGAGCTGTGGGGCGCCGTCGAACGCGGCGACGCCACGGAACTGGCCGCCCTC CTCGGGCTGCGCGACGAACAGCACGCCTCCCTGTACGCCCTGCTGCCCGCGCTGTCCTCC TGGCGCCAGCACCGGCAGGAGAAGGCGCTGCTGGACTCCACCCGCTACCGCGTGGCCTGG CGCCCCGTGCAGGCAACCGCCGCACCCGTACTGGACGGCACCTGGCTGCTCGTCACCGCC GACGGCATCGACAGCGACGAGATCCTCGACGCGCTGCGCGGCCACGGCGCCCAGTTCGAG ACCCTCGTCCTGGACGACGCCTGCCGCGACCGCGCCCATCTCGCCGGCCGGCTCGCCGCC GTACGCGACCAGGACCGGCCCCTGACCGGTGTGCTGTCCCTGCTGCCGCTCGCCGACCGG TCCGGGGCCGAGGCCGGGGCCGAAGCCGGGGCCGAGACCGGCGCCCAGCCGTCCACCGGG CTCGCGCTGAGCCTCGTGCTGATCCAGGCGCTCGCCGACACCGGCCTCGCCGCGCCCCTG TGGACCCTGACCCGGGGCGCCGTCACCACCGGCGCCGACGACCCGCTCACCCACCCCCTC CAGGCCGCGGTCTGGGGACTGGGCCGGGTCGCCGCCCTGGAGCACCCGCAGCTGTGGAGC GGCCTGATCGACCTGCCGGCCGCCCTCGACGCCCCCGCCACCCAGCACCTCGTCAGCGCG CTGGCCGCCGAGGGCGGCGAGGACCAGATCGCCGTCCGCGCCACCGGAGCGTTCGGCCGA CGCCTGGTGCGCCACCCGCAGGCCGAACTGCCCCCGGCCGACGCGTTCACCGCACGCGGC ACCGTGCTCATCACCGGCGGCACCGGAGCGCTCGGCGCCGAGGCCGCCCGCTGGCTCGCC CGCAGCGGCGCCGAGCACCTCCTGCTCACCAGCCGCCGCGGCCCCGAAGCCCCCGGAGCC GCCGAACTGGCCGCCGAAATCGAGGAGTTGGGTGCCCGCGTCACCCTCGCGGCCTGCGAC ACCGCCGACCGCGCCGCACTCGCCGCGCTGCTGGACTCCCTACCCGACGAGCACCCGCTG ACCGGCGTCGTGCACGCGGCCGGTGTCGGCCAGGCGGCCGCCCTCGCCGACACCCCACTG GCCGACGCCGCACAGGCGATGGCCGCCAAGCTGCTCGGCGCGGCCCACCTCGACAGCCTC CTGGACGGCCACGACCTGGACTTCTTCGTCCTGGTCTCCTCGATCGCCGGAGTGTGGGGC AGCGCCGGACAGAGCGCCTACAGCGCCGCCAACGCCTACCTCGACGCCCTCGCCGAGCAC CGCGCCGCCCGCGGCCTGCCCGCCACCTCCGTCGCCTGGGGCCCCTGGGCAGAGGCCGGT ATGGCCACCCACGAGGCCGTCACCGACGAACTGCACAAGCGCGGACTGCGCTTCCTCGCG CCCGCGACCGCGCTCGCCGAACTGCGGCGCGCCGTCGTCCACCGGGACGTCACCGTCACC GTCGCCGACATCGACTGGGAGCGCTACCACCCCGTCTTCACCTCCACCCGCCCCAGCGCC CTCTTCGACGAACTGGCCGAGGTCCAGGCCCTGATACGCCCCGAGGACGAAAGCGCCGCG CCCGAATTCGCCGCGCGCCTGCGGGGCCTGGACCAGGACGGGCAGGAGCGGCTGCTGGGC GACCTGGTGCGCGCCGAGGCGGCCATCGCCCTCGGCCACGACTCCGCGGATGCCATCGCG GAGCGGCGGGCCTTCCGCGACGCCGGCTTCGACTCGCTGACCGCCGTGGAACTGCGCAAG CGGCTCGCCGCCCTCACCGGCCTGGCCCTGCCCGCCACCCTCGTCTTCGACTACCCGACC CCCGTGGCCCTCGCCCGCCACCTGCGCGAGCAACTCCTGGGCACCGCCCAGGAGTCGGCC GCCCCCGTGGCCGTACCGTCGGGGGGCTTCGACGAGCCCATCGCCATCGTCGGTATGAGC TGCCGCTTCCCCGGCGGCGTCCGTTCCCCGCGGCAGCTGTGGGACCTGGTCAGCGAAGGC GTCGACGCCATCAGCGACTTCCCCGTCAACCGCGGCTGGAACACCGGCCTCTTCCACCCC GACCCGGACAACCCCGGCACGACGTACTCCACCCAGGGCGGATTCCTGCACGACGCGGGC GAGTTCGACGCCTCCTTCTTCGGCATCTCGCCGCGCGAGGCGCTGTCGATGGACCCCCAG CAGCGGCTGCTGCTGGAGACCACCTGGGAGGCGTTCGAGCACGCCGGCATCGACCCCACC ACCGTCCACGGCACCACGACCGGCACCTTCATCGGCTCCACCTACCAGGAGTACGGACTC GGCGTCGAGGACGGCTCCGCCGGTCACCTGGTGACCGGCACCAGCCCCAGCGTGCTCTCC GGGCGCCTGGCCTACCTCTTCGGCCTCGAAGGCCCGGCCGTCACCGTCGACACCGCATGC TCCTCCTCCCTGGTCGCCCTGCACCTGGCCTGCCAGTCGCTGCGCAACGGCGAGAGCTCC CTGGCCCTGGCCGGCGGCGCGACCGTGATGACCAACCCCAACCCGTTCGTCGCCTTCAGC CGGCAGCGCGCCCTGGCAGGCGACGGCCGCTGCAAGGCGTTCTCCGAAGGCGCCGACGGC ATGACCCTGGCCGAGGGCGTGGGCGTCCTCGTCCTGGAGCGCCTCTCGGACGCCCAGCGC AACGGGCACGAGATCCTCGCCGTCGTCCGCGGCTCGGCCATCAACCAGGACGGCGCCTCC