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General Information
- General Information
  - General Information Data Description
    - CHRIP_ID C004-692-32A CAS RN 95-53-4
      
      Chemical Substance Name o-Toluidine
      
      Molecular Formula C7H9N
      
      Molecular Weight 107
      
      SMILES NC1=C(C=CC=C1)C
      
      Structure
- Synonym
  - Synonym Data Description
    - Synonym 1-Amino-2-methylbenzene
      
      2-Aminotoluene
      
      2-Methylaniline
      
      2-Methylbenzenamine
      
      Benzenamine, 2-methyl-
      
      o-Methylaniline
      
      ortho-Toluidine
- Nikkaji
  - Information of Japan Chemical Substance Dictionary (Nikkaji) Data Description
    - Nikkaji Number
      J3.953E
      Detail to J-GLOBAL

Laws and Regulations in Japan

Act on the Evaluation of Chemical Substances and Regulation of Their Manufacture, etc. (Chemical Substances Control Law ; CSCL)

Japan CSCL: Canceled Priority Assessment Chemical Substances Data Description

Registration Number	57	Date of Cancellation	2017/03/30
MITI Number	3-186	Date of designation as a priority assessment chemical substance	2011/04/01
Chemical Substance Name	o-Toluidine
Remarks	-
Remarks of Cancellation	-
Details	to J-CHECK

Japan CSCL: Existing Chemical Substances Data Description Definition of the terms of Section 6 [PDF] Definition of the terms of Section 7 [PDF] Import Clearance Procedures[PDF] Notification of the Manufacturing Amount, etc[PDF]

MITI Number	3-186	Category	Section 3
Chemical Substance Name	Toluidine
Remarks	-
Details	to J-CHECK
Remarks to Existing Chemical Substances of Industrial Safety and Health Act	Chemicals have been notified in accordance with the provisions of Chemical Substances Control Law by June 29, 1979
Details to Existing Chemical Substances of Industrial Safety and Health Act	to MHLW site (in Japanese)

Japan CSCL: Type II Monitoring Chemical Substances (before amendment) Data Description Import Clearance Procedures[PDF] Notification of the Manufacturing Amount, etc[PDF]
- Registration Number
  402
  Date of Designation in the Official Gazette 2000/09/22
  
  MITI Number
  3-186
  
  Chemical Substance Name o-Toluidine
  
  Remarks -
  
  Details to J-CHECK

Japan CSCL: Type III Monitoring Chemical Substances (before amendment) Data Description Import Clearance Procedures[PDF] Notification of the Manufacturing Amount, etc[PDF]
- Registration Number
  34
  Date of Designation in the Official Gazette 2006/07/18
  
  MITI Number
  3-186
  
  Chemical Substance Name o-Toluidine
  
  Remarks -
  
  Details to J-CHECK

Japan METI: Biodegradation and Bioconcentration Results Data Description

Chemical Substance Name	o-toluidine
Judgement of Biodegradation	Not readily biodegradable	Judgement of Bioconcentration	Low bioconcentration
Test result of Bioconcentration	-	Test result of Partition Coefficient	-
Details	to J-CHECK

Japan MOE: Results of Eco-toxicity tests of chemicals Data Description
- Chemical Substance Name o-Toluidine
  
  Details to J-CHECK

Act on Confirmation, etc. of Release Amounts of Specific Chemical Substances in the Environment and Promotion of Improvements to the Management Thereof(PRTR-SDS Law)

Japan: PRTR-SDS Law (until March 2023) Data Description Outline PRTR Law (METI site) Analysis of PRTR data

Classification	I	Cabinet Order Number	1-299
Cabinet Order Name	Toluidine
Remarks	-
Basis of selection	Hazard Data (in Japanese)
Link	Releases Map (in Japanese) Atmospheric concentration Map (in Japanese)

Japan: PRTR-SDS Law (from April 2023) Data Description Outline PRTR Law (METI site)

JPSN(Japan PRTR-SDS Number)	299	Classification	Specified Class I	Cabinet Order Number	1-346
Cabinet Order Name	Toluidine
Remarks	-
Basis of selection	Hazard Data (in Japanese)
Link	- -

Industrial Safety and Health Act (ISHA)

Japan ISHA: Existing Chemical Substances Data Description Existing Chemical Substances (MHLW site : in Japanese) Notification of New Chemical Substances, etc. (MHLW site : in Japanese)

Registration Number	7849
ISHA Number	4-(12)-293 ( 4-(12)-412 )
Date of Notification in the Official Gazette	19790630
Chemical Substance Name	o-Toluidine (o-methylaniline)
Details to Existing Chemical Substances of Industrial Safety and Health Act	to MHLW site (in Japanese)
Note	-

The Registration Number., ISHA Number and Date of Notification in the Official Gazette have been provided by the Ministry of Health, Labour and Welfare.

