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General Information

General Information
- General Information Data Description
  - CHRIP_ID C004-666-64A CAS RN 127-18-4
    
    Chemical Substance Name Perchloroethene
    
    Molecular Formula C2Cl4
    
    Molecular Weight 166
    
    SMILES ClC(Cl)=C(Cl)Cl
    
    Structure

Synonym

Synonym Data Description

Synonym	1,1,2,2-Tetrachloroethene
	1,1,2,2-Tetrachloroethylene
	Ethylene tetrachloride
	perc
	Perchloroethylene
	Perclene
	Tetrachloroethene
	Tetrachloroethylene
	Tetrachloroethylene (Perchloroethylene)
	Tetrachloroethylene; Perchloroethylene

Nikkaji
- Information of Japan Chemical Substance Dictionary (Nikkaji) Data Description
  - Nikkaji Number
    J3.261A
    Detail to J-GLOBAL

Laws and Regulations in Japan

Act on the Evaluation of Chemical Substances and Regulation of Their Manufacture, etc. (Chemical Substances Control Law ; CSCL)

Japan CSCL: Class II Specified Chemical Substances Data Description Import Clearance Procedures[PDF] Notification of the Manufacturing Amount, etc (METI site : in Japanese)

Cabinet Order Number	2	Date of Designation in the Official Gazette	1989/03/29
		Date of Enforcement by the Cabinet Order	1989/04/01
Chemical Substance Name	Tetrachloroethylene
Remarks	-
Details	to J-CHECK

Japan CSCL: Existing Chemical Substances Data Description Definition of the terms of Section 6 [PDF] Definition of the terms of Section 7 [PDF] Import Clearance Procedures[PDF] Notification of the Manufacturing Amount, etc[PDF]

MITI Number	2-114	Category	Section 2
Chemical Substance Name	Tetrachloroethylene
Remarks	-
Details	to J-CHECK
Remarks to Existing Chemical Substances of Industrial Safety and Health Act	Chemicals have been notified in accordance with the provisions of Chemical Substances Control Law by June 29, 1979
Details to Existing Chemical Substances of Industrial Safety and Health Act	to MHLW site (in Japanese)

Japan METI: Biodegradation and Bioconcentration Results Data Description

Chemical Substance Name	tetrachloroethylene
Judgement of Biodegradation	Not readily biodegradable	Judgement of Bioconcentration	Low bioconcentration
Test result of Bioconcentration	-	Test result of Partition Coefficient	-
Details	to J-CHECK

Japan MOE: Results of Eco-toxicity tests of chemicals Data Description
- Chemical Substance Name Tetrachloroethylene
  
  Details to J-CHECK

Act on Confirmation, etc. of Release Amounts of Specific Chemical Substances in the Environment and Promotion of Improvements to the Management Thereof(PRTR-SDS Law)

Japan: PRTR-SDS Law (until March 2023) Data Description Outline PRTR Law (METI site) Analysis of PRTR data

Classification	I	Cabinet Order Number	1-262
Cabinet Order Name	Tetrachloroethylene
Remarks	-
Basis of selection	Hazard Data (in Japanese)
Link	Releases Map (in Japanese) Atmospheric concentration Map (in Japanese)

Japan: PRTR-SDS Law (from April 2023) Data Description Outline PRTR Law (METI site)

JPSN(Japan PRTR-SDS Number)	262	Classification	I	Cabinet Order Number	1-301
Cabinet Order Name	Tetrachloroethylene
Remarks	-
Basis of selection	Hazard Data (in Japanese)
Link	- -

Industrial Safety and Health Act (ISHA)

Japan ISHA: Chemical Substances Requiring Labeling and Delivery of Documents, etc. Data Description GHS compatible model label creation method (MH LW site : in Japanese) Risk assessment implementation support tool (MHLW site : in Japanese)

Cabinet Order Number	Attached table 9-359 of Cabinet order
Cabinet Order Name	Tetrachloroethylene(otherwise known as Perchloroethylene)
Range of Application for Label (weight%)	>=0.1
Range of Application for SDS (weight%)	>=0.1