AACGGCCTGTCCGCCCCCAACGGCCCCTCCCAGCAGCGCGTCATCCGCCAGGCCCTGGCC AACTCGGGGCTGACCCCGGCGGACATCGACGCCGTCGAGGCCCACGGCACCGGCACCGCC CTCGGCGACCCCATCGAGGCCCAGGCCCTGCTCGCCACCTACGGACCGGGCCGCGACCCG GACAGTCCGCTGCTGCTGGGCTCGGTGAAGTCCAACATCGGCCACACCCAGTCGGCCGCC GGCGTGGCCGGCGTCATCAAGATGGTCCTGGCCCTGCGCAACGGACAGCTGCCGCGCACC CTGCACGCCGACACCCCCTCCAGCCACATCGACTGGACCCCCGGCACCGTCTCCCTGCTG ACCGAACCCACCGACTGGCCCGAGGGCGAGCGCCCGCGCCGCTGCGCGGTCTCCTCCTTC GGCATCAGCGGCACCAACGCCCACACCCTCCTCGAAGAGGCCCCCCGCCCGCACGAGGCG ACCCCCGCGGGGCCGGTGCCCCCGGCCGGGGACGCCATCCCCTGGGTGCTGTCCGCCCGG ACCCCGGGCGCGCTGCGCGCCCAGGCGGCCCAGCTCGCCGCCCACCTCGACGGCGAGGCA CCCGATGCCCTCGACGTCGGCCACACCCTGGTGGCCGCGCGCACCCTCTTCGACCACCGC GCCGTCGTCGTCGGCACCGACGACGCATCCCGGCGCGCGGCCCTGGACGCCCTCGCCACC GGCGGCTCCGCACCCGGCATCGTCCAGGGCACGGCCGACACCGACGGCAGGACCGTCTTC GTCTTCCCCGGCCAGGGCTCCCAGTGGGCCGGCATGGGAGCGCGGCTCCTTGAGGAGTCC CCGGTCTTCGCCGCGCGCCTGACCGAATGCGCCACCGCCCTCTCGGAGTTCGTCGACTGG TCCCTGCTCGACGTGCTGCGCCAGGCCGACGGCGCGCCGACCCTGGACCGCGTCGACGTC GTCCAGCCCGCCTCCTTCGCCGTCATGGTCTCCCTGGCCGCGCTGTGGACCTCCCACGGC ATCACCCCGGACGCCGTGGTCGGCCACTCGCAGGGCGAGATCGCCGCGGCCGCCGTCGCC GGGGCGCTCTCCCTGGAGGACGCGGCCCGCGTCGTCGCGCTGCGCAGCCAGGCCATCGCC CGCGGGCTGGCCGGAACCGGCGGCATGCTGTCGGTCCCGCTGCCCGCCGCCGACGTCGAA CAGCGCCTCGCCGCCTATGAGGACCTGTCGATCGCCGCCGTCAACGGCCCCCGGTCCACC GTCGTCTCCGGCGCCACCGCGCCGCTGGACGCCCTCCAGGCCGAACTGGTCGGCGAGGAC ATCCGTGCCCGGCGCATCGCCGTGGACTACGCCTCGCACTCCGCCCAGGTCGAGCGGGTG CGCGACGAACTGCGCACCGTCCTCGAACCGGTGCGCCCGCGCCCGGCGCAGGTGCCCTTC TTCTCCACCGTCACCGGTGACTGGCTGGACACCACCGTCATGGACGCGGAGTACTGGTTC ACCAACCTGCGCCGGACCGTCCACTTCCAGCCCGCCATCGGCGAACTCCTCGCCCAGGGC CACCACTTCTTCATCGAGGTCAGCTCCCACCCCGTCCTGTCCATGGGCATCCAGGCGACC GCCGAGGAAGCCGGGGCCGCCGCCGCGGTGCTCGGCACGCTCCGGCGCGACACCGGCGCC ACCGACCGCTTCCTGGCCTCCCTGGCCGAAGCCTTCGTCCGGGGCGCGGACGCCGACTGG TCCGCCGTCTTCGCCGGCACCGGCGCCCGCCGGGTGCCGCTGCCCACGTACGCCTTCCAG CGCGAGCACCTGTGGGCGATCCCCGAGCGGTCCCCGGACCGGCCCGAAGCGGATCCCGCG GACGCCGAGTTCTGGACGGCGGTCGAGGAGGAGGACGTCGAGGCGCTCGCCTCCCGGCTG CGCCTGGACCGCACCTCCCTCGCCCCGGTCCTCCCGGCCCTCTCGCACTGGCGCAAGCGC CGCCGCGAGCTGTCCACCGTGGACTCCTGGCGCTACCGCGCCACCTGGAAGCCGCTGACC GGCCTGCCCGCGGCGGCCCTGACGGGCACCTGGCTCGTCGTCGCCCCCGAAGGAGCCGAC ACCGACACCCTCACCGGTGTCCTCGCCGCCCACGGCGCCGGGACGCGCACCCTCGTCCTG GACGACAGCTGCGCCGACCGCGCCACCCTGACCGCGCGCCTGACCGGCCTCGACGGCGCG GCGGACCTCACGGGCGTGGTGTCCCTGCCGGCCCCGGCAGACGAGGCAAGCGCCACCCAC CCGACGCTCAGTCGCGCGGTGACCCTGACCGTCGCGCTCGTCCAGGCGCTCGGCGACGCC GGAATCGACGCACCCCTGTGGTGCCTGACCCAAGGCGCCGTCTCCACCGGTCGCGCGGAC CGGCTCACCCGCCCCGACCAGGCCCAGATCCTCGGCCTCGGCTGGACGGCCGCGCTCGAA CACCCGCAGCGCTGCGGGGCCGGCCTGGTCGACCTGCCCGAGGAGCTGGACCGGCGGGCC GGCGAGCGCCTGGCTGCCGTCCTGACCGGCCGCAGTGGCGAGGACCAGCTCGCCGTCCGC TCCTCGGGCGTCTTCGCCCGCCGCGTCGTCCGCGCCGCCCCCGCGGACCCCGCCCCGGCC CGCCCCTGGACGCCGAGGGGCACCACCCTCGTCACCGGCGGCACCGGCACCCTCGCCCCG CACCTGGCCCGCTGGCTCGCCCAGCAGGGCGCCGAGCACATCGTGCTCACCAGCCGCCGC