Japan ISHA: Chemical Substances Requiring Labeling and Delivery of Documents, etc. Data Description GHS compatible model label creation method (MH LW site : in Japanese) Risk assessment implementation support tool (MHLW site : in Japanese)
- Cabinet Order Number
  Attached table 9-406 of Cabinet order
  
  Cabinet Order Name Toluidine
  
  Range of Application for Label (weight%) >=0.1
  
  Range of Application for SDS (weight%) >=0.1

Japan ISHA: Chemical substances that cause skin disorders, etc. and other chemical substances that must be handled with impermeable protective equipment etc. based on special chemical regulations. Data Description Target substances list(MHLW site: in japanese)
- Substance Name Ortho-toluidine
  
  Classification of Target Substances Special chemical regulations etc. Cutoff value(weight %) 1
  
  Details to the GHS Classification

Japan ISHA: Specified Chemical Substances Data Description Link to the Ordinance (JISHA site : in Japanese)

Category	Group-2 substances	Cabinet Order Number	Attached Table 3-2-8-2 of Cabinet order
Cabinet Order Name	o-Toluidine
Range of Application (weight %)	>1
Remarks	Substances under special supervision / Specified Group-2 substances

The above information have been provided by the Ministry of Health, Labour and Welfare

Japan ISHA: Administrative Control Levels of Working Environment Evaluation Standards Data Description Working Environment Measurement (MHLW site : in Japanese)
- Registration Number
  9.2
  
  Kinds of substances o-Toluidine
  
  Control Level 1ppm
  
  The above information have been provided by the Ministry of Health, Labour and Welfare

Poisonous and Deleterious Substances Control Act
- Japan Poisonous and Deleterious Substances Control Act Data Description Link to the Act (MOJ site)
  - Classification Deleterious Substances(Law) Law or Cabinet Order Number
    Attached Table 2-61 of the Law
    
    Law or Cabinet Order Name Toluidine

Air Pollution Control Act
- Japan Air Pollution Control Law Data Description Air & Transportation (MOE site)
  - Classification Substances that may be classified as Hazardous Air Pollutants Cabinet Order Number
    140 of Central Environment Council 9th Report (Appendix 1)
    
    Cabinet Order Name Toluidine

Fire Service Act

Fire Service Act : Hazardous Materials Data Description

Number of cabinet order etc.	Article 2, Paragraph 7 of the Act, Appended Table 1, Category IV (5)
Category; Property	Category IV; Inflammable Liquids
Item	Class III petroleums
Property	Non-water soluble liquid
Designated quantity	2,000L
Sources	Hazardous Materials Disaster Information Support System, Hazardous Materials Data Book 2nd edition, MHLW Website; Sample SDS

Laws and Regulations in Other countries

Recommendations on the transport of dangerous goods
- Dangerous Goods List (UN Number and Hazard class) Data Description
  - UN Number
    1708
    Class or Division 6.1
    
    Name and Description TOLUIDINES, LIQUID
    
    UN packing group II
    
    UN Number
    3451
    Class or Division 6.1
    
    Name and Description TOLUIDINES, SOLID
    
    UN packing group II

International Convention on the Commodity Description and Coding Systems (HS Convention)

HS Code: Section VI “Products of the Chemical or Allied Industries" Data Description

Chapter	29	Chapter name	Organic chemicals
Heading	2921	Substance name (Heading)	Amine-function compounds
HS Code	2921.43	Substance Name	Aromatic monoamines and their derivatives; salts thereof : Toluidines and their derivatives; salts thereof

Association of South-East Asian Nations(ASEAN)
- The ASEAN-Japan Chemical Safety Database (AJCSD).: Laws and Regulations Data Description
  - Detail to AJCSD
- The ASEAN-Japan Chemical Safety Database (AJCSD).: GHS-Related Information Data Description
  - Detail to AJCSD

European Union (EU)
- EC Inventory Data Description
  - EC Number
    202-429-0
    
    EC Name o-toluidine
    
    Description -
    
    Substance Infocard Infocard
    
    ECHA Name -
- REACH: Substances of Very High Concern for Authorization (SVHC) Data Description
  - EC Number 202-429-0 Status Candidate List
    
    Substance Name o-toluidine
    
    Reason for inclusion
    Carcinogenic (Article 57a)
    
