遺伝子 : Benzoate 1,2-dioxygenase electron transfer component (BENC)

遺伝子情報

ID	NRULE_0055
遺伝子ID	BENC
作成日	2012/09/26
タンパク質名	Protein name Full Benzoate 1,2-dioxygenase electron transfer component
遺伝子名	benC
遺伝子条件	PFAM; PF00970; hit=1ANDPFAM; PF00175; hit=1ANDPFAM; PF00111; hit=1ANDBLASTP; P07771; hit=1; score=740; pid=43
参照	Gene Ontology GO GO:0051537, F:2 iron, 2 sulfur cluster binding, IEA:UniProtKB-KW GO:0009055, F:electron carrier activity, IEA:InterPro GO:0008860, F:ferredoxin-NAD+ reductase activity, IEA:EC GO:0046872, F:metal ion binding, IEA:UniProtKB-KW GO:0042203, P:toluene catabolic process, IEA:UniProtKB-UniPathway Phylogenomic databases HOGENOM HOG000263663, - KO K05784, - ProtClustDB CLSK2329305, - Enzyme and pathway databases UniPathway UPA00273, - Family and domain databases InterPro IPR001041, 2Fe-2S_ferredoxin-type IPR006058, 2Fe2S_fd_BS IPR012675, Beta-grasp_dom IPR017927, Fd_Rdtase_FAD-bd IPR001709, Flavoprot_Pyr_Nucl_cyt_Rdtase IPR008333, OxRdtase_FAD-bd_dom IPR001433, OxRdtase_FAD/NAD-bd IPR001221, Phe_hydroxylase IPR017938, Riboflavin_synthase-like_b-brl Pfam PF00970, FAD_binding_6, 1 PF00111, Fer2, 1 PF00175, NAD_binding_1, 1 PRINTS PR00371, FPNCR PR00410, PHEHYDRXLASE PROSITE PS00197, 2FE2S_FER_1, 1 PS51085, 2FE2S_FER_2, 1 PS51384, FAD_FR, 1
配列の特徴	P07771 Acinetobacter baylyi (strain ATCC 33305 / BD413 / ADP1). METAL 51 Iron-sulfur (2Fe-2S). METAL 56 Iron-sulfur (2Fe-2S). METAL 59 Iron-sulfur (2Fe-2S). METAL 93 Iron-sulfur (2Fe-2S).
注釈	Function Electron transfer component of benzoate 1,2-dioxygenase system Catalytic activity Reduced ferredoxin + NAD(+) = oxidized ferredoxin + NADH Cofactor FAD Binds 1 [2Fe-2S] cluster per subunit Pathway Aromatic compound metabolism; benzoate degradation via hydroxylation; Subunit structure This dioxygenase system consists of three proteins: the two subunits of the hydroxylase component (BenA and BenB), and an electron transfer component (BenC) Sequence similarities Belongs to the bacterial ring-hydroxylating dioxygenase ferredoxin reductase family Contains 1 2Fe-2S ferredoxin-type domain Contains 1 FAD-binding FR-type domain
参考文献	P07771 Acinetobacter baylyi (strain ATCC 33305 / BD413 / ADP1). 1885518 Nucleotide sequences of the Acinetobacter calcoaceticus benABC genes for benzoate 1,2-dioxygenase reveal evolutionary relationships among multicomponent oxygenases. (J Bacteriol. 1991) 11673430 Cloning and characterization of benzoate catabolic genes in the gram-positive polychlorinated biphenyl degrader Rhodococcus sp. strain RHA1. (J Bacteriol. 2001)

関与する機能

機能名
Benzoate degradation (via hydroxylation by dioxygenase)

