Function : Catechol degradation (beta-ketoadipate pathway)

Function Description

ID	NFUNC_0013
Created	2012-11-02
Description	Ortho cleavage of catechol (1,2-dihydroxybenzene) leads to beta-ketoadipate (3-oxoadipate), which is subsequently converted to succinyl-coenzyme A (CoA) and acetyl-CoA.
Comment	Pathway Aromatic compound metabolism; beta-ketoadipate pathway
Cross Reference	UniPathway UPA00157 MetaCyc Catechol degradation III (ortho-cleavage pathway)


Type	Pattern	Component Gene
Catechol degradation (beta-ketoadipate pathway)(NFUNC_0013)
Require	A	CATA (NRULE_0052)	Catechol 1,2-dioxygenase
		CATB2 (NRULE_0053)	(Chloro)muconate cycloisomerase
		CATC (NRULE_0054)	Muconolactone isomerase
		PCAD (NRULE_0070)	3-oxoadipate enol-lactonase
		PCAI (NRULE_0072)	3-oxoadipate CoA-transferase subunit A
		PCAJ (NRULE_0073)	3-oxoadipate CoA-transferase subunit B
		PCAF (NRULE_0074)	Beta-ketoadipyl-CoA thiolase
	B	CATA (NRULE_0052)	Catechol 1,2-dioxygenase
		CATC (NRULE_0054)	Muconolactone isomerase
		PCAD (NRULE_0070)	3-oxoadipate enol-lactonase
		PCAI (NRULE_0072)	3-oxoadipate CoA-transferase subunit A
		PCAJ (NRULE_0073)	3-oxoadipate CoA-transferase subunit B
		PCAF (NRULE_0074)	Beta-ketoadipyl-CoA thiolase
		CATB1 (NRULE_0386)	Muconate cycloisomerase
	C	CATA (NRULE_0052)	Catechol 1,2-dioxygenase
		CATC (NRULE_0054)	Muconolactone isomerase
		PCAL (NRULE_0071)	3-oxoadipate enol-lactone hydrolase/4-carboxymuconolactone decarboxylase
		PCAI (NRULE_0072)	3-oxoadipate CoA-transferase subunit A
		PCAJ (NRULE_0073)	3-oxoadipate CoA-transferase subunit B
		PCAF (NRULE_0074)	Beta-ketoadipyl-CoA thiolase
		CATB1 (NRULE_0386)	Muconate cycloisomerase
	D	CATA (NRULE_0052)	Catechol 1,2-dioxygenase
		CATB2 (NRULE_0053)	(Chloro)muconate cycloisomerase
		CATC (NRULE_0054)	Muconolactone isomerase
		PCAL (NRULE_0071)	3-oxoadipate enol-lactone hydrolase/4-carboxymuconolactone decarboxylase
		PCAI (NRULE_0072)	3-oxoadipate CoA-transferase subunit A
		PCAJ (NRULE_0073)	3-oxoadipate CoA-transferase subunit B
		PCAF (NRULE_0074)	Beta-ketoadipyl-CoA thiolase

Scientific name	NBRC No.
Acinetobacter sp.	100985
Corynebacterium callunae	15359
Corynebacterium efficiens	100395
Corynebacterium glutamicum	12168
Corynebacterium glutamicum	12153
Cupriavidus metallidurans	102507
Enterobacter aerogenes	13534
Escherichia fergusonii	102419
Gordonia amarae	15530
Pseudomonas putida	100650
Rhodococcus erythropolis	100887
Rhodococcus opacus	108011
Shimwellia blattae	105725
Sphingomonas wittichii	105917