遺伝子 : Beta-ketoadipyl-CoA thiolase (PCAF)

遺伝子情報

ID	NRULE_0074
遺伝子ID	PCAF
作成日	2012/10/23
タンパク質名	Protein name Full Beta-ketoadipyl-CoA thiolase EC EC 2.3.1.174 Synonym Full 3-oxoadipyl-CoA thiolase
遺伝子名	pcaF, catF, paaJ
遺伝子条件	TIGRFAMs; TIGR02430; hit=1 OR BLASTP; Q0SH22; hit=1; score=1070; pid=58 OR BLASTP; Q0SCR8; hit=1; score=1050; pid=50 OR BLASTP; Q9XD81; hit=1; score=1010; pid=50
参照	Gene Ontology GO GO:0033812, F:3-oxoadipyl-CoA thiolase activity, IEA:EC GO:0042952, P:beta-ketoadipate pathway, IEA:UniProtKB-UniPathway GO:0019619, P:protocatechuate catabolic process, IEA:InterPro Phylogenomic databases KO K07823, - Family and domain databases InterPro IPR012793, PcaF IPR002155, Thiolase IPR016039, Thiolase-like IPR016038, Thiolase-like_subgr IPR020615, Thiolase_acyl_enz_int_AS IPR020610, Thiolase_AS IPR020617, Thiolase_C IPR020613, Thiolase_CS IPR020616, Thiolase_N Pfam PF02803, Thiolase_C, 1 PF00108, Thiolase_N, 1 PIRSF PIRSF000429, Ac-CoA_Ac_transf, 1 TIGRFAMs TIGR01930, AcCoA-C-Actrans, 1 TIGR02430, pcaF, 1 PROSITE PS00098, THIOLASE_1, 1 PS00737, THIOLASE_2, 1 PS00099, THIOLASE_3, 1
配列の特徴	P0C7L2 Escherichia coli (strain K12). ACT_SITE 90 Acyl-thioester intermediate. ACT_SITE 357 Proton acceptor. ACT_SITE 387 Proton acceptor.
注釈	Function Catalyzes thiolytic cleavage of beta-ketoadipyl-CoA to succinyl-CoA and acetyl-CoA Catalytic activity Succinyl-CoA + acetyl-CoA = CoA + 3-oxoadipyl- CoA Pathway Aromatic compound metabolism; beta-ketoadipate pathway; acetyl-CoA and succinyl-CoA from 3-oxoadipate: step 2/2 Aromatic compound metabolism; phenylacetate degradation Sequence similarities Belongs to the thiolase family
参考文献	P0C7L2 Escherichia coli (strain K12). 17259607 Characterization of the last step of the aerobic phenylacetic acid degradation pathway. (Microbiology (Reading). 2007) Q8VPF1 Pseudomonas knackmussii (strain DSM 6978 / LMG 23759 / B13). 11741863 Degradation of aromatics and chloroaromatics by Pseudomonas sp. strain B13: cloning, characterization, and analysis of sequences encoding 3-oxoadipate:succinyl-coenzyme A (CoA) transferase and 3-oxoadipyl-CoA thiolase. (J Bacteriol. 2002) Q0SH22 Rhodococcus jostii (strain RHA1). 15937168 Catabolism of benzoate and phthalate in Rhodococcus sp. strain RHA1: redundancies and convergence. (J Bacteriol. 2005) Q0SCR8 Rhodococcus jostii (strain RHA1). 15968060 Phenylacetate catabolism in Rhodococcus sp. strain RHA1: a central pathway for degradation of aromatic compounds. (J Bacteriol. 2005) Q9XD81 Streptomyces sp. 2065. 10742233 Characterization of the protocatechuic acid catabolic gene cluster from Streptomyces sp. strain 2065. (Appl Environ Microbiol. 2000)

関与する機能

機能名
Catechol degradation (beta-ketoadipate pathway)
Chlorocatechol degradation (beta-ketoadipate pathway)
Protocatechuate degradation (beta-ketoadipate pathway)

該当CDS