    Date of inclusion
    2012/12/19
    
    Details to ECHA site
- EU: CLP Harmonised Classification Data Description To ECHA site
  - Index Number 612-091-00-X EC Number 202-429-0
    
    Chemical Name o-toluidine; 2-aminotoluene
    
    Classification Carc. 1B / [Inh.]Acute Tox. 3 * / [Oral]Acute Tox. 3 * / Eye Irrit. 2 / Aquatic Acute 1

US: Toxic Substances Control Act (TSCA)
- TSCA Inventory Data Description
  - TSCA Chemical Substance Name Benzenamine, 2-methyl-
    
    DEF -
    
    UVCB -
    
    FLAG -
    
    ACTIVITY ACTIVE

China
- China: Catalog of Hazardous Chemicals 2015 Data Description
  - Number
    1083
    
    Name 2-Methylaniline
    
    Other Name o-Toluidine; 2-Aminotoluene; o-Aminotoluene
    
    Remarks -

Korea

Korea: ARECs (K-REACH) / CCA; Hazardous Substance(s), Priority Control Substances Data Description
- Number
  97-1-300
  
  Category Toxic Substance(s)
  
  Chemical Substance Name Toluidine and its salts
  
  Range of Application (%)
  >=25
  
  Note
  For o-toluidine, 0.1% and more
  
  Number
  63
  
  Category Priority Control Substances
  
  Chemical Substance Name o-Toluidine

Korea: ARECs (K-REACH); Existing Chemical Substances Data Description

KE Number	KE-23446
Category	Existing Chemical Substances (Domestically distributed commercial purpose before February 2, 1991.)
Chemical Substance Name	o-Toluidine
Remarks	In the case of being hydrated, the resulting hydrate is also applicable.

Korea: ARECs (K-REACH); Others Data Description

Number	77
Category	Phase-in substance(s) subject to registration (by June 30, 2018)
Chemical Substance Name	2-Methylbenzenamine; o-Toluidine; 2-Aminotoluene
Note	The registration grace period is until June 30, 2018

Taiwan
- Taiwan: TCCSCA/OSHA; Existing Chemical Substances Data Description
  - English Name o-toluidine
    
    Chinese Name -
- Taiwan: TCCSCA; Toxic Chemicals Data Description
  - Listed No./Series No. 39/01
    
    Toxicity Classify 1
    
    English Name o-Aminotoluene
    
    Chinese Name 鄰-甲苯胺
    
    Control concentration standard (w/w%) 1
    
    Large-scale handling standard(kg) 50

Chemical Hazard and Risk Information

GHS Classification Results
- NITE Japan-GHS Data Description
  - Edition version_1
    
    Chemical Substance Name o-Toluidine / Toluidines
    
    Classification Result To the resut webpage To the Excel flie
- GHS Classification Results by the Japanese Government Data Description GHS Information
  - Year of implementation /renewal 2006 ID 43_H18_new
    
    Chemical Substance Name o-Toluidine
    
    Classification Result To the resut webpage  To the Excel flie
    
    Year of implementation /renewal 2011 ID 23B5507
    
    Chemical Substance Name o-Toluidine
    
    Classification Result To the resut webpage  To the Excel flie
    
    Year of implementation /renewal 2014 ID H26-B-069 / R-028
    
    Chemical Substance Name o-Toluidine / Toluidines
    
    Classification Result To the resut webpage  To the Excel flie

MHLW:GHS Aligned Sample Label and SDS
- GHS Aligned Sample Label and SDS Data Description Information on GHS Aligned Sample Label and SDS (Workplace Safety Site)
  - Chemical Substance Name o-Toluidine
    
    Sample Label to MHLW Website (in Japanese Only)
    
    Sample SDS to MHLW Website (in Japanese Only)

AIST: Relational Information System for Chemical Accidents Database(RISCAD)
- Relational Information System for Chemical Accidents Database(RISCAD) Data Description RISCAD (in Japanese)
  - Material ID 2018
    
    Name o-toluidine
    
    Material Information to RISCAD
    
    Accident Information to RISCAD

Hazard and Risk Assessment Reports etc. in Japan

Chemical Substances Hazard Assessment Report / Initial Risk Assessment Report Data Description Guidance for Initial Risk Assessment ver.1 (in Japanese) Guidance for Initial Risk Assessment ver.2 (in Japanese)