GGCCCGGCGGCACCCGGCGCAGCGGAACTCGTCCAGGAACTGGCCGAGTTGGGCTGCCAG GCCGAAGCGGTGGCCTGCGACCTGACCGACCGCGACGCGGTCGCGCAGATGCTCGCCGCG CTTCGGGCCGAGGGCCGCACCGTACGCACCGTCGTGCACACCGCCGTCACCATCGAGCTG GCGCCGCTGGACGAGACGACCCTGGACGACTTCGCGAAGGTCATGGACGCCAAGGTCATC GGCGCCCGGCACCTGGACGAACTCCTCGGCGACGACCTGGACGCCTTCGTCCTGTACTCC TCCACCGCCGGTATGTGGGGCAGCGGCGCCCACGCCGCCTACGTCGCCGGAAACGCCTAT CTCAACGCCCTGGCCGAACACCGCCGCGCCCGCGGCGCCCGCGCCACCGCCGTCTCCTGG GGCATCTGGGCCGACGACCTCAAGCTCGGCCGCGTCGACCCCGGCCAGATCCGCCGCAGC GGGCTGGTCTTCATGGATCCCCAACTCGCCCTCACCGGCCTGCGCCAGGCCCTCGACGAC GAGGAAACGCACCTGGCCGTCGCCGACGTGGACTGGGGGCGCTACTACCCCGTCTTCACC GCCGCGCGGCCCACCCGGCTCTTCGAGGACCTGCCCGAGGTGCGGCAGCTGGCGCAGGAG AGCGCCGAAGTCACCGACTCCGGCAGCGAGTTCGCCACCCGGCTCGATGGGCTGGCCGCG GTCGAGCAGGACCGCCTCCTGCTGGATCTCGTCCGTACCGAGGCGGCCACCGCGCTCGGC CATGCCTCACCCGACGTGCTCTCCGAACAACGTGCCTTCCGCGACGTCGGCTTCGACTCC CTGACCGCCGTCGACCTGCGCAACCGCATCGCCTCCGTGACCGGGCTCGCCCTGCCGAGC ACCATGGTCTTCGACTACCCCAACCCGCTCGCACTCGTCGCGTTCCTGCGCGAGTCCCTC GCCGGGTCCGCCACCGGCACCGCCGCCACGACCACGCACACCGCCGCCGCCGACGAGCCC ATCGCCATCATCGGCATGAGCTGCCGCTATCCCGGCGGCGTCGGCTCACCGGAGGACCTG TGGCGACTGGTCACCGAGGGCGGCGACGCCACCGGAGAGTTCCCCGCCGACCGCGGCTGG GACGCCGAGGGCCTCTACGATCCCGACCCCGACCGGGCCGGCCACACCTACTCGACCCGG GGCGGCTTCCTGCATGACGCCGCCGACTTCGACGCCTCCTTCTTCGGCATCTCGCCCCGC GAGGCCCTGGCCATGGACCCCCAGCAGCGCCTGCTGCTGGAGACCTCCTGGGAGGCGATG GAGCGCGCCGGGATCGACCCCGCCACCCTGCGCGGCAGCAGCACCGGCACCTTCATCGGC GCCAGCTACCAGGACTACCGCGCCTTCGGCGCGGGCCCGGACGGCGCCGAGGGACACCTG ATCACCGGCACCATCTCCAGCGTCCTGTCCGGCCGGCTCTCCTACACCTACGGCTTCGAG GGCCCGGCCGTCTCCCTCGACACCGCCTGCTCCTCCTCCCTGGTCGCGCTGCACCTGGCC TGCCAGTCCCTGCGCAACGGCGAGAGCTCCCTGGCCCTCGCGGGCGGTGTCAGCATCATG TCCACGCCGGGCGCGTTCGTCGGCTTCAGCCGGCAGCGCGCGATGGCGGCCGACGGCCGC TGCAAGGCGTACTCCGACCAGGCCGACGGCATGAGCCTGGCCGAAGGCGTCGGCCTCGTC CTCGTCGAGCGGCTCTCCGACGCCCGCCGCAACGGGCACCAGGTCCTGGCCGTCATCCGG GGCTCCGCCGTCAACCAGGACGGCGCCTCCAACGGACTGACCGCGCCCAACGGCCCGTCC CAGCAGCGCGTCATCCGGCAGGCCCTGGCCAACGCCGAGGTGGACCCCGACGGCATCGAC GTCATCGACGGGCACGGCACCGGCACGGCACTCGGCGACCCCATCGAGGCGCAGGCCCTG CTGGCCACGTACGGCCAGGGCCGCGACCCCGAGCACCCGCTGCTCCTGGGCTCCGTCAAA TCCAACATCGGCCACACCCAGATGGCGTCCGGTGTCGCCAGCGTCATCAAGATGGTCATG GCCATGCGCCATGCCGCGGTGCCGCGGAGCCTGCACATCGACCGGCCCTCCAGTCACGTC GACTGGAGCTCCGGCGCCATCCAGCTGCTCACCGAGCCGCTGCCCTGGCCGGCCACCGGG CACCCGCGTCGCGCGGGCGTCTCCTCCTTCGGACTCAGCGGCACCAACGTCCACACCATC CTCGAACAGGCCCCGGAGGACCGGACCGAGGAGGACACCGACACCGCACCGGCCCGCCCG GCCGACCCCACACCCGTCCCCGTGACCCTGTCCGGACGCACCGAAGCGGGCCTGCGCGCC CAGGCCGGACGGCTCCTGACCCACCTCGCCGACCACCCCGAACTTCCGCTCACCGACCTC GCGTTCTCGCTCGCCACCTCCCGGGCCGCCCTGGAGCACCGTGCGGCCGTCGTCACCGAC GACCCCGACACCCTCACCCGCGCCCTGACCGCGCTGCGCGACGCGACCCCCGACGGCGGA CTGCTCACCGGCCGCCCGGACCGCGGCCGGCTCGCCTTCCTCTTCACCGGCCAGGGCAGC CAGCGCCCCGGAATGGGACGCGAGCTCTACGACCGCCACCCGGTCTACGCCGAGGCCCTG GACGCCGTACTGGCCCGCTTCGACCTCGAACTCGACCGCCCGCTGCGGGAGATCCTCTTC GCCGACCCCGGCACCCCCGAGGCCGAACTGCTCGACGACACCGGCTACACCCAGCCGGCC