Japan ISHA: Chemical substances that cause skin disorders, etc. and other chemical substances that must be handled with impermeable protective equipment etc. based on special chemical regulations. Data Description Target substances list(MHLW site: in japanese)
- Substance Name Tetrachloroethylene (synonym: Perchloroethylene)
  
  Classification of Target Substances Special chemical regulations etc. Cutoff value(weight %) 1
  
  Details to the GHS Classification

Japan ISHA: Specified Chemical Substances Data Description Link to the Ordinance (JISHA site : in Japanese)

Category	Group-2 substances	Cabinet Order Number	Attached Table 3-2-22-4 of Cabinet order
Cabinet Order Name	Tetrachloroethylene (synonym: perchloroethylene)
Range of Application (weight %)	>1
Remarks	Substances under special supervision / Special organic solvent, etc.

The above information have been provided by the Ministry of Health, Labour and Welfare

Japan ISHA: Administrative Control Levels of Working Environment Evaluation Standards Data Description Working Environment Measurement (MHLW site : in Japanese)
- Registration Number
  20.4
  
  Kinds of substances Tetrachloroethylene (otherwise known as perchloroethylene)
  
  Control Level 25ppm
  
  The above information have been provided by the Ministry of Health, Labour and Welfare

Japan ISHA: Guidelines for Carcinogenic Substances Data Description
- Name Tetrachloroethylene (synonym: perchloroethylene)
  
  Details to MHLW site (in Japanese)

Air Pollution Control Act

Japan Air Pollution Control Law Data Description Air & Transportation (MOE site)

Classification	Volatile Organic Compounds (VOC)	Cabinet Order Number	Article 2-4 of Act
Cabinet Order Name	Any organic compound (excluding substances specified by a Cabinet Order as not being sources from which suspended particulate matter or oxidants are generated) that is in a gaseous state at the time of its emission or dispersal into the atmosphere.
VOC Emission Inventory Substance Code	63-02-06
VOC Emission Inventory Substance Name	Tetrachloroethylene

Classification	Hazardous Air Pollutants(Designated Substances)	Cabinet Order Number	3-3 of Supplementary Provisions of Cabinet Order
Cabinet Order Name	Tetrachloroethylene
Remarks	Substance specified in Section 9 of the Supplementary Provisions of the Act : Substances whose emission or dispersion must be urgently controlled to prevent damage to human health caused by air pollution by hazardous air pollutants, and which are specified by a Cabinet Order.

Classification	Substances that may be classified as Hazardous Air Pollutants	Cabinet Order Number	122 of Central Environment Council 9th Report (Appendix 1)
Cabinet Order Name	Tetrachloroethylene

Classification	Substances that may be classified as Hazardous Air Pollutants (Priority Action Substances)	Cabinet Order Number	13 of Central Environment Council 9th Report (Appendix 2)
Cabinet Order Name	Tetrachloroethylene

Water Pollution Prevention Act
- Japan Water Pollution Control Law Data Description Water / Soil / Ground Environment (MOE site)
  - Classification Harmful Substances Cabinet Order Number
    Article 2-10 of Cabinet order
    
    Cabinet Order Name Tetrachloroethylene
    
    Effluent Standards 0.1mg/L

Soil Contamination Countermeasures Act

Japan Soil Contamination Countermeasures Act Data Description Water / Soil / Ground Environment (MOE site)

Classification	Class 1	Cabinet Order Number	Article 1-15 of Cabinet order
Cabinet Order Name	Tetrachloroethylene
Soil Leachate Standard	0.01mg/L
Soil Concentration Standard	-
Decomposition products	Chloroethylene, 1, 1-Dichloroethylene, 1, 2-Dichloroethylene, Trichloroethylene

Act on the Control of Household Products Containing Harmful Substances

Japan Act on the Control of Household Products Containing Harmful Substances Data Description Summary of Criteria [PDF]

Cabinet Order Number	8
Cabinet Order Name	Tetrachloroethylene
Applicable Household Goods	Aerosol products for household use, household cleaners
Standards	For details to standards provided for by Ordinance for Enforcement of the Law for the Control of Household Products (Article 1)

