化学物質管理

外部発表文献

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分解性・蓄積性関連

  1.  1.Cheng, F. Ikenaga, Y., Zhou, Y, Yu, Y. Li, W., Shen, J. Du, Z. Chen, L. Xu, C. Liu, G. Lee, P. W. and Tang, Y. 2012. In Silico Assessment of Chemical Biodegradability. J. Chem. Inf. Model. 52: 655-669.
  2.  2.Sakuratani, Y. Noguchi, Y. Kobayashi, K. Yamada, J. and Nishihara, T. 2008. Molecular size as a limiting characteristic for bioconcentration in fish. Journal of Environmental Biology January 29: 89-92.
  3.  3.Sakuratani, Y. Kasai, K. Noguchi, Y. and Yamada, J. 2007. Comparison of predictivities of Log P calculation models based on experimental data for 134 simple organic compounds. QSAR & Combinatorial Science 26: 109-116.
  4.  4.Hori, K. Ikenaga, Y. Arata, K. Takahashi, T. Kasai, K. Noguchi, Y. Sumimoto, M. and Yamamoto, H. 2007. Theoretical study on the reaction mechanism for the hydrolysis of esters and amides under acidic conditions. Tetrahedron, 63: 1264-1269.
  5.  5.Weisbrod, A. V. Burkhard, L. P. Arnot, J. Mekenyan, O. Howard, P. H. Russom, C. Boethling, R. Sakuratani, Y. Traas, T. Bridges, T. Lutz, C. Bonnell, M. Woodburn, K. and Parkerton. T. 2007. Workgroup report: review of fish bioaccumulation databases used to identify persistent, bioaccumulative, toxic substances. Environmental Health Perspectives 115: 255-261.
  6.  6.櫻谷 祐企. 2007. "構造活性相関". 指宿 堯嗣, 上路 雅子, 御園生 誠 編. 環境化学の事典.(朝倉書店, 東京)175: [in Japanese].
  7.  7.中島 基樹, 櫻谷 祐企, 野口 良行, 山田 隼, 堀 憲次. 2007. 量子化学計算による反応解析を用いた加水分解予測システムの開発. Journal of Computer Aided Chemistry 8: 103-113. [in Japanese]
  8.  8.Sakuratani, Y. Yamada, J. Kasai, K. Noguchi, Y. and Nishihara, T. 2005. External validation of the biodegradability prediction model CATABOL using data sets of existing and new chemicals under the Japanese Chemical Substances Control Law. SAR and QSAR in Environmental Research 16: 403-431.
  9.  9.Sakuratani, Y. Kasai, K. Yamada, J. Noguchi, Y. 2004. CERI Biodegradation Prediction System. OECD Series on Testing and Assessment Number 49; The Report From The Expert Group on (Quantitative) Structure-Activity Relationships [(Q)SARs] on The Principles for The Validation of (Q)SARs, (OECD, Paris) ANNEX 10, p186-197.