CTGTTCGCCCTCGAAGTGGCGCTGTTCCGTCTCGCCGAGTCCTGGGGCCTGCGCCCCGAC TACGTCGCGGGACACTCCATCGGCGAGCTCGCCGCCGCGCACGCCGCAGGAGTCCTCTCC CTGGAGGACGCCTGCACCCTCGTAGCGGCTCGCGGCCGGCTGATGGCCGCCCTGCCCTCC GGCGGCGCCATGGCCTCCGTCGAGGCCACCGAGGACGAGGCGGCCGCCGTGCTCGCCCCG TACGAGGGACGAGCCGCGGTCGCCGCCGTCAACACCCCCACGTCCCTGGTCGTCTCGGGC GACGAGGACGCGGTACACGCCGTGGCGGCCCACTTCCACGAACTCGGCCGCCGCACCAAG CAGCTGCGCGTCAGCCACGCCTTCCACTCGCCGCATATGGACGCGATGCTGGACGACTTC ACCCGCGCCGCCGAAGGCATCACCTTCCACGCGCCGGAGCTGCCGCTGGTCTCCACCCTC ACCGGAGAGCTGATCCTGGCCGACGACCTGTGCTCGGCGCCGTACTGGACCCGGCAGGTC CGCGGCACCGTCCGCTTCGCCGACGCCGTACGGCACCTCACCGAGCACGGTGTGACGACC TTCTTCGAGCTCGGCCCGGACGCCGTACTCAGCGGCGCGGTACGCGAGAGCACCGGCGAG CAGACCCCCGCCACCGCCGTCCCGGCACTGCGCCGCGACCGGCCCGAGGCCCCCGCACTG ACCACGGCACTGGCCCGGCTCCACCTCCACGGGGTGCGGGTCGACTGGGACGCCGTGTTC GCGGGCGGCGGCGCCCGGCGGATCGACCTGCCCACCTACCCCTTCCAGCGCGAGCGCTAC TGGCCCGAGGCGGCCGCCGGAGCCGCCGCACCCGCACACCCCGCCGACGCGGCGGACGCG GAGTTCTGGTCGGCCGTCGAGCGCGCGGACCTTCCGTCCCTGGGCTCCTCGCTGGACCTG GACGACGACACCCTCACCGCCGTCGTGCCCGCCCTCTCCTCCTGGCGGCGCAAGAGCCGG GAGCGCTCCACCGTCGACGGCTGGCGCTACCGGACCACCTGGAAGCCCCTCACCGGCACG GCCACCGCCGGACACCCGGCCGGGACCTGGCTGGTGCTCGCACCGGCCGACGGCGACCGG GCCTGGACCGATGCGGTCGCCGGGGCCCTGGGCGCCGACGCCGTACGGGTCGAGGTGAGC ACCGCCCAGCGCCAGGAGCTGGCCGAGCGGCTGAGCGAACTGGCCGCGGAACACGGTGAG TTCGCGGGCGTACTGTCCCTGCTGGCAACGGCCGGCGAAGGCGCAGAGGATGCCGATGAC GCCACGACCGAGGGCCTCCTGCTGACGGCGACCGCCCTCCAGGCCCTGGGCGACGCAGGT ATCGACGCCCCGCTGTGGTGCGTGACCCGTACCGCCGTGGCCGTGGACCGCGCCGAACAC CCGGCCCGCCCCGCCCAGGCCGCCGTCTGGGGCCTGGGCAGGGTCGCCGCACTGGAGCAC CCGCAGCGCTGGGGCGGCCTCGTCGATCTCCCCGACGAGCTCGACGGCGCCACCCTGCGC CGCCTGGCCGCCGTCCTCGCCGACAGCGGCGACGAGGACCAGCTCGCCGTACGGACCACC GCGACCTTCGTCCGCCGCCTGGCGCACCACCGGGCCGCACCGGCCCCCGAGGCAGCCACG TTCCGCCCCACCGGAACGGTGCTCGTCACCGGCGGCACCGGTGCGCTCGGCGGCCACGTC GCCCGCTGGCTGGCCGAGGCGGGCGCCGAACATCTGCTGCTGGTCAGCCGGCGCGGCACC GACGCCCCCGGCGCCGGTGAACTGGCGGCTGAAATCGCCGAGTTGGGTGCTCGCGTCACC GTCGCGGCGTGCGACACCGCCGACCGGGACGCGCTCGCCGCCGTACTGGCCGCGATCCCC GACGAGCACCCGCTCACCGCGGTGTTCCACACCGCCGGCACCGTCGACGACGGCACCCTG GACACGCTCACCCCCGAGCAGTTCGCCTCCGTCCTGCGCACCAAGGTCACCGCCACCCGC AACCTGCACGAGACGACCCGCGAGCAGGACCTGAGCGCCTTCGTGCTCTTCTCCTCCGTC GCCGGCACCCTCGGCGCACCCGGCCAGGGCAACTACGCCGCCGGCAACGCCTTCCTCGAC GCCTTCGCCGCACACCGCCGCGCCCACGGCCTGCCCGCCACCTCGCTGGCCTGGGGCCCC TGGGCCGAGACCGGTATGGCGGCCGACGGCACCGGCATCCAGGACCGCGTCCGCCGCGGC GGCTTCACCCCCATGCCGCCCCGGCTCGCCCTCACCGCACTGCGCCGGGCGATCGAGCAC GACGCCACGGCGCTGACCCTCGCGGACATCGACTGGCAGCGCTACGCAGAGGTCTTCACC GCGACCCGCCCCAGCCTCTTCGTCGCCGACCTGCCCGAACTCCAGCAGGTCACGCCGCCC GCCGGGACACCGGAAGCCGCTCTGCGGGAACCGGCCCTGCGCCAACGGCTCGCCGGACTC TCCCCGGCCGCGCGCCCGCGCTTCGTCCTGGACCTGGTACGCACCCAGGTGGCCGCGGTC CTCGGGCACAGCGGCACCTCGGCCATCGGCGCCGAACGCGCTTTCAGTGACCTCGGCTTC GACTCGCTGACCACCGTCGAACTGCGCAACACCCTCACGGCCACCACCGGCCTGAAACTG CCCGCAACCCTCGTCTACGACTACCCGACCCCGACCGCCCTCGCCGACTTCCTGCTCGCC