Laws and Regulations in Other countries

Recommendations on the transport of dangerous goods
- Dangerous Goods List (UN Number and Hazard class) Data Description
  - UN Number
    1897
    Class or Division 6.1
    
    Name and Description TETRACHLOROETHYLENE
    
    UN packing group III

International Convention on the Commodity Description and Coding Systems (HS Convention)

HS Code: Section VI “Products of the Chemical or Allied Industries" Data Description

Chapter	29	Chapter name	Organic chemicals
Heading	2903	Substance name (Heading)	Halogenated derivatives of hydrocarbons
HS Code	2903.23	Substance Name	Unsaturated chlorinated derivatives of acyclic hydrocarbons : Tetrachloroethylene (perchloroethylene)

Association of South-East Asian Nations(ASEAN)
- The ASEAN-Japan Chemical Safety Database (AJCSD).: Laws and Regulations Data Description
  - Detail to AJCSD
- The ASEAN-Japan Chemical Safety Database (AJCSD).: GHS-Related Information Data Description
  - Detail to AJCSD

European Union (EU)
- EC Inventory Data Description
  - EC Number
    204-825-9
    
    EC Name Tetrachloroethylene
    
    Description -
    
    Substance Infocard Infocard
    
    ECHA Name -
- EU: CLP Harmonised Classification Data Description To ECHA site
  - Index Number 602-028-00-4 EC Number 204-825-9
    
    Chemical Name tetrachloroethylene
    
    Classification Carc. 2 / Aquatic Chronic 2

US: Toxic Substances Control Act (TSCA)
- TSCA Inventory Data Description
  - TSCA Chemical Substance Name Ethene, 1,1,2,2-tetrachloro-
    
    DEF -
    
    UVCB -
    
    FLAG -
    
    ACTIVITY ACTIVE

China
- China: Catalog of Hazardous Chemicals 2015 Data Description
  - Number
    2064
    
    Name Tetrachloroethene
    
    Other Name Perchloroethene
    
    Remarks -

Korea

Korea: ARECs (K-REACH) / CCA; Hazardous Substance(s), Priority Control Substances Data Description
- Number
  06-5-12
  
  Category Restricted Substance(s)
  
  Chemical Substance Name Tetrachloroethylene
  
  Range of Application (%)
  >=0.1
  
  Number
  97-1-297
  
  Category Toxic Substance(s)
  
  Chemical Substance Name Tetrachloroethylene
  
  Range of Application (%)
  >=0.1
  
  Number
  110
  
  Category Priority Control Substances
  
  Chemical Substance Name Tetrachloroethylene

Korea: ARECs (K-REACH); Existing Chemical Substances Data Description

KE Number	KE-33294
Category	Existing Chemical Substances (Domestically distributed commercial purpose before February 2, 1991.)
Chemical Substance Name	Tetrachloroethene ; Tetrachloroethylene
Remarks	In the case of being hydrated, the resulting hydrate is also applicable.

Korea: ARECs (K-REACH); Others Data Description

Number	168
Category	Phase-in substance(s) subject to registration (by June 30, 2018)
Chemical Substance Name	Tetrachloroethene; Tetrachloroethylene
Note	The registration grace period is until June 30, 2018

Taiwan
- Taiwan: TCCSCA/OSHA; Existing Chemical Substances Data Description
  - English Name tetrachloroethylene
    
    Chinese Name -
- Taiwan: TCCSCA; Toxic Chemicals Data Description
  - Listed No./Series No. 63/01
    
    Toxicity Classify 1,2
    
    English Name Tetrachloroethylene
    
    Chinese Name 四氯乙烯
    
    Control concentration standard (w/w%) 10
    
    Large-scale handling standard(kg) 350

Chemical Hazard and Risk Information

GHS Classification Results
- NITE Japan-GHS Data Description
  - Edition version_1
    