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毒性関連

  1.  1.櫻谷 祐企 2013. "化学物質の安全性予測におけるOECD QSAR Toolboxの活用". 小島 肇夫 編. In vitro 毒性・動態評価の最前線.(シーエムシー出版, 東京)第Ⅱ編, 第2章. [in Japanese]
  2.  2.Sakuratani, Y. Zhang, H. Q. Nishikawa, S. Yamazaki, K. Yamada, T. Yamada, J. Gerova, K. Chankov, G, Mekenyan, O. and Hayashi, M. 2013. Hazard Evaluation Support System (HESS) for Predicting Repeated Dose Toxicity Using Toxicological Categories. SAR QSAR Environ. Res. 24: 617-629.
  3.  3.Yamada, T. Hasagawa, R. Nishikawa, S. Sakuratani, Y. Yamada, J. Yamashita, T. Yoshinari, K. Kamata, E. Ono, A, Hirose, A. and Hayashi. M. 2013. A new parameter that supports speculation on the possible mechanism of hypothyroidism induced by chemical substances in repeated-dose toxicity studies. J. Toxicol. Sci. 38:291-299.
  4.  4.Yamada, T. Tanaka, Y. Hasegawa, R. Sakuratani, Y. Yamada, J. Kamata, E. Ono, A. Hirose, A. Yamazoe, Y. Mekenyan, O. and Hayashi, M. 2013. A category approach to predicting the repeated-dose hepatotoxicity of allyl esters. Regul. Toxicol. Pharmacol. 65: 189-195.
  5.  5.Sakuratani, Y. Zhang, H. Q. Nishikawa, S. Yamazaki, K. Yamada, T. Yamada, J. and Hayashi, M. 2013. Categorization of nitrobenzenes for repeated dose toxicity based on adverse outcome pathways. SAR QSAR Environ. Res. 24: 35-46.
  6.  6.阿部 武丸, 小林 克己, 西川 智, 山田 隆志, 長谷川 隆一, 櫻谷 祐企, 山田 隼, 広瀬 明彦, 鎌田 栄一, 吉田 緑,簾内 桃子,本間 正充,山下 辰博,酒井 広太,山添 康, 林 真. 2012. Hazard Evaluation Support System Database (HESS DB) の開発. PHARM STAGE 12(5): 39-47. [in Japanese]
  7.  7.Yamada, T. Tanaka, Y. Zhang, HQ. Hasegawa, R. Sakuratani, Y. Yamada, J. and Hayashi, M. 2012. A category approach to predicting the hemolytic effects of ethylene glycol alkyl ethers in repeated-dose toxicity. J. Toxicol. Sci. 37:503-515.
  8.  8.櫻谷 祐企. 2012. カテゴリーアプローチによる反復投与毒性の評価を支援する有害性評価支援システム統合プラットフォーム(HESS). 産業と環境 41(9) : 101-104. [in Japanese]
  9.  9.Hayashi, M. and Sakuratani, Y. 2012. Development of an Evaluation Support System for Estimating Repeated Dose Toxicity of Chemicals Based on Chemical Structure. In: New Horizons in toxicity Prediction. Wilson, A. G. E. ed. (Royal Society of Chemistry, Cambridge) Chap. 3.
  10. 10.Kobayashi, K. Sakuratani, Y. Abe, T. Yamazaki, K. Nishikawa, S. Yamada, J. Hirose, A. Kamata, E. and Hayashi, M. 2011. Influence of coefficient of variation in determining significant difference of quantitative values obtained from 28-day repeated-dose toxicity studies in rats. J. Toxicol. Sci. 36:63-71.
  11. 11.Hayashi, M. and Sakuratani, Y. 2011. Hemolytic anemia induced by anilines and nephrotoxicity induced by 4-aminophenols. In: OECD Environment, Health and Safety Publications Series on Testing and Assessment No. 138 , Report of the Workshop on Using Mechanistic Information in Forming Chemical Categories. (OECD, Paris): Annex 8.
  12. 12.小林 克己, 櫻谷 祐企, 阿部 武丸, 西川 智, 山田 隼, 広瀬 明彦, 鎌田 栄一, 林 真. 2010. ラットを用いた短期反復投与毒性試験の低用量群に統計学的有意差が検出される割合. 2010. PHARM STAGE 9(10):49-52.
  13. 13.Kobayashi, K. Sakuratani, Y. Abe, T. Nishikawa, S. Yamada, J. Hirose, A. Kamata, E. and Hayashi, M. 2010. Relation between statics and treatment-related changes obtained from toxicity studies in rats: if detected a significant difference in low or middle dose for quantitative values, this change is considered as incidental change? J. Toxicol. Sci. 35:79-85.
  14. 14.Nishikawa, S. Yamashita, T. Imai, T. Yoshida, M. Sakuratani, Y. Yamada, J. Maekawa, A and Hayashi, M. 2010. Thesaurus for histopathological findings in publically available reports of repeated-dose oral toxicity studies in rats for 156 chemicals. J. Toxicol. Sci. 35: 295-298.
  15. 15.小林 克己, 櫻谷 祐企, 阿部 武丸, 西川 智, 山田 隼, 広瀬 明彦, 鎌田 栄一, 林 真. 2010. 毒性試験から得られる定量値に対する有効数値の桁数の差違およびMann-WhitneyのU検定とWikoxonの検定の有意差検出の違い. PHARM STAGE 10(3):45-48. [in Japanese]
  16. 16.小林 克己, 櫻谷 祐企, 阿部 武丸, 山崎 和子, 西川 智, 山田 隼, 広瀬 明彦, 鎌田 栄一, 林 真. 2010. 化審法のラットを用いた28日間反復投与毒性試験に使用された病理組織学所見の統計解析法に対する一考察. 畜産の研究 64:911-914. [in Japanese]
  17. 17.小林 克己, 櫻谷 祐企, 阿部 武丸, 西川 智, 山田 隼, 広瀬 明彦, 鎌田 栄一, 林 真. 2009. ラットを用いた短期反復投与毒性試験から得られた定量値解析法. PHARM STAGE 9(3):62-69. [in Japanese]
  18. 18.Kobayashi, K., Pillai, K. S., Sakuratani, Y. Suzuki, M. and Wang, J. 2008. Do we need to examine the quantitative data obtained from toxicity studies for both normality and homogeneity of variance? The Journal of Environmental Biology, 29: 47-52.
  19. 19.Sakuratani, Y. Sato, S. Nishikawa, S. Yamada, J. Maekawa, A. and Hayashi, M. 2008. Category analysis of the substituted anilines studied in a 28-day repeat-dose toxicity test conducted on rats: Correlation between toxicity and chemical structure. SAR QSAR Environ. Res. 19:681-696.
  20. 20.Kobayashi, K., Pillai, K. S., Sakuratani, Y., Abe, T., Kamata, E. and Hayashi, M. 2008. Evaluation and assessment of statistical tools used in short-term toxicity studies with small number of rodent, Journal of Toxicological Science, 33: 97-104.
  21. 21.小林 克巳, 櫻谷 祐企, 阿部 武丸, 西川 智, 山田 隼, 広瀬 明彦, 鎌田 栄一, 林 真. 2008. 日本と外国のげっ歯類を用いた毒性試験に使用された統計解析法の相違. PHARM STAGE 8(8):40-48. [in Japanese]
  22. 22.小林 克己,櫻谷 祐企,中島 基樹,佐藤 佐和子,山田 隼(2007):化審法によるほ乳類を用いる28日間反復投与毒性試験に使用された統計学的手法の分類と評価,PHARMASTAGE, 7, No. 5, 63-76. [in Japanese]

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