GAACTCCTGGGCGCCCTGCCCGAGTCCGGTGCCCCGGCCTTCGTCGGCCGCGCGGCGGAC GACGATCCCATCGTCATCGTCGGCATGAACTGCCGCTTCCCCGGCGGCATACGGTCCCCC GAGGACCTCTGGCAGCTGCTGAGCAGCGGCGAGGACGCGATCAGCGGATTCCCCGCGGAC CGCGGCTGGGACCTCGACGCGCTCGCCCGCGGCGCCTCCGCCACCCTCGAAGGCGGATTC CTGGACGGCGTCGGCCTCTTCGACGCCCCCTTCTTCGGCATCTCGCCCCGCGAGGCCCTG GCCATGGACCCCCAGCAGCGCCTGCTGCTGGAGACCTCCTGGGAGGCGTTCGAACGCGCC GGAATCGACGCGACCACCCTGCGCGGCAGCCGTACCGGCGTATTCGTCGGCACCAACGGC CAGGACTACGCCACACTCCTGCGCCAGGGCACCGGCACCACCGACATCCGCGGCCATGTC GCCACCGGCAACACCGCCAGCGTCATGTCCGGCCGCCTCTCCTACGCCTTCGGCCTGGAG GGCCCGGCCGTCACCGTCGACACCGCCTGCTCCTCCGCGCTGGTCGCCCTGCACATGGCC GCGGGCGCCCTGCGCAGCGGCGAGTGCACCCTCGCCCTGGCCGGCGGCGTCTCGGTCATG TCCAGCCCCGACTCCTTCACCGAGTTCACGGTCCAGGGAGGGCTGGCCCCCGACGGACGG TGCAAGCCGTTCGCCGATGCGGCCGACGGTACGAGCTGGTCCGAGGGCGTCGGCGTCCTC CTCCTGGAACGGCTCTCCGACGCCCGCCGCAACGGCCACGACGTCTGGGGCATCGTGCGC GGCACCGCGGTCAACCAGGACGGCGCCTCCAACGGGCTGACCGCGCCCAGCGGCCGGGCC CAGCAGCGCGCCATCCGCCAGGCCCTGGCCGACGCCGACCTCGCCCCCGCCGACGTCGAT GTGGTCGAGGCCCACGGCACCGGCACCACCCTCGGCGACCCCATCGAGGCGCACGCCCTC ATCGCCGCCTACGGACAGGACCGGCCGACGGACCGGCCGCTGCTGCTCGGCGCCGTGAAG TCGAACCTGGGTCACACCCAGGCCGCCGCCGGTGTCGCCGGCACCATCAAGGTGCTGCTG GCGATGCGCCACGGCGTGCTGCCCAAGACCCTGCACACCGACTCGCCGTCCGCGCACGTG GACTGGACGGCCGGCACGGTCTCGCTCCTCACCGAACAGCAGGAGTGGCCCGAGACCGGG CACGCCCGGCGGGCCGGTGTCTCCGCCTTCGGCGTCAGCGGCACCAACGCCCACGTCATC ATCGAGCAGGCGCCGGACGCCGAGGAGTCCGTGGCGCCGGAGCCCACCACGGTGCCGGGC CTCGTGCCCTGGCCGGTGTCGGGCAAGTCCGAGGCCGCCCTGGAGGCAGGAATCGAGCGG GTCTCGGCGCTGACCGGCCGGTCACCGGTCGACGTGGGCCACTCCCTCACCACGGGCAGG GCGGCCTTCACCCACCGCGCGGTCCTCGCGGCCGACGGCGCGGGCGTACGGGAACTCGCC CGCGGCGTCGCCCACGAGGCCGACGGGAAGCTGGCGGTGCTGTTCTCGGGCCAGGGCGCT CAACGCGTCGGGATGGGCCGGGAGTTGTATGTCCGGTTCCCGGTGTTCGCCGAGGCGCTG GACGGGGTGCTGGCGCACTTCGATGCCGGGTTGCGGGACGTGATGTTCGGTGATGCGGAG GGCTTGGACGAGACGGGGTTCACGCAGCCCGCGCTGTTCGCCATCGAGGTGGCGTTGTTC CGGCTGGCCGAGTCCCTGGGTGTGCGGCCGGATTTCGTGGGCGGGCACTCGATCGGTGAG ATCGCGGCGGCGCATGTCGCCGGGGTGTTCTCGCTGGCGGATGCGTGTGCGCTGGTGGCG GCCCGTGCGCGGCTGATGCAGGCCCTCCCGGCGGGCGGCGCGATGGTGGCCGTCCAGGCA ACAGCGGAGGAGGCGGCCGCACGGCTGGTCGACGGGGTGTCGATCGCGGCGGTCAACGGC CCGGAGGCGGTGGTGATCGCCGGGGAGCAGCGCGAAGTCCTGCGGATCGCCAAGGAGTTC ACCGGCCTGGGTCGTAAGACACGGCGCCTGCCGGTCAGCCACGCCTTCCACTCGCCGCTG ATGGAGCCAATGCTGGAGGACTTCCGGCGGGTCGCCGAGGGACTGTCGTACGAAGCCCCG CGGATCGCGCTGGTGTCGAACCTCACCGGCGAACTCGCCACCGAGGACCTCGTCCGCTCG GCCGAGTACTGGGTCCGGCATGTGCGCGAGACCGTGCGCTTCGCCGACGGCGTGAGCGCC CTGGCCGCCGAAGGAGCCTCCGTCTTCCTGGAGCTGGGCCCGGACGGGGTGCTGACCGCG ATGGCCCAGCACACCCTGGACGGCACCGCGACCGCCGTACCGGCCCTGCGCAAGGACTGG TCCGAGGAGACCGCGCTGCTGACCGCGCTCGCCCAGCTGCACGTCGTAGGCGTGGGGGTG GACTGGTCCGGGATCTTCGCCGGCACCGGTGCCCGCCGTGTCGACCTGCCCACCTACCCC TTCCAGCACCAGTGGTACTGGCCGGACGGCGCACCCGCCGCGGAGGCGACGACCGGTGCG CAGGACCCCGTGGACGCCGAGTTCTGGGACGCGGTGGAGCGCGCGGACCTCTCGTCGCTC TCCGACAGCCTCGAACTGGACGACGCCGCACTGTCGGCCCTCGTGCCCGCCCTGTCCGCC