学名	NBRC番号	CDS	タンパク質名
Acaricomes phytoseiuli	107788	C501_07870	hypothetical protein
Acetobacter tropicalis	101654	ATPR_0361	beta-ketoadipyl CoA thiolase
Acidiphilium multivorum	100883	ACMV_20880	beta-ketoadipyl-CoA thiolase
Acinetobacter radioresistens	102413	ACRAD_20_00090	beta-ketoadipyl-CoA thiolase PcaF
Acinetobacter sp.	100985	ACT4_036_01090	beta-ketoadipyl-CoA thiolase
		ACT4_038_00390	beta-ketoadipyl-CoA thiolase
Actinomadura atramentaria	14695	G339_12505	acetyl-CoA acetyltransferase
Actinoplanes missouriensis	102363	AMIS_42650	putative acyl-CoA thiolase
Actinosynnema mirum	14064	Amir_0164	acetyl-CoA acetyltransferase
Alicyclobacillus acidocaldarius subsp. acidocaldarius	15652	Aaci_0816	acetyl-CoA acetyltransferase
Amycolatopsis azurea	14573	C791_0884	3-ketoacyl-CoA thiolase
Amycolatopsis mediterranei	13415	RAM_09435	acetyl-CoA acyltransferase
Ardenticatena maritima		ARMA_0725	hypothetical protein
Arthrobacter globiformis	12137	ARGLB_008_00520	putative beta-ketoadipyl-CoA thiolase PaaJ
		ARGLB_036_00440	putative beta-ketoadipyl-CoA thiolase
Austwickia chelonae	105200	AUCHE_22_00410	putative beta-ketoadipyl-CoA thiolase
Azorhizobium caulinodans	14845	AZC_0996	beta-ketoadipyl CoA thiolase
Balneola vulgaris		B155_RS0109355	3-oxoadipyl-CoA thiolase
Bergeyella zoohelcum	16014	HMPREF9699_01792	3-oxoadipyl-CoA thiolase
Bradyrhizobium diazoefficiens	14792	blr0925	beta-ketoadipyl CoA thiolase
Brevibacterium linens	12170	BlinB_010200003739	putative beta-ketoadipyl CoA thiolase
		BlinB_010200004389	acetyl-CoA acetyltransferase
Candidatus Solibacter usitatus		Acid_0251	beta-ketoadipyl CoA thiolase
Catenulispora acidiphila	102108	Caci_6183	beta-ketoadipyl CoA thiolase
Caulobacter segnis	15250	Cseg_1757	beta-ketoadipyl CoA thiolase
Chromobacterium violaceum	12614	CV_4291	Beta-ketoadipyl CoA thiolase
Chryseobacterium gleum	15054	HMPREF0204_10052	beta-ketoadipyl CoA thiolase
Conexibacter woesei	100937	Cwoe_2156	acetyl-CoA acetyltransferase
		Cwoe_2196	beta-ketoadipyl CoA thiolase
Corynebacterium ammoniagenes	12612	HMPREF0281_01021	putative beta-ketoadipyl CoA thiolase
		HMPREF0281_01033	acetyl-CoA C-acetyltransferase
Corynebacterium callunae	15359	H924_10065	acetyl-CoA acetyltransferase
Corynebacterium efficiens	100395	CE0673	putative beta-ketoadipyl CoA thiolase
		CE2295	putative acetyl-CoA acetyltransferase
Corynebacterium glutamicum	12168	Cgl2392	Acetyl-CoA acetyltransferases
Corynebacterium glutamicum	12153	KIQ_00540	acetyl-CoA acetyltransferase
Corynebacterium striatum	15291	HMPREF0308_2551	putative beta-ketoadipyl CoA thiolase
Corynebacterium terpenotabidum	14764	A606_01835	hypothetical protein
Cupriavidus metallidurans	102507	Rmet_3669	acetyl-CoA acetyltransferase
Cystobacter fuscus	100088	D187_005848	3-ketoacyl-CoA thiolase
Enterobacter aerogenes	13534	EAE_18180	acetyl-CoA acetyltransferase