Report Number	No.202
Assessed Chemical Substance Name	o-Toluidine
Details	Hazard Assessment Report (in Japanese)	Date of publication/ renewal	2004/10
	Details Initial Risk Assessment Report (in Japanese)	Date of publication/ renewal	2008/03
	Details Summary of Initial Risk Assessment Report	Date of publication/ renewal	2010/05

ISHA: Risk Assessment Report Data Description to MHLW site (in Japanese)
- Name o-Toluidine
  
  Risk Assessment Report text/cover (in Japanese)

Hazard Data Sheet for Chemical Substances Data Description
- Book Number
  97-21
  Date of publication/ renewal 1997/07
  
  Assessed Chemical Substance Name 2-Methylaniline
  
  Details Hazard Data Sheet (in Japanese)

CSCL: The Japan HPV Challenge Program Data Description
- Chemical Substance Name 2-Methylaniline
  
  Details to J-CHECK

Hazard and Risk Assessment Reports etc. in Other Countries
- OECD: High Production Volume (HPV) Chemicals Data Description
  - Chemical Name Aniline, 2-methyl-
    
    Details to OECD Existing Chemicals Database
- International Chemical Safety Cards (ICSC) Data Description
  - ICSC Number
    341
    
    ICSC Title ortho-Toluidine
    
    Details to ILO site
- Concise International Chemical Assessment Documents (CICADs) Data Description
  - CICADs Number
    7
    
    CICADs Title Toluidine, o- (CICADS 7, 1998)
    
    Details to IPCS site

Japan Society for Occupational Health (JSOH) Recommendation of Occupational Exposure Limits
- JSOH: Occupational Exposure Limits Data Description
  - Substance Name o-Toluidine
    
    Occupational Exposure Limit (ppm) 1
    
    Occupational Exposure Limit (mg/m3) 4.4
    
    Details Documentation in Japanese
    
    Year of proposal 1991
    
    Remarks Skin absorption
- JSOH: Occupational Carcinogens Data Description
  - Substance Name o-Toluidine
    
    Carcinogenicity classification 1
    
    Details Summary
    
    Year of proposal 1986, 1995, 2001, 2016
    
    Remarks Substance whose OEL is set based on non-caninogenic health effects.

Carcinogenicity Assessment
- IARC: Carcinogenicity Assessment Data Description to IARC site
  - Volume Sup 7, 77, 99, 100F Volume publication year 2012
    
    Agent Name ortho-Toluidine
    
    Group 1
    
    Details Sup 7 Vol.77 Vol.99 Vol.100F -
- US NTP: Carcinogenicity Assessment Data Description to NTP site
  - Chemical Substance Name o‑Toluidine
    
    Category
    Known
    
    NAME OR SYNONYM
    o-Toluidine (see o-Toluidine and Its Hydrochloride)
    
    Details to Substance Profile
- European Union (EU): Carcinogenicity Assessment Data Description to ECHA site
  - Substance Name o-toluidine; 2-aminotoluene
    
    Category Code 1B

Test Data and Reports

Japan METI: Biodegradation and Bioconcentration Results Data Description

Chemical Substance Name	o-toluidine
Judgement of Biodegradation	Not readily biodegradable	Judgement of Bioconcentration	Low bioconcentration
Test result of Bioconcentration	-	Test result of Partition Coefficient	-
Details	to J-CHECK

Japan MOE: Results of Eco-toxicity tests of chemicals Data Description
- Chemical Substance Name o-Toluidine
  
  Details to J-CHECK

ISHA: Mutagenicity Test Results for Chemical Substances Data Description to MHLW site (in Japanese)
- Chemical Name o-Toluidine
  
  Bacterial Test Negative
  
  CHL/IU Test -

CHRIP_ID	C004-692-32A	CAS RN	95-53-4
Chemical Substance Name	o-Toluidine
Molecular Formula	C7H9N
Molecular Weight	107
SMILES	NC1=C(C=CC=C1)C
Structure

Synonym	1-Amino-2-methylbenzene
	2-Aminotoluene
	2-Methylaniline
	2-Methylbenzenamine
	Benzenamine, 2-methyl-
	o-Methylaniline
	ortho-Toluidine

Registration Number	402	Date of Designation in the Official Gazette	2000/09/22
MITI Number	3-186
Chemical Substance Name	o-Toluidine
Remarks	-
Details	to J-CHECK

Registration Number	34	Date of Designation in the Official Gazette	2006/07/18
MITI Number	3-186
Chemical Substance Name	o-Toluidine
Remarks	-
Details	to J-CHECK

Cabinet Order Number	Attached table 9-406 of Cabinet order
Cabinet Order Name	Toluidine
Range of Application for Label (weight%)	>=0.1
Range of Application for SDS (weight%)	>=0.1