TGGCGCCGCAAGCGCGTGGAGCGCTCTACCGTCGACGGCTGGCGCTACCACGTGACCTTC AAGCCGCTGACCGGCACCGCGCCCGGCACCCTCGCCGGAACGTGGCTGGCGCTCGTCCCG ACGGGAGCCGCCGACGACGAGTGGACCACTGCCGTACTCGCAGCCCTCGGCGATGCGGTC GTCATCGCGGAAGTCGATCCGGCCGACCGCGGTGCGTTCGCCGGACGGCTCGGCGAACTC GCCGAACGGGGAACCGAGTTCACCGGCGTGGTCTCCTCCTCGCAATCCCGTACGCCTTCG CCCTCCCCTTCGGACCGGCCTGGCCCGACGAGGCGGTGGCGGGCACTGGCCGAGGCGGGC ATCGACGCCCCGCTGTGGTGCGTCACCCGCGACGCGGTGCCGGTGGACCGCTCGGAGAGC GAAGTCAGCCCCGCCCAGGCGGCGGTGTGGGGGCTCGGCAGGGTCGCGGCCCTGGACCAC CCGGACCGCTGGGGCGGCCTGGTCGACGTACCGCAGGAGCACGACCGGCGTACGGCGGAA CGGCTTCGCGCCGTACTGTCCGGCGCCGGCGACGAGGACCAGGTGGCACTGCGGCCCTCC GGCGCCTTCGGACGACGGCTGGTGCGCGCCACGGACGACACCCCCGCGACCCCGTGGCAG CCGGCCGGCACGGTCCTGGTCGTCGGCCCCGCGTCCGGCACCGGCGGACACTGCGCCCGG TGGCTCGCCGGACAGGGTGCCCAGCACCTGGTGCTGGCCGACCGCACCGCACCGGACACG GCGCAGCTGATCGGCGAACTCGACGCCCTGGGCGTGCCGTTGACGGTGCTCGACTGCGCA CCGGCCGACGGTGAGGCGCTGCTGAGCGCGCTCGCCGCGCTCCCGGAGCCGCTGACCGCC GTGATCTACGCGGACGGGCCGTCCGACGCCGACGCCTACGGAACCGCCACCACCGCGGAC CCCGGCGCATCCCTGGCCGCGCTGTACGCGGACGTGGAGAGCCTGGCGGCCGTGGCCGAG GCGGCGACCGGCGCTCGCCCCCTGGGCGCGTTCGTCCTCTTCTCCTCGATCGCCGGGACC TGGGGTGCCGGAGGCCGGGGCACCGAGGCCGCGGCCGGAGCCCAACTCGACGCCCTGGCA GGTATGTTGCGTGCCCGAGGACTGCCTGCCACGGCGGTCTCGTGGGGCGGCTGGGCCGAC GCCACCTCCGGCAGCCTGGCCGCACACCTGCGGGCCAACGGGCTGCCCCCGATGGACCCC GCGCGGGCCCTGACCGCGCTCGCCCGCTCCCTGGGCACCGACACCCCCTCGGTGACGGTC GCCGACGTACGGTGGGACGAGTTCGCGCCCGCCTTCACCCGCAGGCGGCACAGCGCCCTG TTCGCCGAACTCCCCGAGGCCCGCGAGGCGCTGGCGGAGTCGGACGGCAGCGCGCCGGGA ACGGCGGATGCCGCGTCCGGCCTGCGGGCCGAACTCGCCGCCCGCCCGGACGCGGAGCGC ACGGAGCACCTGCTGGCCCTGGTCCGCGACCGCGTGGCGGCCGTGCTCGGGTTCGCGGAC GCCGACGCCGTACCCTCCGGCCAGGCGTTCACGGACCTCGGCTTCGACTCGCTGACCGCG GTCGACCTGCGCAACCAGCTCGCCGTCGCGACGGGTCTGGCCCTGCCCGCCACCCTCGTC TTCGACTACCCCACGGCCGACGCGCTCGCCGGTTACCTGCGGGCCGAACTCCTCGGCGAG GGCGGGAAGGACGCGGAGGAACTCCCCGCGGTGGTGCGGACGAAGGACGCCGACACCGCC GAGGACCCGGTCGTCATCGTCGGCATGAGCTGCCGCTACCCGGGTGGGATCCGCTCGCCC GAGGACCTGTGGCAGCTGGTCATGGGCGAAGCGGACGCCATCGGAGGCTTCCCCACCGAC CGCGGCTGGGACCTGGACCGGCTGCTGCACGGCGACCGGGACGGCCGCGGCCGGACCGTC ACCGGCCAGGGCGGATTCCTCTACGACGTGGCCGACTTCGACCCCGGGTTCTTCGGCATC GCGCCGCGTGAGGCGATGGTGATGGACCCGCAGCAGCGCATCCTGCTGGAAGCCACCTGG GAGGCCCTGGAGCGCACCGGCATCGACCCCGCCCGGCTGCGCGGCGGCGACACCGGCGTG TTCATCGGCGGCGGCTCGGGCGACTACCGGCCCGAAGCGGGCCAGCTGGGGCATGCGCAG ACCGCGCAGTCGGCGAGCCTGCTCTCCGGCCGGGTGGCCTACCACTTCGGCCTGGAAGGA CCCTCCGTCAGCGTCGACACGGCGTGCTCGTCGTCCCTGGTGGCGCTCCACCTGGCCGCC CAGGCCCTGCGCAACGGCGAATGCTCCATCGCCCTGACCGGCGGTGTGACGGTGATGTCC AGCCCGGTGAACTTCGTCGAGTTCGGCGAGATGGGAGCCCTGGCACCGGACGGGCGCTGC CGGCCGTTCGCGTCCGCCGCGGGCGGCACCGGCTGGTCCGAGGGCGTGGGCGTCCTCGTC CTGGAACGGCTCTCCGACGCCCGCCGCAACGGGCACGAGGTGCTCGCGGTACTGCGCGGC TCGGCCGTCAACCAGGACGGCGCCAGCAACGGCATCACCGCGCCCAACGGCCCCTCGCAG CGCCGCGTCATCCAGCGGGCGCTGGCCAACGCGGGGCTGGCGCCGGCCGACGTGGACGCC GTGGAGGCACACGGCACCGGCACCACCCTGGGCGACCCCATCGAGGCGCAGGCGCTGCTG