    Chemical Substance Name Tetrachloroethylene
    
    Classification Result To the resut webpage To the Excel flie
- GHS Classification Results by the Japanese Government Data Description GHS Information
  - Year of implementation /renewal 2006 ID 155_H18_new
    
    Chemical Substance Name Tetrachloroethylene
    
    Classification Result To the resut webpage To the Excel flie
    
    Year of implementation /renewal 2009 ID 21B3144
    
    Chemical Substance Name Tetrachloroethylene
    
    Classification Result To the resut webpage To the Excel flie

MHLW:GHS Aligned Sample Label and SDS
- GHS Aligned Sample Label and SDS Data Description Information on GHS Aligned Sample Label and SDS (Workplace Safety Site)
  - Chemical Substance Name Tetrachloroethylene
    
    Sample Label to MHLW Website (in Japanese Only)
    
    Sample SDS to MHLW Website (in Japanese Only)

AIST: Relational Information System for Chemical Accidents Database(RISCAD)
- Relational Information System for Chemical Accidents Database(RISCAD) Data Description RISCAD (in Japanese)
  - Material ID 463
    
    Name tetrachloroethylene
    
    Material Information to RISCAD

Hazard and Risk Assessment Reports etc. in Japan

Chemical Substances Hazard Assessment Report / Initial Risk Assessment Report Data Description Guidance for Initial Risk Assessment ver.1 (in Japanese) Guidance for Initial Risk Assessment ver.2 (in Japanese)

Report Number	No.65
Assessed Chemical Substance Name	Tetrachloroethylene
Details	Hazard Assessment Report (in Japanese)	Date of publication/ renewal	2005/02
	Details Initial Risk Assessment Report (in Japanese)	Date of publication/ renewal	2006/02
	Details Summary of Initial Risk Assessment Report	Date of publication/ renewal	2010/05

ISHA: Examples of Occupational Accidents Caused by Chemical Substances Data Description
- Name Tetrachloroethylene (synonym: Perchloroethylene)
  
  Examples of Occupational Accidents to MHLW site (in Japanese)

Hazard Data Sheet for Chemical Substances Data Description
- Book Number
  96-11
  Date of publication/ renewal 1997/07
  
  Assessed Chemical Substance Name Tetrachloroethylene
  
  Details Hazard Data Sheet (in Japanese)

CSCL: The Japan HPV Challenge Program Data Description
- Chemical Substance Name tetrachloroethylene
  
  Details to J-CHECK

Hazard and Risk Assessment Reports etc. in Other Countries
- OECD: High Production Volume (HPV) Chemicals Data Description
  - Chemical Name Ethene, tetrachloro-
    
    Details to OECD Existing Chemicals Database
- International Chemical Safety Cards (ICSC) Data Description
  - ICSC Number
    76
    
    ICSC Title Tetrachloroethylene
    
    Details to ILO site
- Concise International Chemical Assessment Documents (CICADs) Data Description
  - CICADs Number
    68
    
    CICADs Title Tetrachloroethene (CICADS 68, 2006)
    
    Details to IPCS site
- Environmental Health Criteria (EHC) Data Description
  - EHC Number
    31
    
    EHC Title Tetrachloroethylene
    
    Details to IPCS site
- US Agency for Toxic Substances and Disease Registry (ATSDR): Toxicological Profiles Data Description
  - Profile Title Tetrachloroethylene (PERC)
    
    Details to ATSDR site
    
    Date of Issue June 2019
- US EPA: Integrated Risk Information System (IRIS) Data Description
  - Chemical Substance Name Tetrachloroethylene (Perchloroethylene)
    
    Details to EPA site Last Revision 2012/02/10
- US EPA: Acute Exposure Guideline Levels (AEGLs) Data Description
  - Chemical Name Tetrachloroethylene
    
    Status Interim
    
    AEGL Values to EPA site
- EU: Risk Assessment Reports (RAR) Data Description
  - EC Number
    204-825-9
    Date 2005/12/23
    
    Report Title tetrachloroethylene Part I - environment
    
    Details to ECHA site
- Advisory Committee on Existing Chemicals (BUA) Reports by the German Chemical Society Data Description
  - BUA Number
    139
    