		EAE_20470	beta-ketoadipyl CoA thiolase
Enterobacter cloacae subsp. cloacae	13535	ECL_02144	beta-ketoadipyl CoA thiolase
Enterobacter hormaechei	105718	HMPREF9086_0303	monovalent cation/proton (H+) antiporter subunit D
Escherichia coli	3972	EcolC_2258	beta-ketoadipyl CoA thiolase
Escherichia coli	13500	WFL_07480	beta-ketoadipyl CoA thiolase
Escherichia coli	12713	Y75_1388	predicted beta-ketoadipyl CoA thiolase
Escherichia fergusonii	102419	EFER_1599	beta-ketoadipyl CoA thiolase
		EFER_1634	Beta-ketoadipyl CoA thiolase
Fluviicola taffensis	106335	Fluta_2912	acetyl-CoA acetyltransferase
Gemmatimonas aurantiaca	100505	GAU_1060	putative beta-ketoadipyl-CoA thiolase
Geodermatophilus obscurus	13315	Gobs_3827	acetyl-CoA acetyltransferase
Gordonia aichiensis	108223	GOACH_04_04990	putative acetyl-CoA acetyltransferase
		GOACH_07_01160	beta-ketoadipyl-CoA thiolase
Gordonia alkanivorans	16433	GOALK_038_00790	putative acetyl-CoA acetyltransferase
		GOALK_047_00190	beta-ketoadipyl-CoA thiolase
		GOALK_092_00090	putative acetyl-CoA acetyltransferase
Gordonia amarae	15530	GOAMR_23_00120	putative acetyl-CoA acetyltransferase
		GOAMR_78_00290	beta-ketoadipyl-CoA thiolase
Gordonia amicalis	100051	GOAMI_26_00380	putative acetyl-CoA acetyltransferase
		GOAMI_40_00540	putative acetyl-CoA acetyltransferase
		GOAMI_53_00120	putative acetyl-CoA acetyltransferase
Gordonia araii	100433	GOARA_068_00030	acetyl-CoA acetyltransferase
Gordonia bronchialis	16047	Gbro_1524	acetyl-CoA acetyltransferase
		Gbro_4166	acetyl-CoA acetyltransferase
Gordonia effusa	100432	GOEFS_092_00490	putative acetyl-CoA acetyltransferase
Gordonia hirsuta	16056	GOHSU_26_00060	putative acetyl-CoA acetyltransferase
Gordonia namibiensis	108229	GONAM_23_00530	putative acetyl-CoA acetyltransferase
		GONAM_25_00240	beta-ketoadipyl-CoA thiolase
		GONAM_61_00670	putative acetyl-CoA acetyltransferase
Gordonia otitidis	100426	GOOTI_123_00380	putative acetyl-CoA acyltransferase
		GOOTI_253_00020	putative acetyl-CoA acetyltransferase
Gordonia polyisoprenivorans	16320	GOPIP_010_00520	putative acetyl-CoA acetyltransferase
		GOPIP_011_00690	beta-ketoadipyl-CoA thiolase
Gordonia rhizosphera	16068	GORHZ_113_00110	putative acetyl-CoA acetyltransferase
		GORHZ_193_00120	putative acetyl-CoA acetyltransferase
		GORHZ_209_00350	beta-ketoadipyl-CoA thiolase
Gordonia rubripertincta	101908	GORBP_060_00230	putative acetyl-CoA acetyltransferase
		GORBP_060_00700	beta-ketoadipyl-CoA thiolase
		GORBP_108_00300	beta-ketoadipyl-CoA thiolase
Gordonia sihwensis	108236	GSI01S_15_00280	putative acetyl-CoA acetyltransferase
		GSI01S_28_00300	beta-ketoadipyl-CoA thiolase
Gordonia soli	108243	GS4_08_00050	beta-ketoadipyl-CoA thiolase
Gordonia sputi	100414	GOSPT_045_01110	putative acetyl-CoA acetyltransferase
		GOSPT_141_00260	beta-ketoadipyl-CoA thiolase
Gordonia terrae	100016	GOTRE_125_00220	beta-ketoadipyl-CoA thiolase