GCCACGTACGGGCAGGGCCGTGACCCCGAACTGCCCTTGCTGCTGGGCTCGGTGAAGTCC AACATCGGCCACACCCAGGCGGCCGCCGGCATCGCCGGTGTGATCAAGATGGTGCTGGCG ATGCGCCACGGCATGCTGCCCAGGAGCCTGCACATCGACGAGCCCTCGGCACATGTCGAC TGGAGCGCCGGGGCCGTCGAACTGCTGGCGCAGGCGGCCGACTGGCCGCGTACCGGCCGC CCGCGACGGGCCGGAATCTCGGCCTTCGGCGCCAGCGGCACCAACTCCCACGTGATCATC GAGCAGCCCGCACCGACCGTTGCGGAGGAGCCCGAGCGCCCGCAGGAGGCGGGCGGCCCG CTGCCGGTGCCGGTGTCCGGCGCCGTACCGGACGCGCTGCGGGCCCAGGCCCGGCAGCTG CACGCCTACGTGGCCGGTCGGCCCGGCCTCACCGTCGCCGAGTTCGCGCTGTCCACCGCC ACCACCCGGTCGGCCTTCACCCACCGGGCCGCCGTCCTCGCCGAAGACCGCGAGGAACTG CTCGCGGGTCTGGCCGCGCTCGCCGGCGGGCTCGACACCCCCCAGGTCCTGCGGGGCCGG GTCGCGGAGCGCCGCGGCAGGCTCGCGGTGCTGTTCTCCGGCCAGGGATCGCAGCGCGTG GGCATGGGACGGGAACTGCACGCCCGCTTCCCGGTGTTCGCGGAGGCCCTGGACGAGGTG ACGGCACGCCTGGAAGCGGAACTGGAACTCCCGCTGCGGGAGGTCATGTTCGGCGACTCG GAGCGGCTGAACGAGACGGGCTACACCCAGCCCGCGCTGTTCGCGATCGAGGTCGCGCTG TTCCGTCTGGTCGCCTCCTGGGGCATCCGCCCGGACTTCGTCGCCGGGCACTCCATCGGC GAGATCGCGGCCGCGCACGTGGCCGGGGTCTTCTCCCTGGACGATGCGTGCCGGCTGGTG GCCGCACGGGCGCGGCTGATGAACGCCCTGCCCGCGGGCGGCGCCATGGTGGCCGTCCAG GCCACCGAGGAGGAGACCCGCGCCTGCCTGACCGACGGCGTGTCCATCGCCGCGGTCAAC GGACCGCGCTCGGTGGTCCTCTCCGGCGACGAGGCCGCCGTACTCGACCTGGCGGAGAAG TTCACCGCCGACGGGCGCAAGACTAGGCGTTTGCGGGTGAGCCATGCATTTCACTCACTG CACATGGACGCCGTTCTCGACGACTTCCGACGAGTCGCCCAAAGCGTCGGCTACGACGCC CCCACGATCCCGCTCGTGTCCAACGTGACCGGCGAGGCGGCGACCGAGCGGCAGGTGTGC TCCCCCGACTACTGGGTGCGCCACGTCCGCGAGGCCGTCCGCTTCGGCGACGGTGTCCGC ACCCTCGCCGACCGCGGAGTGACCGCGTTCCTGGAGCTGGGCCCCGACGGCGCGCTGTGC GCCATGGCCCAGGAGACCCTGGACACCCTGCCCTCGCCGGCGGTCACCGTACCGGCGCTG CGCAGGGACCGCGGTGAGCAGGAGTGTGTGGTCACCGCGCTCGCCCGGCTGCACGTCGAC GGAGTGAGCCCGCACTGGCCCGCCGTACTCACCGGGCCCCGGACCGCGCCCCGCCGCACC GACCTGCCCACCTACCCCTTCCAGCACCAGCGGTTCTGGCCGGCCGCCCAGCCCGCCACC GACCCCACCCCGGCGACCGCCGCGGACGACGGCTTCTGGTCGGCGGTGCGGGAGGCGGAC TTCGCGGACCTCGCCACGACGCTCGACGTCGAGCGCGACGCGCTGTCCACGGTGCTCCCC GCGCTCGCGGACTGGCGCCGCAGGCGCGAGGAGTCCGGCACGGTCGACGGCTGGCGGCAG CAGATCACCTTCGAGCCGCTGACCCGCACGCCCTCCCACACCCCGGCGGGCACCCGGCTC GCCGTGATCCCGGCAGGGCATGAGCAGGACCCATTGGTCGCCGATGTCGTCGCGGCCCTG GGCCCGGACACCGTACGCCTCACCGCGCCCGGCAGCGACCGGGCCGCCCTGGCCGACCTG CTGCGCCAACAGGCCGCCGACGGAACCGAGTTCACCGCCGTGGTCTCCCTGCTCGCCCTC GCCACGGAGCCCGCCCACTCGGAGCCCGCCCACTCGGAGCCCGCCCACCCGGCGCACGCC CCCGAGGCGCTGGCCCTCACCACCACCTTGATCCAGGCGCTCGGCGACGCGGACCTTGCC GCACCCCTGTGGTGCGTCACCCGCGGCGCGGTCGCCGCTGCGCCCGGCGAGCCGGTGTCC GGACCCGCCCAGGCCGCCGTATGGGGACTGGGTCGGGTGGCCGCCCTGGAGTACCCGCAG CGCTGGGGTGGTCTGATCGACCTGCCCGCCGCTCTGGACGACCGCACCGCCGCCCGTCTC GCCGATGTGCTCGCCGCCCCCGGCGGCGAGGACCAGATCGCGATCCGGCCCTCCGCCGTC CTCGGCCGCAGGCTGGTCCCCGTACCGGCCGGGCGGACCACCCGGGAGTGGAACCCCACC GGAACCGTCCTGATCACCGGCGGCACCGGAGCACTGGGCGCCCGCGTGGCACGGGAACTG GCACGGGCGGGCGCAGAGCACCTGCTGCTGCTGAGCCGCCGGGGCCCGGACGCGCCCGGC GCGGACGCACTGCGGGCCGAACTCACCGCGCTCGGCGCGGACGTCACCCTCACCGCATGC GACGCCGCCGACCGCGACGCGCTCGCGAAGGTCCTGGCGGACATCCCCGAGACGTCCCCC