    Substance Name Tetrachloroethylene
    
    Related information to BUA site
- Canada: Priority Substances List (PSL) Data Description
  - Type of Priory Substances List PSL1
    
    Report Title Tetrachloroethylene
    
    Details to Environment Canada site
- Australia: Priority Existing Chemicals (PEC) Assessment Reports Data Description
  - PEC Number
    15
    Date June 2001
    
    Report Title Tetrachloroethylene
    
    Details to AICIS site

Japan Society for Occupational Health (JSOH) Recommendation of Occupational Exposure Limits

JSOH: Occupational Exposure Limits Data Description

Substance Name	Tetrachloroethylene
Occupational Exposure Limit (ppm)	(pending)
Occupational Exposure Limit (mg/m3)	(pending)
Details	Documentation in Japanese
Year of proposal	1972
Remarks	Skin absorption

JSOH: Occupational Carcinogens Data Description

Substance Name	Tetrachloroethylene
Carcinogenicity classification	2B
Details	Documentation in Japanese
Year of proposal	1991, (2001)
Remarks	( ) in the year of proposal indicates year of reconsideration resulting in no classification change.

JSOH: Reproductive Toxicants Data Description
- Substance Name Tetrachloroethylene
  
  Reproductive toxicant classification 3
  
  Details Summary
  
  Year of proposal 2014
  
  Remarks -

Carcinogenicity Assessment
- IARC: Carcinogenicity Assessment Data Description to IARC site
  - Volume Sup 7, 63, 106 Volume publication year 2014
    
    Agent Name Tetrachloroethylene (Perchloroethylene)
    
    Group 2A
    
    Details Sup 7 Vol.63 Vol.106 - -
- US EPA: Carcinogenicity Assessment Data Description to EPA site
  - Chemical Substance Name Tetrachloroethylene (Perchloroethylene)
    
    Guideline: Category 2005 : L
    
    Exporsure Route Oral route, Inhalation route
    
    Details to Substance Profile
- US NTP: Carcinogenicity Assessment Data Description to NTP site
  - Chemical Substance Name Tetrachloroethylene
    
    Category
    RAHC
    
    NAME OR SYNONYM
    Tetrachloroethylene
    
    Details to Substance Profile
- European Union (EU): Carcinogenicity Assessment Data Description to ECHA site
  - Substance Name tetrachloroethylene
    
    Category Code 2

Test Data and Reports

Japan METI: Biodegradation and Bioconcentration Results Data Description

Chemical Substance Name	tetrachloroethylene
Judgement of Biodegradation	Not readily biodegradable	Judgement of Bioconcentration	Low bioconcentration
Test result of Bioconcentration	-	Test result of Partition Coefficient	-
Details	to J-CHECK

Japan MOE: Results of Eco-toxicity tests of chemicals Data Description
- Chemical Substance Name Tetrachloroethylene
  
  Details to J-CHECK

ISHA: Carcinogenicity Test Results for Chemical Substances Data Description to MHLW site (in Japanese)
- Chemical Name Tetrachloroethylene
  
  Summary Inhalation test results (in Japanese)

ISHA: Mutagenicity Test Results for Chemical Substances Data Description to MHLW site (in Japanese)
- Chemical Name Tetrachloroethylene(Gas)
  
  Bacterial Test Positive
  
  CHL/IU Test -

US National Toxicology Program (NTP) : Long-Term Study Reports & Abstracts Data Description

Report Number	TR-13
Report Title	Bioassay of Tetrachloroethylene for Possible Carcinogenicity (CASRN 127-18-4)
Abstract	to NTP site	Full Text	to NTP site

Report Number	TR-311
Report Title	Toxicology and Carcinogenesis Studies of Tetrachloroethylene (Perchloroethylene) (CASRN 127-18-4) in F344/N Rats and B6C3F1 Mice (Inhalation Studies)
Abstract	to NTP site	Full Text	to NTP site