Halomonas elongata	15536	HELO_3960	beta-ketoadipyl CoA thiolase
Hylemonella gracilis	14920	HGR_08769	beta-ketoadipyl CoA thiolase
Hyphomonas neptunium	14232	HNE_0959	beta-ketothiolase
Intrasporangium calvum	12989	Intca_0377	beta-ketoadipyl CoA thiolase
Kineosphaera limosa	100340	KILIM_018_00090	beta-ketoadipyl-CoA thiolase
Kitasatospora setae	14216	KSE_64490	putative 3-oxoadipyl-CoA thiolase
Klebsiella pneumoniae	14438	KPR_2770
		KPR_2865
Klebsiella pneumoniae subsp. rhinoscleromatis	105682	HMPREF0484_3061	beta-ketoadipyl CoA thiolase
		HMPREF0484_4170	beta-ketoadipyl CoA thiolase
Kocuria rhizophila	103217	KRH_02300	putative beta-ketoadipyl-CoA thiolase
Kordia algicida	100336	KAOT1_20542	enoyl-CoA hydratase
Kribbella flavida	14399	Kfla_6850	beta-ketoadipyl CoA thiolase
Ktedonobacter racemifer		Krac_12473	beta-ketoadipyl CoA thiolase
Kyrpidia tusciae	15312	Btus_1243	beta-ketoadipyl CoA thiolase
Kytococcus sedentarius	15357	Ksed_23240	acetyl-CoA acetyltransferase
Labrenzia aggregata	16684	SIAM614_04875	acetyl-CoA acetyltransferase
		SIAM614_11098	acetyl-CoA acetyltransferase
Magnetospirillum gryphiswaldense	15271	MGR_1906	beta-ketoadipyl CoA thiolase
Magnetospirillum magnetotacticum	15272	Magn03007820	COG0183: Acetyl-CoA acetyltransferase
Marinomonas mediterranea	103028	Marme_3635	beta-ketoadipyl CoA thiolase
Meiothermus ruber	106122	Mrub_1323	acetyl-CoA acetyltransferase
Meiothermus silvanus	106475	Mesil_2321	acetyl-CoA acetyltransferase
Micrococcus luteus	3333	Mlut_20220	beta-ketoadipyl CoA thiolase
Micromonospora aurantiaca	16155	Micau_1439	beta-ketoadipyl CoA thiolase
Nakamurella multipartita	105858	Namu_0875	beta-ketoadipyl CoA thiolase
Nitriliruptor alkaliphilus		NitalDRAFT_4772	acetyl-CoA C-acetyltransferase
Nocardiopsis dassonvillei	14626	Ndas_2485	acetyl-CoA acetyltransferase
Ochrobactrum anthropi	15819	Oant_3718	beta-ketoadipyl CoA thiolase
		Oant_4020	beta-ketoadipyl CoA thiolase
Ochrobactrum intermedium	15820	OINT_2000804	beta-ketoadipyl CoA thiolase
Paenibacillus alvei	3343	PAV_4c02980	beta-ketoadipyl-CoA thiolase PcaF
Phaeobacter gallaeciensis	16654	PGA1_c04090	beta-ketoadipyl-CoA thiolase PaaJ
Providencia alcalifaciens	105687	PROVALCAL_02758	beta-ketoadipyl CoA thiolase
Pseudomonas putida	100650	PP_1377	beta-ketoadipyl CoA thiolase PcaF
		PP_3280	beta-ketoadipyl CoA thiolase PhaD
Pseudomonas stutzeri	14165	PSTAB_1164	beta-ketoadipyl CoA thiolase
Renibacterium salmoninarum	15589	RSal33209_2690	3-ketoacyl-CoA thiolase
Rhizobium etli	15573	RHE_PE00203	beta-ketothiolase protein
Rhizobium sp.	101917	NGR_b21430	beta-ketoadipyl CoA thiolase PcaF
Rhizobium tropici	15247	RTCIAT899_PC07430	beta-ketoadipyl CoA thiolase
Rhodobacter sphaeroides	12203	RSP_3536	Thiolase
Rhodococcus erythropolis	100887	RER_52080	putative acetyl-CoA acyltransferase
