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Rule : (Chloro)muconate cycloisomerase (CATB2)

Rule Description

ID NRULE_0053
Rule name CATB2
Created 2012-09-28
Protein name
Protein name
Full
(Chloro)muconate cycloisomerase
EC
EC 5.5.1.-
Gene name catB
Rule Trigger TIGRFAMs; TIGR02534; hit=1
Cross Reference
Gene Ontology
GO
GO:0018850, F:chloromuconate cycloisomerase activity, IEA:InterPro
GO:0030145, F:manganese ion binding, IEA:InterPro
GO:0018849, F:muconate cycloisomerase activity, IEA:EC
GO:0042952, P:beta-ketoadipate pathway, IEA:UniProtKB-UniPathway
GO:0019439, P:aromatic compound catabolic process, IEA:UniProtKB-
Phylogenomic databases
KO
K01860, -
Enzyme and pathway databases
UniPathway
UPA00157, UER00259
UPA00083, -
Family and domain databases
InterPro
IPR013370, Chloromuconate_cycloisomerase
IPR018110, Mandel_Rmase/mucon_lact_enz_CS
IPR013342, Mandelate_racemase_C
IPR013341, Mandelate_racemase_N
IPR001354, MR_MLE
Pfam
PF02746, MR_MLE_N, 1
SMART
SM00922, MR_MLE, 1
TIGRFAMs
TIGR02534, Mucon_cyclo, 1
PROSITE
PS00908, MR_MLE_1, 1
PS00909, MR_MLE_2, 1
Feature
P08310 Pseudomonas putida (Arthrobacter siderocapsulatus).
ACT_SITE171Proton acceptor.
ACT_SITE329Proton donor.
METAL200Manganese.
METAL226Manganese
METAL251Manganese
General annotation
Catalytic activity
2,5-dihydro-5-oxofuran-2-acetate = cis,cis- hexadienedioate
2-chloro-2,5-dihydro-5-oxofuran-2-acetate = 3-chloro-cis,cis-muconate
Cofactor
Mn (2+)
Pathway
Aromatic compound metabolism; beta-ketoadipate pathway; 5-oxo-4,5-dihydro-2-furylacetate from catechol: step 2/3
Aromatic compound metabolism; 3-chlorocatechol degradation.
Subunit structure
Homooctamer (By similarity)
Sequence similarities
Belongs to the mandelate racemase/muconate lactonizing enzyme family
Reference
P08310 Pseudomonas putida (Arthrobacter siderocapsulatus).
7500361
The refined X-ray structure of muconate lactonizing enzyme from Pseudomonas putida PRS2000 at 1.85 A resolution. (J Mol Biol. 1995)
P95608 Rhodococcus opacus (Nocardia opaca).
8990288
Characterization of catechol catabolic genes from Rhodococcus erythropolis 1CP. (J Bacteriol. 1997)
P05404 Cupriavidus pinatubonensis (strain JMP 134 / LMG 1197) (Ralstonia eutropha (strain JMP 134)).
15299479
Crystal structure of chloromuconate cycloisomerase from Alcaligenes eutrophus JMP134 (pJP4) at 3 A resolution. (Acta Crystallogr D Biol Crystallogr. 1994)



Related Function

Function name
Catechol degradation (beta-ketoadipate pathway)
Chlorocatechol degradation (beta-ketoadipate pathway)

CDS

Data Download
Scientific name NBRC No. CDS Product name
Acinetobacter radioresistens102413ACRAD_32_00690muconate cycloisomerase
Acinetobacter sp.100985ACT4_038_00490muconate cycloisomerase
Brevundimonas diminuta12697BDIM_06720muconate cycloisomerase 1-2
Corynebacterium ammoniagenes12612HMPREF0281_01042muconate and chloromuconate cycloisomerase
Corynebacterium callunae15359H924_10110chloromuconate cycloisomerase
Corynebacterium efficiens100395CE2303putative muconate cycloisomerase
Corynebacterium glutamicum12168Cgl2401O-succinylbenzoate synthase and related enzymes
Corynebacterium glutamicum12153KIQ_00495hypothetical protein
Cupriavidus metallidurans102507Rmet_4878muconate cycloisomerase
Enterobacter aerogenes13534EAE_19910muconate and chloromuconate cycloisomerase
Escherichia fergusonii102419EFER_1479Muconate cycloisomerase I (Cis,cis-muconate lactonizing enzyme I) (MLE)
Gordonia amarae15530GOAMR_33_01060muconate cycloisomerase
Labrenzia aggregata16684SIAM614_30761muconate cycloisomerase
Marinomonas mediterranea103028Marme_3630muconate and chloromuconate cycloisomerase
Pseudomonas putida100650PP_3715muconate cycloisomerase
Pseudomonas stutzeri14165PSTAB_1582muconate cycloisomerase
Rhodococcus erythropolis100887RER_54220muconate cycloisomerase
Rhodococcus opacus108011ROP_20860muconate cycloisomerase
Shimwellia blattae105725EB105725_23_00480muconate cycloisomerase
Sphingobium japonicum101211SJA_C1-21130(chloro)muconate cycloisomerase
SJA_C1-25200muconate cycloisomerase I
Sphingomonas wittichii105917Swit_0975muconate cycloisomerase