Substance Name	Ortho-toluidine
Classification of Target Substances	Special chemical regulations etc.	Cutoff value(weight %)	1
Details	to the GHS Classification

Registration Number	9.2
Kinds of substances	o-Toluidine
Control Level	1ppm

Classification	Deleterious Substances(Law)	Law or Cabinet Order Number	Attached Table 2-61 of the Law
Law or Cabinet Order Name	Toluidine

Classification	Substances that may be classified as Hazardous Air Pollutants	Cabinet Order Number	140 of Central Environment Council 9th Report (Appendix 1)
Cabinet Order Name	Toluidine

UN Number	1708	Class or Division	6.1
Name and Description	TOLUIDINES, LIQUID
UN packing group	II

EC Number	202-429-0	Status	Candidate List
Substance Name	o-toluidine
Reason for inclusion	Carcinogenic (Article 57a)
Date of inclusion	2012/12/19
Details	to ECHA site

Index Number	612-091-00-X	EC Number	202-429-0
Chemical Name	o-toluidine; 2-aminotoluene
Classification	Carc. 1B / [Inh.]Acute Tox. 3 * / [Oral]Acute Tox. 3 * / Eye Irrit. 2 / Aquatic Acute 1

TSCA Chemical Substance Name	Benzenamine, 2-methyl-
DEF	-
UVCB	-
FLAG	-
ACTIVITY	ACTIVE

Listed No./Series No.	39/01
Toxicity Classify	1
English Name	o-Aminotoluene
Chinese Name	鄰-甲苯胺
Control concentration standard (w/w%)	1
Large-scale handling standard(kg)	50

UN Number	3451	Class or Division	6.1
Name and Description	TOLUIDINES, SOLID
UN packing group	II

EC Number	202-429-0
EC Name	o-toluidine
Description	-
Substance Infocard	Infocard
ECHA Name	-

Number	1083
Name	2-Methylaniline
Other Name	o-Toluidine; 2-Aminotoluene; o-Aminotoluene
Remarks	-

Number	97-1-300
Category	Toxic Substance(s)
Chemical Substance Name	Toluidine and its salts
Range of Application (%)	>=25
Note	For o-toluidine, 0.1% and more

Number	63
Category	Priority Control Substances
Chemical Substance Name	o-Toluidine

Edition	version_1
Chemical Substance Name	o-Toluidine / Toluidines
Classification Result	To the resut webpage To the Excel flie

Year of implementation /renewal	2006	ID	43_H18_new
Chemical Substance Name	o-Toluidine
Classification Result	To the resut webpage To the Excel flie

Year of implementation /renewal	2011	ID	23B5507
Chemical Substance Name	o-Toluidine
Classification Result	To the resut webpage To the Excel flie

Year of implementation /renewal	2014	ID	H26-B-069 / R-028
Chemical Substance Name	o-Toluidine / Toluidines
Classification Result	To the resut webpage To the Excel flie

Chemical Substance Name	o-Toluidine
Sample Label	to MHLW Website (in Japanese Only)
Sample SDS	to MHLW Website (in Japanese Only)

Material ID	2018
Name	o-toluidine
Material Information	to RISCAD
Accident Information	to RISCAD

Name	o-Toluidine
Risk Assessment Report	text/cover (in Japanese)

Book Number	97-21	Date of publication/ renewal	1997/07
Assessed Chemical Substance Name	2-Methylaniline
Details	Hazard Data Sheet (in Japanese)

Chemical Name	Aniline, 2-methyl-
Details	to OECD Existing Chemicals Database

CICADs Number	7
CICADs Title	Toluidine, o- (CICADS 7, 1998)
Details	to IPCS site

Substance Name	o-Toluidine
Occupational Exposure Limit (ppm)	1
Occupational Exposure Limit (mg/m3)	4.4
Details	Documentation in Japanese
Year of proposal	1991
Remarks	Skin absorption

Substance Name	o-Toluidine
Carcinogenicity classification	1
Details	Summary
Year of proposal	1986, 1995, 2001, 2016
Remarks	Substance whose OEL is set based on non-caninogenic health effects.

Volume	Sup 7, 77, 99, 100F	Volume publication year	2012
Agent Name	ortho-Toluidine
Group	1
Details	Sup 7 Vol.77 Vol.99 Vol.100F -

Chemical Substance Name	o‑Toluidine
Category	Known
NAME OR SYNONYM	o-Toluidine (see o-Toluidine and Its Hydrochloride)
Details	to Substance Profile