		RER_52910	putative beta-ketoadipyl-CoA thiolase
Rhodococcus opacus	108011	ROP_10560	putative beta-ketoadipyl-CoA thiolase
		ROP_22440	acetyl-CoA acetyltransferase
		ROP_25860	beta-ketoadipyl-CoA thiolase
		ROP_27210	acetyl-CoA acetyltransferase
Rubrobacter xylanophilus	100952	Rxyl_1582	Acetyl-CoA C-acetyltransferase
Saccharomonospora azurea	14651	SacazDRAFT_04144	acetyl-CoA acetyltransferase
Saccharomonospora cyanea	14841	SaccyDRAFT_1536	acetyl-CoA acetyltransferase
Saccharomonospora glauca	14831	SacglDRAFT_01422	acetyl-CoA acetyltransferase
Saccharomonospora viridis	12207	Svir_13000	acetyl-CoA acetyltransferase
Saccharopolyspora erythraea	13426	SACE_4011	acetyl-CoA C-acetyltransferase
Saccharopolyspora spinosa	15153	SspiN1_010100028869	acetyl-CoA acetyltransferase
Saccharothrix espanaensis	15066	BN6_27580	Beta-ketoadipyl-CoA thiolase
Salinispora tropica	105044	Strop_1359	beta-ketoadipyl CoA thiolase
Serratia odorifera	102598	HMPREF0758_3090	beta-ketoadipyl CoA thiolase
Shimwellia blattae	105725	EB105725_19_00620	beta-ketoadipyl-CoA thiolase
		EB105725_23_00500	beta-ketoadipyl-CoA thiolase
Sphingobium sp.	103272	SLG_28040	beta-ketoadipyl-CoA thiolase
Sphingomonas wittichii	105917	Swit_0752	beta-ketoadipyl CoA thiolase
		Swit_4336	beta-ketoadipyl CoA thiolase
		Swit_4887	beta-ketoadipyl CoA thiolase
		Swit_5019	beta-ketoadipyl CoA thiolase
Sporichthya polymorpha	12702	Spopo_30_12460	Acetyl-CoA acetyltransferase
Streptomyces avermitilis	14893	SAV1604	putative beta-ketoadipyl-CoA thiolase
Streptomyces cattleya	14057	SCAT_0670	beta-ketoadipyl CoA thiolase
Streptomyces clavuligerus	13307	SCLAV_5504	beta-ketoadipyl-CoA thiolase
Streptomyces ghanaensis	15414	SSFG_00870	beta-ketoadipyl-CoA thiolase
		SSFG_01807	acetyl-CoA acetyltransferase
		SSFG_07165	beta-ketoadipyl-CoA thiolase
Streptomyces mobaraensis	13819	H340_23001	beta-ketoadipyl-CoA thiolase
Streptomyces pristinaespiralis	13074	SSDG_02060	acetyl-CoA acetyltransferase
Streptomyces purpureus	13925	STRPU_17_03110	3-ketoacyl-CoA thiolase @ Acetyl-CoA acetyltrans ferase
Streptomyces sviceus	13980	SSEG_03720	beta-ketoadipyl CoA thiolase
		SSEG_08943	beta-ketoadipyl CoA thiolase
Streptomyces venezuelae	13096	SVEN_6882	3-ketoacyl-CoA thiolase @ Acetyl-CoA acetyltransferase
Streptosporangium roseum	3776	Sros_7930	3-oxoadipyl-CoA thiolase
Thauera linaloolentis	102519	C666_06605	beta-ketoadipyl CoA thiolase
Thermobispora bispora	14880	Tbis_1802	acetyl-CoA acetyltransferase
Thermomonospora curvata	15933	Tcur_1860	acetyl-CoA acetyltransferase
Thermus thermophilus	101084	TTHA0987	beta-ketoadipyl CoA thiolase
Thermus thermophilus	101085	TT_C0623	beta-ketoadipyl CoA thiolase
Tsukamurella paurometabola	16120	Tpau_0619	acetyl-CoA acetyltransferase
Turicella otitidis	106139	HMPREF9719_01826	3-oxoadipyl-CoA thiolase
Zimmermannella faecalis	15706	G328_00785	hypothetical protein