CTGACCGGCGTCGTCCACACCGCCGGCGTCATCGACGACGGTGTCCTGGACAGCCTCACC CCGGACCGGTTCGAGGACGTCTTCCGCGCCAAGGCCGCCTCGGCCCTGGCCCTGCACGAC CTCACCGAGGACCTGGACCTGGCGGTGTTCGCCCTGTTCTCCTCGTCCTCCGGAGCGGTC GGCAACGCGGGCCAGGCCAACTACGCCGCCGCCAACGCCTTCCTGGACGCGCTCGCCGAA CGGCGCCGGGCCCAGGGCCTGGCCGCGACATCCCTCGCCTGGGGTGTATGGGGAGGCGGC GGAATGGCCGCCGACCAGCGCGCGGCCGACGTGGCCCGGCGCACCGGAATCCGCCCGCTG GACCCGGACCTCGCCGTCGTGGCGCTGCGCCGGGCCGTCATGGACGGGCGGCCCACCGAG GTCGTCGCCGACATCGAACGCGACCTGTTCGTCCGCTCCTTCACCGCCGTACGGCCCAGC CCGCTGCTCGGCGCGCCGACCGTCGACGCCGAGCACCGGGCGGCGGGGGACACCGGCGAG GACACCACGGGCGACGCGCTGCGCGCGAAGCTGACGGGCCTGCCGCCCGCCAAGCGCTCC GAGGCCGTACGGGACCTGGTGCGCACCCGGGCCGCGGCCGTACTGGGACACCCCACAGCC GACGCCGTAGGCGCCGACCGGGCGTTCCGTGACCTCGGCTTCGACTCCCTCAGCGCCGTC GAACTGCGCAACCAGCTCGGCGCCGCTACCGGACTGAACCTGACCGCCACGCTCGTCTTC GACCACCCCAACCCCGCCGCCCTGGCAGACCACCTCCTGAGCCTGCTCGTCCCCGACGAG GACCCGGGGGAGGGGACAGCCGACGACGGCGACCCGGACTCCTCCGCCATCAGGGCCCTG CTCGCCTCCGTCTCCGTGGCCCAGCTGCGCGAGATCGGCGTGCTCGAACCCCTGCTGAAG CTCGCCGCCGAGCAGACCGCTGCGTCCGGCGCCGAGGCCGCCGCCGCGACCGCAGCGGAC GCCTACGACGAGTCGATCGACGCGATGGACATCGCCGACCTGGTGCAGGCGGCATTCGAC GGCAATTCCCCCCAAGAGCGCTGA
Feature
| BLASTP Database:UniProtKB:2011_09 |
|
|---|---|
| InterPro Database:interpro:38.0 |
IPR001227 Acyl transferase domain (Domain)
IPR006162 Phosphopantetheine attachment site (PTM)
IPR009081 Acyl carrier protein-like (Domain)
IPR013968 Polyketide synthase, KR (Domain)
IPR014030 Beta-ketoacyl synthase, N-terminal (Domain)
IPR014031 Beta-ketoacyl synthase, C-terminal (Domain)
IPR014043 Acyl transferase (Domain)
IPR015083 Polyketide synthase, docking (Domain)
IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase (Domain)
IPR016036 Malonyl-CoA ACP transacylase, ACP-binding (Domain)
IPR016038 Thiolase-like, subgroup (Domain)
IPR016039 Thiolase-like (Domain)
IPR016040 NAD(P)-binding domain (Domain)
IPR018201 Beta-ketoacyl synthase, active site (Active_site)
IPR020801 Polyketide synthase, acyl transferase domain (Domain)
IPR020806 Polyketide synthase, phosphopantetheine-binding domain (Domain)
IPR020807 Polyketide synthase, dehydratase domain (Domain)
IPR020841 Polyketide synthase, beta-ketoacyl synthase domain (Domain)
IPR020842 Polyketide synthase/Fatty acid synthase, KR (Domain)
|
| SignalP | No significant hit |
| TMHMM | No significant hit |
![[552-686] G3DSA:3.40.366.10](../../img/X2.gif "[552-686] G3DSA:3.40.366.10"){kind=small}
![[1725-1740] PS00012](../../img/P.gif "[1725-1740] PS00012"){kind=small}
![[1701-1766] 2.6e-12 PF00550](../../img/H.gif "[1701-1766] 2.6e-12 PF00550"){kind=small}
![[1697-1767] PS50075](../../img/M.gif "[1697-1767] PS50075"){kind=small}
![[1690-1805] 1e-28 SSF47336](../../img/B.gif "[1690-1805] 1e-28 SSF47336"){kind=small}
![[562-884] 3.699978135861e-107 SM00827](../../img/R.gif "[562-884] 3.699978135861e-107 SM00827"){kind=small}
