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遺伝子 : Choline oxidase (CHOX)

遺伝子情報

ID NRULE_0178
遺伝子ID CHOX
作成日 2013/03/27
タンパク質名
Protein name
Full
Choline oxidase
EC
EC 1.1.3.17
遺伝子名 該当データなし
遺伝子条件 BLASTP; Q7X2H8; hit=1; score=1500; pid=58
参照
Gene Ontology
GO
GO:0008812, F:choline dehydrogenase activity, IEA:InterPro
GO:0033713, F:choline:oxygen 1-oxidoreductase activity, IEA:EC
GO:0050660, F:flavin adenine dinucleotide binding, IEA:InterPro
GO:0019285, P:glycine betaine biosynthetic process from choline, IEA:UniProtKB-UniPathway
GO:0006950, P:response to stress, IEA:UniProtKB-KW
Enzyme and pathway databases
BRENDA
1.1.3.17;,
UniPathway
UPA00529, UER00384
Family and domain databases
InterPro
IPR012132, GMC_OxRdtase
IPR000172, GMC_OxRdtase_N
IPR007867, GMC_OxRtase_C
Pfam
PF05199, GMC_oxred_C, 1
PF00732, GMC_oxred_N, 1
PIRSF
PIRSF000137, Alcohol_oxidase, 1
PROSITE
PS00623, GMC_OXRED_1, FALSE_NEG
PS00624, GMC_OXRED_2, 1
配列の特徴
Q7X2H8 Arthrobacter globiformis.
NP_BIND23 - 24FAD.
NP_BIND90 - 92FAD.
NP_BIND96 - 103FAD.
NP_BIND510 - 512FAD.
BINDING44FAD.
BINDING71FAD.
BINDING232FAD; via amide nitrogen and carbonyl oxygen.
BINDING465FAD.
BINDING500FAD; via amide nitrogen.
MOD_RES99Tele-8alpha-FAD histidine.
注釈
Function
Catalyzes the two-step oxidative conversion of choline to glycine-betaine with betaine aldehyde as an intermediate. Glycine-betaine accumulates to high levels in the cytoplasm of cells to prevent dehydration and plasmolysis in adverse hyperosmotic environments. Accepts either choline or the reaction intermediate betaine-aldehyde as substrate
Catalytic activity
Choline + 2 O(2) + H(2)O = betaine + 2 H(2)O(2)
Cofactor
FAD
Pathway
Amine and polyamine biosynthesis; betaine biosynthesis via choline pathway; betaine from choline: step 1/1
Subunit structure
Homodimer
Sequence similarities
Belongs to the GMC oxidoreductase family
参考文献
Q7X2H8 Arthrobacter globiformis.
14678796
Cloning, sequence analysis, and purification of choline oxidase from Arthrobacter globiformis: a bacterial enzyme involved in osmotic stress tolerance. (Arch Biochem Biophys. 2004)



関与する機能

機能名
Betaine biosynthesis (from choline)

該当CDS

データダウンロード
学名 NBRC番号 CDS タンパク質名
Acaricomes phytoseiuli107788C501_09365choline oxidase
Actinopolyspora iraqiensis103187ACTIR_064_00020GMC family oxidoreductase
Amycolatopsis azurea14573C791_2877Choline dehydrogenase
Brevibacterium linens12170BlinB_010200007905glucose-methanol-choline oxidoreductase
Corynebacterium ammoniagenes12612HMPREF0281_02587GMC oxidoreductase
Corynebacterium terpenotabidum14764A606_06065choline dehydrogenase
Gordonia aichiensis108223GOACH_11_00600putative choline oxidase
Gordonia alkanivorans16433GOALK_050_01160choline oxidase
Gordonia effusa100432GOEFS_052_00390choline oxidase
Gordonia namibiensis108229GONAM_07_01270choline dehydrogenase
Gordonia otitidis100426GOOTI_238_00260putative choline oxidase
Gordonia rubripertincta101908GORBP_012_02140choline oxidase
Gordonia soli108243GS4_36_00290choline oxidase
Gordonia sputi100414GOSPT_109_00030putative choline oxidase
Gordonia terrae100016GOTRE_053_00460choline oxidase
Kocuria rhizophila103217KRH_18100putative choline oxidase
Rhodococcus opacus108011ROP_14830choline oxidase
ROP_15550choline oxidase
Saccharomonospora azurea14651SacazDRAFT_01115choline dehydrogenase-like flavoprotein
Saccharomonospora cyanea14841SaccyDRAFT_3246choline dehydrogenase-like flavoprotein
Saccharomonospora glauca14831SacglDRAFT_02719choline dehydrogenase-like flavoprotein
Saccharopolyspora erythraea13426SACE_5373glucose-methanol-choline oxidoreductase
Saccharopolyspora spinosa15153SspiN1_010100019521choline oxidase
Streptomyces avermitilis14893SAV6946putative GMC-family oxidoreductase
Streptomyces clavuligerus13307SCLAV_5678Putative GMC-family oxidoreductase
Tsukamurella paurometabola16120Tpau_2794glucose-methanol-choline oxidoreductase
Turicella otitidis106139HMPREF9719_01009hypothetical protein