該当CDS

学名	NBRC番号	CDS	タンパク質名
Acinetobacter radioresistens	102413	ACRAD_20_00040	benzoate 1,2-dioxygenase reductase component
Acinetobacter sp.	100985	ACT4_038_00440	benzoate 1,2-dioxygenase reductase component
Corynebacterium ammoniagenes	12612	HMPREF0281_01037	oxidoreductase NAD-binding domain protein
Corynebacterium callunae	15359	H924_10130	benzoate 1,2-dioxygenase ferredoxin reductase subunit
Corynebacterium efficiens	100395	CE2307	putative benzoate 1,2-dioxygenase reductase
Corynebacterium glutamicum	12168	Cgl2406	2-polyprenylphenol hydroxylase and related flavodoxin oxidoreductases
Corynebacterium glutamicum	12153	KIQ_00475	benzoate 1,2-dioxygenase ferredoxin reductase subunit
Cupriavidus metallidurans	102507	Rmet_4884	benzoate 1,2-dioxygenase electron transfer component
Enterobacter aerogenes	13534	EAE_19885	2-chlorobenzoate 1,2-dioxygenase, electron transfer subunit
Escherichia fergusonii	102419	EFER_1484	benzoate 1,2-dioxygenase ferredoxin reductase subunit
Geodermatophilus obscurus	13315	Gobs_1299	Oxidoreductase FAD-binding domain protein
Gordonia aichiensis	108223	GOACH_07_01220	benzoate 1,2-dioxygenase reductase subunit/2-hydro-1,2-dihydroxybenzoate dehydrogenase
Gordonia alkanivorans	16433	GOALK_047_00140	benzoate 1,2-dioxygenase reductase component
Gordonia amicalis	100051	GOAMI_40_00490	hypothetical protein
Gordonia bronchialis	16047	Gbro_4160	oxidoreductase FAD/NAD(P)-binding domain protein
Gordonia namibiensis	108229	GONAM_25_00290	benzoate 1,2-dioxygenase reductase component/2-hydro-1,2-dihydroxybenzoate dehydrogenase
Gordonia polyisoprenivorans	16320	GOPIP_011_00750	benzoate 1,2-dioxygenase reductase component
Gordonia rhizosphera	16068	GORHZ_062_00810	benzoate 1,2-dioxygenase reductase component/2-hydro-1,2-dihydroxybenzoate dehydrogenase
Gordonia rubripertincta	101908	GORBP_060_00750	benzoate 1,2-dioxygenase reductase component/2-hydro-1,2-dihydroxybenzoate dehydrogenase
		GORBP_095_00090	benzoate 1,2-dioxygenase reductase component/2-hydro-1,2-dihydroxybenzoate dehydrogenase
Gordonia sihwensis	108236	GSI01S_28_00270	hypothetical protein
Gordonia sputi	100414	GOSPT_141_00310	benzoate 1,2-dioxygenase reductase component/2-hydro-1,2-dihydroxybenzoate dehydrogenase
Gordonia terrae	100016	GOTRE_125_00140	benzoate 1,2-dioxygenase reductase component/2-hydro-1,2-dihydroxybenzoate dehydrogenase
Klebsiella pneumoniae	14438	KPR_2934
Klebsiella pneumoniae subsp. rhinoscleromatis	105682	HMPREF0484_4609	oxidoreductase, FAD-binding protein
Marinomonas mediterranea	103028	Marme_1559	Ferredoxin--NAD(+) reductase
Pseudomonas putida	100650	PP_3163	benzoate dioxygenase, ferredoxin reductase component
Pseudomonas stutzeri	14165	PSTAB_1580	benzoate dioxygenase, ferredoxin reductase component
Rhodococcus opacus	108011	ROP_21000	benzoate 1,2-dioxygenase reductase component
Saccharomonospora cyanea	14841	SaccyDRAFT_1687	2-polyprenylphenol hydroxylase-like oxidoreductase
Saccharopolyspora erythraea	13426	SACE_4377	oxidoreductase FAD-binding region
Shimwellia blattae	105725	EB105725_23_00430	putative NADH oxidoreductase