CHRIP_ID	C004-666-64A	CAS RN	127-18-4
Chemical Substance Name	Perchloroethene
Molecular Formula	C2Cl4
Molecular Weight	166
SMILES	ClC(Cl)=C(Cl)Cl
Structure

Substance Name	Tetrachloroethylene (synonym: Perchloroethylene)
Classification of Target Substances	Special chemical regulations etc.	Cutoff value(weight %)	1
Details	to the GHS Classification

Registration Number	20.4
Kinds of substances	Tetrachloroethylene (otherwise known as perchloroethylene)
Control Level	25ppm

Name	Tetrachloroethylene (synonym: perchloroethylene)
Details	to MHLW site (in Japanese)

Classification	Harmful Substances	Cabinet Order Number	Article 2-10 of Cabinet order
Cabinet Order Name	Tetrachloroethylene
Effluent Standards	0.1mg/L

UN Number	1897	Class or Division	6.1
Name and Description	TETRACHLOROETHYLENE
UN packing group	III

EC Number	204-825-9
EC Name	Tetrachloroethylene
Description	-
Substance Infocard	Infocard
ECHA Name	-

Index Number	602-028-00-4	EC Number	204-825-9
Chemical Name	tetrachloroethylene
Classification	Carc. 2 / Aquatic Chronic 2

TSCA Chemical Substance Name	Ethene, 1,1,2,2-tetrachloro-
DEF	-
UVCB	-
FLAG	-
ACTIVITY	ACTIVE

Number	2064
Name	Tetrachloroethene
Other Name	Perchloroethene
Remarks	-

Number	06-5-12
Category	Restricted Substance(s)
Chemical Substance Name	Tetrachloroethylene
Range of Application (%)	>=0.1

Number	97-1-297
Category	Toxic Substance(s)
Chemical Substance Name	Tetrachloroethylene
Range of Application (%)	>=0.1

Number	110
Category	Priority Control Substances
Chemical Substance Name	Tetrachloroethylene

Listed No./Series No.	63/01
Toxicity Classify	1,2
English Name	Tetrachloroethylene
Chinese Name	四氯乙烯
Control concentration standard (w/w%)	10
Large-scale handling standard(kg)	350

Edition	version_1
Chemical Substance Name	Tetrachloroethylene
Classification Result	To the resut webpage To the Excel flie

Year of implementation /renewal	2006	ID	155_H18_new
Chemical Substance Name	Tetrachloroethylene
Classification Result	To the resut webpage To the Excel flie

Year of implementation /renewal	2009	ID	21B3144
Chemical Substance Name	Tetrachloroethylene
Classification Result	To the resut webpage To the Excel flie

Chemical Substance Name	Tetrachloroethylene
Sample Label	to MHLW Website (in Japanese Only)
Sample SDS	to MHLW Website (in Japanese Only)

Material ID	463
Name	tetrachloroethylene
Material Information	to RISCAD

Name	Tetrachloroethylene (synonym: Perchloroethylene)
Examples of Occupational Accidents	to MHLW site (in Japanese)

Book Number	96-11	Date of publication/ renewal	1997/07
Assessed Chemical Substance Name	Tetrachloroethylene
Details	Hazard Data Sheet (in Japanese)

Chemical Name	Ethene, tetrachloro-
Details	to OECD Existing Chemicals Database

ICSC Number	76
ICSC Title	Tetrachloroethylene
Details	to ILO site

CICADs Number	68
CICADs Title	Tetrachloroethene (CICADS 68, 2006)
Details	to IPCS site

Profile Title	Tetrachloroethylene (PERC)
Details	to ATSDR site
Date of Issue	June 2019

Chemical Name	Tetrachloroethylene
Status	Interim
AEGL Values	to EPA site

EC Number	204-825-9	Date	2005/12/23
Report Title	tetrachloroethylene Part I - environment
Details	to ECHA site

BUA Number	139
Substance Name	Tetrachloroethylene
Related information	to BUA site

Type of Priory Substances List	PSL1
Report Title	Tetrachloroethylene
Details	to Environment Canada site

PEC Number	15	Date	June 2001
Report Title	Tetrachloroethylene
Details	to AICIS site